RU2067448C1 - Method of preparing hemostatic fibrin paste - Google Patents
Method of preparing hemostatic fibrin paste Download PDFInfo
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- RU2067448C1 RU2067448C1 RU92001958A RU92001958A RU2067448C1 RU 2067448 C1 RU2067448 C1 RU 2067448C1 RU 92001958 A RU92001958 A RU 92001958A RU 92001958 A RU92001958 A RU 92001958A RU 2067448 C1 RU2067448 C1 RU 2067448C1
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- fibrin
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- blood
- fibrin paste
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Abstract
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Изобретение относится к медицине, в частности к биотехнологии и касается поиска получения новых лекарственных препаратов из крови человека и животных. The invention relates to medicine, in particular to biotechnology, and for the search for new drugs from human and animal blood.
Известны способы получения гемостатической фибринной губки из крови человека путем обработки плазмы крови тромбопластином (см. М.Д. Машковский. Лекарственные средства. Москва. Медицина. 1984, с. 82) либо путем обработки вспениваемой смеси сухой плазмы и сыворотки крови гемотромбопластиком мозговой ткани (см. "Способ получения гемостатической фибринной губки", авт. св. СССР, N 83098, 1949, А 61 К 35/16). Known methods for producing hemostatic fibrin sponges from human blood by treating blood plasma with thromboplastin (see M.D. Mashkovsky. Medicines. Moscow. Medicine. 1984, p. 82) or by treating a foamable mixture of dry plasma and blood serum with hemothromboplasty of brain tissue ( see "A method for producing a hemostatic fibrin sponge", ed. St. USSR, N 83098, 1949, A 61 K 35/16).
Однако вышеперечисленные способы основаны на использовании плазмы или сыворотки крови и тромбопластина и после обработки не содержат естественного конечного продукта свертывания крови фибрина сгустка. However, the above methods are based on the use of plasma or blood serum and thromboplastin and, after processing, do not contain the natural final product of blood coagulation of fibrin clot.
Целью настоящего изобретения является разработка способа получения препарата для наружного применения, содержащего конечный продукт свертывания крови фибрин сгустка крови. The aim of the present invention is to develop a method for producing a preparation for external use, containing the final product of blood coagulation fibrin blood clot.
Цель достигается следующим образом. The goal is achieved as follows.
Порошок фибрина сгустка крови человека или животного помещают в глицерин (1 г порошка на 10 мл глицерина) и ставят в термостат при температуре 50oC на 48 часов. За это время от 8 до 15% порошка растворяется в глицерине у животных (домашняя свинья) 8-12% у доноров человека 12-15%
Характеристика конечного продукта.The fibrin powder of a human or animal blood clot is placed in glycerin (1 g of powder per 10 ml of glycerin) and placed in a thermostat at a temperature of 50 o C for 48 hours. During this time, from 8 to 15% of the powder is dissolved in glycerin in animals (domestic pig) 8-12% in human donors 12-15%
The characteristics of the final product.
Растворенный в глицерине фибрин сгустка крови человека или животных представляет собой тягучую жидкость, коричневатого цвета с запахом порошка фибрина, хорошо втираемую в кожу без каких-либо неприятных ощущений. Полученная композиция хорошо сохраняется длительное время (до 3-х лет), при температуре +4o- +7o без потери своих физических свойств (прозрачности, цвета, запаха).The fibrin of human or animal blood clot dissolved in glycerin is a viscous liquid, brownish with the smell of fibrin powder, rubbed well into the skin without any unpleasant sensations. The resulting composition is well preserved for a long time (up to 3 years), at a temperature of +4 o - +7 o without losing its physical properties (transparency, color, smell).
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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RU92001958A RU2067448C1 (en) | 1992-10-23 | 1992-10-23 | Method of preparing hemostatic fibrin paste |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU92001958A RU2067448C1 (en) | 1992-10-23 | 1992-10-23 | Method of preparing hemostatic fibrin paste |
Publications (2)
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RU92001958A RU92001958A (en) | 1995-05-20 |
RU2067448C1 true RU2067448C1 (en) | 1996-10-10 |
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RU92001958A RU2067448C1 (en) | 1992-10-23 | 1992-10-23 | Method of preparing hemostatic fibrin paste |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120003279A1 (en) * | 2006-10-17 | 2012-01-05 | Carnegie Mellon University, a Pennsylvania corporation | Methods and Apparatus for Manufacturing Plasma Based Plastics and Bioplastics Produced Therefrom |
US8529956B2 (en) | 2002-03-18 | 2013-09-10 | Carnell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
RU2602301C1 (en) * | 2015-12-08 | 2016-11-20 | Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Амурская Государственная Медицинская Академия" Министерства Здравоохранения Российской Федерации | Method for preparing fibrin paste |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2483076C1 (en) * | 2011-09-21 | 2013-05-27 | Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Амурская Государственная Медицинская Академия Минздравсоцразвития Российской Федерации" | Method for preparing fibrin paste |
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1992
- 1992-10-23 RU RU92001958A patent/RU2067448C1/en active
Non-Patent Citations (1)
Title |
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Авторское свидетельство СССР N 83093, кл. A 61 K 35/16, 1949. * |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8529956B2 (en) | 2002-03-18 | 2013-09-10 | Carnell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
US8529960B2 (en) | 2002-03-18 | 2013-09-10 | Carnell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
US20120003279A1 (en) * | 2006-10-17 | 2012-01-05 | Carnegie Mellon University, a Pennsylvania corporation | Methods and Apparatus for Manufacturing Plasma Based Plastics and Bioplastics Produced Therefrom |
US8529961B2 (en) | 2006-10-17 | 2013-09-10 | Carmell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
US8529959B2 (en) | 2006-10-17 | 2013-09-10 | Carmell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
US8529958B2 (en) * | 2006-10-17 | 2013-09-10 | Carmell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
US8911789B2 (en) | 2006-10-17 | 2014-12-16 | Carnegie Mellon University | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
US9364503B2 (en) | 2006-10-17 | 2016-06-14 | Carmell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
RU2602301C1 (en) * | 2015-12-08 | 2016-11-20 | Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Амурская Государственная Медицинская Академия" Министерства Здравоохранения Российской Федерации | Method for preparing fibrin paste |
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