SU434653A3 - METHOD OF OBTAINING N-VINYLKHINOLONES - Google Patents
METHOD OF OBTAINING N-VINYLKHINOLONESInfo
- Publication number
- SU434653A3 SU434653A3 SU1618801A SU1618801A SU434653A3 SU 434653 A3 SU434653 A3 SU 434653A3 SU 1618801 A SU1618801 A SU 1618801A SU 1618801 A SU1618801 A SU 1618801A SU 434653 A3 SU434653 A3 SU 434653A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- vinylkhinolones
- obtaining
- quinolones
- allyl
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Изобретение относитс к способу получени новых производных хинолнна, которые обладают лекарственными свойствами и могут найти применение в фармацевтической промышленности .This invention relates to a method for producing new quinoline derivatives that have medicinal properties and can be used in the pharmaceutical industry.
Известно, что под действием сильных щелочей происходит смещение двойной св зи в аллильных производных, например ароматических , в положение, сопр женное с ароматическим кольцом.It is known that under the action of strong alkalis, a double bond is displaced into allyl derivatives, for example aromatic, to a position conjugated with an aromatic ring.
Однако дл получени соединений предлагаемым способом эта реакци не примен лась .However, this compound was not used for the preparation of compounds by the proposed method.
Предлагаемый способ получени N-ВИБИЛхинолонов общей формулы IThe proposed method for the preparation of N-VIBILquinolones of general formula I
NINi
RO IRO I
,, ,,
где один из RI и R2 обозначает водород, а другой вместе с Rs - радикал 1,3-пропилена; R4-«изщий алкил;where one of RI and R2 denotes hydrogen, and the other together with Rs is a 1,3-propylene radical; R4 is "alkyl";
Y - гидроксил, ннзщий алкоксил, незамещенна или замещенна аминогруппа, заключаетс в том,чтоY is a hydroxyl, lower alkoxy, unsubstituted or substituted amino group, is that
N-аллилхинолоны общей формулы IIN-allyl quinolones of general formula II
.0.0
rfrrfr
Б.7 I ,B.7 I,
CH -CH CH-RcCH -CH CH-Rc
где Rb Ra, Rs и Y имеют вышеуказанные значени , Rs - водород или низщий алкил, который имеет на один атом углерода меньще,where Rb Ra, Rs and Y are as defined above, Rs is hydrogen or lower alkyl which has one less carbon atom,
чем R4, подвергают обработке сильным основанием при нагревании, с последующим выделением целевых соединений известным способом в свободном виде или в виде солей. Перегруппировка N-аллилхинолонов формулы П в N-винилхинолоны формулы I проводитс преимущественно нагреванием с водными растворами щелочей, например с водным раствором едкого натра, или нагреванием с сильными органическими основани ми, вthan R4, is treated with a strong base when heated, followed by separation of the target compounds in a known manner in free form or in the form of salts. The rearrangement of the N-allyl quinolones of the formula P into N-vinyl quinolones of the formula I is carried out predominantly by heating with aqueous solutions of alkalis, for example, with an aqueous solution of caustic soda, or by heating with strong organic bases in
носледнем случае реакци проводитс в присутствии растворител , например спирта, цикIn the latter case, the reaction is carried out in the presence of a solvent, e.g. alcohol,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2011885A DE2011885C3 (en) | 1970-03-13 | 1970-03-13 | 1,4-Dihydro-3-carboxy-cyclopentano (h) -quinolone- (4) -derivatives, process for the preparation thereof and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU434653A3 true SU434653A3 (en) | 1974-06-30 |
Family
ID=5764939
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1618801A SU434653A3 (en) | 1970-03-13 | 1971-02-08 | METHOD OF OBTAINING N-VINYLKHINOLONES |
| SU1747931A SU436493A3 (en) | 1970-03-13 | 1971-02-08 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1747931A SU436493A3 (en) | 1970-03-13 | 1971-02-08 |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS4835268B2 (en) |
| AT (2) | AT303734B (en) |
| BG (2) | BG18415A3 (en) |
| CA (1) | CA944355A (en) |
| CH (2) | CH558359A (en) |
| CS (2) | CS161899B2 (en) |
| DE (1) | DE2011885C3 (en) |
| DK (1) | DK129839B (en) |
| ES (1) | ES388909A1 (en) |
| FI (1) | FI49501C (en) |
| FR (1) | FR2085701B1 (en) |
| GB (1) | GB1282076A (en) |
| IE (1) | IE35111B1 (en) |
| IL (1) | IL36397A (en) |
| NL (1) | NL145854B (en) |
| PL (1) | PL82724B1 (en) |
| RO (2) | RO58367A (en) |
| SE (1) | SE361313B (en) |
| SU (2) | SU434653A3 (en) |
| ZA (1) | ZA711607B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3988460A (en) * | 1972-05-10 | 1976-10-26 | Boehringer Mannheim G.M.B.H. | Cyclopentenoquinolone compounds for treating bacterial infections |
| JPS50114345U (en) * | 1974-02-28 | 1975-09-18 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB830832A (en) * | 1957-02-15 | 1960-03-23 | Ici Ltd | New quinolones and therapeutic compositions containing them |
| CA944354A (en) * | 1968-07-23 | 1974-03-26 | Boehringer Mannheim G.M.B.H. | Cycloalkano-quinolone derivatives |
-
1970
- 1970-03-13 DE DE2011885A patent/DE2011885C3/en not_active Expired
-
1971
- 1971-02-08 SU SU1618801A patent/SU434653A3/en active
- 1971-02-08 SU SU1747931A patent/SU436493A3/ru active
- 1971-03-04 BG BG16969A patent/BG18415A3/xx unknown
- 1971-03-04 ES ES388909A patent/ES388909A1/en not_active Expired
- 1971-03-04 BG BG18790A patent/BG18416A3/xx unknown
- 1971-03-10 DK DK112171AA patent/DK129839B/en unknown
- 1971-03-10 CH CH550674A patent/CH558359A/en not_active IP Right Cessation
- 1971-03-10 CH CH352771A patent/CH558358A/en not_active IP Right Cessation
- 1971-03-11 RO RO66229A patent/RO58367A/ro unknown
- 1971-03-11 NL NL717103247A patent/NL145854B/en unknown
- 1971-03-11 CS CS1805A patent/CS161899B2/cs unknown
- 1971-03-11 CS CS5256*A patent/CS161900B2/cs unknown
- 1971-03-11 IL IL36397A patent/IL36397A/en unknown
- 1971-03-11 RO RO68915A patent/RO58563A/ro unknown
- 1971-03-11 ZA ZA711607A patent/ZA711607B/en unknown
- 1971-03-12 FR FR7108638A patent/FR2085701B1/fr not_active Expired
- 1971-03-12 AT AT218371A patent/AT303734B/en not_active IP Right Cessation
- 1971-03-12 SE SE03194/71A patent/SE361313B/xx unknown
- 1971-03-12 CA CA107,660A patent/CA944355A/en not_active Expired
- 1971-03-12 AT AT00541/72A patent/AT303735B/en not_active IP Right Cessation
- 1971-03-12 FI FI710732A patent/FI49501C/en active
- 1971-03-12 IE IE308/71A patent/IE35111B1/en unknown
- 1971-03-12 PL PL1971146843A patent/PL82724B1/en unknown
- 1971-03-13 JP JP46014018A patent/JPS4835268B2/ja not_active Expired
- 1971-04-19 GB GB23663/71A patent/GB1282076A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH558359A (en) | 1975-01-31 |
| RO58367A (en) | 1975-09-15 |
| DK129839B (en) | 1974-11-25 |
| AT303734B (en) | 1972-12-11 |
| BG18416A3 (en) | 1974-10-25 |
| IL36397A (en) | 1974-10-22 |
| ES388909A1 (en) | 1973-05-01 |
| SU436493A3 (en) | 1974-07-15 |
| FR2085701B1 (en) | 1975-08-01 |
| CH558358A (en) | 1975-01-31 |
| NL7103247A (en) | 1971-09-15 |
| IE35111L (en) | 1971-09-13 |
| FI49501C (en) | 1975-07-10 |
| PL82724B1 (en) | 1975-10-31 |
| DE2011885B2 (en) | 1980-08-07 |
| DK129839C (en) | 1975-05-05 |
| BG18415A3 (en) | 1974-10-25 |
| AT303735B (en) | 1972-11-15 |
| IE35111B1 (en) | 1975-11-12 |
| RO58563A (en) | 1975-09-15 |
| DE2011885A1 (en) | 1971-09-30 |
| FI49501B (en) | 1975-04-01 |
| CS161900B2 (en) | 1975-06-10 |
| CA944355A (en) | 1974-03-26 |
| IL36397A0 (en) | 1971-05-26 |
| JPS4835268B2 (en) | 1973-10-26 |
| GB1282076A (en) | 1972-07-19 |
| CS161899B2 (en) | 1975-06-10 |
| JPS462928A (en) | 1971-10-22 |
| NL145854B (en) | 1975-05-15 |
| SE361313B (en) | 1973-10-29 |
| DE2011885C3 (en) | 1981-05-21 |
| FR2085701A1 (en) | 1971-12-31 |
| ZA711607B (en) | 1971-12-29 |
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