SU1503007A1 - Method of titration analysis of iodines - Google Patents

Abstract

The invention relates to analytical chemistry, in particular to methods for the determination of halides, and can be used in chemical laboratories and in chemical-pharmaceutical plants. The aim of the invention is to increase the selectivity of the determination of iodides. The method consists in the titration of the analyzed solution with a 0.002 M solution of copper (II) sulfate in the presence of 0.0067-0.067% ascorbic acid on a T-107 titrator with photometric determination of the final titration point. The method allows iodides to be determined in the presence of 0.5-fold amounts of phenol, codeine, norsulfazole, riboflavin, 2.5-fold novocaine, 4-fold chlorides, 5-fold diphenhydramine and glucose, 20-fold pyridoxine hydrochloride, 30-fold antipyrine 1 tab.

Description

The invention relates to analytical chemistry, in particular to methods for the determination of halides, and can be used in chemical laboratories and in chemical and pharmaceutical plants.

The aim of the invention is to increase the selectivity of the determination of iodides.

Example 1. The exact weight (about 0.05 g) of sodium iodide is placed in a 100 ml measuring flask and the contents of the flask are brought to the mark with water. 1.2 MP of the obtained pc-thpore, 1 ml of a 0.2% ascorbic acid solution and water to a total of 30 ml were added to the titropia glass. A glass is marked with a gigltor T-107 (blue filter) and is titrated at

the included mixer is a 0.002 M solution of copper (II) sulfate, adding the first 0.5 ml of it. After 2 minutes, record the instrument readings. The subsequent addition of the titrant is carried out in O, 1 MP after 1 min.

According to the analysis, the titration curve is constructed in the coordinates c - V (where is the amount of light transmission,, V is the volume of the titrant solution, mp), on which the equivalence point is found.

The content of iodide (in%) in the studied solutions is calculated by form V. V. T-V,

. x .1%,

where T is TIT1) copper (II) sulfate on sodium iodide, g / ml;

SP

about

00

31503007

V is the volume of titrant found by

titration curve, ml ml - sodium iodide sample, g; V is the volume of the volumetric flask, ml, j V V is the volume of solution placed

in titration beaker, ml. The content of iodides (g) is calculated by the formula

G - U-11U.

where P is the volume of the drug mixture according to

recipe, mp {

Vj 15

the volume of the dosage form, introduced into the volumetric flask, ml. Preparation and standardization of a copper (II) sulfate solution is carried out as follows. 12.48 g are placed in a 1 L volumetric flask, 0, the contents of the flask are dissolved in water and made up to the mark with water. Get a 0.05 M solution. 20-25 ml of the solution obtained are added to the titration flask, 3-5 drops are added. 25

 20

murexide solution and titrated with standard 0.05 M solution of trilon B until the appearance of red-violet color. The concentration of copper sulfate (II) is calculated by the formula

MO

 V. where Vp, Md - volume and concentration

copper (II) sulfate, respectively,

Vtr mct volume and concentration of trilon B, respectively.

A 0.002 M copper (II) sulfate solution is prepared from a 0.05 M solution by diluting with Water.

The results of the iodide determination in the presence of phenol, codeine, norsulfazole, pyroxine hydrochloride, antipyrine, novocaine, dimedrol, glucose, chlorides, riboflavin are presented in the table (p 5, P 0.95).

As can be seen from the rolls and glucose given in the table, 20-fold pyrido-data, the determination of iodides is possible syn-hydrochloride, 30-fold anti- in the presence of 0.5-fold amounts of pyrin. phenol, codeine, norsulfazole, ribo-,

Fpavina, 2.5-fold Novocain. According to the prototype, the determination of iodides

4-fold chlorides, 5-fold dimed in the presence of these substances is impossible due to the processes of their oxidation with potassium permanganate.

Claims (1)

Thus, the proposed method, compared with the prototype, makes it possible to increase the selectivity of iodide determination in relation to phenol, codeine, norsulfazole, riboflavin, novocaine, dimedrol, glucose, pyridoxine hydrochloride, antipyrine in 0.5-30 times. Invention Formula The method of titrimetric determination of iodides, consisting of titled component N. Kuzkova Editor S. PekarTehred M.Hodanich Proofreader S. Cherni Order 5079 / 5A. Circulation 789 VNIIPI State Committee for Inventions and Discoveries at the State Committee on Science and Technology of the USSR 113035, Moscow, Zh-35, Raushsk nab. 4/5 Production and publishing plant Paten-i, Uzhgorod, st. Gagarin, 101 The solution to be analyzed is a solution of an inorganic reagent in the presence of an acid, characterized in that, to determine the selectivity of the determination, a 0.002 M solution of copper (II) sulfate is used as a solution of an inorganic reagent, and an acid concentration of 0.0067 M as the acid -0.067%, and the end point of the titration is determined photometrically. Subscription