SU426363A3 - - Google Patents
Info
- Publication number
- SU426363A3 SU426363A3 SU1695204A SU1695204A SU426363A3 SU 426363 A3 SU426363 A3 SU 426363A3 SU 1695204 A SU1695204 A SU 1695204A SU 1695204 A SU1695204 A SU 1695204A SU 426363 A3 SU426363 A3 SU 426363A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- trioxo
- difluoro
- mixture
- pregnadiene
- acetoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Description
(54) СПОСОБ ПОЛУЧЕНИЯ 6а, 9а-ДИФТОР-16аМЕТИЛ-17а-АЦЕТОКСИ-3 ,11,20-ТРИОКСО-Д -ПРЕГНЕНА(54) METHOD OF OBTAINING 6a, 9a-DIFTOR-16AMETHYL-17A-ACETOXI-3, 11,20-TRIOXO-D-PREGNEN
1212
Изобретение иллюстрируетс следующим примером.The invention is illustrated by the following example.
Пример. К смеси 3 г ба, 9а-дифтор-16амет ,ил-17а - окси-3,11,20-Т1риок€о-А - прегнадиена и 30 лгуг лед ной уксусной кислоты прибавл ют нри перемешивании и охлаждении, в токе азота в течение 40 мин. 42 мл трифторуксусного ангидрида. После перемешивани в течение 15 час при комнатной температуре смесь выливают на 400 г льда и медленно прибавл ют 750 мл насышенного раствора би карбоната атри . Через 30 мин осадок отфильтровывают , промывают водой и раствор ют в хлористом метилене. Раствор отдел ют от воды, сушат и выпаривают в вакууме. Кристаллизацией остатка из смеси хлористый метилен - эфир получают 6а, 9а-дифтор-16аметил-17а-ацетокси - 3,11,20-триоксо-Д - прегпадиен с т. пл. 252-254°С.Example. To a mixture of 3 g of ba, 9a-difluoro-16met, il-17a - oxy-3,11,20-T1riok € o-A - pregnadiene and 30 people of glacial acetic acid are added, with stirring and cooling, in a stream of nitrogen for 40 min 42 ml of trifluoroacetic anhydride. After stirring for 15 hours at room temperature, the mixture is poured onto 400 g of ice and 750 ml of saturated solution of bi-carbonate altri are slowly added. After 30 minutes, the precipitate was filtered, washed with water and dissolved in methylene chloride. The solution is separated from water, dried and evaporated in vacuo. By crystallization of the residue from a mixture of methylene chloride - ether, 6a, 9a-difluoro-16methyl-17a-acetoxy-3,11,20-trioxo-D - pregpadien with m. Pl. 252-254 ° C.
Предмет и з о б р е т е ,н и Subject and statement of
Способ получени 6а, 9а-дифтор-16а-метил17а-ацетокси-3 ,11,20-триоксо - A-нрегнена или А Прегнадиена формулы IThe method of obtaining 6a, 9a-difluoro-16a-methyl17a-acetoxy-3, 11,20-trioxo-A-nregnen or A Pregnadiene formula I
0-СО-СНСО-СНз0-CO-SNSO-SNZ
отличающийс тем, что соединение формулы II,characterized in that a compound of formula II,
СО-СНзCO-CH3
где 1,2-св зь может быть насыщена или ненасышена , подвергают ацетилированию с последующим выделением целевого продукта известными приемами.where the 1,2-bond can be saturated or unsaturated, is subjected to acetylation followed by isolation of the target product by known techniques.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1291070A CH542831A (en) | 1970-08-28 | 1970-08-28 | Process for the preparation of 6a, 9a-difluoro-16a-methyl-17a-acetoxy-3,11,20-trioxo-4-pregnene or -1,4-pregnadiene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU426363A3 true SU426363A3 (en) | 1974-04-30 |
Family
ID=4387518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1695204A SU426363A3 (en) | 1970-08-28 | 1971-08-27 |
Country Status (11)
| Country | Link |
|---|---|
| AR (1) | AR196989A1 (en) |
| AT (1) | AT312822B (en) |
| AU (1) | AU3275071A (en) |
| BE (1) | BE771900A (en) |
| BR (1) | BR7105636D0 (en) |
| CH (3) | CH542829A (en) |
| DE (1) | DE2141559A1 (en) |
| FR (1) | FR2103585A1 (en) |
| HU (1) | HU162767B (en) |
| NL (1) | NL7111859A (en) |
| SU (1) | SU426363A3 (en) |
-
1970
- 1970-08-28 CH CH1289373A patent/CH542829A/en not_active IP Right Cessation
- 1970-08-28 CH CH1289173A patent/CH542833A/en not_active IP Right Cessation
- 1970-08-28 CH CH1291070A patent/CH542831A/en not_active IP Right Cessation
-
1971
- 1971-08-19 DE DE19712141559 patent/DE2141559A1/en active Pending
- 1971-08-26 AU AU32750/71A patent/AU3275071A/en not_active Expired
- 1971-08-27 SU SU1695204A patent/SU426363A3/ru active
- 1971-08-27 NL NL7111859A patent/NL7111859A/xx unknown
- 1971-08-27 AT AT751971A patent/AT312822B/en not_active IP Right Cessation
- 1971-08-27 FR FR7131153A patent/FR2103585A1/en active Granted
- 1971-08-27 HU HUCI001152 patent/HU162767B/hu unknown
- 1971-08-27 BE BE771900A patent/BE771900A/en unknown
- 1971-08-27 BR BR563671A patent/BR7105636D0/en unknown
-
1972
- 1972-05-05 AR AR24184272A patent/AR196989A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| CH542829A (en) | 1973-10-15 |
| BR7105636D0 (en) | 1973-05-10 |
| NL7111859A (en) | 1972-03-01 |
| CH542831A (en) | 1973-10-15 |
| HU162767B (en) | 1973-04-28 |
| AR196989A1 (en) | 1974-03-08 |
| BE771900A (en) | 1972-02-28 |
| AU3275071A (en) | 1973-03-01 |
| FR2103585A1 (en) | 1972-04-14 |
| AT312822B (en) | 1974-01-25 |
| DE2141559A1 (en) | 1972-03-02 |
| FR2103585B1 (en) | 1974-11-15 |
| CH542833A (en) | 1973-10-15 |
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