SMT201400192B - Medicamento inalabile comprendente tiotropio - Google Patents
Medicamento inalabile comprendente tiotropioInfo
- Publication number
- SMT201400192B SMT201400192B SM201400192T SM201400192T SMT201400192B SM T201400192 B SMT201400192 B SM T201400192B SM 201400192 T SM201400192 T SM 201400192T SM 201400192 T SM201400192 T SM 201400192T SM T201400192 B SMT201400192 B SM T201400192B
- Authority
- SM
- San Marino
- Prior art keywords
- medicine including
- inhalable medicine
- tiotropium
- including tiotropium
- inhalable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161577315P | 2011-12-19 | 2011-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201400192B true SMT201400192B (it) | 2015-03-05 |
Family
ID=45813952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201400192T SMT201400192B (it) | 2011-12-19 | 2014-12-22 | Medicamento inalabile comprendente tiotropio |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9655969B2 (fr) |
| EP (3) | EP3143998B1 (fr) |
| JP (1) | JP5791166B2 (fr) |
| KR (2) | KR101670564B1 (fr) |
| CN (1) | CN103998039A (fr) |
| AR (1) | AR089302A1 (fr) |
| AU (1) | AU2012358475B2 (fr) |
| BR (1) | BR112014014535A2 (fr) |
| CA (1) | CA2856047C (fr) |
| CY (1) | CY1116142T1 (fr) |
| DK (3) | DK3143998T3 (fr) |
| EA (1) | EA028461B1 (fr) |
| ES (3) | ES2728940T3 (fr) |
| GB (1) | GB201200525D0 (fr) |
| HK (2) | HK1198512A1 (fr) |
| HR (1) | HRP20141176T1 (fr) |
| HU (2) | HUE044647T2 (fr) |
| IL (1) | IL232946A0 (fr) |
| MX (1) | MX361925B (fr) |
| PL (3) | PL2793886T3 (fr) |
| PT (1) | PT2606891E (fr) |
| RS (1) | RS53783B1 (fr) |
| SI (1) | SI2606891T1 (fr) |
| SM (1) | SMT201400192B (fr) |
| TR (1) | TR201908429T4 (fr) |
| TW (1) | TWI468187B (fr) |
| UY (1) | UY34525A (fr) |
| WO (1) | WO2013092237A1 (fr) |
| ZA (2) | ZA201403041B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY156950A (en) | 2009-12-23 | 2016-04-15 | Chiesi Farma Spa | Aerosol formulation for copd |
| GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
| EP2819669B1 (fr) | 2012-02-28 | 2021-04-21 | Boehringer Ingelheim International GmbH | Nouvelle formulation de tiotropium contenant un gaz propulseur |
| EP2897589B1 (fr) * | 2013-11-22 | 2018-01-03 | Teva Branded Pharmaceutical Products R & D, Inc. | Médicament inhalable |
| MX2016006377A (es) * | 2013-11-22 | 2016-10-28 | Teva Branded Pharmaceutical Products R&D Inc | Un medicamento inhalable. |
| US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
| US20190054010A1 (en) * | 2015-10-29 | 2019-02-21 | 3M Innovative Properties Company | Formulation and aerosol canisters, inhalers, and the like containing the formulation |
| EP3922240B1 (fr) * | 2016-09-19 | 2023-06-21 | Mexichem Fluor S.A. de C.V. | Composition pharmaceutique comprenant du bromide de tiotropium |
| WO2020006017A1 (fr) * | 2018-06-27 | 2020-01-02 | 3M Innovative Properties Company | Formulation de tiotropium et inhalateur |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8828477D0 (en) | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
| US5610163A (en) | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
| DE3931041C2 (de) | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| GB9026191D0 (en) * | 1990-12-01 | 1991-01-16 | Harris Pharma Ltd | Breath actuated dispensing device |
| EP0616525B1 (fr) | 1991-12-12 | 1995-09-27 | Glaxo Group Limited | Formulation d'aerosol pharmaceutique |
| IL104068A (en) | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Pharmaceutical preparations in a spray without surfactant containing 1, 1, 1, 2 tetrafluoroethane or 1,1,2,3,3 petafluor N propane as propellant |
| GB2264238A (en) | 1992-05-29 | 1993-08-25 | Norton Healthcare Ltd | Medicament inhalor device |
| AU680227B2 (en) * | 1992-12-09 | 1997-07-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Stabilized medicinal aerosol solution formulations |
| US6258341B1 (en) | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
| US6309671B1 (en) | 1995-04-14 | 2001-10-30 | Inhale Therapeutic Systems | Stable glassy state powder formulations |
| GB9616237D0 (en) | 1996-08-01 | 1996-09-11 | Norton Healthcare Ltd | Aerosol formulations |
| EP1131059B1 (fr) | 1998-11-13 | 2003-03-05 | Jago Research Ag | Poudre seche pour inhalation |
| DZ2947A1 (fr) | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
| EP1238661A1 (fr) | 1999-10-12 | 2002-09-11 | Kaken Pharmaceutical Co., Ltd. | Preparations pour inhalation en poudre et leur procede de production |
| US20060257324A1 (en) | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
| ME00220B (me) | 2000-05-22 | 2010-10-10 | Chiesi Farm Spa | Stabilne farmaceutske formulacije rastvora za inhalatore odmjerene doze pod pritiskom |
| US6553988B1 (en) | 2000-06-09 | 2003-04-29 | Norton Healthcare, Inc. | Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber |
| US6908928B2 (en) | 2000-10-12 | 2005-06-21 | Bi Pharma Kg. | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
| ATE275391T1 (de) | 2000-10-12 | 2004-09-15 | Boehringer Ingelheim Pharma | Neue tiotropium-haltige inhalationspulver |
| WO2002030928A1 (fr) | 2000-10-12 | 2002-04-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Monohydrate cristallin, procede permettant sa preparation et son utilisation pour la preparation d'un produit pharmaceutique |
| ES2185606T3 (es) * | 2001-03-21 | 2003-05-01 | Sanol Arznei Schwarz Gmbh | Nuevo uso de una clase de compuestos peptidicos para tratamiento de la alodinia u otros tipos diferentes de dolor cronico o fantasma. |
| US20030070679A1 (en) | 2001-06-01 | 2003-04-17 | Boehringer Ingelheim Pharma Kg | Capsules containing inhalable tiotropium |
| DE10126924A1 (de) | 2001-06-01 | 2002-12-05 | Boehringer Ingelheim Pharma | Inhalationskapseln |
| US6608055B2 (en) | 2001-06-22 | 2003-08-19 | Boehringer Ingelheim Pharma Kg | Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition |
| BR0210537A (pt) | 2001-06-22 | 2004-06-22 | Boehringer Ingelheim Pharma | Anticolinérgico cristalino, processo para a sua preparação e sua aplicação para a preparação de um medicamento |
| DE10130371A1 (de) * | 2001-06-23 | 2003-01-02 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika |
| US20040126325A1 (en) * | 2002-03-12 | 2004-07-01 | David Lewis | Medicinal aerosol solution formulation products with improved chemical stability |
| US7309707B2 (en) | 2002-03-20 | 2007-12-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament |
| DE10212264A1 (de) | 2002-03-20 | 2003-10-02 | Boehringer Ingelheim Pharma | Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels |
| US7311894B2 (en) | 2002-03-28 | 2007-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations containing an anticholinergic |
| DE10214263A1 (de) | 2002-03-28 | 2003-10-16 | Boehringer Ingelheim Pharma | HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum |
| GB0219511D0 (en) | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Method of preparing dry powder inhalation compositions |
| AU2003303029A1 (en) * | 2002-12-16 | 2004-07-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tiotropium containing hfc solution formulations |
| US20050058606A1 (en) * | 2002-12-16 | 2005-03-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tiotropium containing HFC solution formulations |
| DE10339197A1 (de) | 2003-08-22 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Sprühgetrocknete amorphe Pulver mit geringer Restfeuchte und guter Lagerstabilität |
| US20070189979A1 (en) | 2003-09-18 | 2007-08-16 | Norton Healthcare Limited T/A Ivax Pharmaceuticals | Particles |
| US7968717B2 (en) | 2003-11-03 | 2011-06-28 | Boehringer Ingelhein International Gmbh | Crystalline anhydrate with anticholinergic efficacy |
| AU2004285684B2 (en) | 2003-11-03 | 2011-07-14 | Boehringer Ingelheim International Gmbh | Novel crystalline anhydride with anticholinergic effect |
| SE0303570L (sv) | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
| WO2005086915A2 (fr) | 2004-03-09 | 2005-09-22 | Arriva Pharmaceuticals, Inc. | Traitement de la bronchopneumopathie chronique obstructive par inhalation a faible dose d'inhibiteur de protease |
| US20060079544A1 (en) | 2004-08-13 | 2006-04-13 | Boehringer Ingelheim International Gmbh | Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic |
| EP1850831B1 (fr) * | 2005-02-25 | 2015-12-02 | CHIESI FARMACEUTICI S.p.A. | Preparations pharmaceutiques d'aerosol pour aerosols-doseurs pressurises contenant un agent sequestrant |
| JP2008540367A (ja) | 2005-05-02 | 2008-11-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規結晶性臭化チオトロピウム |
| JP5227790B2 (ja) | 2005-05-02 | 2013-07-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規結晶性臭化チオトロピウム |
| EP1896026B1 (fr) | 2005-06-15 | 2013-10-09 | Boehringer Ingelheim International GmbH | Procedé de fabrication des sels de tiotropium, des sels de tiotropium et compositions pharmaceutiques |
| NZ566399A (en) | 2005-08-06 | 2011-07-29 | Boehringer Ingelheim Int | Use of tiotropium salts in the treatment of severe persistant asthma |
| TWI389692B (zh) | 2005-10-10 | 2013-03-21 | Boehringer Ingelheim Int | 用以吸入β-共效劑的氣溶膠調配物 |
| CN102731494A (zh) | 2005-12-19 | 2012-10-17 | 西科尔公司 | 噻托溴铵的新形式及其制备方法 |
| EP1923393A1 (fr) | 2006-11-17 | 2008-05-21 | Boehringer Ingelheim Pharma GmbH & Co. KG | Forme cristalline de tiotropium bromide avec urée |
| GB0716026D0 (en) | 2007-08-16 | 2007-09-26 | Norton Healthcare Ltd | An inhalable medicament |
| EP2201934A1 (fr) | 2008-12-23 | 2010-06-30 | CHIESI FARMACEUTICI S.p.A. | Produits de formule d'aérosol de tiotropium avec stabilité chimique améliorée |
| EP2389162A1 (fr) | 2009-01-26 | 2011-11-30 | Teva Pharmaceutical Industries Ltd | Procédés d'enrobage d'un support au moyen de microparticules |
| DK2501363T3 (en) * | 2009-11-17 | 2015-03-23 | Cipla Ltd | inhalable |
| SI2627386T1 (sl) | 2010-10-12 | 2015-10-30 | Ivax Pharmaceuticals Ireland | Nosna pršilna naprava |
| GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
| GB201200504D0 (en) | 2011-12-19 | 2012-02-22 | Teva Branded Pharmaceutical Prod R & D Inc | An inhaler |
| EP2819669B1 (fr) | 2012-02-28 | 2021-04-21 | Boehringer Ingelheim International GmbH | Nouvelle formulation de tiotropium contenant un gaz propulseur |
-
2012
- 2012-01-13 GB GBGB1200525.2A patent/GB201200525D0/en not_active Ceased
- 2012-12-06 EP EP16185402.1A patent/EP3143998B1/fr not_active Revoked
- 2012-12-06 PL PL12806382T patent/PL2793886T3/pl unknown
- 2012-12-06 BR BR112014014535A patent/BR112014014535A2/pt not_active Application Discontinuation
- 2012-12-06 KR KR1020147017716A patent/KR101670564B1/ko active IP Right Grant
- 2012-12-06 JP JP2014543943A patent/JP5791166B2/ja not_active Expired - Fee Related
- 2012-12-06 ES ES16185402T patent/ES2728940T3/es active Active
- 2012-12-06 TR TR2019/08429T patent/TR201908429T4/tr unknown
- 2012-12-06 PL PL16185402T patent/PL3143998T3/pl unknown
- 2012-12-06 EP EP12806382.3A patent/EP2793886B1/fr not_active Revoked
- 2012-12-06 CN CN201280060763.4A patent/CN103998039A/zh active Pending
- 2012-12-06 US US14/367,031 patent/US9655969B2/en active Active
- 2012-12-06 ES ES12806382.3T patent/ES2602314T3/es active Active
- 2012-12-06 HU HUE16185402 patent/HUE044647T2/hu unknown
- 2012-12-06 KR KR1020167025194A patent/KR20160111539A/ko not_active Application Discontinuation
- 2012-12-06 AU AU2012358475A patent/AU2012358475B2/en not_active Ceased
- 2012-12-06 HU HUE12806382A patent/HUE030983T2/en unknown
- 2012-12-06 WO PCT/EP2012/074690 patent/WO2013092237A1/fr active Application Filing
- 2012-12-06 EA EA201491206A patent/EA028461B1/ru not_active IP Right Cessation
- 2012-12-06 CA CA2856047A patent/CA2856047C/fr not_active Expired - Fee Related
- 2012-12-06 DK DK16185402.1T patent/DK3143998T3/da active
- 2012-12-06 DK DK12806382.3T patent/DK2793886T3/en active
- 2012-12-06 MX MX2014007357A patent/MX361925B/es active IP Right Grant
- 2012-12-12 PL PL12196725T patent/PL2606891T3/pl unknown
- 2012-12-12 DK DK12196725.1T patent/DK2606891T3/en active
- 2012-12-12 EP EP12196725.1A patent/EP2606891B1/fr not_active Revoked
- 2012-12-12 RS RS20140691A patent/RS53783B1/en unknown
- 2012-12-12 SI SI201230113T patent/SI2606891T1/sl unknown
- 2012-12-12 PT PT121967251T patent/PT2606891E/pt unknown
- 2012-12-12 ES ES12196725.1T patent/ES2526685T3/es active Active
- 2012-12-18 UY UY0001034525A patent/UY34525A/es not_active Application Discontinuation
- 2012-12-18 AR ARP120104795A patent/AR089302A1/es not_active Application Discontinuation
- 2012-12-19 TW TW101148516A patent/TWI468187B/zh not_active IP Right Cessation
-
2014
- 2014-04-25 ZA ZA2014/03041A patent/ZA201403041B/en unknown
- 2014-06-02 IL IL232946A patent/IL232946A0/en active IP Right Grant
- 2014-11-27 HK HK14111996.5A patent/HK1198512A1/xx unknown
- 2014-12-04 HR HRP20141176AT patent/HRP20141176T1/hr unknown
- 2014-12-19 CY CY20141101072T patent/CY1116142T1/el unknown
- 2014-12-22 SM SM201400192T patent/SMT201400192B/xx unknown
-
2015
- 2015-01-27 HK HK15100893.1A patent/HK1200343A1/xx unknown
- 2015-03-23 ZA ZA2015/01986A patent/ZA201501986B/en unknown
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