SU1338778A3 - Способ получени дебрицина - Google Patents
Способ получени дебрицина Download PDFInfo
- Publication number
- SU1338778A3 SU1338778A3 SU762374703A SU2374703A SU1338778A3 SU 1338778 A3 SU1338778 A3 SU 1338778A3 SU 762374703 A SU762374703 A SU 762374703A SU 2374703 A SU2374703 A SU 2374703A SU 1338778 A3 SU1338778 A3 SU 1338778A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- solution
- debricin
- dissolved
- ethanol
- volume
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 44
- 235000019836 ficin Nutrition 0.000 claims description 28
- 230000000694 effects Effects 0.000 claims description 5
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- 229920001817 Agar Polymers 0.000 claims description 2
- 241000206672 Gelidium Species 0.000 claims description 2
- 235000010419 agar Nutrition 0.000 claims description 2
- 150000002170 ethers Chemical class 0.000 claims description 2
- 239000005457 ice water Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920006158 high molecular weight polymer Polymers 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 28
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 abstract description 4
- 229960004194 lidocaine Drugs 0.000 abstract description 4
- 239000002245 particle Substances 0.000 abstract description 2
- NYWSLZMTZNODJM-MCGDBQAWSA-N 2-[5-[(4e,20e)-35-butyl-19-[(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-10,12,14,16,18,22,26,30,34-nonahydroxy-3,5,21,33-tetramethyl-36-oxo-1-oxacyclohexatriaconta-4,20-dien-2-yl]-4-hydroxyhexyl]guanidine Chemical compound OC1CC(O)CC(O)CC(O)CC(O)CCCC\C(C)=C\C(C)C(C(C)C(O)CCCN=C(N)N)OC(=O)C(CCCC)C(O)C(C)CCC(O)CCCC(O)CCCC(O)\C(C)=C\C1O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 NYWSLZMTZNODJM-MCGDBQAWSA-N 0.000 abstract 4
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 61
- 235000019441 ethanol Nutrition 0.000 description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 238000003756 stirring Methods 0.000 description 12
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 238000010438 heat treatment Methods 0.000 description 8
- 239000011521 glass Substances 0.000 description 7
- 239000002674 ointment Substances 0.000 description 7
- 239000004359 castor oil Substances 0.000 description 6
- 235000019438 castor oil Nutrition 0.000 description 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 5
- 239000000443 aerosol Substances 0.000 description 5
- 235000012000 cholesterol Nutrition 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 5
- 239000003889 eye drop Substances 0.000 description 5
- 229940012356 eye drops Drugs 0.000 description 5
- 229920000742 Cotton Polymers 0.000 description 4
- 235000013871 bee wax Nutrition 0.000 description 4
- 239000012166 beeswax Substances 0.000 description 4
- 238000009835 boiling Methods 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 229940040145 liniment Drugs 0.000 description 4
- 239000000865 liniment Substances 0.000 description 4
- 239000011550 stock solution Substances 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 239000004088 foaming agent Substances 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 229930002875 chlorophyll Natural products 0.000 description 2
- 235000019804 chlorophyll Nutrition 0.000 description 2
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000003885 eye ointment Substances 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 235000019271 petrolatum Nutrition 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 239000007944 soluble tablet Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000007669 thermal treatment Methods 0.000 description 2
- 239000003871 white petrolatum Substances 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 108010039491 Ricin Proteins 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000009841 epithelial lesion Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 229960004393 lidocaine hydrochloride Drugs 0.000 description 1
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000013048 microbiological method Methods 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU75CI1593A HU173708B (hu) | 1975-06-20 | 1975-06-20 | Sposob poluchenija geterokolloidnogo 18-arabinozil-2-n-butil-3,7,11,15,19,21,23,27,25,37-dekagidroksi-4,16,32,34,36-pentametil-tetrakona-16,32-dien-35-0-lakton-40-guanidiniumsul'fata |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1338778A3 true SU1338778A3 (ru) | 1987-09-15 |
Family
ID=10994573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU762374703A SU1338778A3 (ru) | 1975-06-20 | 1976-06-18 | Способ получени дебрицина |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS527419A (enrdf_load_stackoverflow) |
| AT (1) | AT344885B (enrdf_load_stackoverflow) |
| BE (1) | BE843115A (enrdf_load_stackoverflow) |
| ES (1) | ES449062A1 (enrdf_load_stackoverflow) |
| FI (1) | FI55609C (enrdf_load_stackoverflow) |
| FR (1) | FR2315910A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1512604A (enrdf_load_stackoverflow) |
| GR (1) | GR60551B (enrdf_load_stackoverflow) |
| HU (1) | HU173708B (enrdf_load_stackoverflow) |
| SU (1) | SU1338778A3 (enrdf_load_stackoverflow) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4404189A (en) * | 1981-01-21 | 1983-09-13 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Synergistic antimicrobial compositions |
| JPS57130916A (en) * | 1981-02-02 | 1982-08-13 | Chinoin Gyogyszer Es Vegyeszet | Cooperative antimicrobial composition |
| HU203476B (en) * | 1988-06-16 | 1991-08-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing stabile, aquous suspoemulsion containing primicin and suspoemulsionic pharmaceutical composition containing them as active component |
| US5217707A (en) * | 1988-06-16 | 1993-06-08 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Pharmaceutical composition and process for the preparation thereof |
| HU201876B (en) * | 1988-11-02 | 1991-01-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing stabile aquous solutions of primicin and pharmaceutical and desinficient compositions containing them |
| HU207222B (en) * | 1990-02-15 | 1993-03-29 | Chinoin Gyogyszer Es Vegyeszet | Process for producing eyedrops containing primycin |
-
1975
- 1975-06-20 HU HU75CI1593A patent/HU173708B/hu unknown
-
1976
- 1976-06-16 AT AT439276A patent/AT344885B/de active
- 1976-06-18 GR GR51035A patent/GR60551B/el unknown
- 1976-06-18 FI FI761772A patent/FI55609C/fi not_active IP Right Cessation
- 1976-06-18 GB GB25407/76A patent/GB1512604A/en not_active Expired
- 1976-06-18 SU SU762374703A patent/SU1338778A3/ru active
- 1976-06-18 BE BE168062A patent/BE843115A/xx not_active IP Right Cessation
- 1976-06-19 ES ES449062A patent/ES449062A1/es not_active Expired
- 1976-06-21 JP JP51072309A patent/JPS527419A/ja active Granted
- 1976-06-21 FR FR7618799A patent/FR2315910A1/fr active Granted
Non-Patent Citations (1)
| Title |
|---|
| Nature, 174, 1954, р. 1105. * |
Also Published As
| Publication number | Publication date |
|---|---|
| FI761772A7 (enrdf_load_stackoverflow) | 1976-12-21 |
| FI55609B (fi) | 1979-05-31 |
| JPS527419A (en) | 1977-01-20 |
| BE843115A (fr) | 1976-10-18 |
| AT344885B (de) | 1978-08-10 |
| FI55609C (fi) | 1979-09-10 |
| ATA439276A (de) | 1977-12-15 |
| FR2315910A1 (fr) | 1977-01-28 |
| HU173708B (hu) | 1979-07-28 |
| GR60551B (en) | 1978-06-14 |
| ES449062A1 (es) | 1977-11-16 |
| JPS6222968B2 (enrdf_load_stackoverflow) | 1987-05-20 |
| GB1512604A (en) | 1978-06-01 |
| FR2315910B1 (enrdf_load_stackoverflow) | 1978-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3583166B2 (ja) | 損傷皮膚修復用粉末製剤 | |
| EP0546018B1 (en) | Pharmaceutical composition of florfenicol | |
| JPH05194215A (ja) | ５−ベンゾイル−２，３−ジヒドロ−１ｈ−ピロリジン−１−カルボン酸を含有する鼻内投与用治療組成物 | |
| KR20090031726A (ko) | 국소용 조성물 | |
| CN108126237A (zh) | 一种磺胺嘧啶银温敏凝胶及其制备方法和应用 | |
| EP2139451B1 (en) | Topical compositions containing magaldrate | |
| CA1267848A (en) | Aqueous composition containing sodium cromoglycate | |
| SU1338778A3 (ru) | Способ получени дебрицина | |
| JPS6321648B2 (enrdf_load_stackoverflow) | ||
| EP1174133A1 (en) | Pharmaceutical compositions containing amorphous mupirocin | |
| CN110946846A (zh) | 一种不含透皮促渗剂的洛索洛芬钠凝胶膏基质及其制备方法 | |
| EP1128809B1 (en) | Aqueous ophthalmic formulations comprising chitosan | |
| EP0594760B1 (fr) | Compositions ophtalmiques a base d'acide polyacrylique | |
| EP0579155B1 (en) | Aqueous preparation of azulene sodium sulfonate | |
| KR20100125318A (ko) | 안과용 플루오로퀴놀론 유도체 | |
| GB2202145A (en) | Topical pharmaceutical compositions | |
| HK1052873A1 (en) | Two-phase hydrogel for application in drops at the eye | |
| JPH03109326A (ja) | フレロキサシン点眼液 | |
| ZA200210076B (en) | Antifungal ketoconazole composition for topical use. | |
| JP7396598B2 (ja) | 皮膚創傷用組成物 | |
| RU2007997C1 (ru) | Линимент метилурацила | |
| CN113230450A (zh) | 一种壳聚糖抑菌凝胶及其制备方法 | |
| CN1074370A (zh) | 使伤口加速愈合的组合物 | |
| JPH05221873A (ja) | 鼻および目に局所使用するためのブラジキニン拮抗剤含有薬学的組成物 | |
| RU2367456C2 (ru) | Фармацевтическая композиция для местного применения, обладающая антибактериальным и некролитическим действием |