SK287333B6 - Derivát piperazinylkarbonylchinolínu alebo piperazinylkarbonylizochinolínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok s jeho obsahom - Google Patents
Derivát piperazinylkarbonylchinolínu alebo piperazinylkarbonylizochinolínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok s jeho obsahom Download PDFInfo
- Publication number
- SK287333B6 SK287333B6 SK865-2003A SK8652003A SK287333B6 SK 287333 B6 SK287333 B6 SK 287333B6 SK 8652003 A SK8652003 A SK 8652003A SK 287333 B6 SK287333 B6 SK 287333B6
- Authority
- SK
- Slovakia
- Prior art keywords
- piperazinylcarbonylquinoline
- piperazinylcarbonylisoquinoline
- formula
- derivative
- disease
- Prior art date
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- FBODQGAVJFLXRJ-UHFFFAOYSA-N isoquinolin-1-yl(piperazin-1-yl)methanone Chemical class N=1C=CC2=CC=CC=C2C=1C(=O)N1CCNCC1 FBODQGAVJFLXRJ-UHFFFAOYSA-N 0.000 title claims description 22
- URMKJJJRIIGKHL-UHFFFAOYSA-N piperazin-1-yl(quinolin-2-yl)methanone Chemical compound C=1C=C2C=CC=CC2=NC=1C(=O)N1CCNCC1 URMKJJJRIIGKHL-UHFFFAOYSA-N 0.000 title claims description 22
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- 239000000080 wetting agent Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10102053A DE10102053A1 (de) | 2001-01-17 | 2001-01-17 | Piperazinylcarbonylchinoline und -isochinoline |
| PCT/EP2001/015311 WO2002057256A1 (en) | 2001-01-17 | 2001-12-24 | Piperazinylcarbonylquinolines and -isoquinolines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK8652003A3 SK8652003A3 (en) | 2003-11-04 |
| SK287333B6 true SK287333B6 (sk) | 2010-07-07 |
Family
ID=7670921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK865-2003A SK287333B6 (sk) | 2001-01-17 | 2001-12-24 | Derivát piperazinylkarbonylchinolínu alebo piperazinylkarbonylizochinolínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok s jeho obsahom |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7329749B2 (enExample) |
| EP (1) | EP1366039B1 (enExample) |
| JP (1) | JP4417624B2 (enExample) |
| KR (1) | KR100854481B1 (enExample) |
| CN (1) | CN1249055C (enExample) |
| AR (1) | AR035682A1 (enExample) |
| AT (1) | ATE304010T1 (enExample) |
| BR (1) | BR0116774A (enExample) |
| CA (1) | CA2434773C (enExample) |
| CZ (1) | CZ304144B6 (enExample) |
| DE (2) | DE10102053A1 (enExample) |
| DK (1) | DK1366039T3 (enExample) |
| ES (1) | ES2248230T3 (enExample) |
| HU (1) | HU230250B1 (enExample) |
| MX (1) | MXPA03006360A (enExample) |
| MY (1) | MY127293A (enExample) |
| PL (1) | PL212087B1 (enExample) |
| RU (1) | RU2280034C2 (enExample) |
| SI (1) | SI1366039T1 (enExample) |
| SK (1) | SK287333B6 (enExample) |
| WO (1) | WO2002057256A1 (enExample) |
| ZA (1) | ZA200306331B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002057435A2 (en) * | 2001-01-18 | 2002-07-25 | Merck Patent Gmbh | Bifunctional fusion proteins with glucocerebrosidase activity |
| AU2003231032B2 (en) * | 2002-04-22 | 2008-07-10 | Johns Hopkins University School Of Medicine | Modulators of hedgehog signaling pathways, compositions and uses related thereto |
| MXPA04012959A (es) * | 2002-06-29 | 2005-05-16 | Zentaris Gmbh | Arilcarbonilpiperacinas y heteroarilcarbonilpiperacinas y su uso para tratamiento de enfermedades de tumor benigno y maligno. |
| US20090311242A1 (en) * | 2004-07-29 | 2009-12-17 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with 5-hydroxytryptamine 2a receptor (5ht2a) |
| GB2497476B (en) * | 2010-09-06 | 2018-01-10 | Guangzhou Inst Biomed & Health | Amide Compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5093341A (en) * | 1987-12-17 | 1992-03-03 | Merrell Dow Pharmaceuticals Inc. | N-aralkyl piperidine derivatives useful as antithrombolytic agents |
| US4970714A (en) * | 1989-01-05 | 1990-11-13 | International Business Machines Corp. | Adaptive data link protocol |
| EP0957100B1 (en) * | 1997-07-07 | 2004-10-27 | Kowa Co., Ltd. | Diamine derivatives and pharmaceutical containing the same |
| CA2342251A1 (en) * | 1998-08-28 | 2000-03-09 | Scios Inc. | Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase |
| DE19934433A1 (de) * | 1999-07-22 | 2001-01-25 | Merck Patent Gmbh | N-(Indolcarbonyl-)piperazinderivate |
-
2001
- 2001-01-17 DE DE10102053A patent/DE10102053A1/de not_active Withdrawn
- 2001-12-24 US US10/466,487 patent/US7329749B2/en not_active Expired - Fee Related
- 2001-12-24 BR BR0116774-0A patent/BR0116774A/pt active Search and Examination
- 2001-12-24 CZ CZ20031861A patent/CZ304144B6/cs not_active IP Right Cessation
- 2001-12-24 SK SK865-2003A patent/SK287333B6/sk not_active IP Right Cessation
- 2001-12-24 JP JP2002557935A patent/JP4417624B2/ja not_active Expired - Fee Related
- 2001-12-24 DK DK01273302T patent/DK1366039T3/da active
- 2001-12-24 SI SI200130444T patent/SI1366039T1/sl unknown
- 2001-12-24 PL PL361741A patent/PL212087B1/pl unknown
- 2001-12-24 WO PCT/EP2001/015311 patent/WO2002057256A1/en not_active Ceased
- 2001-12-24 CA CA2434773A patent/CA2434773C/en not_active Expired - Fee Related
- 2001-12-24 DE DE60113300T patent/DE60113300T2/de not_active Expired - Lifetime
- 2001-12-24 KR KR1020037009081A patent/KR100854481B1/ko not_active Expired - Fee Related
- 2001-12-24 EP EP01273302A patent/EP1366039B1/en not_active Expired - Lifetime
- 2001-12-24 CN CNB018220622A patent/CN1249055C/zh not_active Expired - Fee Related
- 2001-12-24 RU RU2003124077/04A patent/RU2280034C2/ru not_active IP Right Cessation
- 2001-12-24 ES ES01273302T patent/ES2248230T3/es not_active Expired - Lifetime
- 2001-12-24 MX MXPA03006360A patent/MXPA03006360A/es active IP Right Grant
- 2001-12-24 AT AT01273302T patent/ATE304010T1/de active
-
2002
- 2002-01-14 MY MYPI20020115A patent/MY127293A/en unknown
- 2002-01-16 AR ARP020100135A patent/AR035682A1/es not_active Application Discontinuation
-
2003
- 2003-08-14 ZA ZA2003/06331A patent/ZA200306331B/en unknown
-
2015
- 2015-10-12 HU HU0401038A patent/HU230250B1/hu not_active IP Right Cessation
Also Published As
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| Publication | Publication Date | Title |
|---|---|---|
| CA2383779C (en) | N-(indolecarbonyl)piperazine derivatives | |
| SK9712002A3 (en) | Piperidine and piperazine derivatives which function as 5-ht2a receptor antagonists | |
| US6723725B1 (en) | Indole derivatives | |
| SK8652003A3 (en) | Piperazinylcarbonylquinoline and piperazinylcarbonylisoquinoline derivative, process for the preparation thereof, use and pharmaceutical composition comprising same | |
| MXPA02001750A (es) | Alcoholes de piperidina. | |
| AU2002217159B2 (en) | Piperazinylcarbonyliquinolines and -isoquinolines | |
| AU2002217159A1 (en) | Piperazinylcarbonyliquinolines and -isoquinolines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20171224 |