SK57899A3 - N-linked ureas and carbamates of heterocyclic thioesters - Google Patents
N-linked ureas and carbamates of heterocyclic thioesters Download PDFInfo
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- SK57899A3 SK57899A3 SK578-99A SK57899A SK57899A3 SK 57899 A3 SK57899 A3 SK 57899A3 SK 57899 A SK57899 A SK 57899A SK 57899 A3 SK57899 A3 SK 57899A3
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- alkyl
- alkenyl
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- -1 heterocyclic thioesters Chemical class 0.000 title claims abstract description 258
- 235000013877 carbamide Nutrition 0.000 title claims abstract description 31
- 150000003672 ureas Chemical class 0.000 title claims abstract description 26
- 150000004657 carbamic acid derivatives Chemical class 0.000 title claims abstract description 24
- 102000000521 Immunophilins Human genes 0.000 claims abstract description 26
- 108010016648 Immunophilins Proteins 0.000 claims abstract description 26
- 230000000694 effects Effects 0.000 claims abstract description 22
- 230000000508 neurotrophic effect Effects 0.000 claims abstract description 19
- 101710103508 FK506-binding protein Proteins 0.000 claims abstract description 12
- 101710104425 FK506-binding protein 2 Proteins 0.000 claims abstract description 12
- 101710104423 FK506-binding protein 3 Proteins 0.000 claims abstract description 12
- 101710104333 FK506-binding protein 4 Proteins 0.000 claims abstract description 12
- 101710104342 FK506-binding protein 5 Proteins 0.000 claims abstract description 12
- 101710149710 FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims abstract description 12
- 101710121306 FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims abstract description 12
- 101710180800 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA Proteins 0.000 claims abstract description 12
- 101710104030 Long-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims abstract description 12
- 101710114693 Outer membrane protein MIP Proteins 0.000 claims abstract description 12
- 101710116692 Peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims abstract description 12
- 101710111764 Peptidyl-prolyl cis-trans isomerase FKBP10 Proteins 0.000 claims abstract description 12
- 101710111749 Peptidyl-prolyl cis-trans isomerase FKBP11 Proteins 0.000 claims abstract description 12
- 101710111747 Peptidyl-prolyl cis-trans isomerase FKBP12 Proteins 0.000 claims abstract description 12
- 101710111757 Peptidyl-prolyl cis-trans isomerase FKBP14 Proteins 0.000 claims abstract description 12
- 101710111682 Peptidyl-prolyl cis-trans isomerase FKBP1A Proteins 0.000 claims abstract description 12
- 101710111689 Peptidyl-prolyl cis-trans isomerase FKBP1B Proteins 0.000 claims abstract description 12
- 101710147154 Peptidyl-prolyl cis-trans isomerase FKBP2 Proteins 0.000 claims abstract description 12
- 101710147149 Peptidyl-prolyl cis-trans isomerase FKBP3 Proteins 0.000 claims abstract description 12
- 101710147152 Peptidyl-prolyl cis-trans isomerase FKBP4 Proteins 0.000 claims abstract description 12
- 101710147150 Peptidyl-prolyl cis-trans isomerase FKBP5 Proteins 0.000 claims abstract description 12
- 101710147138 Peptidyl-prolyl cis-trans isomerase FKBP7 Proteins 0.000 claims abstract description 12
- 101710147137 Peptidyl-prolyl cis-trans isomerase FKBP8 Proteins 0.000 claims abstract description 12
- 101710147136 Peptidyl-prolyl cis-trans isomerase FKBP9 Proteins 0.000 claims abstract description 12
- 101710174853 Peptidyl-prolyl cis-trans isomerase Mip Proteins 0.000 claims abstract description 12
- 101710200991 Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme Proteins 0.000 claims abstract description 12
- 101710092145 Peptidyl-prolyl cis-trans isomerase-like 1 Proteins 0.000 claims abstract description 12
- 101710092146 Peptidyl-prolyl cis-trans isomerase-like 2 Proteins 0.000 claims abstract description 12
- 101710092148 Peptidyl-prolyl cis-trans isomerase-like 3 Proteins 0.000 claims abstract description 12
- 101710092149 Peptidyl-prolyl cis-trans isomerase-like 4 Proteins 0.000 claims abstract description 12
- 101710113444 Probable parvulin-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims abstract description 12
- 101710090737 Probable peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims abstract description 12
- 101710133309 Putative peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims abstract description 12
- 101710124237 Short-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 claims abstract description 12
- 102000004190 Enzymes Human genes 0.000 claims abstract description 7
- 108090000790 Enzymes Proteins 0.000 claims abstract description 7
- 102100038809 Peptidyl-prolyl cis-trans isomerase FKBP9 Human genes 0.000 claims abstract 5
- 125000000217 alkyl group Chemical group 0.000 claims description 220
- 125000003342 alkenyl group Chemical group 0.000 claims description 170
- 150000001875 compounds Chemical class 0.000 claims description 120
- 125000000623 heterocyclic group Chemical group 0.000 claims description 109
- 125000004432 carbon atom Chemical group C* 0.000 claims description 100
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 84
- 229910052760 oxygen Inorganic materials 0.000 claims description 66
- 125000004001 thioalkyl group Chemical group 0.000 claims description 60
- 229910052739 hydrogen Inorganic materials 0.000 claims description 57
- 150000002148 esters Chemical class 0.000 claims description 55
- 229910052757 nitrogen Inorganic materials 0.000 claims description 55
- 238000000034 method Methods 0.000 claims description 51
- 239000001257 hydrogen Substances 0.000 claims description 50
- 150000007970 thio esters Chemical class 0.000 claims description 48
- 125000003545 alkoxy group Chemical group 0.000 claims description 45
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 45
- 125000003282 alkyl amino group Chemical group 0.000 claims description 44
- 150000002431 hydrogen Chemical class 0.000 claims description 44
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 43
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 43
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 42
- 125000000304 alkynyl group Chemical group 0.000 claims description 41
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims description 39
- 230000004770 neurodegeneration Effects 0.000 claims description 35
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 35
- 229910052736 halogen Inorganic materials 0.000 claims description 34
- 150000002367 halogens Chemical class 0.000 claims description 34
- 125000001188 haloalkyl group Chemical group 0.000 claims description 32
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 31
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 31
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 29
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 28
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 27
- 229910052717 sulfur Inorganic materials 0.000 claims description 27
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 24
- 208000012902 Nervous system disease Diseases 0.000 claims description 24
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 22
- 241001465754 Metazoa Species 0.000 claims description 21
- 229910052799 carbon Chemical group 0.000 claims description 19
- 201000010099 disease Diseases 0.000 claims description 19
- 125000001544 thienyl group Chemical group 0.000 claims description 18
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 16
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 16
- 239000001301 oxygen Substances 0.000 claims description 16
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 16
- 125000003118 aryl group Chemical group 0.000 claims description 15
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 15
- HNTZFWQXXYMHKN-IBGZPJMESA-N N1([C@@H](CCC1)C(=S)OCCCC=1C=CC=CC=1)C(=O)NC1CCCCC1 Chemical compound N1([C@@H](CCC1)C(=S)OCCCC=1C=CC=CC=1)C(=O)NC1CCCCC1 HNTZFWQXXYMHKN-IBGZPJMESA-N 0.000 claims description 14
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- 125000002541 furyl group Chemical group 0.000 claims description 13
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- 150000003839 salts Chemical class 0.000 claims description 13
- 208000024827 Alzheimer disease Diseases 0.000 claims description 12
- 239000012453 solvate Substances 0.000 claims description 12
- 125000000335 thiazolyl group Chemical group 0.000 claims description 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 11
- 208000029028 brain injury Diseases 0.000 claims description 11
- 125000004076 pyridyl group Chemical group 0.000 claims description 11
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 10
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 9
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 9
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 9
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- 239000003574 free electron Substances 0.000 claims description 8
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- KZEFFFJLSJVGCR-SFHVURJKSA-N N1([C@@H](CCC1)C(=S)OCCC=1C=CC=CC=1)C(=O)NC1CCCCC1 Chemical compound N1([C@@H](CCC1)C(=S)OCCC=1C=CC=CC=1)C(=O)NC1CCCCC1 KZEFFFJLSJVGCR-SFHVURJKSA-N 0.000 claims description 7
- 102100027913 Peptidyl-prolyl cis-trans isomerase FKBP1A Human genes 0.000 claims description 7
- 108010006877 Tacrolimus Binding Protein 1A Proteins 0.000 claims description 7
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 7
- 210000002569 neuron Anatomy 0.000 claims description 7
- CMWOIDRCWCHPDE-SANMLTNESA-N o-(3,3-diphenylpropyl) (2s)-1-[(2,4-dimethoxyphenyl)carbamoyl]pyrrolidine-2-carbothioate Chemical compound COC1=CC(OC)=CC=C1NC(=O)N1[C@H](C(=S)OCCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC1 CMWOIDRCWCHPDE-SANMLTNESA-N 0.000 claims description 7
- JCGWDNKLXZPICR-DEOSSOPVSA-N o-(3-cyclohexylpropyl) (2s)-1-[[2,6-di(propan-2-yl)phenyl]carbamoyl]pyrrolidine-2-carbothioate Chemical compound CC(C)C1=CC=CC(C(C)C)=C1NC(=O)N1[C@H](C(=S)OCCCC2CCCCC2)CCC1 JCGWDNKLXZPICR-DEOSSOPVSA-N 0.000 claims description 7
- UIQOEDMRTDAMBC-FQEVSTJZSA-N o-(3-phenylpropyl) (2s)-1-[(2,4-dimethoxyphenyl)carbamoyl]pyrrolidine-2-carbothioate Chemical compound COC1=CC(OC)=CC=C1NC(=O)N1[C@H](C(=S)OCCCC=2C=CC=CC=2)CCC1 UIQOEDMRTDAMBC-FQEVSTJZSA-N 0.000 claims description 7
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- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 5
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- IDNNKPARPBBRLJ-UQQXROCHSA-N o-(3-phenylpropyl) (2s)-1-(1-adamantylcarbamoyl)pyrrolidine-2-carbothioate Chemical compound S=C([C@@H]1CCCN1C(NC12CC3CC(CC(C3)C1)C2)=O)OCCCC1=CC=CC=C1 IDNNKPARPBBRLJ-UQQXROCHSA-N 0.000 claims description 5
- XTYRBJCMICEVIV-IBGZPJMESA-N o-(3-phenylpropyl) (2s)-1-[di(propan-2-yl)carbamoyl]pyrrolidine-2-carbothioate Chemical compound CC(C)N(C(C)C)C(=O)N1CCC[C@H]1C(=S)OCCCC1=CC=CC=C1 XTYRBJCMICEVIV-IBGZPJMESA-N 0.000 claims description 5
- 125000006201 3-phenylpropyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
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- 125000004429 atom Chemical group 0.000 claims description 3
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- ZHUXMBYIONRQQX-UHFFFAOYSA-N hydroxidodioxidocarbon(.) Chemical compound [O]C(O)=O ZHUXMBYIONRQQX-UHFFFAOYSA-N 0.000 claims description 2
- ULFZBFCELQZELF-VWLOTQADSA-N o-(3-phenylpropyl) (2s)-1-(diphenylcarbamoyl)pyrrolidine-2-carbothioate Chemical compound N1([C@@H](CCC1)C(=S)OCCCC=1C=CC=CC=1)C(=O)N(C=1C=CC=CC=1)C1=CC=CC=C1 ULFZBFCELQZELF-VWLOTQADSA-N 0.000 claims description 2
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- URTBTMLZJSHZIM-FQEVSTJZSA-N o-(3-phenylpropyl) (2s)-1-[methyl(phenyl)carbamoyl]pyrrolidine-2-carbothioate Chemical compound S=C([C@@H]1CCCN1C(=O)N(C)C=1C=CC=CC=1)OCCCC1=CC=CC=C1 URTBTMLZJSHZIM-FQEVSTJZSA-N 0.000 claims 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/775,585 US5935989A (en) | 1996-12-31 | 1996-12-31 | N-linked ureas and carbamates of heterocyclic thioesters |
| PCT/US1997/024070 WO1998029117A1 (en) | 1996-12-31 | 1997-12-23 | N-linked ureas and carbamates of heterocyclic thioesters |
| US08/997,451 US5958949A (en) | 1996-12-31 | 1997-12-23 | N-linked ureas and carbamates of piperidyl thioesters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK57899A3 true SK57899A3 (en) | 2000-05-16 |
Family
ID=27119070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK578-99A SK57899A3 (en) | 1996-12-31 | 1997-12-23 | N-linked ureas and carbamates of heterocyclic thioesters |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US5958949A (no) |
| EP (1) | EP0959882A4 (no) |
| JP (1) | JP2002515050A (no) |
| EA (1) | EA002401B1 (no) |
| NO (1) | NO992751L (no) |
| NZ (1) | NZ336386A (no) |
| PE (1) | PE58099A1 (no) |
| SK (1) | SK57899A3 (no) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6395758B1 (en) * | 1998-08-14 | 2002-05-28 | Gpi Nil Holdings, Inc. | Small molecule carbamates or ureas for vision and memory disorders |
| US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
| US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
| MXPA02006134A (es) | 1999-12-21 | 2002-12-13 | Guilford Pharm Inc | Compuestos derivados de hidantoina, composiciones farmaceuticas y metodos de uso de los mismos. |
| US8236048B2 (en) | 2000-05-12 | 2012-08-07 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
| US20050002986A1 (en) * | 2000-05-12 | 2005-01-06 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
| AU2003259846A1 (en) * | 2002-08-16 | 2004-03-03 | The General Hospital Corporation | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
| EP1402888A1 (en) * | 2002-09-18 | 2004-03-31 | Jerini AG | The use of substituted carbocyclic compounds as rotamases inhibitors |
| US10058351B2 (en) | 2015-03-19 | 2018-08-28 | Michael Todd Beauty Lp | Personal care appliance |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0017390A3 (en) * | 1979-03-23 | 1981-06-24 | American Home Products Corporation | Bicyclic oxo-thiolactones, pharmaceutical compositions containing them, processes for their preparation and compounds useful as intermediates for their preparation |
| US4692458A (en) * | 1980-03-05 | 1987-09-08 | University Of Miami | Anti-hypertensive agents |
| US4690936A (en) * | 1980-03-05 | 1987-09-01 | University Of Miami | Anti-hypertensive agents |
| US4578474A (en) * | 1980-06-23 | 1986-03-25 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
| US4390695A (en) * | 1980-06-23 | 1983-06-28 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
| US4310461A (en) * | 1980-06-23 | 1982-01-12 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
| US4596819A (en) * | 1984-01-23 | 1986-06-24 | Warner-Lambert Company | Modified tripeptides |
| US4593102A (en) * | 1984-04-10 | 1986-06-03 | A. H. Robins Company, Inc. | N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-position |
| GB2182938B (en) * | 1985-11-13 | 1989-11-08 | Otsuka Pharma Co Ltd | Antihypertensive proline peptides |
| US5001142A (en) * | 1989-07-19 | 1991-03-19 | American Cyanamid Company | 1-substituted-2-(3-amino-1-propynyl)pyrrolidine derivatives |
| US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
| DE69229782T2 (de) * | 1991-05-09 | 2000-04-27 | Vertex Pharmaceuticals Inc., Cambridge | Neue immunsuppressive verbindungen |
| MX9202466A (es) * | 1991-05-24 | 1994-06-30 | Vertex Pharma | Compuestos inmunosupresores novedosos. |
| HU211101B (en) * | 1992-03-13 | 1995-10-30 | Egyt Gyogyszervegyeszeti Gyar | Process for preparing 1-[/2s/-methyl-3-mercapto-propionyl]-pyrrolidine-/2s/-carboxylic acid |
| IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| NZ314207A (en) * | 1992-09-28 | 2000-12-22 | Vertex Pharma | 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers |
| US5385918A (en) * | 1993-02-09 | 1995-01-31 | Miles Inc. | Aminomethylene-peptides as immunosuppressants |
| US5798355A (en) * | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
| EP0749421B1 (en) * | 1994-03-07 | 1999-09-15 | Vertex Pharmaceuticals Incorporated | Sulphonamide derivatives as aspartyl protease inhibitors |
| US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
| US5463048A (en) * | 1994-06-14 | 1995-10-31 | American Home Products Corporation | Rapamycin amidino carbamates |
| US5614657A (en) | 1994-12-07 | 1997-03-25 | Harada; Shintaro | Three dimensionally measuring apparatus |
| US5726184A (en) * | 1995-05-19 | 1998-03-10 | Vertex Pharmaceuticals Incorporated | Tetralin compounds with improved MDR activity |
| US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
| US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
| US5614547A (en) * | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
| US6037370A (en) * | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
| US5801197A (en) * | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
| US5717092A (en) * | 1996-03-29 | 1998-02-10 | Vertex Pharmaceuticals Inc. | Compounds with improved multi-drug resistance activity |
| US5786378A (en) * | 1996-09-25 | 1998-07-28 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters |
| US5801187A (en) * | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
| US5721256A (en) * | 1997-02-12 | 1998-02-24 | Gpi Nil Holdings, Inc. | Method of using neurotrophic sulfonamide compounds |
-
1997
- 1997-12-23 EA EA199900511A patent/EA002401B1/ru not_active IP Right Cessation
- 1997-12-23 US US08/997,451 patent/US5958949A/en not_active Expired - Fee Related
- 1997-12-23 JP JP51976098A patent/JP2002515050A/ja active Pending
- 1997-12-23 EP EP97953508A patent/EP0959882A4/en not_active Withdrawn
- 1997-12-23 NZ NZ336386A patent/NZ336386A/en unknown
- 1997-12-23 SK SK578-99A patent/SK57899A3/sk unknown
-
1998
- 1998-02-03 PE PE1998000075A patent/PE58099A1/es not_active Application Discontinuation
-
1999
- 1999-06-07 NO NO992751A patent/NO992751L/no not_active Application Discontinuation
- 1999-09-10 US US09/393,650 patent/US6274607B1/en not_active Expired - Fee Related
-
2001
- 2001-06-21 US US09/885,178 patent/US20020049199A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NZ336386A (en) | 2001-09-28 |
| US5958949A (en) | 1999-09-28 |
| EA199900511A1 (ru) | 2000-02-28 |
| EA002401B1 (ru) | 2002-04-25 |
| EP0959882A1 (en) | 1999-12-01 |
| NO992751D0 (no) | 1999-06-07 |
| JP2002515050A (ja) | 2002-05-21 |
| US20020049199A1 (en) | 2002-04-25 |
| EP0959882A4 (en) | 2001-12-05 |
| US6274607B1 (en) | 2001-08-14 |
| PE58099A1 (es) | 1999-06-16 |
| NO992751L (no) | 1999-08-04 |
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