JPS6479168A - Novel synthesis of 6,5-diacyl-7-deacetylforskolin derivative and intermediate - Google Patents
Novel synthesis of 6,5-diacyl-7-deacetylforskolin derivative and intermediateInfo
- Publication number
- JPS6479168A JPS6479168A JP63159382A JP15938288A JPS6479168A JP S6479168 A JPS6479168 A JP S6479168A JP 63159382 A JP63159382 A JP 63159382A JP 15938288 A JP15938288 A JP 15938288A JP S6479168 A JPS6479168 A JP S6479168A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- compound
- acyl
- formula
- deacetylforskolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE:To obtain the title substance by allowing an acylating agent to act on 6-acyl-7-deacetylforskolin derivative into a 1,6,7-triacyl derivative (a novel substance), then removing the acyl group in the 1-position by solvolysis. CONSTITUTION:An acylating agent such as acetic anhydride (2-4 fold moles) is allowed to act on a compound of formula I (R<2> is acyl; R<3> is 2-3C hydrocar bon group) at 0 deg.C to room temperature for several minutes to 2hr to form 1,6,7-triacyl-7-deacetylforskolin derivative (a novel substance) of formula II. Then, the product is preferably hydrolyzed to give a compound of formula III. The hydrolysis is carried out in a solvent in the presence of a base or acid at 0 deg.C to room temperature for 5min-3hr. The solvent is preferably an aqueous alcohol of 1-4C carbon atoms, containing 0.5-20V/V% of water. Thus, the compound of formula III which is expectantly used as a medicines is obtained in high yield.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63159382A JPH0684367B2 (en) | 1987-06-29 | 1988-06-29 | New method for producing forskolin derivative |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62-159638 | 1987-06-29 | ||
JP15963887 | 1987-06-29 | ||
JP63159382A JPH0684367B2 (en) | 1987-06-29 | 1988-06-29 | New method for producing forskolin derivative |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15637793A Division JPH06157505A (en) | 1993-06-03 | 1993-06-03 | 1,6,7-triacylforskolin derivative |
JP5258877A Division JP2504934B2 (en) | 1987-06-29 | 1993-09-24 | 1,6,7-Triacylforskolin derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6479168A true JPS6479168A (en) | 1989-03-24 |
JPH0684367B2 JPH0684367B2 (en) | 1994-10-26 |
Family
ID=26486202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63159382A Expired - Fee Related JPH0684367B2 (en) | 1987-06-29 | 1988-06-29 | New method for producing forskolin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0684367B2 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0200216A2 (en) | 1985-04-30 | 1986-11-05 | Fuji Photo Film Co., Ltd. | Heat-developable light-sensitive material |
US5140369A (en) * | 1989-11-15 | 1992-08-18 | Konica Corporation | Color image forming apparatus having a process cartridge containing a belt shaped image carrier, toner replenishing means and detachable paper cartridge |
JPH051053A (en) * | 1990-11-01 | 1993-01-08 | Nippon Kayaku Co Ltd | New process for producing 6-(3-dimethylamino-propionyl) forskolin |
US5283614A (en) * | 1990-10-31 | 1994-02-01 | Mita Industrial Co., Ltd. | Optical system moving frame unit for use in an exposure device of an optical system movement type |
US5294968A (en) * | 1991-07-09 | 1994-03-15 | Konica Corporation | Developing unit and drive transmission attachment |
US5493366A (en) * | 1990-09-07 | 1996-02-20 | Konica Corporation | Image forming apparatus |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61210081A (en) * | 1985-03-01 | 1986-09-18 | ヘキスト‐ルセル・フアーマシユウテイカルズ・インコーポレイテツド | Labdane derivatives and manufacture |
JPS6289677A (en) * | 1985-10-02 | 1987-04-24 | ヘキスト・アクチエンゲゼルシヤフト | Novel poly-oxidized labdane derivative and its production |
JPS6323878A (en) * | 1986-07-11 | 1988-02-01 | ヘキスト・アクチエンゲゼルシヤフト | 7-acyloxy-6-aminoacyloxypolyoxylabdane and manufacture |
-
1988
- 1988-06-29 JP JP63159382A patent/JPH0684367B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61210081A (en) * | 1985-03-01 | 1986-09-18 | ヘキスト‐ルセル・フアーマシユウテイカルズ・インコーポレイテツド | Labdane derivatives and manufacture |
JPS6289677A (en) * | 1985-10-02 | 1987-04-24 | ヘキスト・アクチエンゲゼルシヤフト | Novel poly-oxidized labdane derivative and its production |
JPS6323878A (en) * | 1986-07-11 | 1988-02-01 | ヘキスト・アクチエンゲゼルシヤフト | 7-acyloxy-6-aminoacyloxypolyoxylabdane and manufacture |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0200216A2 (en) | 1985-04-30 | 1986-11-05 | Fuji Photo Film Co., Ltd. | Heat-developable light-sensitive material |
US5140369A (en) * | 1989-11-15 | 1992-08-18 | Konica Corporation | Color image forming apparatus having a process cartridge containing a belt shaped image carrier, toner replenishing means and detachable paper cartridge |
US5493366A (en) * | 1990-09-07 | 1996-02-20 | Konica Corporation | Image forming apparatus |
US5283614A (en) * | 1990-10-31 | 1994-02-01 | Mita Industrial Co., Ltd. | Optical system moving frame unit for use in an exposure device of an optical system movement type |
JPH051053A (en) * | 1990-11-01 | 1993-01-08 | Nippon Kayaku Co Ltd | New process for producing 6-(3-dimethylamino-propionyl) forskolin |
US5294968A (en) * | 1991-07-09 | 1994-03-15 | Konica Corporation | Developing unit and drive transmission attachment |
Also Published As
Publication number | Publication date |
---|---|
JPH0684367B2 (en) | 1994-10-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
LAPS | Cancellation because of no payment of annual fees |