SU530683A1 - Спазмолитическое средство "феникаберан - Google Patents
Спазмолитическое средство "феникаберанInfo
- Publication number
- SU530683A1 SU530683A1 SU1764901A SU1764901A SU530683A1 SU 530683 A1 SU530683 A1 SU 530683A1 SU 1764901 A SU1764901 A SU 1764901A SU 1764901 A SU1764901 A SU 1764901A SU 530683 A1 SU530683 A1 SU 530683A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- phenicaberan
- antispasmodic
- solution
- day
- drug
- Prior art date
Links
- 230000002921 anti-spasmodic effect Effects 0.000 title claims description 5
- 239000000812 cholinergic antagonist Substances 0.000 title claims description 3
- JXUHSUSCLWIKEW-UHFFFAOYSA-N 4-[(dimethylazaniumyl)methyl]-3-ethoxycarbonyl-2-phenyl-1-benzofuran-5-olate Chemical compound O1C2=CC=C(O)C(CN(C)C)=C2C(C(=O)OCC)=C1C1=CC=CC=C1 JXUHSUSCLWIKEW-UHFFFAOYSA-N 0.000 title description 8
- 239000003814 drug Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- -1 hydrochloride-2-phenyl-3-carbethoxy-4-dimethylaminomethyl-5-hydroxybenzofuran hydrochloride Chemical compound 0.000 claims 1
- 230000008676 import Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 description 8
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 description 4
- 206010052895 Coronary artery insufficiency Diseases 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000001148 spastic effect Effects 0.000 description 3
- 229930008281 A03AD01 - Papaverine Natural products 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 208000007107 Stomach Ulcer Diseases 0.000 description 2
- 230000003444 anaesthetic effect Effects 0.000 description 2
- 201000001352 cholecystitis Diseases 0.000 description 2
- 201000001883 cholelithiasis Diseases 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 229960001789 papaverine Drugs 0.000 description 2
- OBTUDMCEULZBKV-UHFFFAOYSA-N (3-ethoxycarbonyl-5-hydroxy-2-phenyl-1-benzofuran-4-yl)methyl-dimethylazanium;chloride Chemical compound [Cl-].O1C2=CC=C(O)C(C[NH+](C)C)=C2C(C(=O)OCC)=C1C1=CC=CC=C1 OBTUDMCEULZBKV-UHFFFAOYSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010017826 Gastric ulcer haemorrhage Diseases 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 235000011096 Papaver Nutrition 0.000 description 1
- 240000001090 Papaver somniferum Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- PPWHTZKZQNXVAE-UHFFFAOYSA-N Tetracaine hydrochloride Chemical compound Cl.CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 PPWHTZKZQNXVAE-UHFFFAOYSA-N 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 206010000891 acute myocardial infarction Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- WZZJQHPNLFLEMB-UHFFFAOYSA-N ethyl 5-hydroxy-2-phenyl-1-benzofuran-3-carboxylate Chemical compound O1C2=CC=C(O)C=C2C(C(=O)OCC)=C1C1=CC=CC=C1 WZZJQHPNLFLEMB-UHFFFAOYSA-N 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229940053973 novocaine Drugs 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1764901A SU530683A1 (ru) | 1972-04-06 | 1972-04-06 | Спазмолитическое средство "феникаберан |
| GB1381673A GB1406907A (en) | 1972-04-06 | 1973-03-22 | Pharmaceutically active compound |
| DE2316620A DE2316620C2 (de) | 1972-04-06 | 1973-04-03 | Arzneimittel mit spasmolytischer und koronarerweiternder Wirkung |
| FR7312340A FR2182938B1 (cs) | 1972-04-06 | 1973-04-05 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1764901A SU530683A1 (ru) | 1972-04-06 | 1972-04-06 | Спазмолитическое средство "феникаберан |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU530683A1 true SU530683A1 (ru) | 1976-10-05 |
Family
ID=20508233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1764901A SU530683A1 (ru) | 1972-04-06 | 1972-04-06 | Спазмолитическое средство "феникаберан |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE2316620C2 (cs) |
| FR (1) | FR2182938B1 (cs) |
| GB (1) | GB1406907A (cs) |
| SU (1) | SU530683A1 (cs) |
-
1972
- 1972-04-06 SU SU1764901A patent/SU530683A1/ru active
-
1973
- 1973-03-22 GB GB1381673A patent/GB1406907A/en not_active Expired
- 1973-04-03 DE DE2316620A patent/DE2316620C2/de not_active Expired
- 1973-04-05 FR FR7312340A patent/FR2182938B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1406907A (en) | 1975-09-17 |
| DE2316620A1 (de) | 1973-10-11 |
| FR2182938B1 (cs) | 1976-04-09 |
| FR2182938A1 (cs) | 1973-12-14 |
| DE2316620C2 (de) | 1982-10-21 |
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