SK288847B6 - Herbal extract and its use - Google Patents

Abstract

Described is a herbal extract obtained by leaching a mixture of 32 herbs in 1000 ml of leaching medium containing 20 % vol. up to 50% vol. of ethanol and its use in medicine, in particular for the treatment of gastric disorders, for the stimulation of the non-specific immune system, for the short-term prevention and treatment of the common cold, also as an otorhinolaryngology, topical antiseptic, topical antiviral, topical antifungal and dermatological.

Description

Field of the invention

The invention relates to an herbal extract and its use. The extract is suitable for use in medicine and for home treatment, especially for the treatment of stomach upset, for stimulation of the non-specific immune system, for short-term prevention and for the treatment of the common cold, also as an otorhinolaryngology, topical antiseptic, topical antiviral, antifungal and topical dermatological.

Prior art

Herbal extracts are one of the oldest and most widely used uses of medicinal plants. These are processed herbal drugs (dried root, leaves, perch, etc.) and concentrated plant extracts obtained by extraction of the drug with various solvents (water, alcohol, glycerol, etc.). The extracts can be liquid to dry (obtained by complete evaporation of the solvent).

From patent documents CN104906550, medicinal compositions of 18 traditional Chinese herbs are known, which also include a minority of the blackberry species Rubus nutans. This dry herbal mixture is used to treat chronic gastritis. The disadvantage is the dry form of the preparation, which does not guarantee a high effectiveness of the preparation. Another patent document CN104815183 describes a mixture of herbs of one of the species of rubus Rubus xanthocarpus, which contains another 11 species of Chinese herbs. This mixture is used to treat childhood diarrhea. It is prepared by boiling a mixture of herbs in water for 5 hours, followed by filtration and evaporation of the filtrate to dryness. Such treatment will cause degradation of the thermolabile bioactive substances in the formulation, thereby reducing the efficacy of the formulation.

Ukrainian patent document UA94082 describes an herbal extract of dioecious nettle and / or bumblebee with the optional addition of selenium or urea. The product is still exposed to a high-frequency electromagnetic field. The preparation is used as an aid in the treatment of conditions such as HIV infections and AIDS.

Korean patent document KR20120027040 describes an extract prepared from a combination of the species Rubus idaeus and Rubus fructiosuss with influenza effects.

US patent document US2002012708 describes the use of an herbal extract from artichoke, which forms an essential component of the preparation, is in dry form, or may also contain extracts of echinacea and / or nettle in minor amounts. This preparation is administered as an adjunct to the conventional treatment of diseases caused by bacteria and viruses, such as Crohn's disease, inflammation of the pancreas, kidneys, atrophy of the liver, jaundice or skin ulcers, or also in the treatment of viral diseases.

Czech utility model no. 27424 describes a gastric tincture of a mixture of five herbs, such as extracts from the root of yellow gentian, earthworm, which are hot herbs that support digestion. Furthermore, as a supporting herb, it contains a minority of raspberries, butterbur and benedict. But this tincture is used only for stomach problems and no other effects have been shown.

The essence of the invention

The object of the invention is to prepare an herbal extract which has a wide range of effects not only when administered orally but also when applied topically to the skin or mucosa of a patient.

We managed to develop a unique combination of herbs, i. j. an herbal mixture which is leached at ambient temperature, the herbal extract having a number of different therapeutic effects. This herbal extract can be used in the treatment of stomach problems, to stimulate the non-specific immune system, for the short-term prevention and treatment of the common cold, also as an otorhinolaryngological, topical antiseptic, topical antiviral, topical antifungal and dermatological.

Therefore, it fulfills the role and eliminates the said disadvantages and shortcomings of the herbal extract according to the invention, the essence of which is that it is obtained by leaching the following mixture of herbs:

8.6 to 14.9 g of dry spring shoots of nettle,

2.9 to 8.6 g of dry raspberry blackberry leaves,

2.9 to 8.6 g of dry leaves of blackberry,

1.7 to 4.1 g of dry leaves of strawberry,

1.7 to 4.1 g of dry young growths of spruce,

1.7 to 4.1 g of the dry above-ground part of the small-flowered willow in bloom,

1.1 to 3.5 g of dry above-ground part of the pulmonary lung in bloom,

1.1 to 3.5 g of dry flowers of black base,

1.1 to 3.5 g of a dry mixture of the flower and the leaf of the common alchemy,

1.1 to 3.5 g of dry leaves of spearmint,

1.1 to 3.5 g of the dry above-ground part of the honeysuckle in bloom, 0.9 to 3.1 g of the dry above-ground part of the honeysuckle in the flower, 0.9 to 3.1 g of the dry above-ground part of the honeysuckle in the flower, 0, 6 to 2.8 g of a dry mixture of a flower and a leaf of the honeysuckle, 0.6 to 2.8 g of the dry above-ground part of the plant of the mother plant, 0.6 to 2.8 g of a dry flower of the common daisy, 0.6 to 2.8 g of dry flower of St. John's wort, 0.6 to 2.8 g of dry flower of heart-shaped linden, 0.6 to 1.6 g of dry flower of spring primrose, 0.6 to 1.6 g of dry leaf of celery, 0.6 to 1 .6 g dry flower of marigold, 0.6 to 1.6 g dry flower of hawthorn, 0.6 to 1.6 g dry above-ground part of peppermint, 0.6 to 1.6 g dry crown petals of Gallic rose or table roses, 0.6 to 1.6 g of dry above-ground part of horsetail, 0.3 to 0.9 g of dry mixture of flower and leaf of pamajoran, 0.3 to 0.9 g of dry mixture of flower and leaf of fragrant violet, 0 , 3 to 0.9 g of dry chamomile flower 0.3 to 0.9 g of the dry flower of the common woodpecker, 0.3 to 0.6 g of the dry flower of the common ladder, 0.1 to 0.5 g of the dry flower of the wild flowering and 2.4 to 4.4 g for a paste of crushed clove of garlic sown in 1000 ml of leaching medium containing 20% by volume. up to 50 vol. %. ethanol.

According to a preferred embodiment, the herbal extract can be obtained by leaching the following mixture of herbs: 11.5 g of dry spring shoots of nettle, 5.7 g of dry leaves of raspberry, 5.7 g of dry leaves of blackberry, 2.9 g of dry leaves of strawberry, 2.9 g dry young growths of Norway spruce, 2.9 g dry above-ground part of small-flowered willowherb in bloom, 2.3 g dry above-ground part of common lungwort in bloom, 2.3 g dry flowers of black base, 2.3 g dry mixture of bloom and a leaf of alchemilka, 2.3 g of dry leaves of spearmint, 2.3 g of the dry above-ground part of the ryegrass in bloom, 2.0 g of the dry above-ground part of the grayling in bloom, 2.0 g of the dry above-ground part of the honeysuckle in bloom, 1.7 g of a dry mixture of the flower and the leaf of the honeysuckle, 1.7 g of the dry above-ground part of the mother sip, 1.7 g of the dry flower of the common daisy, 1.7 g of the dry flower of St. John's wort, 1.7 g of the dry flower of the heart linden, 1.1 g dry primrose flower Spring leaves, 1.1 g dry leaf of radish, 1.1 g dry flower of garden marigold, 1.1 g dry flower of hawthorn, 1.1 g of dry above-ground part of peppermint in bloom, 1.1 g of dry crown petals Gallic rose or centipede rose, 1.1 g of dry above-ground part of horsetail, 0.6 g of dry mixture of flower and leaf of pamajoran, 0.6 g of dry mixture of flower and leaf of fragrant violet, 0.6 g of dry flower of chamomile, 0 , 6 g of a dry flower of whitefish, 0.4 g of a dry flower of the common ladder, 0.3 g of a dry flower of wild bass and 3.4 g of a paste of crushed clove of garlic sown in 1000 ml of leaching medium containing 30% by volume. ethanol.

For the leaching (extraction) a leaching medium is used with an alcohol content, preferably ethanol, of 20% by volume. up to 45% by volume, more preferably 30% by volume. up to 40% vol.

According to a preferred embodiment, the leaching time can be 20 to 40 days and then the leachate is filtered and quenched.

The term "mixture of flower and leaf" means a mixture which results from the separation of the leaves and flowers from the stems of harvested plants of a given herb. Preferably, the flower and the leaf of the common alchemy are mixed in a ratio of 2 vol. parts of a flower and 1 vol. part of the sheet. The same ratio of flower to leaf is also beneficial for the honeysuckle.

In the case of pamajoran common, the preferred ratio in the mixture is 1 vol. part of flower for 1 vol. part of the sheet. The same ratio of flower to leaf is also advantageous for the fragrant violet.

A great advantage of the herbal extract according to the invention is its versatility of use and wide effect, especially in the prevention and treatment of infectious diseases. It is used orally and / or topically, either in the form of drops or in the form of a spray. For oral use, a small amount of the extract is preferably added dropwise to water or tea. Upon topical application of the extract according to the invention, the affected skin or mucosa is preferably sprayed or sprayed.

The herbal extract according to the invention can be used in the treatment of gastric disorders, for the stimulation of a non-specific immune system, for the short-term prevention or treatment of the common cold, as an otorhinolaryngological, antiseptic, antiviral, antifungal or dermatological agent. Preferably, the herbal extract according to the invention is used for the treatment of psoriasis, nasopharyngitis, diseases caused by herpesviruses, preferably Herpes simplex ', or diseases caused by papillomaviruses.

The prepared herbal extract is effective when administered orally in the form of drops for the treatment of acute and chronic gastritis. It strengthens the overall immunity of the body, in particular it is effective in the prevention and treatment of colds, nasopharyngitis, bronchitis. It is also an effective otorhinolaryngological, cervical, nasal and ear antiseptic. It is an effective antiviral drug for topical administration of the herbal extract according to the invention, in particular in the treatment of herpes caused by the Herpes simplex virus and recurrent Herpes labialis. The preparation has proved very useful in the treatment of skin infections caused by bacteria or in the treatment of local mycoses caused by fungi, molds and yeasts. The herbal extract according to the invention can also be used supportively for the treatment or prevention of dry, scaly, itchy and sensitive skin, for example in atopic eczema.

Examples of embodiments of the invention

Example 1

Prepare a dry herbal mixture according to Table 1.

Table 1

The name of the herb Collected part Amount (g) in the dry herbal mixture Stinging nettle spring shoots 11.5 Raspberry blackberry leaves 5.7 Blackberry leaves 5.7 Strawberry leaves 2.9 Norway spruce young additions 2.9 Small-flowered willowherb the aboveground part of the plant in bloom 2.9 Pulmonary medical the aboveground part of the plant in bloom 2.3 Elderberry flower 2.3 Common alchemy a mixture of flower and leaf in a ratio of 2: 1 2.3 Skorocel lanceolate a letter 2.3 He slammed medical the aboveground part of the plant in bloom 2.3 Lipkavec pravý the aboveground part of the plant in bloom 2.0 Honeydew the aboveground part of the plant in bloom 2.0 Coltsfoot healing a mixture of flower and leaf in a ratio of 2: 1 1.7 Mother's sip the aboveground part of the plant 1.7 Common daisy flower 1.7 St. John's wort dotted flower 1.7 Heart-shaped linden flower 1.7 Spring primrose flower 1.1 Rapeseed a letter 1.1 Garden marigold flower 1.1 Hawthorn flower 1.1 Peppermint the aboveground part of the plant in bloom 1.1 Gallic rose crown petals 1.1 Horsetail the aboveground part of the plant 1.1 Pamajorán common a 1: 1 mixture of flower and leaf 0.6

The name of the herb Collected part Amount (g) in the dry herbal mixture Fragrant violet a 1: 1 mixture of flower and leaf 0.6 Chamomile flower 0.6 Hluchavka white flower 0.6 Ordinary ranking flower 0.4 Large-flowered wild boar flower 0.3

3.4 g of crushed clove of garlic paste are added to the dry mixture of herbs, then this mixture is left to leach in 1 liter of alcoholic distillate with an ethanol content of 40% by volume. for 30 days. After the leaching time has elapsed, the mixture is filtered. The extract (filtrate) is still squeezed out of the mother cake, and then left to stand 5 in a glass vessel for 10 days to clear it. It is then twisted with a tube into the prepared cups.

Example 2

Prepare a dry herbal mixture according to Table 2.

Table 2

The name of the herb Collected part Amount (g) in the dry herbal mixture Stinging nettle spring shoots 8.6 Raspberry blackberry leaves 2.9 Blackberry leaves 2.9 Strawberry leaves 1.7 Norway spruce young additions 1.7 Small-flowered willowherb the aboveground part of the plant in bloom 1.7 Pulmonary medical the aboveground part of the plant in bloom 1.1 elderberry flower 1.1 Common alchemy a mixture of flower and leaf 1.1 Skorocel kopi joxitv a letter 1.1 He slammed medical the aboveground part of the plant in bloom 1.1 Lipkavec pravý the aboveground part of the plant in bloom 0.9 Honeydew the aboveground part of the plant in bloom 0.9 Coltsfoot healing a mixture of flower and leaf 0.6 Mother's sip the aboveground part of the plant 0.6 Common daisy flower 0.6 St. John's wort dotted flower 0.6 Heart-shaped linden flower 0.6 Spring primrose flower 0.6 Rapeseed a letter 0.6 Garden marigold flower 0.6 Hawthorn flower 0.6 Peppermint the aboveground part of the plant in bloom 0.6 Centennial rose crown petals of a flower 0.6 Horsetail the aboveground part of the plant 0.6 Pamajorán common a mixture of flower and leaf 0.3 Fragrant violet a mixture of flower and leaf 0.3 Chamomile flower 0.3 Hluchavka white flower 0.3 Ordinary ranking flower 0.2 Large-flowered wild boar flower 0.1

To the dry mixture of herbs, 2.4 g of a crushed clove of garlic sieve paste is added, then this mixture is left to leach in 1 liter of distillate with an ethanol content of 50% by volume. for 20 days. After the leaching time has elapsed, the mixture is filtered. The extract (filtrate) is then stored in a glass container.

Example 3

Prepare a dry herbal mixture according to Table 3.

Table 3

The name of the herb Collected part Amount (g) in the dry herbal mixture Stinging nettle spring shoots 14.9 Raspberry blackberry leaves 8.6 Blackberry leaves 8.6 Strawberry leaves 4.1 Norway spruce young additions 4.1 Small-flowered willowherb the whole aboveground part of the plant in bloom 4.1 Pulmonary medical the whole aboveground part of the plant in bloom 3.5 elderberry flower 3.5 Common alchemy a mixture of flower and leaf 3.5 Skorocel lanceolate a letter 3.5 He slammed medical the whole aboveground part of the plant in bloom 3.5 Lipkavec pravý the whole aboveground part of the plant in bloom 3.1 Honeydew the whole aboveground part of the plant in bloom 3.1 Coltsfoot healing a mixture of flower and leaf 2.8 Mother's sip the whole above-ground part of the plant 2.8 Common daisy flower 2.8 St. John's wort dotted flower 2.8 Heart-shaped linden flower 2.8 Spring primrose flower 1.6 Rapeseed a letter 1.6 Garden marigold flower 1.6 Hawthorn flower 1.6 Peppermint the whole aboveground part of the plant in bloom 1.6 Gallic rose crown petals 1.6 Horsetail the whole above-ground part of the plant 1.6 Pamajorán common a mixture of flower and leaf 0.9 Fragrant violet a mixture of flower and leaf 0.9 Chamomile flower 0.9 Hluchavka white flower 0.9 Ordinary ranking flower 0.6 Large-flowered wild boar flower 0.5

4.4 g of crushed clove of garlic paste are added to the dry herb mixture, then the mixture is leached in 1 liter of fermented plum distillate with an ethanol content of 20% by volume. for 40 days. After the leaching time has elapsed, the mixture is filtered. The extract is then stored in a glass container.

Example 4

Clinical monitoring of the effect of the herbal extract according to the invention prepared according to Example 1.

The study took place at the DOSŤ Private Dermatology Clinic in Svidník, SK.

Several groups of volunteers were selected. Prior to the application itself, it was confirmed that the persons had not suffered from any allergies to herbs, food and medicines in the past. Epicutaneous testing was performed on probands, all with negative results.

Groups with internal (oral) use of drops of the herbal extract according to the invention, a total of 35 subjects (16 women, 19 men, aged 21-59 years), dose 2 times a day 10 drops, time of use 1 month.

I. Group - recurrent Herpes simplex - 10 subjects - no recurrence of herpes occurred in 6 subjects within 14 months, although previously the frequency was at least once a month.

In 4 people, herpes occurred rarely 1 to 2 times during the year. They consider the effect of the herbal extract to be very good.

II. Group - recurrent verrucae vulgares - 6 subjects - in 5 persons in total in 15 months there was no recurrence of verruca, dose 2 times a day 10 drops, time of use 1 month, one person interrupted monitoring to go abroad, information is not available.

III. Group - meteosensitive patients, frequent colds and problems with HCD - 9 persons, since the beginning of use, according to personal expression, the body's defenses improved significantly in all persons, they were not cold or had no cold within 16 months. Dose 10 drops twice a day, time of use 1 month, after 6 months of repeated use.

IV. The group - patients with recurrent manifestations of psoriasis vulgaris - seasonal occurrence in spring and autumn - of the subjects, significantly improved the body's defenses from the beginning of use, according to personal expression, during 16 months there were no manifestations of psoriasis, if very discreet. Dose 10 drops twice a day, time of use 1 month, after 6 months of repeated use. Topical treatment without corticoids, only emollients.

Groups with topical use of the herbal extract prepared according to Example 1, a total of 25 subjects (12 women, 13 men, ages 23-55 years), rubbing the affected areas on the skin 2 to 3 times a day until the symptoms disappear.

V. Group - recurrent Herpes simplex -10 subjects - 7 subjects did not have a recurrence of herpes during 9 months, although previously the frequency was at least once a month.

In 3 persons, herpes occurred once in 6 months. They consider the effect of the herbal extract to be very good, patients spontaneously demanded it, because the symptoms calmed down within 3 days.

VI. Group - recurrent verrucae vulgares - 6 subjects - in all persons there was no recurrence of warts in a total of 15 months, healing within 12 days.

VIL Group - verrucae planes juvenile - 3 women - after a monthly application of the extract twice a day on the forehead and cheeks, the symptoms disappeared, until then unsuccessfully treated, no recurrence was recorded.

Groups with oral use of the herbal extract prepared according to Example 1, a total of 25 subjects (12 women, 13 men, age from 23-55 years), dose 2 times a day 10 drops, time of use 1 month.

VIII. Group - meteosensitive patients, frequent colds and problems with HCD - 6 people, from the beginning of use significantly in all according to personal expression improved the body's defenses, if the first signs of scratching in the throat or rhinitis appeared, after using the spray of herbal extract according to the invention and had no health problems for 3 days.

IX. Patients after chemotherapy for breast, gastrointestinal, respiratory tract cancer, a total of 9 people (5 women, 4 men, mean age 39-72 years). Dose 10 drops twice a day, time of use 1 month, after 3 months of repeated use (3 times in total). In all the monitored persons, their health and mental condition improved greatly after a month of use, and there was no negative reaction.

From the monitoring of a small group of people with various health problems, the use of the polycomposite herbal extract according to the invention proved to be very effective. No general or local adverse events occurred in any of the subjects. We use the herbal extract according to the invention is very comfortable and effective.

Claims (8)

PATENT CLAIMS An herbal extract obtained by leaching the following mixture of herbs: 8.6 to 14.9 g of dry spring shoots of nettle, 2.9 to 8.6 g of dry leaves of raspberry, 2.9 to 8.6 g of dry leaves of raspberry , 1,7 to 4,1 g of dry leaves of strawberry, 1,7 to 4,1 g of dry young growths of Norway spruce, 1,7 to 4,1 g of dry above-ground part of small-flowered willow in bloom, 1,1 to 3, 5 g of the dry above-ground part of the pulmonary lung in bloom, 1.1 to 3.5 g of dry flowers of black base, 1.1 to 3.5 g of a dry mixture of flower and leaf of common alchemil, 1.1 to 3.5 g of dry leaves of alfalfa lanceolate, 1.1 to 3.5 g of the dry above-ground part of the honeysuckle in bloom, 0.9 to 3.1 g of the dry above-ground part of the honeysuckle in the flower, 0.9 to 3.1 g of the dry above-ground part of the honeysuckle in the flower, 0.6 to 2.8 g of a dry mixture of the flower and the leaf of the honeysuckle, 0.6 to 2.8 g of the dry above-ground part of the plant of the mother plant, 0.6 to 2.8 g of the dry flower of the common daisy, 0.6 to 2 .8 g dry St. John's wort flower, 0.6 to 2.8 g of dry linden flower, 0.6 to 1.6 g of dry spring honeysuckle flower, 0.6 to 1.6 g of dry rape, 0.6 to 1, 6 g of dry flower of marigold, 0.6 to 1.6 g of dry flower of hawthorn, 0.6 to 1.6 g of dry above-ground part of peppermint, 0.6 to 1.6 g of dry crown petals of Gallic rose or rose table, 0.6 to 1.6 g of the dry above-ground part of the horsetail, 0.3 to 0.9 g of a dry mixture of the flower and leaf of the common weevil, 0.3 to 0.9 g of a dry mixture of the flower and the leaf of the fragrant violet, 0, 3 to 0.9 g of dry chamomile flower, 0.3 to 0.9 g of dry flower of whitefish, 0.3 to 0.6 g of dry flower of ladder, 0.1 to 0.5 g of dry flower of wild walleye and 2.4 to 4.4 g per paste of crushed garlic sieve in 1000 ml of leaching medium containing 20% by volume. up to 50% vol. ethanol. Herbal extract according to claim 1, obtained by leaching the following mixture of herbs: 11.5 g of dry spring shoots of nettle, 5.7 g of dry spring leaves of raspberry, 5.7 g of dry spring leaves of blackberry, 2.9 g of dry leaves Strawberries, 2.9 g dry young growths of Norway spruce, 2.9 g dry above-ground part of the small-flowered willow in bloom, 2.3 g dry above-ground part of the common lungwort in bloom, 2.3 g of dry flowers of black base, 2.3 g dry mixture of flower and leaf of common alchemy, 2.3 g of dry leaves of spearmint, 2.3 g of dry above-ground part of ryegrass in bloom, 2.0 g of dry above-ground part of grayling in bloom, 2.0 g of dry above-ground part of honeysuckle in bloom, 1.7 g dry mixture of flower and leaf of honeysuckle, 1.7 g dry above-ground part of the mother sip, 1.7 g dry flower of common daisy, 1.7 g dry flower of St. John's wort, 1.7 g dry flower heart-shaped linden, 1.1 g of dry primrose flower spring ginger, 1.1 g of dry leaf of radish, 1.1 g of dry flower of garden marigold, 1.1 g of dry flower of hawthorn, 1.1 g of dry above-ground part of peppermint in bloom, 1.1 g of dry crown petals Gallic rose or centipede rose, 1.1 g of dry above-ground part of horsetail, 0.6 g of dry mixture of flower and leaf of pamajoran, 0.6 g of dry mixture of flower and leaf of fragrant violet, 0.6 g of dry flower of chamomile, 0 , 6 g of a dry flower of whitefish, 0.4 g of a dry flower of the common ladder, 0.3 g of a dry flower of wild bass and 3.4 g of a paste of crushed clove of garlic sown in 1000 ml of leaching medium containing 30% by volume. ethanol. The herbal extract according to claim 1, wherein the leaching medium contains 30 to 40% by volume. ethanol. The herbal extract according to any one of claims 1 to 3, wherein the leaching time is 20 to. 40 days and then the extract is filtered and drained. An herbal extract according to any one of claims 1 to 4 for use in the treatment of gastric disorders, in the stimulation of a non-specific immune system, for the short-term prevention or treatment of the common cold. An herbal extract according to any one of claims 1 to 4 for use as an otorhinolaryngology, antiseptic, virostatic, antifungal or dermatological. Herbal extract according to claims 5 or 6 for use for oral and / or topical application. An herbal extract according to any one of claims 5 to 7 for use in the treatment of psoriasis, nasopharyngitis, diseases caused by herpesviruses, preferably Herpes simplex; or diseases caused by papillomavirus Russians.