SU563415A1 - Method of producing 2-(1-hydroxyethyl)-4.5.6.7-tetrahydroiso-(or methanoiso)indoles - Google Patents
Method of producing 2-(1-hydroxyethyl)-4.5.6.7-tetrahydroiso-(or methanoiso)indolesInfo
- Publication number
- SU563415A1 SU563415A1 SU7602318528A SU2318528A SU563415A1 SU 563415 A1 SU563415 A1 SU 563415A1 SU 7602318528 A SU7602318528 A SU 7602318528A SU 2318528 A SU2318528 A SU 2318528A SU 563415 A1 SU563415 A1 SU 563415A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- hydroxyethyl
- methanoiso
- tetrahydroiso
- indoles
- producing
- Prior art date
Links
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- Indole Compounds (AREA)
Description
Найдено, %: С 72,34; 72,29; Н 9,39; 9,38; N 7,94; 7,84.Found,%: C 72.34; 72.29; H 9.39; 9.38; N 7.94; 7.84.
CioHisNO.CioHisNO.
Вычислено, %: С 72,69; Н 9,15; N 8,48. ИК-спектр, см-: VOH 3400; ,- 1065; v пиррольного цикла 1555.Calculated,%: C, 72.69; H 9.15; N 8.48. IR spectrum, cm-: VOH 3400; , 1065; v pyrrole cycle 1555.
Пример 2. 5-Метил-2-{Г-оксиэтил)-4,5,6, 7-тетрагидроизоиндол.Example 2. 5-Methyl-2- {G-hydroxyethyl) -4,5,6, 7-tetrahydroisoindole.
Продукт получают и обрабатывают аналогично , исход из 15,2 г (0,076 моль) 5-метил1 ,3-диметоксиоктагидроизобензофурана, 9,1 г (0,15 моль) мопоэтаноламина и 40 мл проиионовой кислоты. Выдел ют фракцию с т. кип. 134-160°С/3 мм рт. ст., которую затем подвергают омылению в услови х опыта, описанных в примере 1 (40 мл метанола и 3,7 г едкого кали). Остаток после удалени метанола обрабатывают 150 мл воды.The product is obtained and processed in the same way, starting with 15.2 g (0.076 mol) of 5-methyl1, 3-dimethoxy-octagidro-isobenzofuran, 9.1 g (0.15 mol) of mopoethanolamine and 40 ml of proionic acid. The fraction with m.p. 134-160 ° C / 3 mm Hg. Art., which is then subjected to saponification under the conditions of experience described in example 1 (40 ml of methanol and 3.7 g of potassium hydroxide). The residue after removal of methanol is treated with 150 ml of water.
Выход 9,5 г (70%); т. кип. 149-152°С/6 мм рт. ст.; Ли 1,5320.Yield 9.5 g (70%); m.p. 149-152 ° C / 6 mm Hg. v .; Whether 1.5320.
Найдено, %: С 73,93; 73,62; Н 10,01; 9,45; N 8,14; 8,01.Found,%: C 73.93; 73.62; H 10.01; 9.45; N 8.14; 8.01.
CnHirNO.CnHirNO.
Вычислено, %: С 73,70; Н 9,56; N 7,81.Calculated,%: C 73.70; H 9.56; N 7.81.
ИК-спектр, Von 3400; Vc lr 1065; v пиррольного цикла 1555.IR Spectrum, Von 3400; Vc lr 1065; v pyrrole cycle 1555.
Пример 3. 2-(Г-Оксиэтил) - 4,5,6,7-тетрагидро-4 ,7-метаноизоиндол.Example 3. 2- (G-hydroxyethyl) - 4,5,6,7-tetrahydro-4, 7-methanoisoindole.
Продукт получают как в примере 1, исход из 2,4 г (0,012 моль) 1,3-диметоксиоктагидро4 ,7-метаноизобензофурана, 1, 5 г (0,024 моль) моноэтаноламина и 6 мл уксусной кислотыThe product is obtained as in Example 1, starting from 2.4 g (0.012 mol) of 1,3-dimethoxy-octahydro4, 7-methanoisobenzofuran, 1.5 g (0.024 mol) of monoethanolamine and 6 ml of acetic acid
После подщелачивани выпадает аморфный осадок, который раствор ют в эфире. Эфирный слой отдел ют и после удалени эфира остаток раствор ют в ацетоне (15 мл) и обрабатывают водой (30 мл). При этом выпадает осадок, который очищают от примесей омылением как описано в примере 1.After alkalinization, an amorphous precipitate is formed, which is dissolved in ether. The ether layer was separated and, after removing the ether, the residue was dissolved in acetone (15 ml) and treated with water (30 ml). When this occurs a precipitate, which is purified from impurities by saponification as described in example 1.
Выход 1,65 г (80%); т. ил. 106-110°С.The output of 1.65 g (80%); T. Il. 106-110 ° C.
Найдено, %: С 74,81; 74,42; Н 8,47; 8,39; N 7,52; 7,69.Found,%: C 74.81; 74.42; H 8.47; 8.39; N 7.52; 7,69.
Вычислено, %: С 74,54; Н 8,53; N 7,90.Calculated,%: C, 74.54; H 8.53; N 7.90.
CnHisNO.CnHisNO.
ИК-спектр, VOH 3400; vc-N-1065; v пирI рольного цикла 1565.IR Spectrum, VOH 3400; vc-N-1065; vpirololnogo cycle 1565.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU7602318528A SU563415A1 (en) | 1976-01-26 | 1976-01-26 | Method of producing 2-(1-hydroxyethyl)-4.5.6.7-tetrahydroiso-(or methanoiso)indoles |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU7602318528A SU563415A1 (en) | 1976-01-26 | 1976-01-26 | Method of producing 2-(1-hydroxyethyl)-4.5.6.7-tetrahydroiso-(or methanoiso)indoles |
Publications (1)
Publication Number | Publication Date |
---|---|
SU563415A1 true SU563415A1 (en) | 1977-06-30 |
Family
ID=20646967
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU7602318528A SU563415A1 (en) | 1976-01-26 | 1976-01-26 | Method of producing 2-(1-hydroxyethyl)-4.5.6.7-tetrahydroiso-(or methanoiso)indoles |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU563415A1 (en) |
-
1976
- 1976-01-26 SU SU7602318528A patent/SU563415A1/en active
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