SU1582553A3 - Method of synthesis of unsaturated simple lipids multiple-labeled with tritium at double bonds - Google Patents

Method of synthesis of unsaturated simple lipids multiple-labeled with tritium at double bonds

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Publication number
SU1582553A3
SU1582553A3 SU4458112/04A SU4458112A SU1582553A3 SU 1582553 A3 SU1582553 A3 SU 1582553A3 SU 4458112/04 A SU4458112/04 A SU 4458112/04A SU 4458112 A SU4458112 A SU 4458112A SU 1582553 A3 SU1582553 A3 SU 1582553A3
Authority
SU
USSR - Soviet Union
Prior art keywords
catalyst
synthesis
ratio
tritium
carried out
Prior art date
Application number
SU4458112/04A
Other languages
Russian (ru)
Inventor
И.Ю. Нагаев
В.П. Шевченко
Н.Ф. Мясоедов
Г.И. Мягкова
Р.П. Евстигнеева
Original Assignee
Институт молекулярной генетики РАН
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Институт молекулярной генетики РАН filed Critical Институт молекулярной генетики РАН
Priority to SU4458112/04A priority Critical patent/SU1582553A3/en
Application granted granted Critical
Publication of SU1582553A3 publication Critical patent/SU1582553A3/en

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Abstract

FIELD: organic chemistry. SUBSTANCE: synthesis is carried out by selective hydrogenation of corresponding aliphatic alcohols of fatty acid methyl esters with gaseous tritium in organic solvent, preferably in mixture heptane-dioxane 4: 1 in the presence of catalyst. Catalyst: 5% Pd/BaSO, which is successively treated with methanolic solutions of lead diacetate at ratio lead-palladium 1: 0.5-1 mg/kg and sodium boron hydride at ratio NaBH-catalyst 0.6: 50 mg/kg. Process is carried out at mass ratio catalyst-initial substance 2-6: 1. After isolation, if necessary, unsaturated lipids containing ester function are hydrolyzed to free acids. Yield of (5,6,8,9,11,12,14, 15-H)- arachidonic acid is up to 95% . Molar radioactivity is increased up to 7.4 PBq/mole. EFFECT: enhanced yield, molar radioactivity, enlarged assortment of products. 2 cl, 6 tbl
SU4458112/04A 1988-07-15 1988-07-15 Method of synthesis of unsaturated simple lipids multiple-labeled with tritium at double bonds SU1582553A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU4458112/04A SU1582553A3 (en) 1988-07-15 1988-07-15 Method of synthesis of unsaturated simple lipids multiple-labeled with tritium at double bonds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU4458112/04A SU1582553A3 (en) 1988-07-15 1988-07-15 Method of synthesis of unsaturated simple lipids multiple-labeled with tritium at double bonds

Publications (1)

Publication Number Publication Date
SU1582553A3 true SU1582553A3 (en) 1994-03-15

Family

ID=60527638

Family Applications (1)

Application Number Title Priority Date Filing Date
SU4458112/04A SU1582553A3 (en) 1988-07-15 1988-07-15 Method of synthesis of unsaturated simple lipids multiple-labeled with tritium at double bonds

Country Status (1)

Country Link
SU (1) SU1582553A3 (en)

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