SU1433411A3 - Способ получени производных 2-(1Н)-хинолона или их фармацевтически приемлемых солей - Google Patents
Способ получени производных 2-(1Н)-хинолона или их фармацевтически приемлемых солей Download PDFInfo
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- SU1433411A3 SU1433411A3 SU853901004A SU3901004A SU1433411A3 SU 1433411 A3 SU1433411 A3 SU 1433411A3 SU 853901004 A SU853901004 A SU 853901004A SU 3901004 A SU3901004 A SU 3901004A SU 1433411 A3 SU1433411 A3 SU 1433411A3
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- 150000003839 salts Chemical class 0.000 title claims abstract 5
- 238000000034 method Methods 0.000 title claims description 11
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 44
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 4
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
- 125000002883 imidazolyl group Chemical group 0.000 claims abstract 2
- 238000007363 ring formation reaction Methods 0.000 claims abstract 2
- 239000002585 base Substances 0.000 claims description 48
- 239000012458 free base Substances 0.000 claims description 29
- 239000007787 solid Substances 0.000 claims description 26
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- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 12
- 238000000354 decomposition reaction Methods 0.000 claims description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 101000760663 Hololena curta Mu-agatoxin-Hc1a Proteins 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
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- 230000015572 biosynthetic process Effects 0.000 abstract 1
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- HYTUDPOPONCSCM-UHFFFAOYSA-N 1-(3-methyl-4-nitrophenyl)imidazole Chemical compound C1=C([N+]([O-])=O)C(C)=CC(N2C=NC=C2)=C1 HYTUDPOPONCSCM-UHFFFAOYSA-N 0.000 description 2
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- 229910052794 bromium Inorganic materials 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- DOBRDRYODQBAMW-UHFFFAOYSA-N copper(i) cyanide Chemical compound [Cu+].N#[C-] DOBRDRYODQBAMW-UHFFFAOYSA-N 0.000 description 1
- LBJNMUFDOHXDFG-UHFFFAOYSA-N copper;hydrate Chemical compound O.[Cu].[Cu] LBJNMUFDOHXDFG-UHFFFAOYSA-N 0.000 description 1
- 239000010779 crude oil Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000000297 inotrophic effect Effects 0.000 description 1
- 230000036450 inotropism Effects 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 239000013081 microcrystal Substances 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 210000005245 right atrium Anatomy 0.000 description 1
- 238000006798 ring closing metathesis reaction Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- YPNVIBVEFVRZPJ-UHFFFAOYSA-L silver sulfate Chemical compound [Ag+].[Ag+].[O-]S([O-])(=O)=O YPNVIBVEFVRZPJ-UHFFFAOYSA-L 0.000 description 1
- 229910000367 silver sulfate Inorganic materials 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- GZNAASVAJNXPPW-UHFFFAOYSA-M tin(4+) chloride dihydrate Chemical compound O.O.[Cl-].[Sn+4] GZNAASVAJNXPPW-UHFFFAOYSA-M 0.000 description 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical class [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
- FWPIDFUJEMBDLS-UHFFFAOYSA-L tin(II) chloride dihydrate Substances O.O.Cl[Sn]Cl FWPIDFUJEMBDLS-UHFFFAOYSA-L 0.000 description 1
- GKYPJLUHGAJKEM-UHFFFAOYSA-N tin;dihydrate Chemical compound O.O.[Sn] GKYPJLUHGAJKEM-UHFFFAOYSA-N 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848413685A GB8413685D0 (en) | 1984-05-29 | 1984-05-29 | Quinolone inotropic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1433411A3 true SU1433411A3 (ru) | 1988-10-23 |
Family
ID=10561640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU853901004A SU1433411A3 (ru) | 1984-05-29 | 1985-05-28 | Способ получени производных 2-(1Н)-хинолона или их фармацевтически приемлемых солей |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS6182A (enrdf_load_stackoverflow) |
| DD (1) | DD237509A5 (enrdf_load_stackoverflow) |
| GB (1) | GB8413685D0 (enrdf_load_stackoverflow) |
| SU (1) | SU1433411A3 (enrdf_load_stackoverflow) |
| ZA (1) | ZA853992B (enrdf_load_stackoverflow) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4700150A (en) * | 1985-06-14 | 1987-10-13 | Stanford University | External laser frequency stabilizer |
| US5358949A (en) * | 1986-03-05 | 1994-10-25 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives |
| MY146795A (en) * | 2005-06-09 | 2012-09-28 | Novartis Ag | Process for the synthesis of organic compounds |
| GT200600207A (es) * | 2005-06-09 | 2007-01-15 | Novartis Ag | Proceso para la síntesis de compuestos orgánicos |
-
1984
- 1984-05-29 GB GB848413685A patent/GB8413685D0/en active Pending
-
1985
- 1985-05-27 ZA ZA853992A patent/ZA853992B/xx unknown
- 1985-05-28 DD DD85276727A patent/DD237509A5/de not_active IP Right Cessation
- 1985-05-28 SU SU853901004A patent/SU1433411A3/ru active
- 1985-05-29 JP JP60116316A patent/JPS6182A/ja active Granted
Non-Patent Citations (1)
| Title |
|---|
| Эльдерфельд Р. Гетероциклические соединени . - М.: Иностранна литера-, тура, 1955, т. IV, с. 26. * |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6182A (ja) | 1986-01-06 |
| DD237509A5 (de) | 1986-07-16 |
| JPH0255431B2 (enrdf_load_stackoverflow) | 1990-11-27 |
| ZA853992B (en) | 1987-01-28 |
| GB8413685D0 (en) | 1984-07-04 |
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