SI3302499T1 - Zdravljenje mitohondrijskih bolezni - Google Patents
Zdravljenje mitohondrijskih bolezniInfo
- Publication number
- SI3302499T1 SI3302499T1 SI201631688T SI201631688T SI3302499T1 SI 3302499 T1 SI3302499 T1 SI 3302499T1 SI 201631688 T SI201631688 T SI 201631688T SI 201631688 T SI201631688 T SI 201631688T SI 3302499 T1 SI3302499 T1 SI 3302499T1
- Authority
- SI
- Slovenia
- Prior art keywords
- treatment
- mitochondrial diseases
- mitochondrial
- diseases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15170825 | 2015-06-05 | ||
PCT/EP2016/062636 WO2016193421A1 (en) | 2015-06-05 | 2016-06-03 | Treatment of mitochondrial diseases |
EP16728892.7A EP3302499B1 (en) | 2015-06-05 | 2016-06-03 | Treatment of mitochondrial diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
SI3302499T1 true SI3302499T1 (sl) | 2023-08-31 |
Family
ID=53298228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201631688T SI3302499T1 (sl) | 2015-06-05 | 2016-06-03 | Zdravljenje mitohondrijskih bolezni |
Country Status (22)
Country | Link |
---|---|
US (2) | US11337980B2 (sl) |
EP (2) | EP3302499B1 (sl) |
JP (3) | JP6885544B2 (sl) |
CN (1) | CN107820430A (sl) |
AU (2) | AU2016273340B2 (sl) |
BR (1) | BR112017025839A2 (sl) |
CA (1) | CA2991271C (sl) |
CY (1) | CY1126058T1 (sl) |
DK (1) | DK3302499T3 (sl) |
ES (1) | ES2944551T3 (sl) |
FI (1) | FI3302499T3 (sl) |
HR (1) | HRP20230277T1 (sl) |
HU (1) | HUE062134T2 (sl) |
IL (2) | IL255988B (sl) |
LT (1) | LT3302499T (sl) |
MX (2) | MX2017015566A (sl) |
PL (1) | PL3302499T3 (sl) |
PT (1) | PT3302499T (sl) |
RS (1) | RS64273B1 (sl) |
RU (1) | RU2745611C2 (sl) |
SI (1) | SI3302499T1 (sl) |
WO (1) | WO2016193421A1 (sl) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016193421A1 (en) * | 2015-06-05 | 2016-12-08 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Treatment of mitochondrial diseases |
KR20220018623A (ko) | 2015-06-17 | 2022-02-15 | 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 | 미토콘드리아 dna 고갈 증후군을 포함하는 불균형 뉴클레오타이드 풀에 의해 야기된 질환에 대한 데옥시뉴클레오타이드 요법 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5246708A (en) * | 1987-10-28 | 1993-09-21 | Pro-Neuron, Inc. | Methods for promoting wound healing with deoxyribonucleosides |
ZA892928B (en) * | 1988-04-25 | 1991-01-30 | Pro Neuron Inc | Pharmaceutical compositions containing deoxyribonucleosides for wound healing |
IT1247510B (it) | 1991-04-19 | 1994-12-17 | Univ Cagliari | Composizioni terapeutiche ad attivita' anti-hiv costituite da 2',3'-didesossiadenosina e sostanze inibitrici della adenosina-deaminasi |
JPH0635389A (ja) | 1992-07-20 | 1994-02-10 | Fujitsu Ltd | ホログラム記録材料 |
US20020006913A1 (en) * | 1997-11-04 | 2002-01-17 | Von Borstel Reid W. | Antimutagenic compositions for treatment and prevention of photodamage to skin |
US6472378B2 (en) * | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
EP1171137B1 (en) * | 1999-02-23 | 2007-12-26 | The Regents of the University of California | Use of triacetyluridine for the treatment of mitochondrial disorders |
DK2424495T3 (en) * | 2009-04-28 | 2018-04-30 | Bioelectron Tech Corp | TREATMENT OF LEVERS HEREDIC OPTICAL NEUROPATHY AND DOMINANT OPTICAL ATROPHY WITH TOCOTRIENOL QUINONES |
US20150065556A1 (en) * | 2013-08-05 | 2015-03-05 | Whitehead Institute For Biomedical Research | Therapeutic targets for mitochondrial disorders |
CN104524546B (zh) | 2014-12-18 | 2019-06-21 | 中国科学院广州生物医药与健康研究院 | 用于治疗Alpers-Huttenlocher综合征的药物组合物 |
WO2016193421A1 (en) * | 2015-06-05 | 2016-12-08 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Treatment of mitochondrial diseases |
-
2016
- 2016-06-03 WO PCT/EP2016/062636 patent/WO2016193421A1/en active Application Filing
- 2016-06-03 HR HRP20230277TT patent/HRP20230277T1/hr unknown
- 2016-06-03 AU AU2016273340A patent/AU2016273340B2/en active Active
- 2016-06-03 CA CA2991271A patent/CA2991271C/en active Active
- 2016-06-03 SI SI201631688T patent/SI3302499T1/sl unknown
- 2016-06-03 DK DK16728892.7T patent/DK3302499T3/da active
- 2016-06-03 PT PT167288927T patent/PT3302499T/pt unknown
- 2016-06-03 EP EP16728892.7A patent/EP3302499B1/en active Active
- 2016-06-03 CN CN201680039230.6A patent/CN107820430A/zh active Pending
- 2016-06-03 PL PL16728892.7T patent/PL3302499T3/pl unknown
- 2016-06-03 FI FIEP16728892.7T patent/FI3302499T3/fi active
- 2016-06-03 EP EP23156608.4A patent/EP4218938A1/en active Pending
- 2016-06-03 RU RU2018123532A patent/RU2745611C2/ru active
- 2016-06-03 BR BR112017025839A patent/BR112017025839A2/pt not_active Application Discontinuation
- 2016-06-03 HU HUE16728892A patent/HUE062134T2/hu unknown
- 2016-06-03 ES ES16728892T patent/ES2944551T3/es active Active
- 2016-06-03 MX MX2017015566A patent/MX2017015566A/es unknown
- 2016-06-03 US US15/578,621 patent/US11337980B2/en active Active
- 2016-06-03 RS RS20230259A patent/RS64273B1/sr unknown
- 2016-06-03 LT LTEPPCT/EP2016/062636T patent/LT3302499T/lt unknown
- 2016-06-03 JP JP2017562304A patent/JP6885544B2/ja active Active
-
2017
- 2017-11-29 IL IL255988A patent/IL255988B/en unknown
- 2017-12-01 MX MX2022012719A patent/MX2022012719A/es unknown
-
2021
- 2021-04-28 JP JP2021075504A patent/JP2021121594A/ja active Pending
- 2021-12-08 AU AU2021282462A patent/AU2021282462B2/en active Active
-
2022
- 2022-01-10 IL IL289747A patent/IL289747A/en unknown
- 2022-04-25 US US17/728,698 patent/US11998551B2/en active Active
-
2023
- 2023-05-26 CY CY20231100251T patent/CY1126058T1/el unknown
- 2023-05-30 JP JP2023088479A patent/JP2023123444A/ja active Pending
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