SI2970377T1 - Postopki za proizvodnjo IGG-pripravka, pridobljenega iz človeške plazme in obogatenega z naravnimi IGG-ji, ki so povezani z boleznijo možganov - Google Patents
Postopki za proizvodnjo IGG-pripravka, pridobljenega iz človeške plazme in obogatenega z naravnimi IGG-ji, ki so povezani z boleznijo možganovInfo
- Publication number
- SI2970377T1 SI2970377T1 SI201431472T SI201431472T SI2970377T1 SI 2970377 T1 SI2970377 T1 SI 2970377T1 SI 201431472 T SI201431472 T SI 201431472T SI 201431472 T SI201431472 T SI 201431472T SI 2970377 T1 SI2970377 T1 SI 2970377T1
- Authority
- SI
- Slovenia
- Prior art keywords
- produce
- methods
- human plasma
- brain disease
- igg preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/027—Nanofiltration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2623—Ion-Exchange
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4717—Plasma globulins, lactoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Water Supply & Treatment (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Endocrinology (AREA)
- Virology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361794378P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/028953 WO2014144511A1 (en) | 2013-03-15 | 2014-03-14 | Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs |
EP14721128.8A EP2970377B1 (en) | 2013-03-15 | 2014-03-14 | Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2970377T1 true SI2970377T1 (sl) | 2020-04-30 |
Family
ID=50631072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201431472T SI2970377T1 (sl) | 2013-03-15 | 2014-03-14 | Postopki za proizvodnjo IGG-pripravka, pridobljenega iz človeške plazme in obogatenega z naravnimi IGG-ji, ki so povezani z boleznijo možganov |
Country Status (12)
Country | Link |
---|---|
US (4) | US9896501B2 (sl) |
EP (2) | EP2970377B1 (sl) |
AU (1) | AU2013203043B2 (sl) |
DK (1) | DK2970377T3 (sl) |
ES (1) | ES2763396T3 (sl) |
HR (1) | HRP20200035T1 (sl) |
HU (1) | HUE047475T2 (sl) |
LT (1) | LT2970377T (sl) |
PL (1) | PL2970377T3 (sl) |
PT (1) | PT2970377T (sl) |
SI (1) | SI2970377T1 (sl) |
WO (1) | WO2014144511A1 (sl) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201250247A (en) * | 2011-04-01 | 2012-12-16 | Baxter Int | Use of cytokine levels in intravenous immunoglobulin treatment of Alzheimer's disease |
AU2013203043B2 (en) | 2013-03-15 | 2016-10-06 | Takeda Pharmaceutical Company Limited | Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs |
EP3118210B1 (en) * | 2014-03-11 | 2019-11-13 | Green Cross Holdings Corporation | Method for purifying immunoglobulin |
ES2785375T3 (es) * | 2014-03-11 | 2020-10-06 | Green Cross Holdings Corp | Procedimiento de purificación de inmunoglobulina |
US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
CN109311948B (zh) | 2016-05-11 | 2022-09-16 | 思拓凡生物工艺研发有限公司 | 清洁和/或消毒分离基质的方法 |
US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
JP7106187B2 (ja) | 2016-05-11 | 2022-07-26 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックスを保存する方法 |
US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
US10513537B2 (en) | 2016-05-11 | 2019-12-24 | Ge Healthcare Bioprocess R&D Ab | Separation matrix |
US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
EP3275897A1 (en) * | 2016-07-27 | 2018-01-31 | Biotest AG | Process for preparing immunoglobulin compositions |
JP7316931B2 (ja) * | 2016-08-18 | 2023-07-28 | アルカヘスト,インコーポレイテッド | 加齢性認知障害の処置としての血漿画分 |
KR102573778B1 (ko) | 2017-02-17 | 2023-08-31 | 브리스톨-마이어스 스큅 컴퍼니 | 알파-시뉴클레인에 대한 항체 및 그의 용도 |
AU2018418814B2 (en) * | 2018-04-13 | 2024-05-23 | Tricoya Technologies Ltd | Acetylated wood and method of making same |
RU2694620C1 (ru) * | 2018-10-17 | 2019-07-16 | Закрытое акционерное общество "БиоХимМак СТ" | Способ хроматографического выделения и очистки иммуноглобулинов |
AU2021303496A1 (en) * | 2020-07-10 | 2023-02-02 | Grifols Worldwide Operations Limited | Method for obtaining a composition comprising human plasma-derived immunoglobulin M |
WO2023215722A1 (en) * | 2022-05-02 | 2023-11-09 | Takeda Pharmaceutical Company Limited | Methods of preparing cohn pool concentrate from blood plasma through ultrafiltration |
Family Cites Families (38)
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US4296027A (en) * | 1977-08-31 | 1981-10-20 | The Regents Of The University Of Minnesota | Pure intravenous human and animal gamma globulins |
US4434093A (en) * | 1982-07-26 | 1984-02-28 | Ortho Diagnostic Systems Inc. | Methods for preparation of HBs Ag free gamma globulins |
US5258503A (en) * | 1987-09-08 | 1993-11-02 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Autoantibody adsorbent and apparatus for removing autoantibodies using the same |
GB9022547D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Purified immunoglobulin |
ES2129076T5 (es) | 1993-12-27 | 2003-05-16 | Zlb Bioplasma Ag | Procedimiento para la preparacion de un concentrado de inmunoglobulina g anti-d y composicion farmaceutica que lo contiene. |
DE4344824C1 (de) * | 1993-12-28 | 1995-08-31 | Immuno Ag | Hochkonzentriertes Immunglobulin-Präparat und Verfahren zu seiner Herstellung |
AT404358B (de) * | 1997-02-04 | 1998-11-25 | Immuno Ag | Verfahren zur chromatographischen reinigung bzw. fraktionierung von von willebrand-faktor aus einem vwf-hältigen ausgangsmaterial |
IL140155A (en) | 1998-06-09 | 2005-12-18 | Statens Seruminstitut | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products |
DK2270044T3 (en) * | 1998-06-09 | 2015-01-26 | Csl Behring Ag | Liquid immunoglobulin G (IgG) product |
SE0001128D0 (sv) * | 2000-03-30 | 2000-03-30 | Amersham Pharm Biotech Ab | A method of producing IgG |
US20020009445A1 (en) | 2000-07-12 | 2002-01-24 | Yansheng Du | Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease |
ES2629602T5 (es) | 2002-09-11 | 2021-06-08 | Genentech Inc | Purificación de proteínas |
US20050221414A1 (en) * | 2004-03-31 | 2005-10-06 | Katalin Varadi | Kit for measuring the thrombin generation in a sample of a patient's blood or plasma |
US20060099211A1 (en) * | 2004-04-12 | 2006-05-11 | Carmen Monthe | Safer, more potent human immunoglobulin preparations for treating Alzheimer's disease |
US7993580B2 (en) * | 2004-08-24 | 2011-08-09 | Baxter International Inc. | Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors |
US8354249B2 (en) | 2005-08-11 | 2013-01-15 | Omrix Biopharmaceuticals Ltd. | Intravenous immunoglobulin composition |
PL2104682T3 (pl) | 2007-01-11 | 2017-03-31 | Michael Bacher | Diagnostyka i leczenie choroby Alzheimera i innych chorób neurodegeneracyjnych |
WO2008087184A2 (en) | 2007-01-17 | 2008-07-24 | Merck Serono S.A. | Process for the purification of fc-containing proteins |
US20100143377A1 (en) | 2007-04-12 | 2010-06-10 | Orgad Laub | Products for prophylaxis and/or treatment of viral diseases and methods of making and using same |
WO2009043103A1 (en) * | 2007-10-02 | 2009-04-09 | Csl Limited | Therapeutic antibody purification method and method of use |
KR101627157B1 (ko) * | 2007-12-27 | 2016-06-03 | 박스알타 인코퍼레이티드 | 샘플 내의 재조합 단백질로부터 혈장-유래 단백질의 분별 방법 |
AU2009236305B2 (en) | 2008-04-15 | 2014-04-10 | Grifols Therapeutics Inc. | Two-stage ultrafiltration/diafiltration |
US20100040601A1 (en) | 2008-06-10 | 2010-02-18 | Cantin Edouard M | Compositions and methods for treating herpes simplex virus infections and related diseases |
FR2939667B1 (fr) * | 2008-12-17 | 2012-01-27 | Fractionnement Et Des Biotechonologies Lab Franc | Composition d'immunoglobine g comme medicament pour le traitement de l'ictere neonatal par incompatibilite foetomaternelle dans le systeme abo |
AU2010253830B2 (en) | 2009-05-27 | 2016-03-03 | Takeda Pharmaceutical Company Limited | A method to produce a highly concentrated immunoglobulin preparation for subcutaneous use |
EP2366714A1 (en) * | 2010-03-03 | 2011-09-21 | Dr. Rentschler Holding GmbH & Co. KG | Naturally occuring autoantibodies against alpha-synuclein that inhibit the aggregation and cytotoxicity of alpha-synuclein |
US8796430B2 (en) * | 2010-05-26 | 2014-08-05 | Baxter International Inc. | Method to produce an immunoglobulin preparation with improved yield |
AU2010202125B1 (en) | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
US8772462B2 (en) | 2010-05-26 | 2014-07-08 | Baxter International Inc. | Removal of serine proteases by treatment with finely divided silicon dioxide |
WO2012049245A1 (en) | 2010-10-13 | 2012-04-19 | Octapharma Ag | Method for purification of complement factor h |
US20120183527A1 (en) * | 2011-01-18 | 2012-07-19 | Baxter International Inc. | Measurement of anti-amyloid antibodies in human blood |
TW201250247A (en) * | 2011-04-01 | 2012-12-16 | Baxter Int | Use of cytokine levels in intravenous immunoglobulin treatment of Alzheimer's disease |
IL212911A0 (en) | 2011-05-16 | 2011-07-31 | Omrix Biopharmaceuticals Ltd | Immunoglobulin reduced in thrombogenic contaminants and preparation thereof |
US20140341843A1 (en) | 2011-07-29 | 2014-11-20 | Eleven Biotherapeutics, Inc. | Purified proteins |
CN103874708B (zh) * | 2011-08-26 | 2018-07-10 | 百深有限责任公司 | 用于降低血浆来源免疫球蛋白组合物的血栓栓塞可能性的方法 |
AU2012321074B2 (en) | 2011-12-13 | 2015-12-03 | Takeda Pharmaceutical Company Limited | Measurement of autoantibodies at low conductivity conditions with increased sensitivity |
TWI629283B (zh) * | 2012-02-23 | 2018-07-11 | 巴克斯歐塔公司 | 來自血漿中的免疫球蛋白之i-iv-1部分沉澱 |
AU2013203043B2 (en) | 2013-03-15 | 2016-10-06 | Takeda Pharmaceutical Company Limited | Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs |
-
2013
- 2013-04-09 AU AU2013203043A patent/AU2013203043B2/en active Active
-
2014
- 2014-03-14 PL PL14721128T patent/PL2970377T3/pl unknown
- 2014-03-14 HU HUE14721128A patent/HUE047475T2/hu unknown
- 2014-03-14 US US14/213,335 patent/US9896501B2/en active Active
- 2014-03-14 LT LTEP14721128.8T patent/LT2970377T/lt unknown
- 2014-03-14 PT PT147211288T patent/PT2970377T/pt unknown
- 2014-03-14 EP EP14721128.8A patent/EP2970377B1/en active Active
- 2014-03-14 US US14/213,585 patent/US9556261B2/en active Active
- 2014-03-14 WO PCT/US2014/028953 patent/WO2014144511A1/en active Application Filing
- 2014-03-14 SI SI201431472T patent/SI2970377T1/sl unknown
- 2014-03-14 EP EP19204540.9A patent/EP3623377A1/en active Pending
- 2014-03-14 DK DK14721128.8T patent/DK2970377T3/da active
- 2014-03-14 ES ES14721128T patent/ES2763396T3/es active Active
-
2016
- 2016-12-20 US US15/385,721 patent/US10738107B2/en active Active
-
2020
- 2020-01-09 HR HRP20200035TT patent/HRP20200035T1/hr unknown
- 2020-06-30 US US16/917,701 patent/US20210054058A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20140271679A1 (en) | 2014-09-18 |
PT2970377T (pt) | 2020-01-21 |
AU2013203043A1 (en) | 2014-10-02 |
US20210054058A1 (en) | 2021-02-25 |
EP3623377A1 (en) | 2020-03-18 |
US9896501B2 (en) | 2018-02-20 |
HUE047475T2 (hu) | 2020-04-28 |
WO2014144511A1 (en) | 2014-09-18 |
US9556261B2 (en) | 2017-01-31 |
LT2970377T (lt) | 2020-02-10 |
AU2013203043B2 (en) | 2016-10-06 |
EP2970377A1 (en) | 2016-01-20 |
US20170218051A1 (en) | 2017-08-03 |
ES2763396T3 (es) | 2020-05-28 |
US20140271669A1 (en) | 2014-09-18 |
US10738107B2 (en) | 2020-08-11 |
PL2970377T3 (pl) | 2020-04-30 |
DK2970377T3 (da) | 2020-01-27 |
HRP20200035T1 (hr) | 2020-10-30 |
EP2970377B1 (en) | 2019-12-04 |
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