SU1148564A3

SU1148564A3 - Способ получени производных простых арилфениловых эфиров или их кислотно-аддитивных солей,или их металлических комплексов

Способ получени производных простых арилфениловых эфиров или их кислотно-аддитивных солей,или их металлических комплексов Download PDF

Info

Publication number: SU1148564A3
Authority: SU; USSR - Soviet Union
Prior art keywords: alkyl; water; acid; atom; hydrogen
Prior art date: 1981-05-12

Application number

SU823528400A

Other languages

English (en)

Russian (ru)

Inventor

Хубеле Адольф

Рибли Петер

Original Assignee

Циба-Гейги Аг (Фирма)

Priority date

1981-05-12

Filing date

1982-12-27

Publication date

1985-03-30

1982-12-27 Application filed by Циба-Гейги Аг (Фирма) filed Critical Циба-Гейги Аг (Фирма)

1985-03-30 Application granted granted Critical

1985-03-30 Publication of SU1148564A3 publication Critical patent/SU1148564A3/ru

1993-06-09 Priority to LTRP633A priority Critical patent/LT2133B/xx

1994-01-31 Priority to MD94-0036A priority patent/MD58C2/ro

Links

150000003839 salts Chemical class 0.000 title claims abstract description 24
239000000654 additive Substances 0.000 title claims abstract description 13
238000000034 method Methods 0.000 title claims abstract description 12
150000002170 ethers Chemical class 0.000 title claims abstract description 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 33
150000001875 compounds Chemical class 0.000 claims abstract description 29
239000002253 acid Substances 0.000 claims abstract description 17
125000000217 alkyl group Chemical group 0.000 claims abstract description 13
125000005843 halogen group Chemical group 0.000 claims abstract description 11
229910052751 metal Inorganic materials 0.000 claims abstract description 10
239000002184 metal Substances 0.000 claims abstract description 10
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 9
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 9
239000001257 hydrogen Substances 0.000 claims abstract description 7
229910052783 alkali metal Inorganic materials 0.000 claims abstract description 6
150000001340 alkali metals Chemical group 0.000 claims abstract description 6
230000000996 additive effect Effects 0.000 claims abstract description 4
125000001624 naphthyl group Chemical group 0.000 claims abstract description 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 6
241001331845 Equus asinus x caballus Species 0.000 claims abstract 3
125000004429 atom Chemical group 0.000 claims abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 2
238000002360 preparation method Methods 0.000 claims description 28
239000002585 base Substances 0.000 claims description 10
125000004432 carbon atom Chemical group C* 0.000 claims description 6
239000003960 organic solvent Substances 0.000 claims description 4
238000006243 chemical reaction Methods 0.000 claims description 3
150000004696 coordination complex Chemical class 0.000 claims description 2
125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
239000003795 chemical substances by application Substances 0.000 abstract description 11
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract description 5
229910052799 carbon Inorganic materials 0.000 abstract description 4
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 90
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 87
-1 methyl methyl phenyl Chemical group 0.000 description 72
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 53
239000000203 mixture Substances 0.000 description 53
239000002904 solvent Substances 0.000 description 44
241000196324 Embryophyta Species 0.000 description 33
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 31
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235000011152 sodium sulphate Nutrition 0.000 description 28
239000013543 active substance Substances 0.000 description 27
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235000014113 dietary fatty acids Nutrition 0.000 description 17
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 16
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 15
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239000007787 solid Substances 0.000 description 14
239000013078 crystal Substances 0.000 description 13
JLYXXMFPNIAWKQ-UHFFFAOYSA-N γ Benzene hexachloride Chemical compound ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl JLYXXMFPNIAWKQ-UHFFFAOYSA-N 0.000 description 13
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
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150000002148 esters Chemical class 0.000 description 11
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239000000825 pharmaceutical preparation Substances 0.000 description 10
159000000000 sodium salts Chemical class 0.000 description 10
238000003756 stirring Methods 0.000 description 10
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239000002775 capsule Substances 0.000 description 9
239000000839 emulsion Substances 0.000 description 9
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 8
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
230000015572 biosynthetic process Effects 0.000 description 8
239000008187 granular material Substances 0.000 description 8
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 8
235000019359 magnesium stearate Nutrition 0.000 description 8
239000003208 petroleum Substances 0.000 description 8
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 8
239000000600 sorbitol Substances 0.000 description 8
239000000454 talc Substances 0.000 description 8
229910052623 talc Inorganic materials 0.000 description 8
235000012222 talc Nutrition 0.000 description 8
241001465754 Metazoa Species 0.000 description 7
239000006071 cream Substances 0.000 description 7
150000002191 fatty alcohols Chemical class 0.000 description 7
239000000463 material Substances 0.000 description 7
125000000896 monocarboxylic acid group Chemical group 0.000 description 7
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 7
239000000843 powder Substances 0.000 description 7
229910052708 sodium Inorganic materials 0.000 description 7
239000011734 sodium Substances 0.000 description 7
238000003786 synthesis reaction Methods 0.000 description 7
230000009885 systemic effect Effects 0.000 description 7
238000012360 testing method Methods 0.000 description 7
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IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
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