SU453839A3 - Способ получения фенилимидазолидинонов - Google Patents
Способ получения фенилимидазолидиноновInfo
- Publication number
- SU453839A3 SU453839A3 SU1791532A SU1791532A SU453839A3 SU 453839 A3 SU453839 A3 SU 453839A3 SU 1791532 A SU1791532 A SU 1791532A SU 1791532 A SU1791532 A SU 1791532A SU 453839 A3 SU453839 A3 SU 453839A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- imidazolidinone
- piperazine
- hydrogen
- group
- chr
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 8
- 150000001875 compounds Chemical class 0.000 description 14
- 125000000217 alkyl group Chemical group 0.000 description 8
- 238000000354 decomposition reaction Methods 0.000 description 8
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 8
- 125000003545 alkoxy group Chemical group 0.000 description 7
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 6
- 125000005843 halogen group Chemical group 0.000 description 6
- -1 aralkyl radical Chemical class 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 150000002431 hydrogen Chemical group 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 125000000304 alkynyl group Chemical group 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 125000004663 dialkyl amino group Chemical group 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- GVONPBONFIJAHJ-UHFFFAOYSA-N imidazolidin-4-one Chemical compound O=C1CNCN1 GVONPBONFIJAHJ-UHFFFAOYSA-N 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 2
- WICKLEOONJPMEQ-UHFFFAOYSA-N 1-(2-methylphenyl)piperazine Chemical compound CC1=CC=CC=C1N1CCNCC1 WICKLEOONJPMEQ-UHFFFAOYSA-N 0.000 description 1
- GPRYKVSEZCQIHD-UHFFFAOYSA-N 1-(4-aminophenyl)ethanone Chemical compound CC(=O)C1=CC=C(N)C=C1 GPRYKVSEZCQIHD-UHFFFAOYSA-N 0.000 description 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 1
- 239000012359 Methanesulfonyl chloride Substances 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 125000000033 alkoxyamino group Chemical group 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- MOIPGXQKZSZOQX-UHFFFAOYSA-N carbonyl bromide Chemical compound BrC(Br)=O MOIPGXQKZSZOQX-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- RIZMRRKBZQXFOY-UHFFFAOYSA-N ethion Chemical compound CCOP(=S)(OCC)SCSP(=S)(OCC)OCC RIZMRRKBZQXFOY-UHFFFAOYSA-N 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000005429 oxyalkyl group Chemical group 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT492071A AT311956B (de) | 1971-06-07 | 1971-06-07 | Verfahren zur Herstellung neuer Phenylimidazolidinonderivate und ihrer Salze |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU453839A3 true SU453839A3 (ru) | 1974-12-15 |
Family
ID=3569889
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1970169A SU493067A3 (ru) | 1971-06-07 | 1972-05-31 | Способ получени фенилимидазолидинонов |
| SU1791532A SU453839A3 (ru) | 1971-06-07 | 1972-05-31 | Способ получения фенилимидазолидинонов |
| SU1970170A SU498907A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени фенилимидазолидинонов |
| SU1970167A SU505358A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
| SU1970242A SU509228A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производныхпиперазина |
| SU1970164A SU499806A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
| SU1970171A SU492085A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени фенилимидазолидинонов |
| SU1970168A SU503516A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1970169A SU493067A3 (ru) | 1971-06-07 | 1972-05-31 | Способ получени фенилимидазолидинонов |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1970170A SU498907A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени фенилимидазолидинонов |
| SU1970167A SU505358A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
| SU1970242A SU509228A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производныхпиперазина |
| SU1970164A SU499806A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
| SU1970171A SU492085A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени фенилимидазолидинонов |
| SU1970168A SU503516A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
Country Status (20)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2772429C2 (ru) * | 2015-07-09 | 2022-05-19 | Мицубиси Танабе Фарма Корпорейшн | Новые имидные производные и их использование в качестве лекарственного средства |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW279864B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1993-02-19 | 1996-07-01 | Janssen Pharmaceutica Nv | |
| US5607932A (en) * | 1994-07-12 | 1997-03-04 | Janssen Pharmaceutica N.V. | Heterocyclic derivatives of azolones |
| DE19822678A1 (de) * | 1998-05-20 | 1999-11-25 | Bayer Ag | Substituierte 1,3-Diaza-2-(thi)oxo-cycloalkane |
| WO2004106291A1 (en) * | 2003-05-28 | 2004-12-09 | Imotep Inc. | Haloethyl urea compounds and the use thereof to attenuate, inhibit or prevent cancer cell migration |
| WO2004106292A1 (en) * | 2003-05-28 | 2004-12-09 | Imotep Inc. | Haloethyl urea compounds and their use to attenuate, inhibit or prevent non-cancerous pathogenic cellular proliferation and diseases associated therewith |
| RU2497810C1 (ru) * | 2012-06-28 | 2013-11-10 | Общество с ограниченной ответственностью "Объединенный центр исследований и разработок" | Способ получения n,n-диарилзамещенных 2-трихлорометилимидазолидинов |
-
1971
- 1971-06-07 AT AT492071A patent/AT311956B/de not_active IP Right Cessation
-
1972
- 1972-05-16 DE DE19722223751 patent/DE2223751A1/de active Pending
- 1972-05-31 SU SU1970169A patent/SU493067A3/ru active
- 1972-05-31 SU SU1791532A patent/SU453839A3/ru active
- 1972-06-05 CA CA143,854A patent/CA1011336A/en not_active Expired
- 1972-06-05 BG BG020655A patent/BG22822A3/xx unknown
- 1972-06-06 AU AU43129/72A patent/AU473287B2/en not_active Expired
- 1972-06-06 ES ES403542A patent/ES403542A1/es not_active Expired
- 1972-06-06 IL IL39620A patent/IL39620A/en unknown
- 1972-06-06 FR FR7220319A patent/FR2140492B1/fr not_active Expired
- 1972-06-06 CH CH1507375A patent/CH590269A5/xx not_active IP Right Cessation
- 1972-06-06 CH CH1507275A patent/CH591475A5/xx not_active IP Right Cessation
- 1972-06-06 SE SE7207420A patent/SE392902B/xx unknown
- 1972-06-06 CH CH1507175A patent/CH583729A5/xx not_active IP Right Cessation
- 1972-06-06 ZA ZA723840A patent/ZA723840B/xx unknown
- 1972-06-06 NO NO2007/72A patent/NO136841C/no unknown
- 1972-06-06 CH CH1507475A patent/CH589644A5/xx not_active IP Right Cessation
- 1972-06-06 CH CH1507575A patent/CH589645A5/xx not_active IP Right Cessation
- 1972-06-06 HU HUBO1379A patent/HU165493B/hu unknown
- 1972-06-06 BE BE784475A patent/BE784475A/xx unknown
- 1972-06-06 CH CH1507675A patent/CH589646A5/xx not_active IP Right Cessation
- 1972-06-06 DD DD163478A patent/DD101403A5/xx unknown
- 1972-06-06 CH CH840072A patent/CH573425A5/xx not_active IP Right Cessation
- 1972-06-07 AR AR242433A patent/AR200112A1/es active
- 1972-06-07 IE IE791/72A patent/IE37812B1/xx unknown
- 1972-06-07 NL NL7207701A patent/NL7207701A/xx unknown
- 1972-06-07 GB GB2662372A patent/GB1391491A/en not_active Expired
-
1973
- 1973-01-01 AR AR249758A patent/AR205522A1/es active
- 1973-01-01 AR AR249754A patent/AR207109A1/es active
- 1973-08-24 AR AR249757A patent/AR200139A1/es active
- 1973-08-24 AR AR249755A patent/AR202904A1/es active
- 1973-08-24 AR AR249752A patent/AR202903A1/es active
- 1973-08-24 AR AR249753A patent/AR203017A1/es active
- 1973-11-14 SU SU1970170A patent/SU498907A3/ru active
- 1973-11-14 SU SU1970167A patent/SU505358A3/ru active
- 1973-11-14 SU SU1970242A patent/SU509228A3/ru active
- 1973-11-14 SU SU1970164A patent/SU499806A3/ru active
- 1973-11-14 SU SU1970171A patent/SU492085A3/ru active
- 1973-11-14 SU SU1970168A patent/SU503516A3/ru active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2772429C2 (ru) * | 2015-07-09 | 2022-05-19 | Мицубиси Танабе Фарма Корпорейшн | Новые имидные производные и их использование в качестве лекарственного средства |
| RU2785158C1 (ru) * | 2022-07-18 | 2022-12-05 | Акционерное общество "Щелково Агрохим" | Способ получения имазапира |
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