SK4842000A3 - Contrast-enhanced diagnostic imaging method for monitoring interventional therapies - Google Patents
Contrast-enhanced diagnostic imaging method for monitoring interventional therapies Download PDFInfo
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- SK4842000A3 SK4842000A3 SK484-2000A SK4842000A SK4842000A3 SK 4842000 A3 SK4842000 A3 SK 4842000A3 SK 4842000 A SK4842000 A SK 4842000A SK 4842000 A3 SK4842000 A3 SK 4842000A3
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- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
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- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
Landscapes
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- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Transforming Light Signals Into Electric Signals (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (2)
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| PT (1) | PT1019094E (da) |
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| US6167297A (en) * | 1999-05-05 | 2000-12-26 | Benaron; David A. | Detecting, localizing, and targeting internal sites in vivo using optical contrast agents |
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| CA2513044A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| CA2477836A1 (en) | 2002-03-01 | 2003-09-12 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| PL1944312T3 (pl) | 2003-03-03 | 2012-12-31 | Dyax Corp | Peptydy, które specyficznie wiążą receptor HGF (CMET) i ich zastosowanie |
| US20050064045A1 (en) * | 2003-09-18 | 2005-03-24 | Sheng-Ping Zhong | Injectable therapeutic formulations |
| US7585492B2 (en) | 2004-05-18 | 2009-09-08 | Siemens Aktiengesellschaft | Biomolecular contrast agents for therapy success and dose monitoring in radiation therapy with proton or ion beams |
| EP1747026A1 (en) * | 2004-05-18 | 2007-01-31 | Siemens Aktiengesellschaft | Biomolecular contrast agents for therapy control in radiation therapy with proton or ion beams |
| JP2006248978A (ja) * | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| CN101317100A (zh) * | 2005-11-29 | 2008-12-03 | 皇家飞利浦电子股份有限公司 | 使用磁共振区分结合和未结合造影剂 |
| WO2007073792A1 (de) * | 2005-12-19 | 2007-07-05 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur herstellung von 4,4-diphenylcyclohexanol |
| CA2660717A1 (en) | 2006-08-17 | 2008-02-21 | Epix Pharmaceuticals, Inc. | Methods for lymph system imaging |
| DE102006049821A1 (de) | 2006-10-18 | 2008-04-24 | Bayer Schering Pharma Aktiengesellschaft | Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung |
| US20100092389A1 (en) * | 2008-10-10 | 2010-04-15 | The General Hospital Corporation | Detection of atherosclerosis using indocyanine green |
| US9423480B2 (en) * | 2008-10-27 | 2016-08-23 | The University Of Western Ontario | System and method for magnetic resonance imaging |
| WO2010121133A2 (en) | 2009-04-17 | 2010-10-21 | The General Hospital Corporation | Multimodal imaging of fibrin |
| MX2011009716A (es) | 2009-03-19 | 2011-10-17 | Wyeth Llc | Metodos para la preparacion de acido [2-(8,9-dioxo)-2,6-diazabicic lo[5.2.0]non-1(7)-en-2-il)etil]fosfonico y precursores de este. |
| WO2011095898A1 (en) | 2010-02-02 | 2011-08-11 | Koninklijke Philips Electronics N.V. | Functional imaging |
| TW201514188A (zh) * | 2013-03-13 | 2015-04-16 | Lantheus Medical Imaging Inc | 製備釓磷維塞三鈉單水合物之方法 |
| EP2983581B1 (en) * | 2013-04-08 | 2023-11-15 | Sunnybrook Research Institute | Method for imaging biomarkers indicative of cardiac thermal ablation lesions |
| JP2015087167A (ja) * | 2013-10-29 | 2015-05-07 | キヤノン株式会社 | 画像処理方法、画像処理システム |
| WO2015089505A2 (en) | 2013-12-13 | 2015-06-18 | The Trustees Of The University Of Pennsylvania | Coaxial ablation probe and method and system for real-time monitoring of ablation therapy |
| WO2015171543A1 (en) | 2014-05-05 | 2015-11-12 | California Institute Of Technology | Mutant akt-specific capture agents, compositions, and methods of using and making |
| US10471162B2 (en) | 2014-06-20 | 2019-11-12 | The General Hospital Corporation | Collagen targeted imaging probes |
| EP3270951B1 (en) | 2015-03-16 | 2020-09-09 | California Institute of Technology | Botulinum neurotoxin-specific capture agents, compositions, and methods of using and making |
| CN108290927B (zh) | 2015-07-15 | 2022-06-24 | 加州理工学院 | Il-17f-特异性捕获剂、组合物以及使用和制造的方法 |
| US10383590B2 (en) | 2015-09-28 | 2019-08-20 | General Electric Company | Methods and systems for adaptive scan control |
| EP3519425B1 (en) | 2016-09-29 | 2024-02-28 | Indi Molecular, Inc. | Compositions for detection, inhibition and imaging of indoleamine 2,3-dioxygenase 1 (ido1) and methods of making and using same |
| WO2018085375A1 (en) | 2016-11-01 | 2018-05-11 | Ohio State Innovation Foundation | Methods for the iodination of biomolecules |
| US11719705B2 (en) | 2017-06-15 | 2023-08-08 | Indi Molecular, Inc. | IL-17F and IL-17A-specific capture agents, compositions, and methods of using and making |
| US20190370956A1 (en) | 2018-05-30 | 2019-12-05 | General Electric Company | Contrast imaging system and method |
| WO2020093055A2 (en) | 2018-11-02 | 2020-05-07 | Indi Molecular, Inc. | Peptide libraries with non-canonical amino acids |
| WO2020097531A1 (en) | 2018-11-08 | 2020-05-14 | Indi Molecular, Inc. | Theranostic capture agents, compositions, and methods of using and making |
| US11414460B2 (en) | 2019-07-19 | 2022-08-16 | Institute For Systems Biology | KRAS-specific capture agents, compositions, and methods of making and using |
| WO2022098743A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1) |
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| US5250285A (en) | 1985-05-08 | 1993-10-05 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic NMR imaging |
| US5094848A (en) | 1989-06-30 | 1992-03-10 | Neorx Corporation | Cleavable diphosphate and amidated diphosphate linkers |
| IT1269839B (it) | 1994-05-26 | 1997-04-15 | Bracco Spa | Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi |
| CA2539215A1 (en) | 1995-02-01 | 1996-08-08 | Epix Pharmaceuticals, Inc. | Diagnostic imaging contrast agents with extended blood retention |
| TW319763B (da) * | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| DE19529512C2 (de) | 1995-08-10 | 2000-11-23 | Siemens Ag | Verfahren zur Phasenkontrast-MR-Angiographie und Anordnung zur Durchführung des Verfahrens |
| DE19543785A1 (de) | 1995-11-24 | 1997-05-28 | Philips Patentverwaltung | MR-Verfahren und Anordnung zur Durchführung des Verfahrens |
| EP0907379B1 (en) * | 1996-04-01 | 2004-06-02 | Epix Medical, Inc. | Bioactivated diagnostic imaging contrast agents |
| IT1283650B1 (it) | 1996-08-02 | 1998-04-23 | Bracco Spa | Chelati paramagnetici ad alta relassivita' in siero |
| US5919967A (en) | 1997-04-11 | 1999-07-06 | Epix Medical, Inc. | Process for synthesizing phosphodiesters |
| WO1999017809A2 (en) * | 1997-10-02 | 1999-04-15 | Epix Medical, Inc. | Contrast-enhanced diagnostic imaging method for monitoring interventional therapies |
| IT1304501B1 (it) | 1998-12-23 | 2001-03-19 | Bracco Spa | Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza |
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1998
- 1998-09-24 WO PCT/US1998/020182 patent/WO1999017809A2/en not_active Application Discontinuation
- 1998-09-24 DK DK98950704T patent/DK1019094T3/da active
- 1998-09-24 AU AU96686/98A patent/AU742438C/en not_active Ceased
- 1998-09-24 BR BR9812716-0A patent/BR9812716A/pt not_active Application Discontinuation
- 1998-09-24 CA CA002303426A patent/CA2303426C/en not_active Expired - Fee Related
- 1998-09-24 EP EP98950704A patent/EP1019094B1/en not_active Expired - Lifetime
- 1998-09-24 JP JP2000514677A patent/JP2001518523A/ja active Pending
- 1998-09-24 DE DE69819925T patent/DE69819925T2/de not_active Expired - Lifetime
- 1998-09-24 AT AT98950704T patent/ATE254479T1/de not_active IP Right Cessation
- 1998-09-24 NZ NZ503402A patent/NZ503402A/en unknown
- 1998-09-24 PT PT98950704T patent/PT1019094E/pt unknown
- 1998-09-24 IL IL13498598A patent/IL134985A0/xx not_active IP Right Cessation
- 1998-09-24 SK SK484-2000A patent/SK4842000A3/sk unknown
- 1998-09-24 ES ES98950704T patent/ES2206996T3/es not_active Expired - Lifetime
- 1998-09-24 HU HU0101245A patent/HUP0101245A3/hu unknown
- 1998-09-24 KR KR1020007003527A patent/KR20010030854A/ko not_active Application Discontinuation
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2000
- 2000-03-10 IS IS5399A patent/IS2041B/is unknown
- 2000-04-03 NO NO20001707A patent/NO321966B1/no not_active IP Right Cessation
- 2000-09-08 US US09/887,706 patent/US6861045B1/en not_active Expired - Fee Related
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2001
- 2001-01-12 HK HK01100360A patent/HK1030744A1/xx not_active IP Right Cessation
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2004
- 2004-10-08 US US10/961,872 patent/US7175829B2/en not_active Expired - Fee Related
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2005
- 2005-09-22 JP JP2005276942A patent/JP2006077020A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1019094B1 (en) | 2003-11-19 |
| CA2303426A1 (en) | 1999-04-15 |
| IS5399A (is) | 2000-03-10 |
| JP2006077020A (ja) | 2006-03-23 |
| JP2001518523A (ja) | 2001-10-16 |
| KR20010030854A (ko) | 2001-04-16 |
| NO20001707D0 (no) | 2000-04-03 |
| IL134985A0 (en) | 2001-05-20 |
| PT1019094E (pt) | 2004-03-31 |
| ES2206996T3 (es) | 2004-05-16 |
| US6861045B1 (en) | 2005-03-01 |
| US7175829B2 (en) | 2007-02-13 |
| AU742438B2 (en) | 2002-01-03 |
| US20050118103A1 (en) | 2005-06-02 |
| DE69819925D1 (de) | 2003-12-24 |
| DE69819925T2 (de) | 2004-09-02 |
| WO1999017809A3 (en) | 1999-05-20 |
| CA2303426C (en) | 2008-09-23 |
| NO20001707L (no) | 2000-05-31 |
| NO321966B1 (no) | 2006-07-31 |
| HK1030744A1 (en) | 2001-05-18 |
| WO1999017809A2 (en) | 1999-04-15 |
| EP1019094A2 (en) | 2000-07-19 |
| BR9812716A (pt) | 2000-08-22 |
| NZ503402A (en) | 2002-03-01 |
| AU9668698A (en) | 1999-04-27 |
| AU742438C (en) | 2003-05-22 |
| ATE254479T1 (de) | 2003-12-15 |
| IS2041B (is) | 2005-09-15 |
| HUP0101245A3 (en) | 2003-10-28 |
| HUP0101245A2 (hu) | 2001-08-28 |
| DK1019094T3 (da) | 2004-02-16 |
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