SU108301A1 - The method of obtaining avdipiridil from anabazina - Google Patents
The method of obtaining avdipiridil from anabazinaInfo
- Publication number
- SU108301A1 SU108301A1 SU553098A SU563098A SU108301A1 SU 108301 A1 SU108301 A1 SU 108301A1 SU 553098 A SU553098 A SU 553098A SU 563098 A SU563098 A SU 563098A SU 108301 A1 SU108301 A1 SU 108301A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- obtaining
- avdipiridil
- anabazina
- distilled
- vacuum
- Prior art date
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Предлагаетс препаративный метод получени а -дипиридила дегидрировапием анабазина очищенной порошкообразной серой.A preparative method is proposed for the preparation of α-dipyridyl anabasine dehydrirovapium with purified powdered sulfur.
Реакци дегидрировани анабазина проводитс в вакууме следующим образом.The anabasine dehydrogenation reaction is conducted under vacuum as follows.
64,8 г анабазина и 38,4 г порошкообразной серы помещают в коническую колбу дл перегонки в вакууме , соединенную с приемниками и водоструйным насосом. Смесь нагревают на песчаной бане до 250- 260°. Нагревание выше 150-155° провод т так, чтобы реакци шла быстро, что наблюдаетс по скорости выделени сероводорода. Нагревание продолжаетс до прекращени выделени сероводорода. В конце реакции колба нагреваетс на голом пламени горелки (примерно 30 мин.). При этом не допускаетс перегонка жидкости. Затем начинают обычную вакуумную перегонку . При 171 -174° перегон ют маслообразную жидкость, котора собираетс в приемник.64.8 g of anabasine and 38.4 g of powdered sulfur are placed in a conical flask for distillation in vacuum, connected to receivers and a water-jet pump. The mixture is heated on a sand bath to 250-260 °. Heating above 150-155 ° is carried out so that the reaction proceeds rapidly, as observed in the rate of release of hydrogen sulfide. Heating continues until hydrogen sulphide is released. At the end of the reaction, the flask is heated on the low flame of the burner (approximately 30 minutes). It is not allowed to distill the liquid. Then begin the usual vacuum distillation. At 171 - 174 °, the oily liquid is distilled, which is collected in the receiver.
Затем эту жидкость взбалтывают с раствором марганцевокислого кали , отфильтровывают от двуокиси марганца, подщелачивают и экстрагируют хлороформом. Экстракт высушивают и после отгонки растворител а(3-дипиридил перегон ют в вакууме при 126-128°. Выход 57,79%. Пикрат 154-156° (из воды).Then this liquid is shaken with a solution of potassium permanganate, filtered from manganese dioxide, alkalinized and extracted with chloroform. The extract is dried and after distilling off the solvent a (3-dipyridyl is distilled under vacuum at 126-128 °. Yield 57.79%. Picrate 154-156 ° (from water).
Предмет изобретени Subject invention
Способ получени а -дипиридила из анабазина, отличающийс тем, что, с целью получени продукта , доступного дл разнообразных исследований, смесь анабазина и серы нагреваетс в пределах 250-260° до прекращени выделени сероводорода, маслообразна жидкость перегон етс в вакууме при 171 - 174°, перегнанна жидкость взбалтываетс с перманганатом кали , отфильтрованный от двуокиси марганца раствор подщелачиваетс , и экстрагируетс хлороформом , экстракт высушиваетс , растворитель отгон етс и ар-дипиридил перегон етс в вакууме при 126-128°.The method of obtaining α-dipyridyl from anabasine, characterized in that, in order to obtain a product available for various studies, the mixture of anabazine and sulfur is heated in the range of 250-260 ° until the release of hydrogen sulfide stops, the oily liquid is distilled in vacuum at 171-174 ° , the distilled liquid is agitated with potassium permanganate, the solution filtered from manganese dioxide is made alkaline, and extracted with chloroform, the extract is dried, the solvent is distilled off and ar-dipyridyl is distilled in vacuum at 126-128 °.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU553098A SU108301A1 (en) | 1956-12-21 | 1956-12-21 | The method of obtaining avdipiridil from anabazina |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU553098A SU108301A1 (en) | 1956-12-21 | 1956-12-21 | The method of obtaining avdipiridil from anabazina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU108301A1 true SU108301A1 (en) | 1957-11-30 |
Family
ID=50029306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU553098A SU108301A1 (en) | 1956-12-21 | 1956-12-21 | The method of obtaining avdipiridil from anabazina |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU108301A1 (en) |
-
1956
- 1956-12-21 SU SU553098A patent/SU108301A1/en active
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