SI4349406T1 - Kristalne trdne oblike 6-karboksi-2-(3,5-diklorofenil)-benzoksazola za uporabo kot zdravilo - Google Patents
Kristalne trdne oblike 6-karboksi-2-(3,5-diklorofenil)-benzoksazola za uporabo kot zdraviloInfo
- Publication number
- SI4349406T1 SI4349406T1 SI201532089T SI201532089T SI4349406T1 SI 4349406 T1 SI4349406 T1 SI 4349406T1 SI 201532089 T SI201532089 T SI 201532089T SI 201532089 T SI201532089 T SI 201532089T SI 4349406 T1 SI4349406 T1 SI 4349406T1
- Authority
- SI
- Slovenia
- Prior art keywords
- benzoxazole
- dichlorophenyl
- carboxy
- crystalline solid
- solid forms
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462047614P | 2014-09-08 | 2014-09-08 | |
| US201562203953P | 2015-08-12 | 2015-08-12 | |
| EP24152053.5A EP4349406B1 (en) | 2014-09-08 | 2015-08-31 | Crystalline solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole for use as a medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI4349406T1 true SI4349406T1 (sl) | 2026-02-27 |
Family
ID=54199901
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201532089T SI4349406T1 (sl) | 2014-09-08 | 2015-08-31 | Kristalne trdne oblike 6-karboksi-2-(3,5-diklorofenil)-benzoksazola za uporabo kot zdravilo |
| SI201531753T SI3191461T1 (sl) | 2014-09-08 | 2015-08-31 | Kristalinske trdne oblike 6-karboksi-2-(3,5-diklorofenil)-benzoksazola |
| SI201532001T SI3977993T1 (sl) | 2014-09-08 | 2015-08-31 | Kristalne trdne oblike 6-karboksi-2-(3,5-diklorofenil)-benzoksazola za uporabo kot zdravilo |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201531753T SI3191461T1 (sl) | 2014-09-08 | 2015-08-31 | Kristalinske trdne oblike 6-karboksi-2-(3,5-diklorofenil)-benzoksazola |
| SI201532001T SI3977993T1 (sl) | 2014-09-08 | 2015-08-31 | Kristalne trdne oblike 6-karboksi-2-(3,5-diklorofenil)-benzoksazola za uporabo kot zdravilo |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9770441B1 (https=) |
| EP (3) | EP3977993B1 (https=) |
| JP (5) | JP2016065042A (https=) |
| KR (1) | KR102004059B1 (https=) |
| CN (2) | CN115368313A (https=) |
| AU (1) | AU2015313875B2 (https=) |
| BR (1) | BR112017003421B1 (https=) |
| CA (1) | CA2903194A1 (https=) |
| CY (1) | CY1124843T1 (https=) |
| DK (2) | DK4349406T3 (https=) |
| ES (3) | ES2901785T3 (https=) |
| FI (2) | FI4349406T3 (https=) |
| HR (1) | HRP20211834T1 (https=) |
| HU (2) | HUE065233T2 (https=) |
| IL (1) | IL251037B1 (https=) |
| LT (1) | LT3191461T (https=) |
| MX (1) | MX374012B (https=) |
| PL (3) | PL3191461T3 (https=) |
| PT (3) | PT4349406T (https=) |
| RS (1) | RS62634B1 (https=) |
| SG (1) | SG11201700958YA (https=) |
| SI (3) | SI4349406T1 (https=) |
| TW (1) | TWI644902B (https=) |
| WO (1) | WO2016038500A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2571950A (en) * | 2018-03-13 | 2019-09-18 | Azad Pharma Ag | New polymorph and new path to synthesize tafamidis |
| WO2020128816A2 (en) | 2018-12-20 | 2020-06-25 | Pfizer Inc. | Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent |
| US12116352B2 (en) | 2019-04-11 | 2024-10-15 | Inke, S.A. | Process for preparing 1-deoxy-1-methylamino-d-glucitol 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate |
| EP3969443B1 (en) * | 2019-05-16 | 2024-11-20 | Teva Pharmaceuticals International GmbH | Solid state forms of tafamidis and salts thereof |
| US20220251052A1 (en) * | 2019-07-04 | 2022-08-11 | Msn Laboratories Private Limited, R&D Center | Improved process for the preparation of 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid or its pharmaceutically acceptable salts and polymorphs thereof |
| WO2021093809A1 (zh) | 2019-11-15 | 2021-05-20 | 苏州科睿思制药有限公司 | 他发米帝司的晶型及其制备方法和用途 |
| EP4077287B1 (en) * | 2019-12-20 | 2025-11-19 | Pfizer Ireland Pharmaceuticals Unlimited Company | Efficient process for making 6-carboxy benzoxazole derivatives |
| WO2021152623A1 (en) * | 2020-01-27 | 2021-08-05 | Dr. Reddy’S Laboratories Limited | Improved processes for the preparation of tafamidis and its meglumine salt |
| WO2021232619A1 (zh) * | 2020-05-19 | 2021-11-25 | 苏州科睿思制药有限公司 | 一种他发米帝司游离酸的晶型及其制备方法和用途 |
| US20230265059A1 (en) * | 2020-07-04 | 2023-08-24 | Nuray Chemicals Private Limited | Solid state forms of 6-carboxy-2-(3, 5-dichlorophenyl)-benzoxazole of formula-i and pharmaceutically acceptable salts thereof |
| US12522573B2 (en) * | 2020-10-19 | 2026-01-13 | Alivus Life Sciences Limited | Process for preparation of tafamidis and salts thereof |
| WO2022107166A1 (en) * | 2020-11-20 | 2022-05-27 | Natco Pharma Limited | Novel crystalline form of tafamidis and its process thereof |
| WO2022112919A1 (en) | 2020-11-25 | 2022-06-02 | Pfizer Inc. | (aza)benzothiazolyl substituted pyrazole compounds |
| CN114907283B (zh) * | 2021-02-07 | 2025-01-28 | 南京正大天晴制药有限公司 | 一种2-(3，5-二氯苯基)-苯并噁唑-6-羧酸的制备方法 |
| CN114989106A (zh) * | 2021-02-09 | 2022-09-02 | 齐鲁制药有限公司 | 氯苯唑酸的新晶型及其制备方法 |
| EP4083027A1 (en) * | 2021-04-26 | 2022-11-02 | Química Sintética, S.A. | A solid state form of tafamidis and a process for its preparation |
| WO2023020762A1 (en) | 2021-08-16 | 2023-02-23 | Synthon B.V. | Crystalline forms of tafamidis nicotinamide adduct |
| US20250042864A1 (en) | 2021-11-17 | 2025-02-06 | Teva Pharmaceuticals International Gmbh | Solid state form of tafamidis |
| CN119604278A (zh) | 2022-07-28 | 2025-03-11 | 辉瑞大药厂 | 氯苯唑酸药物组合物 |
| WO2024084362A1 (en) * | 2022-10-17 | 2024-04-25 | Biophore India Pharmaceuticals Pvt. Ltd | A process for the preparation of crystalline form of tafamidis |
| US11980685B1 (en) | 2022-12-23 | 2024-05-14 | Tap Pharmaceuticals, Ag | Liquid pharmaceutical formulations of tafamidis |
| US11878081B1 (en) | 2022-12-23 | 2024-01-23 | Tap Pharmaceuticals Ag | Pharmaceutical formulations of tafamidis |
| WO2026050334A1 (en) | 2024-08-29 | 2026-03-05 | Alexion Pharmaceuticals, Inc. | Transthyretin stabilizers and methods of use thereof |
| EP4717262A1 (en) | 2024-09-26 | 2026-04-01 | Galenicum Health S.L.U. | Pharmaceutical compositions of 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid |
| EP4717261A1 (en) | 2024-09-26 | 2026-04-01 | Galenicum Health S.L.U. | Pharmaceutical compositions of 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| CA2800237C (en) | 2002-12-19 | 2016-05-17 | The Scripps Research Institute | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
| CN103951583B (zh) * | 2006-12-06 | 2016-01-06 | 科内图斯医药公司 | 一种抑制剂的结晶形式 |
| US8576985B2 (en) | 2009-09-01 | 2013-11-05 | Aptuit (West Lafayette) Llc | Methods for indexing solid forms of compounds |
| RU2586330C2 (ru) * | 2011-09-16 | 2016-06-10 | Пфайзер Инк. | Твердые формы ингибитора диссоциации транстиретина |
| US9499527B2 (en) * | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of familial amyloid polyneuropathy |
| GB2571950A (en) | 2018-03-13 | 2019-09-18 | Azad Pharma Ag | New polymorph and new path to synthesize tafamidis |
| EP3969443B1 (en) | 2019-05-16 | 2024-11-20 | Teva Pharmaceuticals International GmbH | Solid state forms of tafamidis and salts thereof |
| US20220251052A1 (en) | 2019-07-04 | 2022-08-11 | Msn Laboratories Private Limited, R&D Center | Improved process for the preparation of 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid or its pharmaceutically acceptable salts and polymorphs thereof |
| WO2021152623A1 (en) | 2020-01-27 | 2021-08-05 | Dr. Reddy’S Laboratories Limited | Improved processes for the preparation of tafamidis and its meglumine salt |
-
2015
- 2015-08-31 PT PT241520535T patent/PT4349406T/pt unknown
- 2015-08-31 EP EP21203965.5A patent/EP3977993B1/en active Active
- 2015-08-31 CN CN202211071641.7A patent/CN115368313A/zh active Pending
- 2015-08-31 IL IL251037A patent/IL251037B1/en unknown
- 2015-08-31 PL PL15771276T patent/PL3191461T3/pl unknown
- 2015-08-31 WO PCT/IB2015/056597 patent/WO2016038500A1/en not_active Ceased
- 2015-08-31 MX MX2017002954A patent/MX374012B/es active IP Right Grant
- 2015-08-31 PT PT212039655T patent/PT3977993T/pt unknown
- 2015-08-31 HU HUE21203965A patent/HUE065233T2/hu unknown
- 2015-08-31 DK DK24152053.5T patent/DK4349406T3/da active
- 2015-08-31 PL PL24152053.5T patent/PL4349406T3/pl unknown
- 2015-08-31 SI SI201532089T patent/SI4349406T1/sl unknown
- 2015-08-31 CN CN201580048168.2A patent/CN106715405A/zh active Pending
- 2015-08-31 LT LTEPPCT/IB2015/056597T patent/LT3191461T/lt unknown
- 2015-08-31 HR HRP20211834TT patent/HRP20211834T1/hr unknown
- 2015-08-31 BR BR112017003421-2A patent/BR112017003421B1/pt active IP Right Grant
- 2015-08-31 AU AU2015313875A patent/AU2015313875B2/en active Active
- 2015-08-31 HU HUE15771276A patent/HUE056583T2/hu unknown
- 2015-08-31 KR KR1020177006011A patent/KR102004059B1/ko active Active
- 2015-08-31 SG SG11201700958YA patent/SG11201700958YA/en unknown
- 2015-08-31 SI SI201531753T patent/SI3191461T1/sl unknown
- 2015-08-31 EP EP15771276.1A patent/EP3191461B1/en active Active
- 2015-08-31 EP EP24152053.5A patent/EP4349406B1/en active Active
- 2015-08-31 DK DK21203965.5T patent/DK3977993T3/da active
- 2015-08-31 SI SI201532001T patent/SI3977993T1/sl unknown
- 2015-08-31 PL PL21203965.5T patent/PL3977993T3/pl unknown
- 2015-08-31 FI FIEP24152053.5T patent/FI4349406T3/fi active
- 2015-08-31 US US15/509,343 patent/US9770441B1/en active Active
- 2015-08-31 ES ES15771276T patent/ES2901785T3/es active Active
- 2015-08-31 FI FIEP21203965.5T patent/FI3977993T3/fi active
- 2015-08-31 ES ES21203965T patent/ES2975633T3/es active Active
- 2015-08-31 RS RS20211481A patent/RS62634B1/sr unknown
- 2015-08-31 ES ES24152053T patent/ES3061774T3/es active Active
- 2015-08-31 PT PT157712761T patent/PT3191461T/pt unknown
- 2015-09-02 JP JP2015172636A patent/JP2016065042A/ja not_active Withdrawn
- 2015-09-03 CA CA2903194A patent/CA2903194A1/en not_active Abandoned
- 2015-09-07 TW TW104129562A patent/TWI644902B/zh active
-
2019
- 2019-12-02 JP JP2019218244A patent/JP7357525B2/ja active Active
-
2021
- 2021-11-09 JP JP2021182622A patent/JP2022024014A/ja not_active Withdrawn
- 2021-12-16 CY CY20211101109T patent/CY1124843T1/el unknown
-
2023
- 2023-07-13 JP JP2023115087A patent/JP2023134645A/ja active Pending
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2025
- 2025-04-15 JP JP2025066606A patent/JP2025108584A/ja active Pending
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