RU2067448C1 - Method of preparing hemostatic fibrin paste - Google Patents

Method of preparing hemostatic fibrin paste Download PDF

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Publication number
RU2067448C1
RU2067448C1 RU92001958A RU92001958A RU2067448C1 RU 2067448 C1 RU2067448 C1 RU 2067448C1 RU 92001958 A RU92001958 A RU 92001958A RU 92001958 A RU92001958 A RU 92001958A RU 2067448 C1 RU2067448 C1 RU 2067448C1
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Russia
Prior art keywords
fibrin
paste
blood
fibrin paste
human
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RU92001958A
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Russian (ru)
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RU92001958A (en
Inventor
Валентин Александрович Фигурнов
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Валентин Александрович Фигурнов
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Priority to RU92001958A priority Critical patent/RU2067448C1/en
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Abstract

FIELD: medicine, pharmacy. SUBSTANCE: method involves the use of human or animal (pig) fibrin from blood clot. New aspect: part of fibrin powder from blood clot is dissolved in glycerol at 50 C for 48 hr. Proposed fibrin paste is used for external application. EFFECT: preparing fibrin paste indicated above.

Description

Изобретение относится к медицине, в частности к биотехнологии и касается поиска получения новых лекарственных препаратов из крови человека и животных. The invention relates to medicine, in particular to biotechnology, and for the search for new drugs from human and animal blood.

Известны способы получения гемостатической фибринной губки из крови человека путем обработки плазмы крови тромбопластином (см. М.Д. Машковский. Лекарственные средства. Москва. Медицина. 1984, с. 82) либо путем обработки вспениваемой смеси сухой плазмы и сыворотки крови гемотромбопластиком мозговой ткани (см. "Способ получения гемостатической фибринной губки", авт. св. СССР, N 83098, 1949, А 61 К 35/16). Known methods for producing hemostatic fibrin sponges from human blood by treating blood plasma with thromboplastin (see M.D. Mashkovsky. Medicines. Moscow. Medicine. 1984, p. 82) or by treating a foamable mixture of dry plasma and blood serum with hemothromboplasty of brain tissue ( see "A method for producing a hemostatic fibrin sponge", ed. St. USSR, N 83098, 1949, A 61 K 35/16).

Однако вышеперечисленные способы основаны на использовании плазмы или сыворотки крови и тромбопластина и после обработки не содержат естественного конечного продукта свертывания крови фибрина сгустка. However, the above methods are based on the use of plasma or blood serum and thromboplastin and, after processing, do not contain the natural final product of blood coagulation of fibrin clot.

Целью настоящего изобретения является разработка способа получения препарата для наружного применения, содержащего конечный продукт свертывания крови фибрин сгустка крови. The aim of the present invention is to develop a method for producing a preparation for external use, containing the final product of blood coagulation fibrin blood clot.

Цель достигается следующим образом. The goal is achieved as follows.

Порошок фибрина сгустка крови человека или животного помещают в глицерин (1 г порошка на 10 мл глицерина) и ставят в термостат при температуре 50oC на 48 часов. За это время от 8 до 15% порошка растворяется в глицерине у животных (домашняя свинья) 8-12% у доноров человека 12-15%
Характеристика конечного продукта.
The fibrin powder of a human or animal blood clot is placed in glycerin (1 g of powder per 10 ml of glycerin) and placed in a thermostat at a temperature of 50 o C for 48 hours. During this time, from 8 to 15% of the powder is dissolved in glycerin in animals (domestic pig) 8-12% in human donors 12-15%
The characteristics of the final product.

Растворенный в глицерине фибрин сгустка крови человека или животных представляет собой тягучую жидкость, коричневатого цвета с запахом порошка фибрина, хорошо втираемую в кожу без каких-либо неприятных ощущений. Полученная композиция хорошо сохраняется длительное время (до 3-х лет), при температуре +4o- +7o без потери своих физических свойств (прозрачности, цвета, запаха).The fibrin of human or animal blood clot dissolved in glycerin is a viscous liquid, brownish with the smell of fibrin powder, rubbed well into the skin without any unpleasant sensations. The resulting composition is well preserved for a long time (up to 3 years), at a temperature of +4 o - +7 o without losing its physical properties (transparency, color, smell).

Claims (1)

Способ получения гемостатической фибринной пасты путем обработки фибрина сгустка крови, отличающийся тем, что при температуре 50oС в течение 48 ч 8 15% порошка фибрина растворяют в глицерине.A method of obtaining a hemostatic fibrin paste by treating fibrin of a blood clot, characterized in that at a temperature of 50 ° C. for 48 hours, 8 15% fibrin powder is dissolved in glycerol.
RU92001958A 1992-10-23 1992-10-23 Method of preparing hemostatic fibrin paste RU2067448C1 (en)

Priority Applications (1)

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RU92001958A RU2067448C1 (en) 1992-10-23 1992-10-23 Method of preparing hemostatic fibrin paste

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Application Number Priority Date Filing Date Title
RU92001958A RU2067448C1 (en) 1992-10-23 1992-10-23 Method of preparing hemostatic fibrin paste

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RU92001958A RU92001958A (en) 1995-05-20
RU2067448C1 true RU2067448C1 (en) 1996-10-10

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120003279A1 (en) * 2006-10-17 2012-01-05 Carnegie Mellon University, a Pennsylvania corporation Methods and Apparatus for Manufacturing Plasma Based Plastics and Bioplastics Produced Therefrom
US8529956B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
RU2602301C1 (en) * 2015-12-08 2016-11-20 Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Амурская Государственная Медицинская Академия" Министерства Здравоохранения Российской Федерации Method for preparing fibrin paste

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2483076C1 (en) * 2011-09-21 2013-05-27 Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Амурская Государственная Медицинская Академия Минздравсоцразвития Российской Федерации" Method for preparing fibrin paste

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Авторское свидетельство СССР N 83093, кл. A 61 K 35/16, 1949. *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8529956B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8529960B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US20120003279A1 (en) * 2006-10-17 2012-01-05 Carnegie Mellon University, a Pennsylvania corporation Methods and Apparatus for Manufacturing Plasma Based Plastics and Bioplastics Produced Therefrom
US8529961B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8529959B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8529958B2 (en) * 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8911789B2 (en) 2006-10-17 2014-12-16 Carnegie Mellon University Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US9364503B2 (en) 2006-10-17 2016-06-14 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
RU2602301C1 (en) * 2015-12-08 2016-11-20 Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Амурская Государственная Медицинская Академия" Министерства Здравоохранения Российской Федерации Method for preparing fibrin paste

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