SK92798A3 - Novel substituted imidazole compounds - Google Patents
Novel substituted imidazole compounds Download PDFInfo
- Publication number
- SK92798A3 SK92798A3 SK927-98A SK92798A SK92798A3 SK 92798 A3 SK92798 A3 SK 92798A3 SK 92798 A SK92798 A SK 92798A SK 92798 A3 SK92798 A3 SK 92798A3
- Authority
- SK
- Slovakia
- Prior art keywords
- alkyl
- formula
- imidazole
- compound
- substituted
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US990996P | 1996-01-11 | 1996-01-11 | |
PCT/US1997/000529 WO1997025046A1 (en) | 1996-01-11 | 1997-01-10 | Novel substituted imidazole compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SK92798A3 true SK92798A3 (en) | 1999-05-07 |
Family
ID=21740430
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK928-98A SK92898A3 (en) | 1996-01-11 | 1997-01-10 | Novel substituted imidazole compounds |
SK927-98A SK92798A3 (en) | 1996-01-11 | 1997-01-10 | Novel substituted imidazole compounds |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK928-98A SK92898A3 (en) | 1996-01-11 | 1997-01-10 | Novel substituted imidazole compounds |
Country Status (27)
Country | Link |
---|---|
US (3) | US5716955A (tr) |
EP (1) | EP0935465B1 (tr) |
JP (2) | JP2000503303A (tr) |
KR (1) | KR19990077165A (tr) |
CN (1) | CN1213307A (tr) |
AR (1) | AR006307A1 (tr) |
AT (1) | ATE264105T1 (tr) |
AU (1) | AU726084C (tr) |
BR (1) | BR9706934A (tr) |
DE (1) | DE69728685T2 (tr) |
DK (1) | DK0935465T3 (tr) |
EA (1) | EA001430B1 (tr) |
ES (1) | ES2219750T3 (tr) |
HK (1) | HK1022624A1 (tr) |
HU (1) | HUP9900645A3 (tr) |
IL (1) | IL125282A (tr) |
MX (1) | MX9805634A (tr) |
NO (1) | NO316625B1 (tr) |
NZ (1) | NZ327052A (tr) |
OA (1) | OA11514A (tr) |
PL (1) | PL187616B1 (tr) |
PT (1) | PT935465E (tr) |
SK (2) | SK92898A3 (tr) |
TR (1) | TR199801360T2 (tr) |
TW (1) | TW523512B (tr) |
WO (1) | WO1997025046A1 (tr) |
ZA (1) | ZA97175B (tr) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5916891A (en) | 1992-01-13 | 1999-06-29 | Smithkline Beecham Corporation | Pyrimidinyl imidazoles |
ZA9610687B (en) * | 1995-12-22 | 1997-09-29 | Smithkline Beecham Corp | Novel synthesis. |
AP9700912A0 (en) | 1996-01-11 | 1997-01-31 | Smithkline Beecham Corp | Novel cycloalkyl substituted imidazoles |
PL187516B1 (pl) * | 1996-01-11 | 2004-07-30 | Smithkline Beecham Corp | Nowe podstawione pochodne imidazolu, sposób ich wytwarzania oraz kompozycja farmaceutyczna zawierająca te związki |
ZA97175B (en) | 1996-01-11 | 1997-11-04 | Smithkline Beecham Corp | Novel substituted imidazole compounds. |
US6046208A (en) * | 1996-01-11 | 2000-04-04 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US6096739A (en) * | 1996-03-25 | 2000-08-01 | Smithkline Beecham Corporation | Treatment for CNS injuries |
EP0956018A4 (en) | 1996-08-21 | 2000-01-12 | Smithkline Beecham Corp | IMIDAZOLE COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE |
US6608060B1 (en) | 1996-12-18 | 2003-08-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
US5945418A (en) * | 1996-12-18 | 1999-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
US6147080A (en) * | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
US5929076A (en) * | 1997-01-10 | 1999-07-27 | Smithkline Beecham Corporation | Cycloalkyl substituted imidazoles |
US6087381A (en) | 1997-05-22 | 2000-07-11 | G. D. Searle & Company | Pyrazole derivatives as p38 kinase inhibitors |
US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
EP1023066A4 (en) | 1997-06-13 | 2001-05-23 | Smithkline Beecham Corp | NEW PYRAZOLE AND PYRAZOLINE SUBSTITUTED COMPOUND |
EP0994870A4 (en) | 1997-06-19 | 2002-10-23 | Smithkline Beecham | NEW IMIDAZOLE COMPOUNDS SUBSTITUTED BY AN ARYLOXYREST |
US6562832B1 (en) | 1997-07-02 | 2003-05-13 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US6489325B1 (en) | 1998-07-01 | 2002-12-03 | Smithkline Beecham Corporation | Substituted imidazole compounds |
TW517055B (en) | 1997-07-02 | 2003-01-11 | Smithkline Beecham Corp | Novel substituted imidazole compounds |
US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
WO1999001452A1 (en) | 1997-07-02 | 1999-01-14 | Smithkline Beecham Corporation | Novel cycloalkyl substituted imidazoles |
WO1999017776A1 (en) | 1997-10-08 | 1999-04-15 | Smithkline Beecham Corporation | Novel cycloalkenyl substituted compounds |
AU1924699A (en) | 1997-12-19 | 1999-07-12 | Smithkline Beecham Corporation | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositionsand uses |
WO1999061437A1 (en) | 1998-05-22 | 1999-12-02 | Smithkline Beecham Corporation | Novel 2-alkyl substituted imidazole compounds |
US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
ATE266399T1 (de) | 1998-08-20 | 2004-05-15 | Smithkline Beecham Corp | Neue substituierte triazolverbindungen |
ES2212657T3 (es) * | 1998-11-04 | 2004-07-16 | Smithkline Beecham Corporation | Pirazinas sustituidas piridin-4-il o pirimidin-4-il. |
US6239279B1 (en) | 1998-12-16 | 2001-05-29 | Smithkline Beecham Corporation | Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives |
US7122666B2 (en) * | 1999-07-21 | 2006-10-17 | Sankyo Company, Limited | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
WO2001038314A1 (en) | 1999-11-23 | 2001-05-31 | Smithkline Beecham Corporation | 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors |
EP1235814B1 (en) | 1999-11-23 | 2004-11-03 | Smithkline Beecham Corporation | 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/p38 KINASE INHIBITORS |
US6982270B1 (en) | 1999-11-23 | 2006-01-03 | Smithkline Beecham Corporation | 3,4-dihydro-(1H)quinazolin-2-one compounds as CSBP/p38 kinase inhibitors |
US6759410B1 (en) | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
AU784490B2 (en) * | 1999-12-08 | 2006-04-13 | Pharmacia Corporation | Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect |
US7235551B2 (en) * | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
CA2414674A1 (en) * | 2000-07-13 | 2002-01-24 | Pharmacia Corporation | Use of cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders |
PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
AU7090201A (en) | 2000-07-20 | 2002-02-05 | Lauras As | Method |
EP1337255A4 (en) * | 2000-10-19 | 2006-01-25 | Smithkline Beecham Corp | USE OF P38 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY COUGH |
JP4524072B2 (ja) * | 2000-10-23 | 2010-08-11 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 新規化合物 |
US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
JP2004526727A (ja) | 2001-03-09 | 2004-09-02 | ファイザー・プロダクツ・インク | ベンゾイミダゾール抗炎症化合物 |
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US7695736B2 (en) | 2001-04-03 | 2010-04-13 | Pfizer Inc. | Reconstitutable parenteral composition |
EP1247810B1 (en) * | 2001-04-04 | 2005-09-07 | Pfizer Products Inc. | Novel benzotriazoles anti-inflammatory compounds |
UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
US20040122008A1 (en) * | 2002-09-05 | 2004-06-24 | Protter Andrew A. | Treatment of pain by inhibition of p38 MAP kinase |
AR039241A1 (es) * | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
US20030225089A1 (en) * | 2002-04-10 | 2003-12-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors |
CA2492033A1 (en) | 2002-07-09 | 2004-01-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
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1997
- 1997-01-09 ZA ZA9700175A patent/ZA97175B/xx unknown
- 1997-01-10 JP JP9525459A patent/JP2000503303A/ja not_active Ceased
- 1997-01-10 IL IL12528297A patent/IL125282A/xx not_active IP Right Cessation
- 1997-01-10 WO PCT/US1997/000529 patent/WO1997025046A1/en not_active Application Discontinuation
- 1997-01-10 KR KR1019980705303A patent/KR19990077165A/ko not_active Application Discontinuation
- 1997-01-10 ES ES97902013T patent/ES2219750T3/es not_active Expired - Lifetime
- 1997-01-10 SK SK928-98A patent/SK92898A3/sk unknown
- 1997-01-10 CN CN97193002A patent/CN1213307A/zh active Pending
- 1997-01-10 EA EA199800633A patent/EA001430B1/ru not_active IP Right Cessation
- 1997-01-10 BR BR9706934-5A patent/BR9706934A/pt not_active Application Discontinuation
- 1997-01-10 HU HU9900645A patent/HUP9900645A3/hu not_active Application Discontinuation
- 1997-01-10 PT PT97902013T patent/PT935465E/pt unknown
- 1997-01-10 US US08/781,466 patent/US5716955A/en not_active Expired - Fee Related
- 1997-01-10 AT AT97902013T patent/ATE264105T1/de not_active IP Right Cessation
- 1997-01-10 DK DK97902013T patent/DK0935465T3/da active
- 1997-01-10 NZ NZ327052A patent/NZ327052A/xx unknown
- 1997-01-10 EP EP97902013A patent/EP0935465B1/en not_active Expired - Lifetime
- 1997-01-10 PL PL97327934A patent/PL187616B1/pl not_active IP Right Cessation
- 1997-01-10 AU AU15782/97A patent/AU726084C/en not_active Ceased
- 1997-01-10 SK SK927-98A patent/SK92798A3/sk unknown
- 1997-01-10 DE DE69728685T patent/DE69728685T2/de not_active Expired - Fee Related
- 1997-01-10 US US09/101,550 patent/US6214844B1/en not_active Expired - Fee Related
- 1997-01-10 AR ARP970100104A patent/AR006307A1/es not_active Application Discontinuation
- 1997-01-10 TR TR1998/01360T patent/TR199801360T2/tr unknown
- 1997-08-22 TW TW086112052A patent/TW523512B/zh not_active IP Right Cessation
- 1997-11-21 US US08/976,522 patent/US5811549A/en not_active Expired - Fee Related
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1998
- 1998-07-10 MX MX9805634A patent/MX9805634A/es not_active IP Right Cessation
- 1998-07-10 NO NO19983181A patent/NO316625B1/no not_active IP Right Cessation
- 1998-07-10 OA OA9800113A patent/OA11514A/en unknown
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2000
- 2000-02-17 HK HK00100942A patent/HK1022624A1/xx not_active IP Right Cessation
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2004
- 2004-01-08 JP JP2004003158A patent/JP2004107358A/ja active Pending
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