SK134399A3 - Cefdinir in the form of a salt with dicyclohexylamine, a process for its production and its use - Google Patents
Cefdinir in the form of a salt with dicyclohexylamine, a process for its production and its use Download PDFInfo
- Publication number
- SK134399A3 SK134399A3 SK1343-99A SK134399A SK134399A3 SK 134399 A3 SK134399 A3 SK 134399A3 SK 134399 A SK134399 A SK 134399A SK 134399 A3 SK134399 A3 SK 134399A3
- Authority
- SK
- Slovakia
- Prior art keywords
- formula
- compound
- salt
- dicyclohexylamine
- cefdinir
- Prior art date
Links
- XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical compound C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 title claims abstract description 44
- 150000003839 salts Chemical class 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims abstract description 15
- RTXOFQZKPXMALH-GHXIOONMSA-N cefdinir Chemical compound S1C(N)=NC(C(=N\O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 RTXOFQZKPXMALH-GHXIOONMSA-N 0.000 title abstract description 34
- 229960003719 cefdinir Drugs 0.000 title abstract description 34
- 238000004519 manufacturing process Methods 0.000 title abstract description 5
- 238000000746 purification Methods 0.000 claims abstract description 7
- 150000001875 compounds Chemical class 0.000 claims description 51
- 239000012453 solvate Substances 0.000 claims description 12
- RTXOFQZKPXMALH-JWWVUAFXSA-N (6r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1C(N)=NC(C(=N\O)\C(=O)NC2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 RTXOFQZKPXMALH-JWWVUAFXSA-N 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 239000002904 solvent Substances 0.000 claims description 11
- 239000012535 impurity Substances 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 150000004682 monohydrates Chemical class 0.000 description 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 6
- 239000000725 suspension Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 239000000010 aprotic solvent Substances 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- -1 amine salt Chemical class 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- OBRMMFBYPFFKFA-YHYXMXQVSA-N (2z)-2-acetyloxyimino-2-(2-amino-1,3-thiazol-4-yl)acetic acid Chemical compound CC(=O)O\N=C(/C(O)=O)C1=CSC(N)=N1 OBRMMFBYPFFKFA-YHYXMXQVSA-N 0.000 description 1
- GQLGFBRMCCVQLU-XCGJVMPOSA-N (6r)-7-amino-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(C=C)=C(C(O)=O)N2C(=O)C(N)[C@H]21 GQLGFBRMCCVQLU-XCGJVMPOSA-N 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- QIJIUJYANDSEKG-UHFFFAOYSA-N 2,4,4-trimethylpentan-2-amine Chemical compound CC(C)(C)CC(C)(C)N QIJIUJYANDSEKG-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- LULXBAGMGMJJRW-UHFFFAOYSA-N n,2-bis(trimethylsilyl)acetamide Chemical compound C[Si](C)(C)CC(=O)N[Si](C)(C)C LULXBAGMGMJJRW-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0057097A AT405283B (de) | 1997-04-04 | 1997-04-04 | Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung |
| PCT/EP1998/001953 WO1998045299A1 (en) | 1997-04-04 | 1998-04-02 | Crystalline amine salt of cefdinir |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK134399A3 true SK134399A3 (en) | 2000-05-16 |
Family
ID=3494111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1343-99A SK134399A3 (en) | 1997-04-04 | 1998-04-02 | Cefdinir in the form of a salt with dicyclohexylamine, a process for its production and its use |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6350869B1 (ko) |
| EP (1) | EP0973779B1 (ko) |
| JP (1) | JP3421354B2 (ko) |
| KR (1) | KR100442717B1 (ko) |
| CN (1) | CN1139596C (ko) |
| AT (2) | AT405283B (ko) |
| AU (1) | AU731413B2 (ko) |
| BR (1) | BR9809745A (ko) |
| CA (1) | CA2283718A1 (ko) |
| DE (1) | DE69816056T2 (ko) |
| HU (1) | HUP0002987A3 (ko) |
| ID (1) | ID22536A (ko) |
| IL (1) | IL131755A0 (ko) |
| NO (1) | NO994466D0 (ko) |
| PL (1) | PL335620A1 (ko) |
| SK (1) | SK134399A3 (ko) |
| TR (1) | TR199902406T2 (ko) |
| WO (1) | WO1998045299A1 (ko) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080113025A1 (en) * | 1998-11-02 | 2008-05-15 | Elan Pharma International Limited | Compositions comprising nanoparticulate naproxen and controlled release hydrocodone |
| KR100451672B1 (ko) * | 2001-06-05 | 2004-10-08 | 한미약품 주식회사 | 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법 |
| ITMI20020913A0 (it) * | 2002-04-29 | 2002-04-29 | Acs Dobfar Spa | Nuova forma cristallina del cefdinir |
| DE60336331D1 (de) | 2002-08-13 | 2011-04-21 | Sandoz Ag | Ein cefdinir-zwischenprodukt |
| ITMI20022076A1 (it) | 2002-10-01 | 2004-04-02 | Antibioticos Spa | Sali di intermedi del cefdinir. |
| AU2003276525A1 (en) * | 2002-11-15 | 2004-06-15 | Orchid Chemicals And Pharmaceuticals Ltd | Novel amorphous hydrate of a cephalosporin antibiotic |
| ITMI20022724A1 (it) * | 2002-12-20 | 2004-06-21 | Antibioticos Spa | Sali cristallini del cefdinir. |
| CA2520083A1 (en) * | 2003-03-24 | 2004-10-07 | Acs Dobfar S.P.A. | Novel crystal of 7-[2-[(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) and method for preparation thereof |
| WO2004104010A1 (en) * | 2003-05-20 | 2004-12-02 | Ranbaxy Laboratories Limited | Crystalline form of cefdinir |
| US20050137182A1 (en) * | 2003-06-02 | 2005-06-23 | Ramesh Dandala | Novel crystalline form of cefdinir |
| US20040242556A1 (en) * | 2003-06-02 | 2004-12-02 | Ramesh Dandala | Novel crystalline form of cefdinir |
| US20050059818A1 (en) * | 2003-09-12 | 2005-03-17 | Duerst Richard W. | Polymorph of a pharmaceutical |
| US20050059819A1 (en) * | 2003-09-12 | 2005-03-17 | Duerst Richard W. | Cefdinir pyridine salt |
| US20050113355A1 (en) * | 2003-09-12 | 2005-05-26 | Duerst Richard W. | Cefdinir pyridine salt |
| US20060211676A1 (en) * | 2004-03-16 | 2006-09-21 | Devalina Law | Crystalline anhydrous cefdinir and crystalline cefdinir hydrates |
| US20050209211A1 (en) * | 2004-03-16 | 2005-09-22 | Devalina Law | Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir |
| US20060142261A1 (en) * | 2004-03-16 | 2006-06-29 | Devalina Law | Crystalline anhydrous cefdinir and crystalline cefdinir hydrates |
| US20060142563A1 (en) * | 2004-03-16 | 2006-06-29 | Devalina Law | Crystalline anhydrous cefdinir and crystalline cefdinir hydrates |
| WO2005090360A1 (en) * | 2004-03-19 | 2005-09-29 | Orchid Chemicals & Pharmaceuticals Limited | Novel polymorph of cefdinir |
| US20060069079A1 (en) * | 2004-09-27 | 2006-03-30 | Sever Nancy E | Stable amorphous cefdinir |
| US20050245738A1 (en) * | 2004-05-03 | 2005-11-03 | Lupin Ltd | Stable bioavailable crystalline form or cefdinir and a process for the preparation thereof |
| WO2006010978A1 (en) * | 2004-06-30 | 2006-02-02 | Wockhardt Limited | Cefdinir polymorphic forms, and imidazole salt |
| EP1765833A2 (en) | 2004-07-05 | 2007-03-28 | Orchid Chemicals and Pharmaceuticals Limited | News salts in the preparation of cephalosporin antibiotics |
| WO2006018807A1 (en) * | 2004-08-16 | 2006-02-23 | Ranbaxy Laboratories Limited | Crystalline forms of cefdinir |
| ITMI20042231A1 (it) * | 2004-11-19 | 2005-02-19 | Antibioticos Spa | Cefdinir sale d'ammonio in forma cristallina |
| MX2007006018A (es) * | 2004-11-30 | 2007-06-07 | Astellas Pharma Inc | Suspension farmaceutica oral novedosa de cristal de cefdinir. |
| GB2421024A (en) * | 2004-12-07 | 2006-06-14 | Sandoz Ag | Cefdinir crystalline form C |
| WO2006117794A1 (en) * | 2005-05-02 | 2006-11-09 | Hetero Drugs Limited | A novel crystalline form of cefdinir |
| EP1899356A1 (en) * | 2005-06-15 | 2008-03-19 | Hetero Drugs Limited | Cefdinir process |
| CN1903860B (zh) * | 2005-07-25 | 2012-01-18 | 四川抗菌素工业研究所有限公司 | 溶媒法制备高纯度头孢他美钠工艺及医药用途 |
| JP2008526782A (ja) * | 2005-10-31 | 2008-07-24 | テバ ファーマシューティカル インダストリーズ リミティド | セフジニルセシウム塩結晶 |
| US20070128268A1 (en) * | 2005-12-07 | 2007-06-07 | Herwig Jennewein | Pharmaceutical compositions comprising an antibiotic |
| CN101481383B (zh) * | 2008-12-31 | 2012-01-11 | 杭州奥默医药技术有限公司 | 头孢地尼酸式复盐化合物及制备方法 |
| TR200909784A1 (tr) * | 2009-12-25 | 2011-07-21 | Bi̇lgi̇ç Mahmut | Yeni sefdinir tuzları |
| US8614315B2 (en) | 2009-12-25 | 2013-12-24 | Mahmut Bilgic | Cefdinir and cefixime formulations and uses thereof |
| CN102010427B (zh) * | 2010-11-19 | 2012-09-12 | 苏州中联化学制药有限公司 | 一种头孢地尼的制备方法 |
| CN101974020B (zh) * | 2010-11-19 | 2012-09-12 | 苏州中联化学制药有限公司 | 一种头孢地尼的合成方法 |
| CN103012433B (zh) * | 2012-12-13 | 2015-06-24 | 珠海保税区丽珠合成制药有限公司 | 头孢地尼晶型b的制备方法 |
| CN108546270B (zh) * | 2017-05-31 | 2019-11-08 | 郑州大学第一附属医院 | 制备头孢地尼的方法 |
| CN107286148B (zh) * | 2017-06-20 | 2019-10-15 | 广州市桐晖通医药科技有限公司 | 一种头孢地尼的制备方法及其新的中间体化合物 |
| CN111635419B (zh) * | 2020-07-13 | 2022-05-24 | 广药白云山化学制药(珠海)有限公司 | 一种头孢地尼精制母液的处理方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR5564M (ko) * | 1964-03-14 | 1968-01-02 | ||
| GB8323034D0 (en) | 1983-08-26 | 1983-09-28 | Fujisawo Pharmaceutical Co Ltd | 7-substituted-3-vinyl-3-cephem compounds |
| ZA885709B (en) | 1987-08-19 | 1989-04-26 | Fujisawa Pharmaceutical Co | Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid(syn isomer) |
| WO1993016084A1 (en) * | 1992-02-05 | 1993-08-19 | Biochemie Gesellschaft M.B.H. | Process for the purification of a 3-cephem-4-carboxylic acid derivative |
| US5750682A (en) * | 1994-07-22 | 1998-05-12 | Antibioticos S.P.A. | Glutaryl 7-ACA derivatives and processes for obtaining them |
| AT403049B (de) * | 1995-08-14 | 1997-10-27 | Biochemie Gmbh | Abreicherung von 7-adca in 3-vinyl-aca |
| JP3948628B2 (ja) | 1995-12-27 | 2007-07-25 | ハンミ ファーマシューティカル シーオー．，エルティーディー． | セフディニルの製造方法 |
| AT404251B (de) * | 1996-08-14 | 1998-10-27 | Biochemie Gmbh | Neues kristallines salz von cefixim |
-
1997
- 1997-04-04 AT AT0057097A patent/AT405283B/de active
-
1998
- 1998-04-02 US US09/381,947 patent/US6350869B1/en not_active Expired - Lifetime
- 1998-04-02 BR BR9809745-8A patent/BR9809745A/pt not_active IP Right Cessation
- 1998-04-02 IL IL13175598A patent/IL131755A0/xx unknown
- 1998-04-02 TR TR1999/02406T patent/TR199902406T2/xx unknown
- 1998-04-02 CN CNB988038501A patent/CN1139596C/zh not_active Expired - Fee Related
- 1998-04-02 ID IDW991137A patent/ID22536A/id unknown
- 1998-04-02 EP EP98921425A patent/EP0973779B1/en not_active Expired - Lifetime
- 1998-04-02 AU AU74288/98A patent/AU731413B2/en not_active Ceased
- 1998-04-02 AT AT98921425T patent/ATE244249T1/de not_active IP Right Cessation
- 1998-04-02 PL PL98335620A patent/PL335620A1/xx unknown
- 1998-04-02 HU HU0002987A patent/HUP0002987A3/hu unknown
- 1998-04-02 JP JP54235898A patent/JP3421354B2/ja not_active Expired - Fee Related
- 1998-04-02 WO PCT/EP1998/001953 patent/WO1998045299A1/en active IP Right Grant
- 1998-04-02 DE DE69816056T patent/DE69816056T2/de not_active Expired - Fee Related
- 1998-04-02 KR KR10-1999-7008984A patent/KR100442717B1/ko not_active IP Right Cessation
- 1998-04-02 SK SK1343-99A patent/SK134399A3/sk unknown
- 1998-04-02 CA CA002283718A patent/CA2283718A1/en not_active Abandoned
-
1999
- 1999-09-15 NO NO994466A patent/NO994466D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100442717B1 (ko) | 2004-08-02 |
| KR20010005907A (ko) | 2001-01-15 |
| AU731413B2 (en) | 2001-03-29 |
| DE69816056D1 (de) | 2003-08-07 |
| EP0973779B1 (en) | 2003-07-02 |
| TR199902406T2 (xx) | 2000-02-21 |
| HUP0002987A3 (en) | 2001-04-28 |
| HUP0002987A2 (hu) | 2001-02-28 |
| JP2000514833A (ja) | 2000-11-07 |
| IL131755A0 (en) | 2001-03-19 |
| ATA57097A (de) | 1998-11-15 |
| ID22536A (id) | 1999-11-04 |
| BR9809745A (pt) | 2000-06-20 |
| DE69816056T2 (de) | 2004-04-15 |
| AT405283B (de) | 1999-06-25 |
| CN1139596C (zh) | 2004-02-25 |
| NO994466L (no) | 1999-09-15 |
| WO1998045299A1 (en) | 1998-10-15 |
| NO994466D0 (no) | 1999-09-15 |
| AU7428898A (en) | 1998-10-30 |
| JP3421354B2 (ja) | 2003-06-30 |
| US6350869B1 (en) | 2002-02-26 |
| ATE244249T1 (de) | 2003-07-15 |
| PL335620A1 (en) | 2000-05-08 |
| CA2283718A1 (en) | 1998-10-15 |
| EP0973779A1 (en) | 2000-01-26 |
| CN1251590A (zh) | 2000-04-26 |
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