SU1534406A1 - Method of diagnosis of latent form of diabetes mellitus - Google Patents

Abstract

The invention relates to medicine, in particular to endocrinology. The aim of the invention is to accelerate and simplify the diagnosis of latent diabetes. For this, the glucose concentration is determined in the tear fluid 60 to 90 minutes after ingesting the glucose solution at the rate of 1 g per 1 kg of mass by a biochemical indicator. The end of the strip from the set "Biofan-1" is placed behind the lower eyelid of the subject. After 2/3 of the indicator zone is moistened with a tear, the strip is removed and after 50 seconds the color of the wetted part is compared with the scale. When its color changes from yellow to greenish blue, the latent form of diabetes is diagnosed. The method allows shortening the study to 3 minutes.

Description

The invention relates to medicine, namely to endocrinology, and can be used to diagnose a latent form of diabetes mellitus.

The purpose of the invention is to accelerate and simplify the diagnosis by examining the glucose content in the tear fluid 60-90 minutes after a single sugar load using the biochemical indicator Biofan 1 and if it is positive, latent diabetes is diagnosed.

The method is carried out as follows.

Initially on an empty stomach, the patient being examined with suspicion of the indicated disease is offered to take inside a glucose solution at the rate of 1 g per I kg of weight. Then, after 60-90 minutes (optimal time 75 minutes), the concentration of glucose in the tear fluid is determined by a biochemical indicator.

Use scissors to cut off the short end of the Biofan-1 set that protrudes beyond the indicator zone. Next, bend the indicator area in the midline and the short end of the strip is placed in the lower eyelid of the subject. After 2/3 of the indicator zone is moistened with a tear, the strip is removed from the conjunctive cavity and after 50 s the color of the wetted part (on the border with the dry one) is compared with the scale included in the YaioLan- set. When its color changes from yellow to greenish blue, a form of diabetes is diagnosed. The whole study takes no more than 3 minutes.

Example 1. Ill. U., 43 g. Complained of increased fatigue, itchy skin in the area of

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intertiding and the frequent appearance of pustular diseases on the skin. Biochemical examination of blood and urine revealed no pathology. Glycemia made 4.8 mmol / l on an empty stomach. When carrying out a single sugar load, the dynamics of glycemia did not reveal the pathology of carbohydrate metabolism. The biofan-1 strip, placed for the lower eyelid, 60 minutes after a single sugar load, changed the color of its indicator zone from yellow to greenish after a single sugar load. On this basis, the patient was diagnosed with latent diabetes. In the future, the diagnosis was confirmed by in-depth examination of the patient in the endocrinological hospital.

Example 2. Patient V., 69 years old. He turned to the clinic of eye diseases with retinopathy of unequal etiology. Blood and urine analysis is normal, glycemia is 4.75 mmol / l. The patient was given a one-time sugar load, at which the glucose concentration was determined by the indicator strip of the Biofan-1 rapid test at the 90th minute. The indicator zone of the strip colored at the same time in an intense green color. Considering this fact, the patient was diagnosed with latent diabetes.

Example 3. Patient M., 63 g. In the anamnesis - surgical intervention for Itsenko-Kumin syndrome

ha, produced 10 years ago. In order to clarify the question of the normalization of hormonal disorders affecting the patient before the operation, a single sugar load was made with determination of the glucose content in the tear fluid under normal results of clinical blood and urine tests.

 It was not possible to reveal the pathology of carbohydrate metabolism in a rosy way (the indicator zone of the strip did not change its color in the conjunctival cavity of the patient at the 75th minute of the sugar load), which was later confirmed by an in-depth examination of the patient in the endocrinological hospital.

The invention will make it possible to detect carbohydrate metabolism disorders by a rather simple method at an early stage of the development of diabetes mellitus, when the use of conventional methods, including the known methods, is ineffective.

The proposed method is more sensitive than the known. In particular, out of 1 1 patients with diabetes mellitus, only 2 had a positive test (according to a known method, when applying the proposed method, all 11 patients were taught a positive effect. The whole study takes 3 minutes, which is significantly less than the tics of diabetes.

than in the known method of diagnostics Formula

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A method for diagnosing a latent form of diabetes mellitus by examining the glucose content in biological material, characterized in that, in order to speed up and simplify diagnosis, the glucose concentration is determined in the lacrimal fluid 60-90 minutes after a single sugar load, using a biochemical indicator, and positive reactions diagnose latent diabetes. I

Claims (1)

2Q claims A method for diagnosing the latent form of diabetes mellitus by examining the glucose content in biological material 25, characterized in that, in order to accelerate and simplify clarification of the normalization of iEopMOHanbHbix disorders that the patient had before the operation, a one-time sugar load was made with determination of the glucose content in the lacrimal Liquid normal results of clinical blood and urine tests. diagnosis, glucose concentration is determined in the lacrimal fluid 60-90 min after a single sugar load using a biochemical indicator, and if it is positive, latent diabetes mellitus is diagnosed.