CZ2016431A3 - An herbal extract and its use - Google Patents

Description

Technical field

The invention relates to an herbal extract and to its use. The extract is suitable for use by the immune system, for the short-term prevention and treatment of common cold, as well as an otorhinolaryngological, topical antiseptic, topical virostatic, topical antifungal and dermatological.

BACKGROUND OF THE INVENTION

Herbal extracts are one of the oldest and most used ways of using medicinal plants. These are processed herbal drugs (dried root, leaves, stem etc.). These are concentrated plant extracts obtained by extracting the drug with various solvents (water, alcohol, glycerol, etc.). The extracts may be liquid to dry (obtained by complete evaporation of the solvent).

From the patent documents CN104906550 medicinal compositions of 18 traditional Chinese herbs are known, which include a species of blackberry Rubus nutans in minor amounts. This dry herbal mixture is used to treat chronic gastritis. The disadvantage is the dry form of the preparation, which does not guarantee high efficiency of the preparation. Another patent document CN104815183 discloses a mixture of herbs of one of the species of blackberry Rubus xanthocarpus, which contains a further 11 kinds of Chinese herbs. This mixture is used to treat childhood diarrhea. It is prepared by boiling a mixture of herbs in water for 5 hours followed by filtration and evaporation of the filtrate to dryness. Such treatment causes degradation of the thermolabile bioactive substances in the formulation, thereby reducing the efficacy of the formulation.

Ukrainian patent document UA94082 discloses a herbal extract of Stinging nettle and / or tansy with optional addition of selenium and / or urea. The preparation is also exposed to a high-frequency electromagnetic field. It is used as a support to treat conditions such as HIV infection and AIDS.

Korean patent document KR20120027040 describes an extract prepared from a combination of blackberry species Rubus idaeus and Rubus fructiosus with anti-influenza effects.

US patent document US2002012708 describes the use of an herbal extract of artichoke, which constitutes an essential component of the preparation, is in dry form, or may also contain extracts of Echinacea and / or nettle in minor amounts. It is given as a support for the conventional treatment of diseases caused by bacteria and viruses, such as Crohn's disease, pancreatitis, kidney inflammation, liver atrophy, jaundice or skin ulcers, or also for the treatment of viral diseases.

Czech utility model No. 27424 describes the gastric tincture of a mixture of five herbs, such as extracts of the root of Yellow Gentian, Centaury, which are bitter, digestive-promoting herbs. It also contains, in minority quantities, Raspberry, Rufus and Chubet Benedict. However, this tincture is only used for stomach problems and no other effects have been shown.

SUMMARY OF THE INVENTION

SUMMARY OF THE INVENTION It is an object of the present invention to provide a herbal extract which exhibits a wide spectrum of effects not only when administered orally, but also when applied topically to the skin or mucosa of a patient.

We have succeeded in developing a unique combination of herbs, i.e. a herbal mixture that is leached at ambient temperature, and the herbal extract obtained has a number of different therapeutic effects. This herbal extract can be used to treat stomach problems, to stimulate the non-specific immune system, to short-term prevent and treat common colds, as well as an otorhinolaryngological, topical antiseptic, topical virostatic, topical antifungal, and dermatological.

Therefore, the present invention fulfills the above-mentioned disadvantages and drawbacks, which is based on the fact that in 1000 ml of leaching medium containing 20 vol% to 50 vol%. at least 8.6 to 14.9 g of dry spring shoots of Stinging Nettle, at least 2.9 to 8.6 g of dry leaves of Raspberry, at least 2.9 to 8.6 g of dry leaves of Blackberry at least 1.7 to ethanol 4.1 g of dry leaves of Strawberry, at least 1.7 to 4.1 g of dry young spruce increments, at least 1.7 to 4.1 g of dry aboveground part of small-flowered Willow in bloom, at least 1.1 to 3.5 g dry aerial parts of Lungwort in bloom, at least 1.1 to 3.5 g of dry elderberry flowers, at least 1.1 to 3.5 g of dry flower and Kontryhele leaf, at least 1.1 to 3.5 g of dry leaves Plantain of lanceolate, at least 1.1 to 3.5 g of dry ground aerial part of Speedwell in bloom, at least 0.9 to 3.1 g of dry ground aerial part of Ground Squirrel in bloom, at least 0.9 to 3.1 g of dry ground aerial part of Lemongrass medical in bloom,. At least 0.6 to 2.8 g of a dry blend of flower and coltsfoot leaf, at least 0.6 to 2.8 g of the above ground part of the Thyme plant, at least 0.6 to 2.8 g of dry flower Daisies, at least 0.6 to 2.8 g of dry flower St John's wort, at least 0.6 to 2.8 g of dry flower Linden, at least 0.6 to 1.6 g dry flower Primrose spring, at least 0.6 to 1.6 g dry leaf of Agrimony, at least 0.6 to 1.6 g dry flower of Marigold, at least 0.6 to 1.6 g dry flower Sharp-hawthorn, at least 0 , 6 to 1,6 g of dry overhead part Peppermint mint, at least 0,6 to 1,6 g of dry crown petals Rose of Gallic or Rose of Rose, at least 0,6 to 1,6 g of dry overhead part Horsetail, at least 0, 3 to 0.9 g dry blend of flower and leaf Dobromysli at least 0.3 to 0.9 g dry blend of flower and leaf Violka fragrance, at least 0.3 to 0.9 g dry flower of chamomile, at least 0.3 to 0.9 g dry flower White nettle, at least 0.3 to 0.6 g dry flower of yarrow, at least 0.1 to 0.5 g dry flower of mullein, and at least 2.4 to 4.4 g per paste crushed garlic clove.

A preferred embodiment of the invention is a herbal extract wherein in 1000 ml of leaching medium containing 30 vol%. ethanol is leached:

11,5 g dry spring shoots of Stinging nettle,

5.7 g dry leaves of raspberry blackberry,

5.7 g of dry leaves of blackberry,

2,9 g of dry leaves of strawberry

2,9 g of dry young growths of Norway spruce,

2,9 g of dry above-ground part of small-flowered willow in bloom,

2.3 g of dry aerial part of Lungwort in bloom,

2.3 g of elderberry dry flowers,

2,3 g dry mixture of flower and leaf of Kontryhele,

2,3 g dry plantain leaves,

2.3 g of dry aerial part of Speedwell in bloom • • · ·

2.0 g of dry ground part of Ground Squirrel in bloom,

2,0 g of dry aerial part of Lemon balm in bloom,

1,7 g of dry mixture of flower and leaf of Coltsfoot,

1,7 g of dry ground part of thyme,

1,7 g dry flower Daisies,

1,7 g dry flower St John's wort,

1,7 g of dry linden flower,

1,1 g dry flower Primrose spring,

1,1 g dry leaf of Agrimony,

1,1 g of dry marigold flower,

1,1 g dry hawthorn flower,

1,1 g dry part of peppermint in flower,

1.1 g of dry crown petals of the Gallic Rose or the Rose of the Rose,

1.1 g of dry ground part Horsetail,

0,6 g of dry mixture of flower and leaf

0,6 g dry blend of flower and violet fragrance,

0,6 g dry flower of camomile,

0,6 g dry flower White nipples,

0,4 g dry flower of Yarrow,

0,3 g of dry flower of the Mullein, a

3.4 g per paste of crushed garlic clove.

The leaching medium containing an alcohol, preferably ethanol, 20 vol% to 45 vol%, more preferably 30 vol% to 40 vol% is used for the extraction.

The term "blend of flower and leaf" means a mixture that results from the separation of leaves and flowers from the stalks of the collected plants of a given herb. Preferably, the flower and leaf are mixed in a ratio of 2 parts by volume of flower and 1 part by volume of leaf mollusk. The same flowering to leaf ratio is also beneficial for Coltsfoot.

In Dobromysli the preferred ratio in the mixture is 1 part by volume of flower to 1 part by volume of leaf. The same flowering to leaf ratio is also beneficial for Violet fragrance.

A great advantage of the herbal extract according to the invention is its versatility of use and wide effect especially in the prevention and treatment of infectious diseases. It is used orally and / or topically, either in the form of drops or in the form of a spray. For oral use, preferably a small amount of extract is dripped into water or tea. In the topical (topical) application of the extract according to the invention, preferably the affected skin or mucous membrane is rubbed or sprayed.

The herbal extract of the invention may be used in the treatment of stomach problems, to stimulate the non-specific immune system, to prevent or treat common cold for a short time, as well as an otorhinolaryngologic, antiseptic, virostatic, antifungal or dermatological. Preferably, the herbal extract of the invention is used to treat psoriasis, nasopharyngitis, diseases caused by herpesviruses, preferably Herpes simplex; or diseases caused by papillomaviruses.

The prepared herbal extract is effective for oral administration in the form of drops in the treatment of acute and chronic gastritis. It strengthens the overall immunity of the organism, especially it is effective in preventing and treating colds, nasopharyngitis, bronchitis. It is also an effective otorhinolaryngologic, cervical, nasal and ear antiseptic. In topical administration of the herbal extract of the invention, it is an effective virostatic, particularly in the treatment of cold sores caused by Herpes simplex virus and recurrent Herpes labialis. It has proven to be very effective in the treatment of skin infections caused by bacteria or in the treatment of local mycoses caused by fungi, molds and yeasts. The herbal extract of the invention may also be used as an adjunct to treat or prevent dry, scaly, itchy and sensitive skin, such as atopic eczema.

DETAILED DESCRIPTION OF THE INVENTION

Example 1

A dry herbal blend is prepared according to Table 1 below

Table 1

Herb name Collected part amount (g) in the dry herbal mixture Stinging nettle spring sprouts 11.5 Blackberry raspberry leaves 5.7 Blackberry leaves 5.7 Strawberry leaves 2.9 Spruce young additions 2.9 Willow Willow aboveground part of the plant in bloom 2.9 Lungwort aboveground part of the plant in bloom 2.3

Black berries flower 2.3 Lady's mantle a 2: 1 mixture of flower and leaf 2.3 Plantain lanceolate blade 2.3 Speedwell aboveground part of the plant in bloom 2.3 Ground squirrel aboveground part of the plant in bloom 2.0 Lemon balm aboveground part of the plant in bloom 2.0 Coltsfoot medicinal a 2: 1 mixture of flower and leaf 1.7 Thyme aboveground part of the plant 1.7 Daisy poorie flower 1.7 St John's wort flower 1.7 small-leaved lime flower 1.7 Spring primrose flower 1.1 Agrimony blade 1.1 Marigold flower 1.1 Hawthorn flower 1.1 Peppermint aboveground part of the plant in bloom 1.1 Gallic roses crown petals 1.1 Field horsetail aboveground part of the plant 1.1 Dobromysl obecná 1: 1 mixture of flower and leaf 0.6 Violka vonná 1: 1 mixture of flower and leaf 0.6 Camomile flower 0.6 Illuchavka bílá flower 0.6 Yarrow flower 0.4 Divizna velkokvětá flower 0.3

3.4 g of crushed garlic clove clove paste are added to the dry herb mixture, and this mixture is allowed to infuse in 1 liter of alcoholic distillate with an ethanol content of 40% by volume for 30 days. After the infusion time, the mixture was filtered. The leachate (filtrate) is still squeezed out of the mother cake and then allowed to stand in a glass container for 10 days to drain. Then the tube is curled into prepared glasses.

Example 2

A dry herbal mixture is prepared according to Table 2 below

Table 2

Herb name Collected part amount (g) in the dry herbal mixture Stinging nettle spring sprouts 8.6 Blackberry raspberry leaves 2.9 Blackberry leaves 2.9 Strawberry leaves 1.7 Spruce young additions 1.7 Willow Willow aboveground part of a plant in bloom 1.7 Lungwort aboveground part of the plant in bloom 1.1 Black berries flower 1.1 Lady's mantle mixture of flower and leaf 1.1 Plantain lanceolate blade 1.1 Speedwell aboveground part of the plant in bloom 1.1 Ground squirrel aboveground part of the plant in bloom 0.9 Lemon balm aboveground part of the plant in bloom 0.9 Coltsfoot medicinal mixture of flower and leaf 0.6 Thyme aboveground part of the plant 0.6 Daisy poorie flower 0.6 St John's wort flower 0.6 small-leaved lime flower 0.6 Spring primrose flower 0.6 Agrimony blade 0.6 Marigold flower 0.6 Hawthorn flower 0.6 Peppermint aboveground part of the plant in bloom 0.6 Rosa stolistá crown flower petals 0.6 Field horsetail aboveground part of the plant 0.6 Dobromysl obecná mixture of flower and leaf 0.3

• · · · ·

Violka vonná mixture of flower and leaf 0.3 Camomile flower 0.3 White nettle flower 0.3 in Rebříček obecný flower 0.2 Divizna velkokvětá flower 0.1

2.4 g per crushed garlic clove paste are added to the dry herb mixture, and this mixture is allowed to infuse in 1 liter of distillate with an ethanol content of 50% by volume for 20 days. After the infusion time, the mixture was filtered. The extract (filtrate) is then stored in a glass container.

Example 3

A dry herbal blend is prepared according to Table 3 below

Table 3

Herb name Collected part amount (g) in dry herbal mixtures Stinging nettle spring sprouts 14.9 Blackberry raspberry leaves 8.6 Blackberry leaves 8.6 Strawberry leaves 4.1 Spruce young additions 4.1 Willow Willow the whole above-ground part of the plant in bloom 4.1 Lungwort the whole above-ground part of the plant in bloom 3.5 Black berries flower 3.5 Lady's mantle mixture of flower and leaf 3.5 Plantain lanceolate blade 3.5 Speedwell the whole above-ground part of the plant in bloom 3.5 Ground squirrel the whole above-ground part of the plant in bloom 3.1 Lemon balm the whole above-ground part of the plant in bloom 3.1 Coltsfoot medicinal mixture of flower and leaf 2.8 Thyme the whole above-ground part of the plant 2.8

Daisy poorie flower 2.8 St John's wort flower 2.8 small-leaved lime flower 2.8 Spring primrose flower 1.6 in Agrimony blade 1.6 Marigold flower 1.6 Hawthorn flower 1.6 Peppermint the whole above-ground part of the plant in bloom 1.6 Gallic roses crown flower petals 1.6 Field horsetail the whole above-ground part of the plant 1.6 Dobromysl obecná mixture of flower and leaf 0.9 Violka vonná mixture of flower and leaf 0.9 Camomile flower 0.9 White nettle flower 0.9 Rebříček obecný flower 0.6 Divizna velkokvětá flower 0.5

4.4 g per pulverized garlic clove paste are added to the dry herb mixture, and this mixture is allowed to infuse in 1 liter of fermented plum distillate with an ethanol content of 20% by volume for 40 days. After the infusion time, the mixture was filtered. The extract is then stored in a glass container.

Example 4

Clinical monitoring of the effect of the herbal extract according to the invention prepared according to example 1. The study was conducted at the Private Skin Clinic DOST in Svidník, SK.

Several groups of volunteers were selected. Prior to application, it was confirmed that people did not suffer from any allergy to herbs, food and medicine in the past. Probands were subjected to epicutaneous testing, all with negative results.

Groups with internal (oral) drops of herbal extract according to the invention, a total of 35 subjects (16 women, 19 men, aged 21-59 years), 10 drops twice a day, duration of use 1 month.

• · ······ · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·

I. Group - relapsing Herpes simplex -10 subjects under observation - 6 people had no recurrence of herpes in 14 months, although the frequency had been at least once a month.

In 4 people, herpes occurred rarely 1-2x during the year. They consider the effect of herbal extract to be very good.

II. Group - relapsing verrucae vulgares - 6 subjects - in 5 subjects in 15 months there was no recurrence of verrucae, dose of 10 drops twice a day, usage period of 1 month, one person interrupted monitoring for going abroad, information is not available.

III. The group - patients with meteosensitive, frequent colds and problems with HCD - 9 persons, since the beginning of use significantly improved the body 's defenses, according to personal expression, were neither cold nor cold within 16 months. Dose twice a day 10 drops, duration of use 1 month, after 6 months of repeated use.

IV. Group - patients with recurrent manifestations of psoriasis vulgaris - seasonal occurrence in spring and autumn - 10 subjects, since the beginning of use significantly improved the body's immunity in all according to personal expression, no symptoms of psoriasis occurred in 16 months, if so, only very discreet . Dose twice a day 10 drops, duration of use 1 month, after 6 months of repeated use. Local treatment without corticoids, only emollients.

Groups with local use of herbal extract prepared according to Example 1, a total of 25 subjects (12 women, 13 men, age 23-55 years), combating affected skin areas 2-3 times a day until the symptoms disappear.

V. Group - relapsing Herpes simplex -10 follow-ups - Seven people did not recur cold sores in 9 months, even though the frequency was at least once a month.

In 3 subjects, herpes developed 1x during 6 months. They consider the effect of herbal extract to be very good, spontaneously demanded by the patients, as the symptoms calmed down within 3 days.

VI. The group - relapsing verrucae vulgares - 6 subjects - no warts relapsed in all subjects in 15 months, healing within 12 days.

• · · ·

VII. Group - verrucae burning juvenile - 3 women - after monthly application of the extract twice a day on the forehead and cheeks, manifestations, previously unsuccessfully treated, disappeared, no recurrence was noted.

Groups with oral herbal extract prepared according to Example 1, total of 25 subjects (12 women, 13 men, age 23-55 years), 10 drops twice a day, duration of use 1 month.

VIII. Group - patients with meteosensitive, frequent colds and problems with HCD - 6 persons, since the beginning of use, all of them according to personal expression significantly improved the body's defenses, when the first manifestations of sore throat or rhinitis appeared, after using the herbal extract spray according to and they had no health problems within 3 days.

IX Patients after chemotherapy in the case of breast, digestive, respiratory tract cancer, a total of 9 persons (5 women, 4 men, mean age 39-72 years). Dose twice daily 10 drops, duration of use 1 month, after 3 months of repeated use (3 times in total). In all the monitored persons their health and mental condition improved after one month of use and there was no negative reaction.

From the observation of a small group of people with various health problems, the use of the polycomposite herbal extract according to the invention has proved to be very effective. No adverse overall or local manifestations occurred in any of the subjects. The use of the herbal extract according to the invention is very comfortable and efficient.

Claims (7)

PATENT CLAIMS Herbal extract, characterized in that in 1000 ml of leaching medium containing 20 vol% to 50 vol%. ethanol is leached: at least 8.6 to 14.9 g of dry spring shoots of Stinging Nettle, at least 2.9 to 8.6 g of dry leaves of Raspberry, at least 2.9 to 8.6 g of dry leaves of Blackberry, at least 1.7 to 4, 1 g of dry leaves of Strawberry, at least 1.7 to 4.1 g of dry young spruce increments, at least 1.7 to 4.1 g of dry aboveground part of small-flowered Willow in bloom, at least 1.1 to 3.5 g of dry above-ground at least 1.1 to 3.5 g of dry flowers of elderberry, at least 1.1 to 3.5 g of dry mix of flower and leaf of Kontryhele, at least 1.1 to 3.5 g of dry plantain leaves , at least 1.1 to 3.5 g of dry aerial part of Rosemary in bloom, at least 0.9 to 3.1 g of dry aerial part of Ground Squirrel in bloom, at least 0.9 to 3.1 g of dry aerial part of Melissa flowering, at least 0.6 to 2.8 g of dry mixture of flower and coltsfoot leaf ho, at least 0,6 to 2,8 g of dry aerial part of the plant Thyme, at least 0,6 to 2,8 g of dry flower Daisies, at least 0,6 to 2,8 g of dry flower St John's wort, at least 0,6 up to 2,8 g dry flower Linden, at least 0,6 to 1,6 g dry flower Primrose spring, at least 0,6 to 1,6 g dry leaf Agrimony, at least 0,6 to 1,6 g dry flower Marigold at least 0.6 to 1.6 g of dry flower of hawthorn, at least 0.6 to 1.6 g of dry peppermint, at least 0.6 to 1.6 g of dry crown petals, at least 0.6 to 1.6 g of dry ground part Horsetail, at least 0.3 to 0.9 g of dry flower and leaf mixture Dobromysli obecný at least 0.3 to 0.9 g of dry flower and Violka fragrant leaf, • * .... ».... * ... • · · · · · ··. ··· ·. ·.,, * · · · ·. ··· · »· ... _t at least 0.3 to 0.9 g of dry chamomile flower, at least 0.3 to 0.9 g of dry nettle white flower, at least 0.3 to 0.6 g of dry of yarrow, at least 0,1 to 0,5 g of dry flower of the Mullein and at least 2,4 to 4,4 g of crushed garlic clove paste. Herbal extract according to claim 1, characterized in that in 1000 ml of leaching medium containing 30% by volume. ethanol is leached: 11,5 g dry spring shoots of Stinging nettle, 5.7 g of dry spring leaves of raspberry blackberry, 5.7 g of dry spring leaves of Blackberry, 2,9 g of dry leaves of strawberry 2,9 g of dry young growths of Norway spruce, 2,9 g of dry above-ground part of Vrbovka small flower in bloom, 2.3 g of dry aerial part of Lungwort in flower, 2.3 g of elderberry dry flowers, 2,3 g dry mixture of flower and leaf of Kontryhele, 2,3 g dry plantain leaves, 2,3 g of dry aerial part of Speedwell in bloom, 2.0 g of dry ground part of Ground Squirrel in bloom, 2,0 g dry aerial part of Lemon balm in bloom, 1.7 g dry mixture of flower and leaf of Coltsfoot, 1,7 g of dry ground part of thyme, 1,7 g dry flower Daisies, 1,7 g dry flower St John's wort, 1,7 g of dry linden flower, 1,1 g dry flower Primrose spring, 1,1 g dry leaf of Agrimony, 1,1 g of dry marigold flower, 1,1 g dry hawthorn flower, 1.1 g of dry peppermint above the flower, 1.1 g of dry crown petals of the Gallic Rose or the Rose of the Rose, 1.1 g of dry ground horsetail, horsetail, horsetail, horsetail 0,6 g of dry mixture of flower and leaf 0,6 g dry blend of flower and violet fragrance, 0,6 g dry flower of camomile, 0,6 g dry flower White nipples, 0,4 g dry flower of Yarrow, 0,3 g of dry flower 3.4 g per crushed garlic clove paste. The herbal extract according to any one of claims 1 to 2, characterized in that the leaching medium contains 30 to 40% by volume of ethanol. The herbal extract according to any one of claims 1 to 3, for use in the treatment of stomach problems, for stimulating the non-specific immune system, for the short-term prevention or treatment of common cold. The herbal extract of any one of claims 1 to 3, for use as an otorhinolaryngologic, antiseptic, virostatic, antifungal or dermatological. The herbal extract according to claim 4 or claim 5, for use in oral and / or topical application. The herbal extract according to any one of claims 4 to 6, for use in the treatment of psoriasis, nasopharyngitis, diseases caused by herpesviruses, preferably Herpes simplex; or diseases caused by papillomaviruses.