SK94598A3 - Disinfecting compositions and processes for disinfecting surfaces - Google Patents

Abstract

The present invention relates to the disinfection of surfaces with a disinfecting composition comprising from 0.1 % to 15 % by weight of the total composition of hydrogen peroxide, and an antimicrobial essential oil or mixtures thereof.

Description

Technical field

The present invention relates to antimicrobial compositions which are used to disinfect and clean various surfaces including living surfaces (e.g., human skin, mouth, and the like) and inanimate surfaces including, but not limited to, solid surfaces such as walls, tiles, table tops, glass, bathroom surfaces, kitchen surfaces, dishes, fabrics, dresses, carpets, and the like.

BACKGROUND OF THE INVENTION

Antimicrobial / antibacterial agents include substances capable of disinfecting. Generally, the disinfectant substantially reduces or even destroys microorganisms, e.g. bacteria on the surface. For disinfecting purposes, many formulations based on halogen containing compounds such as hypochlorite or quaternary compounds have been described in the art. Peroxyacid-containing compositions are also known as disinfectants.

A disadvantage of peroxyacid based disinfectants is that they can destroy disinfected surfaces that come into contact with them. Users have noted that peroxyacid-based compositions are not safe for various surfaces including solid surfaces and fabrics, especially delicate fabrics such as silk, wool, and the like.

It is an object of the present invention to provide disinfectants that are safer for cleaned surfaces without reducing their disinfectant effect on the surfaces, even at large dilutions used. .

This has been shown to achieve a composition comprising 0.1% to 15% hydrogen peroxide of the total weight of the composition and an antimicrobial essential oil or mixtures thereof. In particular, it has been shown that the compositions of the present invention comprising hydrogen peroxide and antimicrobial essential oil are safer for cleaned surfaces and also achieve a perfect disinfection of clean surfaces, i.e., clean surfaces. surfaces free of organic and / or inorganic stains even at high dilution, ie. up to a 1: 100 dilution (composition: water).

The compositions of the present invention are suitable for use on all types of surfaces, including living surfaces (e.g., human skin and / or mouth when used as an oral preparation or toothpaste) and inanimate surfaces. This technology is particularly suitable for applications on solid surfaces as well as underwear, e.g. as a detergent or additive in a so-called " 'Soaking cycle', 'washing cycle' or pre-treatment of laundry in the 'pre-treatment cycle'. The compositions of the present invention are particularly suitable for use on delicate surfaces including surfaces for safe contact with food and / or children. By using the diluted compositions of the present invention, the amount of chemical compounds remaining on the disinfected surface is reduced. For example, it is not necessary to rinse solid surfaces after application of the diluted compositions of the present invention.

The advantage of the present invention is the perfect disinfection acting on a wide range of pure bacterial strains including Gram positive and Gram negative bacterial strains and more resistant microorganisms than fungi.

A further advantage of the compositions according to the present invention is, in addition to the disinfecting properties, also good cleaning effects, especially in embodiments of the present invention, wherein the compositions further comprise a surfactant and / or solvent.

A further advantage of the compositions of the present invention is that they can be in various forms, e.g. as a liquid packaged in a conventional detergent container or spray or foam packaged in a spray / foam dispenser, or as wipes containing the composition of the invention, or in a non-liquid state (e.g., gel, paste or solid state).

For example, WO88 / 00795 discloses liquid disinfectants comprising a compound of the group of organic acids, perborates, peracids and salts thereof, together with a quaternary ammonium salt and essential oil. Hydrogen peroxide is not mentioned or its content.

EP-B-288 689 discloses a solid surface liquid comprising an effective amount of an antimicrobial pine oil and at least one oleic soluble organic acid. Hydrogen peroxide is not mentioned.

US-5,403,587 discloses aqueous antimicrobial compositions used for sanitizing, disinfecting and cleaning solid surfaces. In particular, US-5,403,587 discloses aqueous compounds (pH 1 to 12) containing essential oils (0.02% to 5%) which exhibit potent antimicrobial properties such as thymol essential oil, eucalyptic essential oil, clove essential oil and the like, and solubilizing or

a dispersing agent necessary to form an aqueous solution or dispersion of essential oils in an aqueous medium. Hydrogen peroxide is not mentioned.

I

SUMMARY OF THE INVENTION

The present invention includes a disinfectant composition comprising 0.1% to 15% hydrogen peroxide of the total weight of the composition and an antimicrobial essential oil or mixtures thereof.

The present invention further comprises a method of disinfecting a surface with a disinfectant of the present invention.

DETAILED DESCRIPTION OF THE INVENTION.

Disinfectants:

The compositions of the present invention comprise 0.1% to 15% hydrogen peroxide of the total weight of the composition and an antimicrobial essential oil.

The compositions of the present invention are either liquid or non-flowable (e.g., gel, paste, or in solid form as a powder or granules). The solid compositions are mixed with a suitable solvent, usually water, before use. Liquid formulations are aqueous or non-aqueous formulations. For convenience of use, liquid formulations are preferred.

The compositions of the present invention comprise hydrogen peroxide as a constituent.

The presence of hydrogen peroxide in the compositions of the present invention contributes to the disinfectant properties of the compositions of the present invention. Hydrogen peroxide can attack the vital functions of microorganism cells, for example, it can inhibit the arrangement of ribosomal units in the cytoplasm of microorganism cells. Hydrogen peroxide is a strong oxidizing agent that generates free hydroxyl radicals that attack proteins and nucleic acids. In addition, the presence of hydrogen peroxide has a strong stain removal effect, which is noticeable, for example, when applied to linen and solid surfaces.

The compositions of the invention comprise 0.1% to 15% hydrogen peroxide, based on the total weight of the composition, preferably 0.5% to 10%, and more preferably 1% to 8%.

The compositions of the present invention comprise as a second essential component an antimicrobial essential oil or mixtures thereof. The compositions typically comprise at least 0.003% antimicrobial essential oils or mixtures thereof, based on the total weight of the composition, preferably 0.006% to 10%, more preferably 0.2% to 4%, and most preferably 0.2% to 2%.

Suitable antimicrobial essential oils useful in the compositions of the invention are those that exhibit antimicrobial activity. Antimicrobial essential oils induce protein denaturation. The antimicrobial essential oils contribute to the safe profile of the compositions of the present invention when used to disinfect any surfaces. A further advantage of the antimicrobial essential oils is that they provide a pleasant fragrance to the disinfectants of the present invention without the need for perfume. The disinfectants of the present invention not only perfectly disinfect clean surfaces, but also give them a pleasant scent and are safe for the surfaces.

Suitable antimicrobial essential oils include, but are not limited to, essential oils derived from thymol, lemon grass, citrus, lemons, oranges, anise, clove, anise pepper, cinnamon, geranium, lipstick, mint, peppermint, lavender, lemon essential oil, eucalyptus camphor, sandalwood, cedar, rosemary, pine, verbena, ratanhiae and mixtures thereof. Especially preferred are eucalyptus silica, thymol silica, clove oil, cinnamon oil, geranium oil, eucalyptus oil, peppermint oil, peppermint oil and mixtures thereof.

The compositions of the present invention containing 0.1% to 15% hydrogen peroxide by weight of the composition and the antimicrobial essential oil or mixtures thereof have been shown to give a higher surface safety, compared to the same peroxyacid-containing composition instead of hydrogen peroxide. solid surfaces and fabrics such as silk, wool and the like, while maintaining perfect disinfection of clean surfaces even at high dilution.

An advantage of the present invention is that the use of the compositions according to the invention for the disinfection of colored fabrics also suppresses the deterioration of the color while maintaining the perfect disinfection of the fabrics even at high dilution. The observed change in color and / or discolouration of colored fabrics using the composition of the present invention comprising hydrogen peroxide and antimicrobial essential oil or mixtures thereof is less while maintaining perfect fabric disinfection even at high dilution compared to the same composition containing peracid instead of hydrogen peroxide.

Surface safety is evaluated on fabrics by measuring the tensile strength of the fabric. The tensile strength of the fabric is measured by the tensile strength method. This method is based on measuring the tensile strength of a given fabric by stretching the fabric until rupture. The breaking force of the fabric, expressed in kg, is the 'Ultimate Tensile Strength' and can be measured with the INSTRON Stress Strength Instrument.

Perfect disinfection is achieved by the compositions of the present invention in a variety of microorganisms including Gram positive bacteria such as Staphylococcus aureus and Gram negative bacteria such as Pseudomonas aeroginosa, as well as fungi such as Candida albicans present on clean surfaces, i. on any surface free of organic and / or inorganic stains even at high dilution.

The disinfectant properties of the composition are measured by the bactericidal activity of the composition. A test method suitable for the determination of bactericidal activity of the composition on clean surfaces is described in Europian Standard, prEN 1040, CEN / TC 216 N 78 of November 1995, issued by the European Commission for Standardization in Brussels. Europian Standard, prEN 1040, CEN / TC 216 N 78 specifies the test method and the requirements for the minimum bactericidal activity of the disinfectant. The test is positive when the bacterial colony forming units (cfu) are reduced from 10 ⁷ cfu (baseline) to 10 ² cfu (final count after contact with the disinfectant product), ie. it is necessary to reduce viability of the order of 10 ⁵ . The compositions of the present invention pass this test on clean surfaces even at high dilution.

Another suitable test method for determining bactericidal activity of the present compositions on clean surfaces is AFNOR T72-190® and T72-301®.

In a preferred embodiment, the compositions of the present invention are liquid cleaning compositions. The liquid compositions preferably have a pH of not more than 12.0, more preferably 2 to 6, and most preferably 3 to 5. The pH of the compositions is adjusted using organic acids such as citric, succinic, acetic, aspartic, lactic and the like, or inorganic acids or alkalinizing agents.

The compositions of the present invention may further comprise surfactants known to those skilled in the art, including nonionic, anionic, cationic, amphoteric and / or zwitterionic surfactants. Surfactants contribute to the cleaning properties of the compositions of the invention.

The compositions of the present invention typically comprise surfactants or mixtures thereof in up to 50% of the total weight of the composition, preferably 0.01% to 30%, and most preferably 0.1% to 25%.

The compositions of the present invention preferably comprise amphoteric surfactants or mixtures thereof. Suitable amphoteric surfactants include betaine and sulfobetaine surfactants, derivatives thereof or mixtures thereof. Betaine and sulfobetaine surfactants preferably contribute to the disinfectant properties of the compositions of the invention. They assist disinfection by increasing the permeability of the bacterial cell wall, thus allowing other active ingredients to enter the cell.

Due to the mild activity of the betaine and sulfobetaine surfactants represented therein, the compositions of the present invention are particularly suitable for cleaning delicate surfaces such as delicate laundry or solid surfaces in contact with food and / or children. Betaine and sulfobetaine surfactants are very gentle on cleansed skin and / or cleaned surfaces.

Suitable betaine and sulfobetaine surfactants to be used in the compositions of the present invention are betaine / sulfobetaine and betaine-like detergents whose molecule contains both basic and acidic groups that form an internal salt and impart cationic and anionic hydrophilic groups to the molecule over a wide range of pH values. Some common examples of such detergents are described in U.S. Pat. Patentoch. 2,082,275, 2,702,279 and 2,255,082, herein incorporated by reference.

Preferred betaine and sulfobetaine surfactants have the general formula I:

R ₂ -N (CH ₃ ) n (I) wherein R 1 is an alkyl radical containing 1 to 24 carbon atoms, preferably 8 to 18, more preferably 12 to 14, wherein R ₂ and R ₃ contain 1 to 3 carbon atoms, preferably 1 a carbon atom wherein n is an integer of 1 to 10, preferably 1 to 6, and more preferably 1, Y is selected from the group of carboxyl and sulfonyl radicals and wherein the sum of the R 1, R ₂ and R ₃ radicals is 14 to 24 carbon atoms or mixtures thereof.

Examples of particularly suitable betaine surfactants include C ₁₂ -C 18 alkyldimethylbetaine such as coconut betaine and C 10 -C 18 alkyldimethylbetaine such as lauylbetaine.

Coconut betaine is commercially available from Seppic under the trade name Amonyl 265®. Laurylbetaine is commercially available from Albright & Wilson under the trade name Empigen BB / L®. '

Other suitable amphoteric surfactants include amine oxides or mixtures thereof. The amine oxides preferably contribute to the disinfectant properties of the compositions of the invention. They assist disinfection by disrupting the cell wall / membrane of the bacterium, thereby allowing other antimicrobial components to enter the cell and, for example, attack the inner cell space.

Suitable amine oxides have the general formula R 1 R ₂ R ₃ NO, wherein each R 1, R ₂ and R ₃ is independently a saturated linear or branched hydrocarbon chain having 1 to 30 carbon atoms. Suitable amine oxides of the present invention have the general formula R 1 R 2 R 3 NO, wherein R 1 is a hydrocarbon chain containing 1 to 30 carbon atoms, preferably 6 to 20, more preferably 6 to 14, and most preferably 8 to 10, and wherein R ₂ and R 3 are independently unsubstituted or substituted linearly or branched hydrocarbon chains containing 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, and more preferably methyl groups. R 1 is a saturated linear or branched hydrocarbon chain.

Preferred amine oxides of the present invention are, for example, a natural mixture of C8-C10 amine oxides and C12-C16 amine oxides commercially available from Hoechst.

In a preferred embodiment of the present invention where the compositions are particularly suitable for disinfecting solid surfaces, the surfactant is typically a surfactant system comprising an amine oxide and a betaine or sulfobetaine surfactant, preferably in a weight ratio amine oxide and betaine or sulfobetaine of 2: 1 to 100: 1, more preferably 6: 1. up to 100: 1 and most preferably 10: 1 to 50: 1. The use of such a surfactant system in compositions suitable for the disinfection of solid surfaces provides effective cleaning and luster to the surfaces to be cleaned, i. The amount of surfactant left by coating or spraying the surface cleaned with the compositions of the invention is minimal.

The compositions of the invention also preferably contain anionic surfactants or mixtures thereof. Particularly suitable anionic surfactants include water soluble salts or acids of the formula ROSO 3 M wherein R preferably is a C ₆ -C ₂ 4 hydrocarbyl, preferably ¹ t alkyl or hydroxyalkyl group of _C8-20 alkyl component, more preferably C ₈ alkyl -Ci6 or a hydroxyalkyl group and M is H or a cation, e.g. alkali metal cations (e.g., sodium, potassium, lithium) or ammonium or substituted ammonium cations (e.g., methyl, dimethyl, and trimethylammonium cations and quaternary ammonium cations such as tetramethylammonium and dimethylpiperidine cation and quaternary ammonium cations such as alkylammonium cations such as ethylammonium cations) , triethylamine and mixtures thereof, and the like).

Other suitable anionic surfactants include alkyl diphenyl ether sulfonates and alkyl carboxylates. Other anionic surfactants can include salts (including, for example, sodium, potassium, ammonium, and substituted ammonium salts such as mono-, di- and triethanolamine salts) of C9-C20 linear alkyl benzene sulfonates, C ₈ -C 22 primary or secondary alkanesulfonates, _C8 C24 olefinsulfonates, sulfonic polycarboxylic acids prepared by sulfonating the pyrolysis product of alkaline earth metal citrates, e.g. in British patent no. 1,082,179, C ₈ -C ₂₄ alkyl polyglycol ether sulfates (containing up to 10 moles of ethylene oxide); alkyl sulfonate esters such as C14-C16 methyl sulfonate; acylglycerol sulfonates, fatty oleylglycerol sulfates, alkylphenolethylene oxide ether sulfonates, paraffin sulfonates, alkyl phosphates, isethionates such as acyl isethionates, N-acyl taurates, alkyl succinamates and sulfosuccinates, monoesters of sulfosuccinates sulfosuccinates acyl sarcosinates, alkylpolysaccharide sulfates such as alkylpolyglucoside sulfates (nonionic unsulfonated compounds are described below), branched primary alkyl sulfates, alkylpolyethoxycarboxylates of formula RO (CH ₂ CH ₂ O) to CH ₂ COO-M ⁺ , where R is C ₈ -C ₂ the group k is an integer from 0 to 10 and M is a soluble salt-forming cation. Also suitable are bituminous acids and hydrogenated bituminous acids such as rosin, hydrogenated rosin and bituminous acids represented in or derived from tall oil. Further examples are given in 'Surface Active Agents and Detergents' (Vol. I and II, Schwartz, Perry and Berch). Various surfactants are also generally described in U.S. Patent 3,929,678, issued December 30, 1975 to Laughlin et al., Column 23, line 58 to column 29, line 23.

Preferred anionic surfactants useful in the compositions herein are the C ₈ -C ₆ alkyl sulfates, C ₈ -Whose alkyl, C ₈ -Ci6 alkyl alkoxy sulfates (e.g. C ₈ -Ci6 alkyl ethoxy sulfates), and mixtures thereof. Such anionic surfactants preferably contribute to the disinfecting properties of disinfectants containing hydrogen peroxide and / or antimicrobial essential oils. For example, C ₈ -C 16 alkyl sulfate causes disruption of the bacterial cell membrane, inhibits enzymatic activities, disrupts cell transport and / or denatures cellular proteins. It is believed that the improved disinfection action associated with the addition of an anionic surfactant, in particular a C ₈ -C ₁₆ alkylsulfonate, C ₈ -C 16 alkylsulfate and / or C ₈ -C 16 alkylalkoxysulfate to the composition of the present invention is due to a multiplicity of bacterial surfactant attack. Another aspect of the present invention is the use of an anionic surfactant, in particular a C ₈ -C ₁₆ alkylsulfonate, C ₈ -C 16 alkylsulfate and / or C ₈ -C 16 alkyl alkoxysulfate in a hydrogen peroxide disinfectant and / or antimicrobial essential oil to improve the disinfectant properties of the Gram negative and / or Gram positive bacteria.

Suitable nonionic surfactants are fatty alcohol ethoxylates and / or propoxylates which are commercially available with different fatty alcohol chain lengths and varying degrees of ethoxylation. The HLB values of these alkoxylated nonionic surfactants depend mainly on the chain length of the fatty alcohol, the type of alkoxylation and the degree of alkoxylation. The amount of surfactants, including nonionic, together with their respective HLB values, is listed in the surfactant catalogs.

Particularly suitable nonionic surfactants are hydrophobic nonionic surfactants having an HLB (hydrophilic lipophilic balance) value below 16, preferably below 15 and more preferably below 14. These hydrophobic nonionic surfactants well penetrate the grease.

Preferred hydrophobic nonionic surfactants to be used in the compositions of the present invention are surfactants having a clip 16 of the formula RO- (C2H4O) _n (C ₃ H6O) _m H, wherein R is a C6 to C22 alkyl chain or a C6 to C28 alkyl benzene chain, and wherein n + m is 0 to 20 and n is 0 to 15 and m is 0 to 20, preferably n + m is from 1 to 15 µm, and more preferably n + m is from 1 to 10, and n is 0 to 10. Preferred R chains are C 8 -C 22 alkyl chains. Suitable hydrophobic nonionic surfactants are Dobanol ^R 91-2.5 (HBL = 8.1; R is a mixture of C9 and Cu alkyl chains, n is 2.5 am is 0) or Lutensol ^R TO3 (HBL = 8; R is Cb alkyl) chain, n is 3 am is 0) or Lutensol ^R AO3 (HBL = 8; R is a mixture of C13 and C15 alkyl chains, n is 3 am is 0) or Tergitol ^R 25L3 (HBL = 7.7; R is in the length range alkyl chains of C12-C15, n is 3 am is 0) or Dobanol ^R 23-3 (HBL = 8.1; R is a mixture of C12 and C13 alkyl chains, n is 3 am is 0) or Dobanol ^R 23-2 (HBL = 6.2; R is a mixture of C ₂ and C 13 alkyl chains, n is 2 and m is 0), or Dobanol ^R 45-7 (HLB = 11.6; R is a mixture of C44 and C15 alkyl chains, n is 7 and m is 0) Dobanol ^R 23-6.5 (HBL = 11.9; R is a mixture of C12 and C13 alkyl chains, n is 6.5 am is 0) or Dobanol ^R 25-7 (HBL = 12; R is a mixture of C12 and C15 alkyl chains of chains, n is 7 and m is 0) or Dobanol ^R 91-5 (HBL = 11.6; R is a mixture of C9 and Cu alkyl chains, n is 5 and am is 0) or Dobanol ^R 91-6 (HBL = 12.5 R is a mixture of C 9 and C 9; Cu alkyl chains, n is 6 and m is 0) or Dobanol ^R 91-8 (HBL - 13.7; R is a mixture of C 9 and C 11 alkyl chains, n is 8 and m is 0) or Dobanol ^R 91-10 (HBL = 14.2; R is a mixture of C 9 and C 11 alkyl chains, n is 10 and m is 0) or mixtures thereof. Preferred are Dobanol ^R 91-2.5 or Lutensol ^R TO3 or Lutensol ^R AO3 or Tergitol ^R 25L3 or Dobanol ^R 23-3 or Dobanol ^R 23-2 or mixtures thereof. Dobanol ^R surfactants are commercially available from Shell. Lutensol ^R surfactants are commercially available from BASF and Tergitol ^R surfactants are commercially available from UNION CARBIDE.

Other suitable surfactants also include C6-C20 conventional soaps (alkali metal salts of C6-C20 fatty acids, preferably sodium salts).

The compositions of the present invention include, as a further preferred component, other antimicrobial ingredients that contribute to the antimicrobial activity of the compositions of the present invention. Such additives include parabens such as ethylparaben, propylparaben, methylparaben, gluteraldehyde or mixtures thereof.

¹

The compositions of the invention may further comprise a chelating agent as a further preferred component. Suitable chelating agents are known to those skilled in the art, and are selected from the group of phosphonate chelating agents, aminophosphonate chelating agents, substituted heteroaromatic chelating agents, aminocarboxylate chelating agents, other carboxylate chelating agents, polyfunctionally substituted aromatic chelating agents, biodegradable chelating agents as biodegradable chelating agents. acid or mixtures thereof.

Suitable phosphonate chelating agents include etidronic acid (1-hydroxyethylenediphosphonic acid HEDP) and / or alkali metal ethane 1-hydroxydiphosphonate.

Suitable aminophosphonate chelating agents include aminoalkylene polyalkylene phosphonates, nitrilotris (methylene) triphosphonates, ethylenediamine tetramethylene phosphonates and / or diethylene triamine pentamethylene phosphonates. Preferred aminophosphonate chelating agents are diethylene triamine pentamethylene phosphonates.

These phosphonate / aminophosphonate chelating agents are represented or in the form of acids or salts of some or all of the acid functions with different cations. Such phosphonate / aminophosphonate chelating agents are commercially available from Monsanto under the trade name DEQUEST®.

Substituted heteroaromatic chelating agents include hydroxypiperidine N-oxide or derivatives thereof.

Suitable hydroxypiperidine-N-oxides and derivatives thereof useful according to the present invention have the general formula II:

wherein X is nitrogen, Y is oxygen, -CHO, -OH, - (CH 2) _n -COOH, wherein n is an integer from 0 to 20, preferably 0 to 10, and more preferably 0 and Y is preferably oxygen. A particularly preferred hydroxypiperidine-N-oxide is 2-hydroxypiperidine-N-oxide and derivatives thereof.

Hydroxypiperidine N-oxides and derivatives thereof are commercially available from Sigma.

Polyfunctionally-substituted aromatic chelating agents are also useful in the compositions of the invention. See U.S. Pat. No. 3,812,044, issued to Connor et al. May 21, 1974.

Preferred compounds of this type in acid form are dihydroxydisulfobenzenes such as 1,2-dihydroxy-3,5-disulfobenzene.

A preferred biodegradable chelating agent is ethylenediamine Ν, Ν'-disuccinic acid or its alkali metal, alkaline earth, ammonium or substituted ammonium salts or mixtures thereof. Ethylenediamine Ν, Ν'-disuccinic acid, especially the (S, S) -isomer is disclosed in the US No. 4,704,233 issued to Hartman and Perkins on Nov. 3, 1987. Ethylenediamine Ν, ij'disuccinic acid is commercially available, for example, from Palmer Research Laboratories under the trade name ssEDDS®. Ethylenediamine Ν, Ν-disuccinic acid is particularly suitable for use in the compositions of the present invention.

Suitable amino carboxylate chelating agents useful herein include ethylene diamine tetra acetates, diethylene triamine (DTPA), N- hydroxyethylethylenediamine triacetates, nitrilotriacetates, ethylenediamine, triethylenetetraamine, ethanoldiglycines, propylene acid (PDTA) and methyl acid (MGDA), both in their acid form, as well as alkali metal , ammonium or substituted ammonium salts. Particularly suitable are diethylenetriaminepentaacetic acid (DTPA), propylenediaminetetraacetic acid (PDTA), which is commercially available, for example, from BASF under the trade name Trilon FS® and methylglycine diacetic acid (MGDA).

In ¹

Other carboxylate chelating agents include malonic acid, salicylic acid, glycine, aspartic acid, glutamic acid, or mixtures thereof.

Chelating agents, especially phosphonate chelating agents such as diethylenetriamine pentamethylene phosphonates, preferably contribute to the disinfecting properties of hydrogen peroxide in the disinfectants of the invention. Another aspect of the present invention is the use of a chelating agent, in particular a phosphonate chelating agent, such as diethylene triamine pentamethylene phosphonate in a hydrogen peroxide-containing disinfectant to improve the disinfectant properties of the composition for Gram negative and / or Gram positive bacteria.

The compositions of the present invention typically comprise a chelating agent or mixtures thereof in up to 5% of the total weight of the composition, preferably 0.002% to 3% by weight, and more preferably 0.002% to 1.5%.

The compositions of the invention include a further preferred radical scavenger component. Suitable radical scavengers include the well-known substituted mono- and dihydroxybenzenes and their derivatives, alkyl and aryl carboxylates and mixtures thereof. Preferred radical scavengers include di-tert-butylhydroxytoluene (BHT), p-hydroxytoluene, hydroquinone (HQ), di-tert-butyl hydroquinone (DTBHQ), mono-tert-butyl hydroquinone (MTBHQ), tert-butylhydroxyanisole (BHA), p-hydroxyanisole, benzoic acid, 2,5-dihydroxybenzoic acid, 2,5-dihydroxyterephthalic acid, toluylic acid, catechol, t-butylcatechol, 4-allylcatechol, 4-acetylcatechol, 2-methoxyphenol, 2-ethoxyphenol, 2-methoxy- 4- (2-propenyl) phenol, 3,4-dihydroxybenzaldehyde, 2,3-dihydroxybenzaldehyde, benzylamine, 1,1,3-tris- (2-methyl-4-hydroxy-5-t-butylphenyl) butane, tert-butylhydroxyaniline , p-hydroxyaniline and n-propyl gallate. Highly preferred is di-tert-butylhydroxytoluene, which is available, for example, from SHELL under the trade name IONOL CP®, and / or tert-butyl-hydroxyanisole. These radical scavengers further contribute to the stability of the hydrogen peroxide-containing compositions.

The compositions of the present invention typically comprise radical scavengers or mixtures thereof in up to 5% of the total weight of the composition, preferably 0.001% to 1.5% by weight, and more preferably 0.01% to 1%.

The compositions of the invention include, as a further preferred component, solvents or mixtures thereof. The solvents used preferably improve the cleaning properties of the compositions. Suitable solvents included in the compositions of the present invention include derivatives, propylene glycol such as n-butoxypropanol or n-butoxypropoxypropanol, water-soluble solvents CARBITOL® or water-soluble solvents CELLOSOLVE®. Water-soluble CARBITOL® solvents are compounds of the 2- (2-alkoxyethoxy) ethanol class wherein the alkoxy group is derived from an ethyl, propyl or butyl group. A preferred water-soluble carbitol is 2- (2-butoxyethoxy) ethanol, also known as butylcarbitol. CELLOSOLVE® water-soluble solvents are compounds of the 2-alkoxyethoxyethanol class, preferably 2-butoxyethoxyethanol. Other suitable solvents are benzyl alcohol, methanol, ethanol, isopropyl alcohol, and diols such as 2-ethyl-1,3-hexanediol and 2,2,4-trimethyl-1,3-pentadiol, and mixtures thereof. Preferred solvents are n-butoxypropoxypropanol, Butylcarbitol® and mixtures thereof.

¹ f

Most preferred solvents are Butylcarbitol (R), benzyl alcohol and isopropanol.

The compositions of the invention typically contain solvents in up to 15% by weight of the total composition, preferably 2% to 7% by weight of the composition.

The compositions of the invention may further comprise various other preferred components such as buffers (e.g., borate buffers), fillers, stabilizers, bleach activators, stain suspensions, dye transfer agents, brighteners, perfumes, dusting agents, enzymes, dispersants, dye transfer inhibitors, pigments , fragrances and coloring matter.

Packaging of funds.

The compositions of the invention are packaged in various suitable detergent packages known to those skilled in the art. The liquid compositions of the invention are conveniently packaged in hand-held spray containers, which are usually made of synthetic organic polymeric plastics. The present invention also encompasses liquid disinfectants comprising hydrogen peroxide and an antimicrobial essential oil packaged in a sprayer, preferably with a trigger or pump.

The sprayers allow uniform application of the liquid disinfectants of the present invention to a relatively large portion of the disinfected surface, thereby enhancing the disinfectant properties of the compositions. Sprayers are particularly suitable for disinfecting vertical surfaces.

Suitable nebulisers useful in the present invention include hand-operated trigger foam nebulisers sold, for example, by Specialty Packaging Products, Inc. or Continental Sprayers, Inc. These types of nebulizers are described, for example, in U.S.-4,701,311 to Dunnining et al. and U.S.-4,646,973, Focarracci and U.S.-4,538,745, Focarracci. Sprayers such as T 8500® or T 8900®, commercially available from Continental Spray Intemational or T 8100®, commercially available from Canyon, North Ireland are particularly preferred. In such a sprayer, the liquid composition forms fine liquid spray droplets which are sprayed directly onto the surface to be cleaned. In pumping, when the user activates the pumping mechanism, the device is discharged from the spray container through the spray head. The agent in the sprayer head is pushed over an obstacle, e.g. a grid or coil, and the like, and impacts help to disperse the liquid composition, i. aid in the formation of liquid droplets.

The compositions of the present invention may also be in the form of wipes. "Wipes" herein refers to disposable paper towels impregnated with the liquid composition of the present invention. The present invention also includes wipes, e.g. disposable paper towels impregnated with the liquid composition of the present invention. In a preferred embodiment, the wipes are moistened with the liquid compositions of the invention. The wipes are preferably packaged in a plastic box. The advantage of this design is the faster use of the disinfectant by the user also outside the home, ie. it is not necessary to pour the liquid compositions of the present invention onto cleaned / disinfected surfaces and to dry them with a cloth. In other words, wipes allow surface disinfection in one step.

Method of disinfection.

Broadly, the present invention encompasses a method of disinfecting surfaces with a composition of the present invention, "Surface" refers to any surface including living surfaces such as human skin, mouth, teeth and inanimate surfaces. Inanimate surfaces include, without limitation, solid surfaces, typically found in kitchens, bathrooms or car interiors, e.g. tiles, walls, floors, chromed surfaces, glass, plain vinyl, any plastic, plasticized wood, table tops, sinks, cooker tops, dishes, sanitaryware such as sinks, showers, shower curtains, bathtubs, toilet, glass, and the like as well as fabrics including dresses, curtains, drapes, bed linen, bath linen, tablecloths, sleeping bags, tents, upholstered-furniture, carpets, and so on. Inanimate surfaces also include household appliances including, but not limited to, refrigerators, freezers, washing machines, automatic dryers, ovens, microwave ovens, dishwashers, etc.

In the surface disinfection method of the present invention, the compositions of the invention may be applied undiluted or diluted to the disinfected surface.

'Diluted' here means that the user can dilute the liquid or solid disinfectant compositions with water up to 100 times, preferably 80 to 30 times, and more preferably 60 to 40 times.

In a preferred embodiment of the disinfectant of the present invention, the composition is applied to a disinfected solid surface diluted, after application of the composition there is no need to rinse the surface with no visible residue left.

The present invention is further illustrated by the following examples.

DETAILED DESCRIPTION OF THE INVENTION

The following compositions were prepared by mixing the components in the proportions indicated (weight percent unless otherwise indicated). These products have been tested by the European Commission standardization prEN 1040. These products allow perfect disinfection of clean surfaces using both undiluted and diluted form, eg. at a dilution of 1: 100, 1:25, 1:50 and are also perfectly safe for surfaces and skin friendly.

resources I Π ΙΠ IV IN VI Hydrogen peroxide 7.0 6.0 6.0 6.0 2.0 7.0 Thymol silica 0.5 - - 0.5 - 0.5 Clove silica - 1.0 - - 0.1 0.5 Pelargóniová silica 0.5 - - - - Eucalyptus silica - - 1.0 - - 0.5 Water and minor components fill up to 100%

H ₂ SO ₄ to pH 4

resources VII VIII IX X Hydrogen peroxide 7.0 6.0 1.0 2.0 Thymol silica - 0.5 - - Clove / Eucalyptus silica (1: 1) 1.0 - 0.5 0.05 Pelargóniová silica - 0.5 - -

Add water and minor components up to 100%

H ₂ SO ₄ to pH 4

resources XI XII XIII XIV XV Hydrogen peroxide 7.0 6.0 1.0 2.0 1.0 C10 Alkyl sulphate 3.0 4.0 - 1.5 - C10 Amine oxide 1.5 and 1.5 - 0.9 lauryl 1 · - - 0.05 Thymol silica 1 1 - 0.5 - - 0.03 Eucalyptus silica and 1 - - - - 0.02 Clove / Eucalyptus silica (1: 1) 1.0 - 0.5 0.05 - Pelargóniová silica 1 - 0.5 - - - l Water and minor components fill up to 100%

H2SO4 to pH 4

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Industrial usability

The antimicrobial compositions of the present invention are used to disinfect and clean various surfaces including living surfaces (e.g., human skin, mouth) and non-living surfaces (e.g., solid surfaces, fabrics). The disinfectants of the present invention perfectly disinfect clean surfaces even when used in large dilutions and are suitable for delicate fabrics, even when used on delicate surfaces for safe contact with food and / or children. The disinfectant compositions of the present invention perfectly act on Gram positive and Gram negative bacterial strains as well as fungi. The compositions of the present invention are packaged in conventional detergent containers, or as a spray or foam, in a spray / foam sprayer, or impregnated wipes for rapid cleaning in one step.

Claims (14)

PATENT CLAIMS Disinfectant composition, characterized in that it contains 0.1% to 15% hydrogen peroxide of the total weight of the composition and antimicrobial essential oil or mixtures thereof. Disinfectant composition according to claim 1, characterized in that it contains 0.5% to 10% hydrogen peroxide based on the total weight of the composition and preferably 1% to 8%. Disinfectant according to any one of the preceding claims 1 and 2, characterized in that the antimicrobial silica is thymic silica, lemon grass, citrus silica, lemon silica, orange silica, aniseed silica, clove oil, aniseed pepper silica, cinnamon oil. , silica geranium, silica pink, lavender silica, lemon citrus, eucalyptus silica, peppermint oil, peppermint oil, silica camphor, sandalwood silica, cedar silica, rosemary silica, pine silica, silica verbene, silica fleagrass, lemon grass silica , silica ratanhiae and / or mixtures thereof and preferred are thymol silica, clove silica, cinnamon silica, geranium silica, eucalyptus silica, peppermint silica, peppermint silica and mixtures thereof. Disinfectant composition according to any one of the preceding claims 1 to 3, characterized in that it contains antimicrobial essential oils or mixtures thereof in at least 0.003% of the total weight of the composition, preferably 0.006% to 10% and more preferably 0.2% to 4%. Disinfectant according to any one of claims 1 to 4, characterized in that it contains a surfactant selected from the group of anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, zwitterionic surfactants or mixtures thereof, the surfactant being present in up to 50% of the total weight. % of the composition, preferably 0.01% to 30% and more preferably 0.1% to 25%. Disinfectant according to claim 5, characterized in that the surfactant is an amphoteric surfactant or a mixture thereof, preferably a betaine or sulfobetaine surfactant or a derivative thereof or a mixture thereof according to the general formula I: R ₂ N (CH _{3) n} -Y R 3 ()) wherein R 1 is an alkyl radical of 1 to 24 carbon atoms, preferably 8 to 18, more preferably up to 14, wherein R 2 and R 3 contain 1 to 3 carbon atoms, preferably 1 carbon atom, wherein n is an integer of 1 to 10, preferably 1 to 6 and more preferably 1, Y is selected from the group of carboxyl and sulfonyl radicals and wherein the sum of R1, R2 and R3 radicals is 14 to 24 carbon atoms and / or an amine oxide of the formula R1R2R3NO, wherein each R1, R2 and R3 is independently a saturated linear or branched hydrocarbon chain containing 1 to 30 carbon atoms, preferably 6 to 20, and wherein R 2 and R 3 are independently unsubstituted or substituted linear or branched hydrocarbon chains containing 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, and more preferably methyl groups. The disinfectant of any one of the preceding claims, further comprising an additional antimicrobial ingredient selected from the group consisting of glutaraldehyde, ethyl paraben, propylparaben, methylparaben, and mixtures thereof. · ' Disinfectant according to any one of claims 1 to 7, further comprising a chelating agent selected from the group of phosphonate chelating agents, aminophosphonate chelating agents, substituted heteroaromatic chelating agents, aminocarboxylate chelating agents, other carboxylate chelating agents, polyfunctionally substituted aromatic chelating agents agents, ethylenediamine N, N-disuccinic acid, and mixtures thereof. , t. · Disinfectant according to any one of claims 1 to 8, characterized in that it further comprises at least one preferred component from the group of radical scavengers, solvents, buffers, fillers, stabilizers, bleach activators, stain suspensions, dye transfer agents, gloss-setting agents, perfumes, dusting agents, enzymes, dispersants, dye transfer inhibitors, pigments, fragrances, dyes and mixtures thereof. Disinfectant composition according to any one of the preceding claims 1 to 9, characterized in that it is a liquid composition, preferably a liquid composition with a pH not exceeding 12.0, preferably not exceeding 7, more preferably 2 to 6 and most preferably 3 to 5. A wipe impregnated with a liquid composition according to claim 10. Disinfectant according to claim 10, characterized in that it is packaged in a dispenser. T Surface disinfection method, characterized in that a composition according to any one of the preceding claims 1 to 10 is applied to the surface. The surface disinfection method according to claim 13, characterized in that the composition is applied to the surface after dilution with up to 100 times by weight of water, preferably 80 to 40 times by weight and even more preferably from 60 to 30 times by weight. f ¹ I Use of a chelating agent, preferably a phosphonate chelating agent, more preferably diethylenetriamine pentamethylene phosphonate in a hydrogen peroxide-containing disinfectant to improve the disinfectant properties of the composition to Gram negative and / or Gram Positive bacteria. ló.Použitie anionic surfactant, especially Cg-C ₆ alkyl sulfonate, Cg-CI6 alkyl sulfate and / or Cg-Cie alkyl alkoxylated sulfate, in a disinfecting composition comprising hydrogen peroxide and / or an antimicrobial essential oil to improve the disinfecting properties of said composition on gram negative and ¹ t 'and / or Gram positive bacteria.