SI3302499T1 - Zdravljenje mitohondrijskih bolezni - Google Patents

Zdravljenje mitohondrijskih bolezni

Info

Publication number
SI3302499T1
SI3302499T1 SI201631688T SI201631688T SI3302499T1 SI 3302499 T1 SI3302499 T1 SI 3302499T1 SI 201631688 T SI201631688 T SI 201631688T SI 201631688 T SI201631688 T SI 201631688T SI 3302499 T1 SI3302499 T1 SI 3302499T1
Authority
SI
Slovenia
Prior art keywords
treatment
mitochondrial diseases
mitochondrial
diseases
Prior art date
Application number
SI201631688T
Other languages
English (en)
Inventor
Seves Ramon Marti
Vioque Emiliano Gonzalez
Bermejo Cora Blazquez
Torronteras Javier Torres
Perez Raquel Cabrera
Navarro Yolanda Camara
Original Assignee
Fundacio Hospital Universitari Vall D'Hebron- Institut De Recerca
Centro De Investigacion Biomedica En Red (Ciber)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacio Hospital Universitari Vall D'Hebron- Institut De Recerca, Centro De Investigacion Biomedica En Red (Ciber) filed Critical Fundacio Hospital Universitari Vall D'Hebron- Institut De Recerca
Publication of SI3302499T1 publication Critical patent/SI3302499T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SI201631688T 2015-06-05 2016-06-03 Zdravljenje mitohondrijskih bolezni SI3302499T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15170825 2015-06-05
PCT/EP2016/062636 WO2016193421A1 (en) 2015-06-05 2016-06-03 Treatment of mitochondrial diseases
EP16728892.7A EP3302499B1 (en) 2015-06-05 2016-06-03 Treatment of mitochondrial diseases

Publications (1)

Publication Number Publication Date
SI3302499T1 true SI3302499T1 (sl) 2023-08-31

Family

ID=53298228

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201631688T SI3302499T1 (sl) 2015-06-05 2016-06-03 Zdravljenje mitohondrijskih bolezni

Country Status (22)

Country Link
US (2) US11337980B2 (sl)
EP (2) EP3302499B1 (sl)
JP (3) JP6885544B2 (sl)
CN (1) CN107820430A (sl)
AU (2) AU2016273340B2 (sl)
BR (1) BR112017025839A2 (sl)
CA (1) CA2991271C (sl)
CY (1) CY1126058T1 (sl)
DK (1) DK3302499T3 (sl)
ES (1) ES2944551T3 (sl)
FI (1) FI3302499T3 (sl)
HR (1) HRP20230277T1 (sl)
HU (1) HUE062134T2 (sl)
IL (2) IL255988B (sl)
LT (1) LT3302499T (sl)
MX (2) MX2017015566A (sl)
PL (1) PL3302499T3 (sl)
PT (1) PT3302499T (sl)
RS (1) RS64273B1 (sl)
RU (1) RU2745611C2 (sl)
SI (1) SI3302499T1 (sl)
WO (1) WO2016193421A1 (sl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016193421A1 (en) * 2015-06-05 2016-12-08 Fundació Hospital Universitari Vall D'hebron - Institut De Recerca Treatment of mitochondrial diseases
KR20220018623A (ko) 2015-06-17 2022-02-15 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 미토콘드리아 dna 고갈 증후군을 포함하는 불균형 뉴클레오타이드 풀에 의해 야기된 질환에 대한 데옥시뉴클레오타이드 요법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246708A (en) * 1987-10-28 1993-09-21 Pro-Neuron, Inc. Methods for promoting wound healing with deoxyribonucleosides
ZA892928B (en) * 1988-04-25 1991-01-30 Pro Neuron Inc Pharmaceutical compositions containing deoxyribonucleosides for wound healing
IT1247510B (it) 1991-04-19 1994-12-17 Univ Cagliari Composizioni terapeutiche ad attivita' anti-hiv costituite da 2',3'-didesossiadenosina e sostanze inibitrici della adenosina-deaminasi
JPH0635389A (ja) 1992-07-20 1994-02-10 Fujitsu Ltd ホログラム記録材料
US20020006913A1 (en) * 1997-11-04 2002-01-17 Von Borstel Reid W. Antimutagenic compositions for treatment and prevention of photodamage to skin
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
EP1171137B1 (en) * 1999-02-23 2007-12-26 The Regents of the University of California Use of triacetyluridine for the treatment of mitochondrial disorders
DK2424495T3 (en) * 2009-04-28 2018-04-30 Bioelectron Tech Corp TREATMENT OF LEVERS HEREDIC OPTICAL NEUROPATHY AND DOMINANT OPTICAL ATROPHY WITH TOCOTRIENOL QUINONES
US20150065556A1 (en) * 2013-08-05 2015-03-05 Whitehead Institute For Biomedical Research Therapeutic targets for mitochondrial disorders
CN104524546B (zh) 2014-12-18 2019-06-21 中国科学院广州生物医药与健康研究院 用于治疗Alpers-Huttenlocher综合征的药物组合物
WO2016193421A1 (en) * 2015-06-05 2016-12-08 Fundació Hospital Universitari Vall D'hebron - Institut De Recerca Treatment of mitochondrial diseases

Also Published As

Publication number Publication date
HRP20230277T1 (hr) 2023-06-23
MX2017015566A (es) 2018-08-15
CA2991271A1 (en) 2016-12-08
AU2016273340A1 (en) 2018-01-25
US20230060544A1 (en) 2023-03-02
PL3302499T3 (pl) 2023-07-24
AU2021282462B2 (en) 2023-10-05
IL255988A (en) 2018-04-30
US20180161332A1 (en) 2018-06-14
CN107820430A (zh) 2018-03-20
FI3302499T3 (fi) 2023-05-04
US11998551B2 (en) 2024-06-04
RU2018123532A (ru) 2019-12-30
US11337980B2 (en) 2022-05-24
IL289747A (en) 2022-03-01
LT3302499T (lt) 2023-05-25
JP2021121594A (ja) 2021-08-26
JP2023123444A (ja) 2023-09-05
DK3302499T3 (da) 2023-04-03
WO2016193421A1 (en) 2016-12-08
CA2991271C (en) 2023-10-17
ES2944551T3 (es) 2023-06-22
RU2745611C2 (ru) 2021-03-29
RS64273B1 (sr) 2023-07-31
AU2016273340B2 (en) 2021-09-09
MX2022012719A (es) 2022-11-07
IL255988B (en) 2022-02-01
HUE062134T2 (hu) 2023-09-28
AU2021282462A1 (en) 2022-01-06
EP4218938A1 (en) 2023-08-02
JP2018516923A (ja) 2018-06-28
BR112017025839A2 (pt) 2018-08-14
JP6885544B2 (ja) 2021-06-16
PT3302499T (pt) 2023-05-12
CY1126058T1 (el) 2023-11-15
EP3302499B1 (en) 2023-03-15
EP3302499A1 (en) 2018-04-11
RU2018123532A3 (sl) 2019-12-30

Similar Documents

Publication Publication Date Title
HK1256795A1 (zh) 可用於治療自身免疫疾病的二吡唑基衍生物
IL285882A (en) Medicinal uses for l–4–chlorokynurenine
HK1258994A1 (zh) 用於疾病治療的方法
GB201516905D0 (en) Treatment of Neurodegenerative diseases
HK1249865B (zh) 疼痛的治療
HK1244711A1 (zh) Hmgb1介導的炎症的治療
GB201412578D0 (en) Treatment of neurological diseases
EP3606522C0 (en) NOVEL TREATMENT OF MITOCHONDRIAL DISEASES
HK1246679A1 (zh) 絲蟲病的治療
HK1243937A1 (zh) 治療疾病的方法
HUE062134T2 (hu) Mitokondriális betegségek kezelése
PL3182980T3 (pl) Leczenie chorób niedoboru glikozylacji
GB201412010D0 (en) Treatment of hypertransaminasemia
GB201621398D0 (en) Treatment of emt-associated disease
SG10201913141UA (en) Treatment of alphavirus-induced inflammation
GB201514909D0 (en) Treatment of autoimmune diseases
GB201504413D0 (en) Treatment of disease
GB201517565D0 (en) Treatment of genetic diseases
GB201512723D0 (en) Treatment of cancer
GB201414023D0 (en) Treatment of autoimmune diseases
GB201507928D0 (en) Treatment of cancer
GB201501800D0 (en) Treatment of medical conditions
GB201504617D0 (en) Treatment of cancer