SU561564A1 - The method of obtaining hemostatic material - Google Patents

The method of obtaining hemostatic material

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Publication number
SU561564A1
SU561564A1 SU939135A SU939135A SU561564A1 SU 561564 A1 SU561564 A1 SU 561564A1 SU 939135 A SU939135 A SU 939135A SU 939135 A SU939135 A SU 939135A SU 561564 A1 SU561564 A1 SU 561564A1
Authority
SU
USSR - Soviet Union
Prior art keywords
hemostatic material
thrombin
obtaining
blood
coagulation
Prior art date
Application number
SU939135A
Other languages
Russian (ru)
Inventor
Леонид Прокофьевич Истранов
Николай Владимирович Чернов
Анатолий Мизайлович Хилькин
Анатолий Борисович Шехтор
Владимир Леонович Леменев
Анатолий Федорович Дронов
Виктор Ефимович Багдатьев
Дмитрий Георгиевич Аракчеев
Виктор Филиппович Булк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to SU939135A priority Critical patent/SU561564A1/en
Application granted granted Critical
Publication of SU561564A1 publication Critical patent/SU561564A1/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)

Description

1one

Изобретение относитс  к области медицины , а именно, к фармакологии и способам изготовлени  лекарственных препаратов.The invention relates to the field of medicine, namely, to pharmacology and methods for the manufacture of medicaments.

Известен способ получени  гемостатической губки фибриновой (1) путем вспенивани  и лиофильного высушивани  крови донора с добавлением в нее тромбина и других веществ с целью повышени  гемостатических свойств.A known method for producing a fibrin sponge (1) hemostatic sponge by foaming and freeze-drying the blood of a donor with the addition of thrombin and other substances to it in order to improve hemostatic properties.

Однако полученна  этим способом гемостатическа  губка обладает низкой адсорбционной способностью и не обеспечивает быстрое впитывание и свертывание крови.However, the hemostatic sponge obtained by this method has a low adsorption capacity and does not provide rapid absorption and coagulation of blood.

Целью изобретени   вл етс  увеличение адсорбционной способности и ускорение впитывани  и свертывани  крови.The aim of the invention is to increase the adsorption capacity and accelerate the absorption and coagulation of blood.

По предлагаемому способу коллаген обрабатывают тромбином и затем ввод т антибиотики , например биомицин.In the proposed method, the collagen is treated with thrombin and then antibiotics, for example, biomycin, are administered.

Способ осуществл ют следующим образом.The method is carried out as follows.

Дл  получени  гемостатического материала - пеноколла используют кислые или нейтральные дисперсии коллагена, полученные после интенсивной щелочно-солевой обрабогки из кожи и сухожилий животных.Acid or neutral dispersions of collagen obtained after intensive alkali-salt treatment of the skin and tendons of animals are used to obtain a hemostatic material - penocoll.

Пример 1. 1 кг дисперсии с концентрацией 0,5-3% и рН 2,5-9.0 разливают в кюветы. Дисперсию в кюветах замораживают при температуре - (20-150)С и подвергают сушке в вакууме в течение 12-24 ч. После высушивани  материал готов к употреблению.Example 1. 1 kg of dispersion with a concentration of 0.5-3% and a pH of 2.5-9.0 is poured into cuvettes. Dispersion in cuvettes is frozen at a temperature of - (20-150) C and dried in vacuum for 12-24 hours. After drying, the material is ready for use.

Пример 2. К 1 кг дисперсии с концентрацией 0,5-3% ц рН 2,5-9,0 добавл ют при перемешивании 1-5 млн. ед. стрептомицина и 1-3 млк. ед. тетрациклина или биомицина. Смесь с антибиотиками перемешивают в течение 10-20 мин, после чего в смесь добавл ют 0,01 - 0,1 г тромбина, растворенного в 20 мл дистиллированной воды. После перемешивани  смесь выдерживают при температуре 20-25°С в течение 20-40 мин и разливают в кюветы. Последующие операции апалогичны, описанным в примере 1.Example 2. To 1 kg of a dispersion with a concentration of 0.5–3%, pH 2.5–9.0, 1–5 million units are added with stirring. Streptomycin and 1-3 ml. units tetracycline or biomycin. The mixture with antibiotics is stirred for 10-20 minutes, after which 0.01-0.1 g of thrombin dissolved in 20 ml of distilled water is added to the mixture. After stirring, the mixture is maintained at a temperature of 20-25 ° C for 20-40 minutes and poured into cuvettes. Subsequent operations are similar to those described in example 1.

Полученный гемостатический материал представл ет собой пористую губку, больша  адсорбционна  поверхность, гидрофильность и капилл рность которой вызывают быстрое впитывание и свертывание крови. Паличие в его составе антибиотиков обеспечивает антибактсрпальность материала.The resulting hemostatic material is a porous sponge, a large adsorption surface, the hydrophilicity and capillaryity of which cause rapid absorption and coagulation of blood. The effect of antibiotics in its composition ensures the antibacterial effect of the material.

Claims (1)

Формула изобретен и  Formula invented and Способ получени  гемостатического материала путем обработки биополимера тромбином и лиофильным высушиванием, отличающийс  тем, что, с целью увеличени  адсорбi .uioijiioii способности и ускорени  впитывани  и свертывани  крови, тромбином обрабатывают коллаген и затем ввод т антибиотики, например биОМИЩП. 3 Источники информации, прин тые во внимание при экспертизе: 1. Авторское свидетельство ° 83093, МКИ А 61К 37/00, 1949.A method of obtaining a hemostatic material by treating the biopolymer with thrombin and freeze drying, characterized in that, in order to increase the adsorption capacity of the .uioijiioii and accelerate the absorption and coagulation of blood, collagen is thrombin treated and then antibiotics, for example biomeschp, are administered. 3 Sources of information taken into account during the examination: 1. Copyright certificate ° 83093, MKI A 61K 37/00, 1949.
SU939135A 1965-01-22 1965-01-22 The method of obtaining hemostatic material SU561564A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU939135A SU561564A1 (en) 1965-01-22 1965-01-22 The method of obtaining hemostatic material

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU939135A SU561564A1 (en) 1965-01-22 1965-01-22 The method of obtaining hemostatic material

Publications (1)

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SU561564A1 true SU561564A1 (en) 1977-06-15

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SU (1) SU561564A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0145970A2 (en) * 1983-11-16 1985-06-26 Seton Company Collagen-thrombin compositions
US4913904A (en) * 1985-06-19 1990-04-03 Fyodorov Svyatoslav N Ophthalmological collagen coverings
WO1998031403A1 (en) * 1997-01-16 1998-07-23 Cohesion Corporation Lyophilized collagen-based biomaterials, process of preparation and uses thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0145970A2 (en) * 1983-11-16 1985-06-26 Seton Company Collagen-thrombin compositions
US4913904A (en) * 1985-06-19 1990-04-03 Fyodorov Svyatoslav N Ophthalmological collagen coverings
WO1998031403A1 (en) * 1997-01-16 1998-07-23 Cohesion Corporation Lyophilized collagen-based biomaterials, process of preparation and uses thereof
AU716137B2 (en) * 1997-01-16 2000-02-17 Cohesion Corporation Lyophilized collagen-based biomaterials, process of preparation and uses thereof

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