SU1473755A1 - Method of detoxicating organism in purulent septic diseases - Google Patents

Abstract

This invention relates to medicine, namely to surgery. To reduce the number of complications associated with blood loss during blood perfusion, the xeno-spleen is cut into sections 2-3 mm thick, placed in a 400 cm ³ sterile chamber through which the patient's blood is perfused at a rate of 100-120 ml / min for 30-60 min

Description

one

The invention relates to medicine, and more specifically to surgery, and can be used in the treatment of patients with septic complications of purulent diseases.

The purpose of the invention is to reduce the number of complications associated with blood loss when blood is perfused through a xenozelenis, which increases in size, is ruptured, and after perfusion, the patient's blood is deposited in it.

PRI me R. Patient K, 71, was admitted to the surgical department about blunt abdominal trauma, ileal rupture, diffuse fecal peritonitis three days old, and a septic condition. An emergency operation was performed: closure of the ileal rupture with resection of its wall along Melnikov, drainage of the abdominal cavity.

In the postoperative period, the patient’s condition is extremely severe, due to diffuse fecal peritonitis,

intestinal paresis, severe intoxication, hepato-renal, respiratory and heart failure. For the purpose of stimulation and prosthetics of macrophage activity and detoxification, extracorporeal blood perfusion was carried out in a complex of therapeutic measures through sections of porcine spleen. The spleen was cut into 2-3 mm thick sections that were washed and placed in a 400 cm5 sterile chamber. Extracorporeal perfusion system after heparinization of 10 thousand units. heparin is connected to the main veins (femoral vein - subclavian vein). The perfusion was carried out for 60 minutes at a rate of 120 ml / min using a roller pump. Hemodynamic parameters during the perfusion are stable (pulse - 100- 104 beats / min, blood pressure 100 / 60-90 / 60 mm Hg). Subsequently, infusion detoxification, antibacterial therapy,

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WITH

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4 sessions of hyperbaric oxygen therapy. Intestinal noises began to be heard in the patient, intestinal peristalsis appeared distinctly. The phenomena of paresis of the stomach cropped. The patient's condition improved progressively, urea decreased to 3.1 mM / L, the average molecules decreased from 0.657 to 0.355, and the temperature and bteloe values normalized. There was a slow recovery and, in a satisfactory condition, the patient was discharged from the clinic. According to the proposed method, 30 perfusions were performed in 23 of the most severe patients with purulent-septic diseases. This technique was used with the ineffectiveness of the combined drug therapy, including hemosorption, hyperbaric oxygenation, llamapheresis, blood AFP, etc. There were never any complications

typical for perfusion of whole spleen: block of perfusion outflow, ruptures of the stroma of the organ, uncontrolled bleeding from the parenchyma, hemodynamic disturbances in recipients, forcing them to stop perfusion and to conduct intensive therapy.

Claims (1)

Invention Formula A method of detoxifying the body for purulent-septic diseases by extracorporeal perfusion of blood through a xeno-spleen, characterized in that, in order to reduce the number of complications associated with blood loss, xenoseleen sections are placed in a sterile chamber 350-400 cm through which blood perfusion at a rate of 100-120 ml / min for 30-60 minutes.