SU488847A1 - The control system of the periodic process of microbial biosynthesis - Google Patents

Description

one

The invention relates to microbiology. chesk and industry.

A known system for automatically controlling the process of continuous cultivation of microorganisms, for example, biomass of fodder yeast, contains circuits for stabilizing temperature, aeration and acidity of the medium, including, respectively, a sensor of the measured parameter, for example pH, a regulator and an optional mechanism.

However, it is not possible to use such a system for the optimal maintenance of batch processes of microbiological synthesis. as in the apparatus, during one cycle of operation, the conditions for the development of culture change: metabolic products accumulate, inhibiting the further development of culture; reduce the amount of nutrients; the acidity of the medium changes, and it is therefore difficult to obtain an adequate mathematical model of the process without conducting deep search studies.

Therefore, depending on the changing conditions of cultural development, it is necessary to search for and maintain optimal values of the basic ones and logical parameters of the process.

The purpose of the invention is to increase production; the duration of the fermenter to grow

1 MIKROORGa1 ZMOB.

This is achieved by the fact that the proposed control system is equipped with a block

working out control actions and an adaptive model implementation unit, serving cmkm to determine the difference between the calculated and current values of the concentration of microorganisms. At the same time, the sensors of the measured parameters are connected to the input of the implementation of the adaptive mode of the process, and the outputs are connected to the corresponding master inputs of the regulators of the stabilization circuits using the control action testing unit.

The drawing shows a schematic diagram of the system for automatically controlling the periodic process of microbial biosynthesis. Skstvmv. coagulation circuit stabilization temperature, aerocomm scott cg and hongrolma & air of FJ fetal valve 1 n collector, computing device including unit 2 of realization of adaptive model of process and unit 3 of control actions, input of the last and connected to output of the design unit adaptive model; a device for fixing the moment of termination of the fermentation process, which is an element 4 of the secondary vacuum and a device for the storage of pharmacite tert. The contour of the PizTsEI t81-l11 zhlkuratura zhlk - loop; sensor 5 is connected to the input of the converter 6, the output of which is connected to the generatorN / input of the regulator 7, connected to the actuator, mechanism 8, installed on the cooling line . The contour of stabilization of aeration consists of a sensor 9 flow, exit. which is connected to the input jrpf-generator 1O, targeted to the Variable input of the flow controller 1, connected with the actuators 12 and 13, installed respectively on the input and output lines of air supply to the air, n. The stabilization circuit for the medium swept includes a pH 14 meter sensor immersed in the fermenter, connected via a 15 L converter to an input of a regulator 16 whose output is connected to an actuator 17 installed on the medium supply line to the medium regulating the volume of natural fluid. The control circuits of the pressure in the sterile air collector: g; a and a in the fermenter contain sensors 18 and 19, the outputs of which are coherence, are not corresponding to the indicating and signaling devices, 20, 21 and 2. The output signal of the terminal 22 is connected to the indigraph -23 and actuators 12 and 13. The outputs of the sensors 24, 25, 2.6, 5 and 14 of the main technological parameters of the process: concentration, amount of nutrient medium, amount of oxygen in the exhaust air, he , temperature of acidity. In addition, the center sensor 24 is connected to the input of the positive chamber of the comparison element 4 by means of the maximum memory element 27, and the concentration sensor is connected directly to the input chamber of the comparison element. The output 3 (T MeHTa control is connected to the indicator 28 LH-6jiOKOM 3 control actions. The circuit of the automatic blocking of the apoarate contains a signal that has a pressure; an input to the sensor 14 d, akle: and output to the indicator 23 and the inlet of the return switch 29, the output of the coordinator is connected to the actuators and, 12 and 13, to the outputs of the normally open contact 30 connected to the remote control code 11. The system of automatic control, operation process, It follows in a mathematical way. Mathematical expression of B as a function of expectancy My concentration of the antibiotic in the source of information about the state of the culture is set in block 2. When information arrives at the input of block 2 from sensors 14, 5, 24, 25: i 26, this reduction is solved, and can serve as a recommendation -sUSTEEN: b, while 3 controllers: bs) and deistvies, In the etching system BF, ji4Hc.neHHbie, paragliders of the model pu-step into the input of block 3 and illusions: effects, where each parameter depends on of the stage of development by practicing otos, the control of a certain impact on each The parameter that Cherb, e communication channels are sent to the driver inputs, respectively, their regulators 11.7 and 16, which set, by means of actuators, the values of the flow rate, air, temperature, acidity, contributing, optimal, to the antibiotic. When a new information is received from the sensors, in block 2, the implementation of the adaptive first model receives the new decision (assignment to the controllers) and the third block, the effects in the control inputs of the control of the stabilization contours of the ocHOBHbsx parameters so that conditions are established in the fermenter , favorable to the release of the antibiotic at this stage of the raE; culture eithium. iEcnH the amount of product in the cultured liquid grows, then the signal from the sensor concentrates, and 24 increases, is detected and put a TjTiaeT B, put, or, to the negative in: x; oa element 4 compare; When the biosynthesis is stopped and the signal from the sensor decreases, it passes only into the O1, the input. And B is positive for the camera, remember the larger previous signal. 1a output Element 4 comparison occurs;