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Priority claimed from PCT/JP1995/002045external-prioritypatent/WO1996011002A1/en
Application filed by Helsinn Healthcare SafiledCriticalHelsinn Healthcare Sa
Publication of SI9620016ApublicationCriticalpatent/SI9620016A/en
Publication of SI9620016BpublicationCriticalpatent/SI9620016B/en
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Steroid Compounds
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
An external antiinflammatory agent containing an active ingredient comprising nimesulide dispersed in the base component and being readily absorbable, safe and nondiscolorable.
Claims (8)
17 PATENTNI ZAHTEVKI 1. Antiinflamatoren pripravek v obliki kreme za zunanjo rabo, značilen po tem, da obsega nimesulid v dispergirani fazi s srednjim premerom delcev od 0.01 do 75 pm v množini od 0.1 do 5 mas. % umešan v gelasto osnovo za kreme, ki obsega karboksivinilni polimer v množini od 0.2 do 3 mas. %, oljno snov, ki obsega diizopropil sebakat ter izopropil miristat v množini od 2 do 20 mas. %, neionsko površinsko aktivno sredstvo v množini od 0.5 do 7 mas. %, bazično snov v množini od 0.01 do 5 mas. % ter vodo v množini od 50 do 90 mas. %.An anti-inflammatory preparation in the form of a cream for external use, characterized in that it comprises nimesulide in a dispersed phase with a mean particle diameter of from 0.01 to 75 pm in an amount of from 0.1 to 5% by weight. % mixed into a gel base for creams comprising a carboxyvinyl polymer in an amount of 0.2 to 3 wt. %, an oily substance comprising diisopropyl sebacate and isopropyl myristate in an amount of 2 to 20 wt. %, nonionic surfactant in an amount of from 0.5 to 7 wt. %, basic substance in an amount of 0.01 to 5 wt. % and water in an amount of from 50 to 90 wt. %.2. Antiinflamatomo sredstvo za zunanjo rabo po zahtevku 1, značilno po tem, da ima pH od 4 do 8.Anti-inflammatory agent for external use according to Claim 1, characterized in that it has a pH of 4 to 8.3. Antiinflamatomo sredstvo za zunanjo rabo po zahtevku 1, značilno po tem, da nadalje obsega sredstvo za izboljšanje absorpcije, ki je organska baza, krotamiton, ester maščobne kisline s srednjo dolžino verige, 1-mentol in/ali benzil alkohol.The anti-inflammatory agent for external use according to claim 1, characterized in that it further comprises an absorption enhancing agent which is an organic base, crotamiton, a medium chain fatty acid ester, 1-menthol and / or benzyl alcohol.4. Antiinflamatomo sredstvo za zunanjo rabo po zahtevku 3, značilno po tem, da je navedena organska baza diizopropanolamin, meglumin, trietanolamin, in/ali l-(2-hidroksietil)pirolidin.Antiinflammatory agent for external use according to claim 3, characterized in that said organic base is diisopropanolamine, meglumine, triethanolamine, and / or 1- (2-hydroxyethyl) pyrrolidine.5. Antiinflamatomi pripravek v obliki mazila za zunanjo rabo, značilen po tem, da obsega nimesulid v dispergirani fazi s srednjim premerom delcev od 0.01 do 75 pm v množini od 0.1 do 5 mas. %, umešan v petrolatum, ki rabi kot osnova za mazilo, ter obsega beli petrolatum v množini od 35 do 80 mas. %, oljno snov, ki obsega diizopropil sebakat ter izopropil miristat v množini od 2 do 20 mas %, ter neionsko površinsko aktivno sredstvo v množini od 0.5 do 7 mas. %. 18Antiinflammatory preparation in the form of an ointment for external use, characterized in that it comprises nimesulide in the dispersed phase with a mean particle diameter of from 0.01 to 75 pm in an amount of from 0.1 to 5 wt. % mixed with petrolatum, which is used as a base for ointment, and comprises white petrolatum in an amount of from 35 to 80 wt. %, an oily substance comprising diisopropyl sebacate and isopropyl myristate in an amount of 2 to 20% by weight, and a nonionic surfactant in an amount of 0.5 to 7% by weight. %. 186. Postopek za pripravo anntiinflamatomega sredstva za zunanjo rabo, značilen po tem, da obsega: postopno dodajanje od 0.1 do 5 mas. % nimesulida kot učinkovine v obliki drobnih delcev v osnovno komponento, in dispergiranje nimesulida z mešanjem, pri čemer imajo navedeni delci srednji premer delcev od 0.01 do 75 pm ter navedena osnovna komponenta obsega karboksivinilni polimer v množini od 0.2 do 3 mas. %, oljna snov pa obsega diizopropil sebakat in izopropil miristat v množini od 2 do 20 mas. %, neionsko površinsko aktivno sredstvo v množini od 0.5 do 7 mas. %, vodo v množini od 50 do 90 mas. % ter od 0.01 do 5 mas. % bazične snovi.A process for the preparation of an anti-inflammatory agent for external use, characterized in that it comprises: the gradual addition of 0.1 to 5% by weight. % of nimesulide as active ingredient in the form of fine particles into the basic component, and dispersing the nimesulide by stirring, said particles having a mean particle diameter of 0.01 to 75 pm and said basic component comprising a carboxyvinyl polymer in an amount of 0.2 to 3 wt. %, and the oily substance comprises diisopropyl sebacate and isopropyl myristate in an amount of from 2 to 20 wt. %, nonionic surfactant in an amount of from 0.5 to 7 wt. %, water in an amount of from 50 to 90 wt. % and from 0.01 to 5 wt. % basic substance.7. Postopek po zahtevku 6, značilen po tem, da kot osnovno komponento uporabimo oljno komponento, ki je staljena s segrevanjem.Process according to Claim 6, characterized in that an oil-melted oil component is used as the basic component.8. Postopek po zahtevku 6, značilen po tem, da oljno fazo iz toplotno staljenih oljnih komponent ter vodno fazo, v kateri so raztopljene vodotopne komponente, pomešamo z mešanjem ter uporabimo kot osnovno komponento. Za: HELSINN HEALTHCARE S.A.Process according to Claim 6, characterized in that the oil phase from the thermally molten oil components and the aqueous phase in which the water-soluble components are dissolved are mixed with mixing and used as the basic component. For: HELSINN HEALTHCARE S.A.
SI9620016A1995-10-051996-04-01Antiinflammatory agent for external use
SI9620016B
(en)
Poloxamer Compositions With Reduced Sol-Gel Transition Temperatures and Methods of Reducing the Sol-Gel Transition Temperature of Poloxamer Compositions