SK278390B6 - Proteolytic enzymes inhibitors on saccharine derivatives base - Google Patents

Proteolytic enzymes inhibitors on saccharine derivatives base Download PDF

Info

Publication number
SK278390B6
SK278390B6 SK3746-92A SK374692A SK278390B6 SK 278390 B6 SK278390 B6 SK 278390B6 SK 374692 A SK374692 A SK 374692A SK 278390 B6 SK278390 B6 SK 278390B6
Authority
SK
Slovakia
Prior art keywords
lower alkyl
group
compound
formula
lower alkoxy
Prior art date
Application number
SK3746-92A
Other languages
English (en)
Slovak (sk)
Other versions
SK374692A3 (en
Inventor
Dennis J Hlasta
James H Ackerman
Albert J Mura
Original Assignee
Hlasta Dennis J.
Ackerman James H.
Mura Albert J.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hlasta Dennis J., Ackerman James H., Mura Albert J. filed Critical Hlasta Dennis J.
Publication of SK278390B6 publication Critical patent/SK278390B6/sk
Publication of SK374692A3 publication Critical patent/SK374692A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Fertilizers (AREA)
  • Medicinal Preparation (AREA)
SK3746-92A 1991-12-19 1992-12-18 Proteolytic enzymes inhibitors on saccharine derivatives base SK374692A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81026591A 1991-12-19 1991-12-19

Publications (2)

Publication Number Publication Date
SK278390B6 true SK278390B6 (en) 1997-02-05
SK374692A3 SK374692A3 (en) 1997-02-05

Family

ID=25203432

Family Applications (1)

Application Number Title Priority Date Filing Date
SK3746-92A SK374692A3 (en) 1991-12-19 1992-12-18 Proteolytic enzymes inhibitors on saccharine derivatives base

Country Status (19)

Country Link
EP (1) EP0547708B1 (cg-RX-API-DMAC10.html)
JP (1) JP3179600B2 (cg-RX-API-DMAC10.html)
KR (2) KR100292995B1 (cg-RX-API-DMAC10.html)
AT (1) ATE233250T1 (cg-RX-API-DMAC10.html)
AU (1) AU668694B2 (cg-RX-API-DMAC10.html)
CA (1) CA2084857A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ283257B6 (cg-RX-API-DMAC10.html)
DE (1) DE69232929D1 (cg-RX-API-DMAC10.html)
FI (1) FI925787A7 (cg-RX-API-DMAC10.html)
HU (1) HU219950B (cg-RX-API-DMAC10.html)
IL (1) IL104154A (cg-RX-API-DMAC10.html)
MX (1) MX9207449A (cg-RX-API-DMAC10.html)
MY (1) MY110104A (cg-RX-API-DMAC10.html)
NO (1) NO300770B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ245518A (cg-RX-API-DMAC10.html)
RU (1) RU2107685C1 (cg-RX-API-DMAC10.html)
SG (1) SG52659A1 (cg-RX-API-DMAC10.html)
SK (1) SK374692A3 (cg-RX-API-DMAC10.html)
TW (1) TW225532B (cg-RX-API-DMAC10.html)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378720A (en) * 1991-12-19 1995-01-03 Sterling Winthrop Inc. Saccharin derivative proteolytic enzyme inhibitors
US5541168A (en) * 1994-12-02 1996-07-30 Sterling Winthrop Inc. Substituted 2-(phosphinyloxymethyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
US5512576A (en) * 1994-12-02 1996-04-30 Sterling Winthrop Inc. 2-substituted 1,2,5,-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
DE19533643A1 (de) * 1995-09-12 1997-03-13 Nycomed Arzneimittel Gmbh Neue cyclische Derivate von Benzolsulfonamiden
US5750550A (en) * 1995-09-15 1998-05-12 Sanofi 2-(pyrazol-5-yl-oxymethyl)-1,2-benzisothiazol-3 (2H)-One 1, 1-dioxides and compositions and method of use thereof
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
US7998986B2 (en) 2001-12-21 2011-08-16 Exelixis Patent Company Llc Modulators of LXR
JP4164031B2 (ja) 2002-02-14 2008-10-08 ファルマシア コーポレーション Ｐ３８ｍａｐキナーゼのモジュレータとしての置換されたピリジノン
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
NZ575685A (en) * 2006-10-04 2012-04-27 Bionomics Ltd Novel benzofuran potassium channel blockers and uses thereof
WO2008076427A2 (en) 2006-12-18 2008-06-26 Amgen Inc. Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
US8048892B2 (en) 2006-12-18 2011-11-01 Amgen Inc. Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
US7569726B2 (en) 2007-04-18 2009-08-04 Amgen Inc. Indanone derivatives that inhibit prolyl hydroxylase
ES2442847T3 (es) 2007-04-18 2014-02-13 Amgen, Inc Quinolonas y azaquinolonas que inhiben la prolil hidroxilasa
AU2008248165B2 (en) 2007-05-04 2011-12-08 Amgen Inc. Diazaquinolones that inhibit prolyl hydroxylase activity
EP2150251B9 (en) 2007-05-04 2013-02-27 Amgen, Inc Thienopyridine and thiazolopyridine derivatives that inhibit prolyl hydroxylase activity
CA2696948C (en) 2007-09-14 2013-04-30 Jose Maria Cid-Nunez 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
CN102143955B (zh) 2008-09-02 2013-08-14 Omj制药公司 作为代谢型谷氨酸受体调节剂的3-氮杂二环[3.1.0]己烷衍生物
JP5690277B2 (ja) 2008-11-28 2015-03-25 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体
ES2440001T3 (es) 2009-05-12 2014-01-27 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-A]piridina y su uso para el tratamiento o prevención de trastornos neurológicos y psiquiátricos
CN102439015B (zh) 2009-05-12 2015-05-13 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2552879T3 (es) 2010-11-08 2015-12-02 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
CA2814998C (en) 2010-11-08 2019-10-29 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
US9271967B2 (en) 2010-11-08 2016-03-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
LT3431106T (lt) 2014-01-21 2021-02-10 Janssen Pharmaceutica Nv Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas
EA033889B1 (ru) 2014-01-21 2019-12-05 Янссен Фармацевтика Нв Комбинация на основе лиганда sv2a и положительного аллостерического модулятора метаботропного глутаматергического рецептора 2 подтипа

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195023A (en) * 1975-08-20 1980-03-25 Merck & Co., Inc. 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin
US4276298A (en) * 1978-03-24 1981-06-30 Merck & Co., Inc. 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
DE3617976A1 (de) * 1986-05-28 1988-01-14 Alter Sa 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten
DK0471756T3 (da) * 1989-05-04 1998-05-18 Sanofi Sa Saccharinderivater, der er egnede som proteolytiske enzyminhibitorer, og fremstilling deraf
AU642537B2 (en) * 1990-11-01 1993-10-21 Sanofi 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU656027B2 (en) * 1991-11-15 1995-01-19 Sanofi Saccharin derivative proteolytic enzime inhibitors

Also Published As

Publication number Publication date
NO924915L (no) 1993-06-21
NZ245518A (en) 1995-06-27
TW225532B (cg-RX-API-DMAC10.html) 1994-06-21
FI925787L (fi) 1993-06-20
MX9207449A (es) 1994-03-31
HUT67039A (en) 1995-01-30
FI925787A0 (fi) 1992-12-18
CZ374692A3 (en) 1993-08-11
IL104154A0 (en) 1993-05-13
FI925787A7 (fi) 1993-06-20
AU668694B2 (en) 1996-05-16
JP3179600B2 (ja) 2001-06-25
NO300770B1 (no) 1997-07-21
HU9204029D0 (en) 1993-04-28
AU2829292A (en) 1993-07-08
HU219950B (hu) 2001-09-28
JPH05345771A (ja) 1993-12-27
EP0547708A1 (en) 1993-06-23
SK374692A3 (en) 1997-02-05
EP0547708B1 (en) 2003-02-26
KR100378968B1 (ko) 2003-04-08
KR100292995B1 (ko) 2001-09-17
CA2084857A1 (en) 1993-06-20
NO924915D0 (no) 1992-12-18
DE69232929D1 (de) 2003-04-03
IL104154A (en) 1996-09-12
SG52659A1 (en) 1998-09-28
CZ283257B6 (cs) 1998-02-18
MY110104A (en) 1998-01-27
ATE233250T1 (de) 2003-03-15
RU2107685C1 (ru) 1998-03-27

Similar Documents

Publication Publication Date Title
SK278390B6 (en) Proteolytic enzymes inhibitors on saccharine derivatives base
AU685785B2 (en) Saccharin derivative proteolytic enzyme inhibitors
KR900007780B1 (ko) 축합된 피롤리논 유도체의 제조방법
AU672224B2 (en) 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and whichhave antitumor properties
US5104889A (en) Thiazole derivatives
CZ386892A3 (en) Novel 2-saccharinylmethyl heterocyclic carboxylates usable as proteolytic enzymes inhibitors and their compositions and method of application
CZ386992A3 (en) Novel 2-saccharinylmethylaryl- and aryloxyacetates usable as proteolytic enzymes inhibitors, said acetates composition and method of use
IL103747A (en) Saccharin derivatives and pharmaceutical compositions containing them
WO2001014384A1 (en) Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents
US5773456A (en) Saccharin derivative proteolytic enzyme inhibitors
HU211286A9 (hu) Proteolitikus enzimeket gátló szacharinszármazékok Az átmeneti oltalom az 1-5. és 8. igénypontokra vonatkozik.
IL119685A (en) 4,5,6,7-tetrahydro-2-saccharinylmethyl aryl and aryloxy acetates
JPWO1999042442A1 (ja) アミノグアニジンヒドラゾン誘導体、その製法及び剤