SK106699A3 - Synthetic polynucleotide, immunogenic composition and pharmaceutical composition containing the same and its use - Google Patents
Synthetic polynucleotide, immunogenic composition and pharmaceutical composition containing the same and its use Download PDFInfo
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- SK106699A3 SK106699A3 SK1066-99A SK106699A SK106699A3 SK 106699 A3 SK106699 A3 SK 106699A3 SK 106699 A SK106699 A SK 106699A SK 106699 A3 SK106699 A3 SK 106699A3
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (3)
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| US3785497P | 1997-02-07 | 1997-02-07 | |
| GBGB9705040.5A GB9705040D0 (en) | 1997-03-12 | 1997-03-12 | Synthetic HIV GAG genes |
| PCT/US1998/002293 WO1998034640A2 (en) | 1997-02-07 | 1998-02-03 | Synthetic hiv gag genes |
Publications (1)
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| SK106699A3 true SK106699A3 (en) | 2000-06-12 |
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| SK1066-99A SK106699A3 (en) | 1997-02-07 | 1998-02-03 | Synthetic polynucleotide, immunogenic composition and pharmaceutical composition containing the same and its use |
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| JP (1) | JP2001512308A (no) |
| KR (1) | KR20000070865A (no) |
| CN (1) | CN1252075A (no) |
| AT (1) | ATE342916T1 (no) |
| AU (1) | AU743616B2 (no) |
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| IL (1) | IL131131A0 (no) |
| NO (1) | NO993810L (no) |
| PL (1) | PL335050A1 (no) |
| SK (1) | SK106699A3 (no) |
| WO (1) | WO1998034640A2 (no) |
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| US6492110B1 (en) | 1998-11-02 | 2002-12-10 | Uab Research Foundation | Reference clones and sequences for non-subtype B isolates of human immunodeficiency virus type 1 |
| GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| JP2003523721A (ja) * | 1998-12-31 | 2003-08-12 | カイロン コーポレイション | 抗原性ｈｉｖｃ型ポリペプチドをコードするポリヌクレオチド、ポリペプチド、およびそれらの使用 |
| US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
| CA2360347C (en) * | 1998-12-31 | 2013-05-07 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
| CA2369119A1 (en) | 1999-03-29 | 2000-05-25 | Statens Serum Institut | Nucleotide construct with optimised codons for an hiv genetic vaccine based on a primary, early hiv isolate and synthetic envelope |
| US8647864B2 (en) | 1999-04-14 | 2014-02-11 | Novartis Ag | Compositions and methods for generating an immune response utilizing alphavirus-based vector systems |
| RU2001131728A (ru) * | 1999-04-26 | 2004-02-20 | К.Ю. Левен Рисерч Энд Дивелопмент (Be) | Синтетический ген для экспрессии активного ретровирусного белка в эукариотах |
| EP1200622A4 (en) | 1999-07-06 | 2004-12-22 | Merck & Co Inc | HIV VACCINE COMPRISING A GAG GENE VEHICLE ADENOVIRUS |
| JP4799789B2 (ja) * | 1999-08-25 | 2011-10-26 | メルク・シャープ・エンド・ドーム・コーポレイション | ヒト細胞中での発現用に最適化された合成ヒトパピローマウイルス遺伝子 |
| EP2278022A3 (en) | 1999-11-01 | 2011-05-18 | Novartis Vaccines and Diagnostics, Inc. | Expression vectors, transfection systems, and method of use thereof |
| US6656706B2 (en) | 1999-12-23 | 2003-12-02 | The United States Of America As Represented By The Department Of Health And Human Services | Molecular clones with mutated HIV gag/pol, SIV gag and SIV env genes |
| US7655774B2 (en) * | 2000-02-18 | 2010-02-02 | University Of Washington | Ancestral and COT viral sequences, proteins and immunogenic compositions |
| EP1156112B1 (en) | 2000-05-18 | 2006-03-01 | Geneart GmbH | Synthetic gagpol genes and their uses |
| GB0014288D0 (en) | 2000-06-10 | 2000-08-02 | Smithkline Beecham Biolog | Vaccine |
| BR0112637A (pt) * | 2000-07-21 | 2003-06-10 | Glaxo Group Ltd | Sequências do vìrus do papiloma códon-otimizadas |
| AU9215101A (en) | 2000-08-17 | 2002-02-25 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| US7022830B2 (en) * | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| US6858590B2 (en) | 2000-08-17 | 2005-02-22 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| US6733993B2 (en) | 2000-09-15 | 2004-05-11 | Merck & Co., Inc. | Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-gag, pol, nef and modifications |
| DK1857122T3 (da) * | 2001-06-05 | 2011-03-21 | Curevac Gmbh | Stabiliseret mRNA med forøget G/C-indhold, kodende for et viralt antigen |
| AU2002310438B2 (en) | 2001-06-14 | 2008-05-01 | The Scripps Research Institute | Stabilized proteins with engineered disulfide bonds |
| EP2280074A3 (en) | 2001-07-05 | 2011-06-22 | Novartis Vaccines and Diagnostics, Inc. | Polynucleotides encoding antigenic HIV type B and/or type C polypeptides, polypeptides and uses thereof |
| US7211659B2 (en) | 2001-07-05 | 2007-05-01 | Chiron Corporation | Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof |
| WO2003012117A1 (en) * | 2001-07-28 | 2003-02-13 | The Secretary Of State For Defence | Dna vaccine |
| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| DE10162480A1 (de) | 2001-12-19 | 2003-08-07 | Ingmar Hoerr | Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen |
| FR2845918A1 (fr) * | 2002-10-16 | 2004-04-23 | Pasteur Institut | Preparations immunogenes et vaccinantes a base d'arn |
| AU2003235707A1 (en) * | 2002-01-18 | 2003-07-30 | Curevac Gmbh | Immunogenic preparations and vaccines on the basis of mrna |
| DE10260805A1 (de) * | 2002-12-23 | 2004-07-22 | Geneart Gmbh | Verfahren und Vorrichtung zum Optimieren einer Nucleotidsequenz zur Expression eines Proteins |
| AU2004224335B2 (en) | 2003-03-24 | 2010-01-28 | Merck Sharp & Dohme Llc | Optimized expression of HPV 31 L1 in yeast |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| GB0321615D0 (en) | 2003-09-15 | 2003-10-15 | Glaxo Group Ltd | Improvements in vaccination |
| GB0321614D0 (en) * | 2003-09-15 | 2003-10-15 | Glaxo Group Ltd | Vaccines |
| MY140664A (en) | 2003-09-29 | 2010-01-15 | Merck Sharp & Dohme | Optimized expression of hpv 45 l1 in yeast |
| MY139500A (en) | 2003-11-12 | 2009-10-30 | Merck Sharp & Dohme | Optimized expression of hpv 58 l1 in yeast |
| WO2005063286A1 (en) | 2003-12-23 | 2005-07-14 | Arbor Vita Corporation | Antibodies for oncogenic strains of hpv and methods of their use |
| TWI349036B (en) | 2004-03-24 | 2011-09-21 | Merck Sharp & Dohme | Optimized expression of hpv 52 l1 in yeast |
| DE102004037611B4 (de) * | 2004-08-03 | 2013-10-02 | Geneart Ag | Induzierbare Genexpression |
| EP1814583A2 (en) | 2004-11-01 | 2007-08-08 | Novartis Vaccines and Diagnostics, Inc. | Combination approaches for generating immune responses |
| KR101158756B1 (ko) | 2006-12-20 | 2012-06-22 | (주) 에빅스젠 | 코돈 최적화시킨 ｈｉｖ의 ｎｃ 폴리뉴클레오티드, 상기폴리뉴클레오티드를 포함하는 벡터 및 이를 이용한 ｎｃ단백질의 생산방법 |
| EP2185195A2 (en) | 2007-08-16 | 2010-05-19 | Tripep Ab | Immunogen platform |
| US8815253B2 (en) | 2007-12-07 | 2014-08-26 | Novartis Ag | Compositions for inducing immune responses |
| UY32341A (es) | 2008-12-19 | 2010-07-30 | Glaxo Group Ltd | Proteínas de unión antígeno novedosas |
| AU2011209713B2 (en) | 2010-01-28 | 2014-04-03 | Glaxo Group Limited | CD127 binding proteins |
| UA108227C2 (xx) | 2010-03-03 | 2015-04-10 | Антигензв'язуючий білок | |
| TW201210612A (en) | 2010-06-03 | 2012-03-16 | Glaxo Group Ltd | Humanised antigen binding proteins |
| BR112013001637A2 (pt) | 2010-07-22 | 2016-05-24 | Glaxosmithkline Biolog Sa | proteína ligadora de antígeno, molécula de ácido nucleico, vetor de expressão, célula hospedeira recombinante, métodos para produção de proteína ligadora de antígeno, e para detectar mage-a3 e/ou mage-a6 em tecido de humano fixado com formalina e infiltrado em parafina. |
| EP2600901B1 (en) | 2010-08-06 | 2019-03-27 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| WO2012021730A2 (en) | 2010-08-11 | 2012-02-16 | Genvec, Inc. | Respiratory syncytial virus (rsv) vaccine |
| HRP20220796T1 (hr) | 2010-10-01 | 2022-10-14 | ModernaTX, Inc. | Ribonukleinske kiseline koje sadrže n1-metil-pseudouracil i njihove uporabe |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3492109B1 (en) | 2011-10-03 | 2020-03-04 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| RS63244B1 (sr) | 2011-12-16 | 2022-06-30 | Modernatx Inc | Kompozicije modifikovane mrna |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| WO2013151664A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
| US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| JP6211597B2 (ja) | 2012-05-01 | 2017-10-11 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | 新規抗体 |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
| SG11201602503TA (en) | 2013-10-03 | 2016-04-28 | Moderna Therapeutics Inc | Polynucleotides encoding low density lipoprotein receptor |
| CA2925021A1 (en) | 2013-11-01 | 2015-05-07 | Curevac Ag | Modified rna with decreased immunostimulatory properties |
| WO2016059602A2 (en) | 2014-10-16 | 2016-04-21 | Glaxo Group Limited | Methods of treating cancer and related compositions |
| WO2020190750A1 (en) | 2019-03-15 | 2020-09-24 | Modernatx, Inc. | Hiv rna vaccines |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP129A (en) * | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
| CA2072351A1 (en) * | 1990-01-05 | 1991-07-06 | Andrew J. Mcmichael | Hiv-1 core protein fragments |
| EP0565794A1 (en) * | 1992-04-14 | 1993-10-20 | British Biotech Pharmaceuticals Limited | Induction of CTL responses |
| NZ262582A (en) * | 1993-01-26 | 1997-10-24 | David B Weiner | Compositions and methods for delivery of genetic material |
| US5795737A (en) * | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
| US5786464C1 (en) * | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
| EE9800257A (et) * | 1996-02-22 | 1999-02-15 | Merck & Co., Inc. | Sünteetilised HIV geenid |
| US6114148C1 (en) * | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
-
1998
- 1998-02-03 IL IL13113198A patent/IL131131A0/xx unknown
- 1998-02-03 DK DK98904971T patent/DK0969862T3/da active
- 1998-02-03 KR KR1019997007130A patent/KR20000070865A/ko not_active Application Discontinuation
- 1998-02-03 AT AT98904971T patent/ATE342916T1/de not_active IP Right Cessation
- 1998-02-03 AU AU62711/98A patent/AU743616B2/en not_active Ceased
- 1998-02-03 DE DE69836206T patent/DE69836206T2/de not_active Expired - Fee Related
- 1998-02-03 SK SK1066-99A patent/SK106699A3/sk unknown
- 1998-02-03 PL PL98335050A patent/PL335050A1/xx unknown
- 1998-02-03 JP JP53490598A patent/JP2001512308A/ja active Pending
- 1998-02-03 CN CN98803975A patent/CN1252075A/zh active Pending
- 1998-02-03 ES ES98904971T patent/ES2274566T3/es not_active Expired - Lifetime
- 1998-02-03 EE EEP199900343A patent/EE9900343A/xx unknown
- 1998-02-03 WO PCT/US1998/002293 patent/WO1998034640A2/en active IP Right Grant
- 1998-02-03 EP EP98904971A patent/EP0969862B1/en not_active Expired - Lifetime
- 1998-02-03 CA CA002280195A patent/CA2280195A1/en not_active Abandoned
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1999
- 1999-08-06 NO NO993810A patent/NO993810L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2280195A1 (en) | 1998-08-13 |
| KR20000070865A (ko) | 2000-11-25 |
| PL335050A1 (en) | 2000-03-27 |
| DE69836206D1 (de) | 2006-11-30 |
| EP0969862A2 (en) | 2000-01-12 |
| ATE342916T1 (de) | 2006-11-15 |
| AU6271198A (en) | 1998-08-26 |
| WO1998034640A2 (en) | 1998-08-13 |
| NO993810L (no) | 1999-10-07 |
| JP2001512308A (ja) | 2001-08-21 |
| EE9900343A (et) | 2000-02-15 |
| AU743616B2 (en) | 2002-01-31 |
| WO1998034640A3 (en) | 1998-11-19 |
| DK0969862T3 (da) | 2007-02-12 |
| DE69836206T2 (de) | 2007-08-23 |
| CN1252075A (zh) | 2000-05-03 |
| EP0969862B1 (en) | 2006-10-18 |
| IL131131A0 (en) | 2001-01-28 |
| NO993810D0 (no) | 1999-08-06 |
| ES2274566T3 (es) | 2007-05-16 |
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