SU561564A1 - The method of obtaining hemostatic material - Google Patents
The method of obtaining hemostatic materialInfo
- Publication number
- SU561564A1 SU561564A1 SU939135A SU939135A SU561564A1 SU 561564 A1 SU561564 A1 SU 561564A1 SU 939135 A SU939135 A SU 939135A SU 939135 A SU939135 A SU 939135A SU 561564 A1 SU561564 A1 SU 561564A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- hemostatic material
- thrombin
- obtaining
- blood
- coagulation
- Prior art date
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Description
1one
Изобретение относитс к области медицины , а именно, к фармакологии и способам изготовлени лекарственных препаратов.The invention relates to the field of medicine, namely, to pharmacology and methods for the manufacture of medicaments.
Известен способ получени гемостатической губки фибриновой (1) путем вспенивани и лиофильного высушивани крови донора с добавлением в нее тромбина и других веществ с целью повышени гемостатических свойств.A known method for producing a fibrin sponge (1) hemostatic sponge by foaming and freeze-drying the blood of a donor with the addition of thrombin and other substances to it in order to improve hemostatic properties.
Однако полученна этим способом гемостатическа губка обладает низкой адсорбционной способностью и не обеспечивает быстрое впитывание и свертывание крови.However, the hemostatic sponge obtained by this method has a low adsorption capacity and does not provide rapid absorption and coagulation of blood.
Целью изобретени вл етс увеличение адсорбционной способности и ускорение впитывани и свертывани крови.The aim of the invention is to increase the adsorption capacity and accelerate the absorption and coagulation of blood.
По предлагаемому способу коллаген обрабатывают тромбином и затем ввод т антибиотики , например биомицин.In the proposed method, the collagen is treated with thrombin and then antibiotics, for example, biomycin, are administered.
Способ осуществл ют следующим образом.The method is carried out as follows.
Дл получени гемостатического материала - пеноколла используют кислые или нейтральные дисперсии коллагена, полученные после интенсивной щелочно-солевой обрабогки из кожи и сухожилий животных.Acid or neutral dispersions of collagen obtained after intensive alkali-salt treatment of the skin and tendons of animals are used to obtain a hemostatic material - penocoll.
Пример 1. 1 кг дисперсии с концентрацией 0,5-3% и рН 2,5-9.0 разливают в кюветы. Дисперсию в кюветах замораживают при температуре - (20-150)С и подвергают сушке в вакууме в течение 12-24 ч. После высушивани материал готов к употреблению.Example 1. 1 kg of dispersion with a concentration of 0.5-3% and a pH of 2.5-9.0 is poured into cuvettes. Dispersion in cuvettes is frozen at a temperature of - (20-150) C and dried in vacuum for 12-24 hours. After drying, the material is ready for use.
Пример 2. К 1 кг дисперсии с концентрацией 0,5-3% ц рН 2,5-9,0 добавл ют при перемешивании 1-5 млн. ед. стрептомицина и 1-3 млк. ед. тетрациклина или биомицина. Смесь с антибиотиками перемешивают в течение 10-20 мин, после чего в смесь добавл ют 0,01 - 0,1 г тромбина, растворенного в 20 мл дистиллированной воды. После перемешивани смесь выдерживают при температуре 20-25°С в течение 20-40 мин и разливают в кюветы. Последующие операции апалогичны, описанным в примере 1.Example 2. To 1 kg of a dispersion with a concentration of 0.5–3%, pH 2.5–9.0, 1–5 million units are added with stirring. Streptomycin and 1-3 ml. units tetracycline or biomycin. The mixture with antibiotics is stirred for 10-20 minutes, after which 0.01-0.1 g of thrombin dissolved in 20 ml of distilled water is added to the mixture. After stirring, the mixture is maintained at a temperature of 20-25 ° C for 20-40 minutes and poured into cuvettes. Subsequent operations are similar to those described in example 1.
Полученный гемостатический материал представл ет собой пористую губку, больша адсорбционна поверхность, гидрофильность и капилл рность которой вызывают быстрое впитывание и свертывание крови. Паличие в его составе антибиотиков обеспечивает антибактсрпальность материала.The resulting hemostatic material is a porous sponge, a large adsorption surface, the hydrophilicity and capillaryity of which cause rapid absorption and coagulation of blood. The effect of antibiotics in its composition ensures the antibacterial effect of the material.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU939135A SU561564A1 (en) | 1965-01-22 | 1965-01-22 | The method of obtaining hemostatic material |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU939135A SU561564A1 (en) | 1965-01-22 | 1965-01-22 | The method of obtaining hemostatic material |
Publications (1)
Publication Number | Publication Date |
---|---|
SU561564A1 true SU561564A1 (en) | 1977-06-15 |
Family
ID=20438187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU939135A SU561564A1 (en) | 1965-01-22 | 1965-01-22 | The method of obtaining hemostatic material |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU561564A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0145970A2 (en) * | 1983-11-16 | 1985-06-26 | Seton Company | Collagen-thrombin compositions |
US4913904A (en) * | 1985-06-19 | 1990-04-03 | Fyodorov Svyatoslav N | Ophthalmological collagen coverings |
WO1998031403A1 (en) * | 1997-01-16 | 1998-07-23 | Cohesion Corporation | Lyophilized collagen-based biomaterials, process of preparation and uses thereof |
-
1965
- 1965-01-22 SU SU939135A patent/SU561564A1/en active
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0145970A2 (en) * | 1983-11-16 | 1985-06-26 | Seton Company | Collagen-thrombin compositions |
US4913904A (en) * | 1985-06-19 | 1990-04-03 | Fyodorov Svyatoslav N | Ophthalmological collagen coverings |
WO1998031403A1 (en) * | 1997-01-16 | 1998-07-23 | Cohesion Corporation | Lyophilized collagen-based biomaterials, process of preparation and uses thereof |
AU716137B2 (en) * | 1997-01-16 | 2000-02-17 | Cohesion Corporation | Lyophilized collagen-based biomaterials, process of preparation and uses thereof |
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