SU490285A3 - Method for preparing amidophenyl isothiourea derivatives - Google Patents
Method for preparing amidophenyl isothiourea derivativesInfo
- Publication number
- SU490285A3 SU490285A3 SU1966532A SU1966532A SU490285A3 SU 490285 A3 SU490285 A3 SU 490285A3 SU 1966532 A SU1966532 A SU 1966532A SU 1966532 A SU1966532 A SU 1966532A SU 490285 A3 SU490285 A3 SU 490285A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- amidophenyl
- preparing
- isothiourea derivatives
- alkyl
- isothiourea
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/38—Isothioureas containing any of the groups, X being a hetero atom, Y being any atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Furan Compounds (AREA)
Description
1one
Изобретение отпоситс к области получени производных амидофенилизотиомочевины общей формулы IThe invention relates to the field of producing amidophenyl isothiourea derivatives of general formula I
SRSR
N-C-NH-СООБ/ I NH-CORгде X - алкил Ci-Се;N-C-NH-MNB / I NH-COR, where X is Ci-Ce alkyl;
R - алкил-Ci-Ci2, циклоалкил-Ci-Cs, алкенил , содержащий до 12 атомов углерода, аралкил иезамещешшхй или замещенный в арильпой части галоген-, алкил-Ci-С. или алкоксигруппой с R is alkyl-Ci-Ci2, cycloalkyl-Ci-Cs, alkenyl containing up to 12 carbon atoms, aralkyl or substituted, or substituted in the aryl part, halogen-, alkyl-Ci-C. or alkoxy with
R - алкил-Ci-С4;R is alkyl-Ci-C4;
R2-водород с Ci-Ci8 незамещенный или замещенный галоген-, циан-, алкокси-Ci-С.ь алкоксикарбонил-Са-Cs, фенокси-, галогенфенокси- , алкилфенокси-, алкоксифеноксигруппой , циклоалкил-Сб-Cs, аралкил незамещенный или замещенный галоген-, алкилCi-€4 или алкоксигруппой с Ci-C.i, а 1-фурил, которые обладают антигельментным действием.R2-hydrogen with Ci-Ci8 unsubstituted or substituted halogen, cyano, alkoxy-Ci-C halogen-, alkyl-Ci- € 4 or alkoxy with Ci-Ci, and 1-furyl, which have an anti-gel action.
Соединени предложенного способа получены известным аналоговым методом, одпакоThe compounds of the proposed method are obtained by a known analog method,
использование соответствзющих исходных реагентов .позвол ет получать новые соединени с улучшенными свойствами по сравнепию с известными.The use of appropriate starting materials allows the preparation of new compounds with improved properties in comparison with the known ones.
Способ, согласно изобретению, заключаетс в том, что тпомочевины общей формулы IIThe method according to the invention is that the urea of the general formula II
- H- :--KH-COOR - H-: - KH-COOR
XX
ll -N И-С О Tiгде X, R1 11 R- имеют вышеуказанные значени , подвергают взаимодействию в среде пол рного растворител при температуре от -10 до -г40°С с эквимол рным количеством алкплирующего агента общей формулы IIIll -N ICC TiTi, where X, R1 11 R- has the above-mentioned values, is reacted in a polar solvent at a temperature of from -10 to -40 ° C with an equimolar amount of the allymplating agent of general formula III
R - Y,IIIR - Y, III
где R имеет вышеприведенное значение, аwhere R has the above value, and
Y - галоген, арнлсульфонат или алкилсульфонат ,Y is halogen, arnlsulfonate or alkylsulfonate,
в присутствии эквимол риого количества основани , с последующим выделением целевого продукта известными приемами.in the presence of an equimolar amount of base, followed by isolation of the target product by known techniques.
Пюаесс провод т преимущественно с использованием в качестве растворите.тей воды.Puaess is preferably carried out using water as a solvent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2252691A DE2252691A1 (en) | 1972-10-27 | 1972-10-27 | AMIDOPHENYLISOTHIOURA, METHOD OF MANUFACTURING AND USE AS A MEDICINAL PRODUCT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU490285A3 true SU490285A3 (en) | 1975-10-30 |
Family
ID=5860198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1966532A SU490285A3 (en) | 1972-10-27 | 1973-10-23 | Method for preparing amidophenyl isothiourea derivatives |
Country Status (23)
| Country | Link |
|---|---|
| JP (2) | JPS4980216A (en) |
| AR (1) | AR199590A1 (en) |
| AT (1) | AT330199B (en) |
| AU (1) | AU475884B2 (en) |
| BE (1) | BE806549A (en) |
| CA (1) | CA1016349A (en) |
| CH (1) | CH588458A5 (en) |
| CS (1) | CS165965B2 (en) |
| DE (1) | DE2252691A1 (en) |
| DK (1) | DK134398C (en) |
| ES (1) | ES419990A1 (en) |
| FR (1) | FR2204420B1 (en) |
| GB (1) | GB1393329A (en) |
| HU (1) | HU167555B (en) |
| IE (1) | IE38427B1 (en) |
| IL (1) | IL43483A (en) |
| KE (1) | KE2586A (en) |
| LU (1) | LU68690A1 (en) |
| NL (1) | NL7314614A (en) |
| PH (1) | PH10384A (en) |
| PL (1) | PL91111B1 (en) |
| SU (1) | SU490285A3 (en) |
| ZA (1) | ZA738287B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2434183C2 (en) * | 1974-07-16 | 1982-07-01 | Bayer Ag, 5090 Leverkusen | Substituted phenylisothioureas, a process for their preparation and their use as pharmaceuticals |
-
1972
- 1972-10-27 DE DE2252691A patent/DE2252691A1/en active Pending
-
1973
- 1973-10-23 SU SU1966532A patent/SU490285A3/en active
- 1973-10-23 AR AR250650A patent/AR199590A1/en active
- 1973-10-24 PH PH15148A patent/PH10384A/en unknown
- 1973-10-24 AU AU61768/73A patent/AU475884B2/en not_active Expired
- 1973-10-24 NL NL7314614A patent/NL7314614A/xx unknown
- 1973-10-25 LU LU68690A patent/LU68690A1/xx unknown
- 1973-10-25 AT AT904173A patent/AT330199B/en not_active IP Right Cessation
- 1973-10-25 CA CA184,274A patent/CA1016349A/en not_active Expired
- 1973-10-25 CH CH1504773A patent/CH588458A5/xx not_active IP Right Cessation
- 1973-10-25 JP JP48119502A patent/JPS4980216A/ja active Pending
- 1973-10-25 JP JP48119501A patent/JPS4976836A/ja active Pending
- 1973-10-25 IL IL43483A patent/IL43483A/en unknown
- 1973-10-26 IE IE1935/73A patent/IE38427B1/en unknown
- 1973-10-26 PL PL1973166117A patent/PL91111B1/pl unknown
- 1973-10-26 HU HUBA2989A patent/HU167555B/hu unknown
- 1973-10-26 ZA ZA738287A patent/ZA738287B/en unknown
- 1973-10-26 DK DK580973A patent/DK134398C/en active
- 1973-10-26 BE BE137089A patent/BE806549A/en unknown
- 1973-10-26 ES ES419990A patent/ES419990A1/en not_active Expired
- 1973-10-26 CS CS7387A patent/CS165965B2/cs unknown
- 1973-10-26 FR FR7338264A patent/FR2204420B1/fr not_active Expired
- 1973-10-26 GB GB4993573A patent/GB1393329A/en not_active Expired
-
1975
- 1975-12-02 KE KE2586*UA patent/KE2586A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH588458A5 (en) | 1977-06-15 |
| AT330199B (en) | 1976-06-25 |
| IE38427L (en) | 1974-04-27 |
| DK134398C (en) | 1977-03-28 |
| KE2586A (en) | 1975-12-19 |
| FR2204420B1 (en) | 1977-09-09 |
| JPS4980216A (en) | 1974-08-02 |
| AU475884B2 (en) | 1976-09-09 |
| PL91111B1 (en) | 1977-02-28 |
| ZA738287B (en) | 1974-09-25 |
| AR199590A1 (en) | 1974-09-13 |
| IL43483A0 (en) | 1974-01-14 |
| NL7314614A (en) | 1974-05-01 |
| LU68690A1 (en) | 1974-01-08 |
| CA1016349A (en) | 1977-08-30 |
| IL43483A (en) | 1976-08-31 |
| AU6176873A (en) | 1975-04-24 |
| ATA904173A (en) | 1975-09-15 |
| ES419990A1 (en) | 1976-03-16 |
| CS165965B2 (en) | 1975-12-22 |
| HU167555B (en) | 1975-11-28 |
| DK134398B (en) | 1976-11-01 |
| FR2204420A1 (en) | 1974-05-24 |
| GB1393329A (en) | 1975-05-07 |
| DE2252691A1 (en) | 1974-05-02 |
| IE38427B1 (en) | 1978-03-15 |
| PH10384A (en) | 1977-03-02 |
| JPS4976836A (en) | 1974-07-24 |
| BE806549A (en) | 1974-04-26 |
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