SI2909204T1 - Inhibitorji GSK3 in postopki njihove uporabe - Google Patents

Inhibitorji GSK3 in postopki njihove uporabe

Info

Publication number
SI2909204T1
SI2909204T1 SI201331368T SI201331368T SI2909204T1 SI 2909204 T1 SI2909204 T1 SI 2909204T1 SI 201331368 T SI201331368 T SI 201331368T SI 201331368 T SI201331368 T SI 201331368T SI 2909204 T1 SI2909204 T1 SI 2909204T1
Authority
SI
Slovenia
Prior art keywords
methods
gsk3 inhibitors
gsk3
inhibitors
Prior art date
Application number
SI201331368T
Other languages
English (en)
Slovenian (sl)
Inventor
Florence Fevrier Wagner
Jennifer Q. Pan
Sivaraman Dandapani
Andrew Germain
Edward Holson
Benito Munoz
Partha P. Nag
Michel Weiwer
Michael C. Lewis
Stephen J. Haggarty
Joshua A. Bishop
Kimberly Stegmaier
Versha Banerji
Original Assignee
The Broad Institute, Inc.
Dana-Farber Cancer Institute, Inc.
The General Hospital Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc., The General Hospital Corporation filed Critical The Broad Institute, Inc.
Publication of SI2909204T1 publication Critical patent/SI2909204T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4747—Quinolines; Isoquinolines spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SI201331368T 2012-10-12 2013-10-11 Inhibitorji GSK3 in postopki njihove uporabe SI2909204T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261713314P 2012-10-12 2012-10-12
US201361779394P 2013-03-13 2013-03-13
PCT/US2013/064716 WO2014059383A1 (en) 2012-10-12 2013-10-11 Gsk3 inhibitors and methods of use thereof
EP13780300.3A EP2909204B1 (en) 2012-10-12 2013-10-11 Gsk3 inhibitors and methods of use thereof

Publications (1)

Publication Number Publication Date
SI2909204T1 true SI2909204T1 (sl) 2019-06-28

Family

ID=49474737

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201331368T SI2909204T1 (sl) 2012-10-12 2013-10-11 Inhibitorji GSK3 in postopki njihove uporabe

Country Status (16)

Country Link
US (4) US9096594B2 (cg-RX-API-DMAC7.html)
EP (1) EP2909204B1 (cg-RX-API-DMAC7.html)
JP (2) JP6321662B2 (cg-RX-API-DMAC7.html)
CA (1) CA2887701C (cg-RX-API-DMAC7.html)
CY (1) CY1122601T1 (cg-RX-API-DMAC7.html)
DK (1) DK2909204T3 (cg-RX-API-DMAC7.html)
ES (1) ES2719776T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20190406T1 (cg-RX-API-DMAC7.html)
HU (1) HUE043853T2 (cg-RX-API-DMAC7.html)
LT (1) LT2909204T (cg-RX-API-DMAC7.html)
PL (1) PL2909204T3 (cg-RX-API-DMAC7.html)
PT (1) PT2909204T (cg-RX-API-DMAC7.html)
RS (1) RS58700B1 (cg-RX-API-DMAC7.html)
SI (1) SI2909204T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201900136T1 (cg-RX-API-DMAC7.html)
WO (1) WO2014059383A1 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
PL2909204T3 (pl) 2019-07-31
JP2015536307A (ja) 2015-12-21
LT2909204T (lt) 2019-05-10
CY1122601T1 (el) 2021-03-12
WO2014059383A1 (en) 2014-04-17
US10137122B2 (en) 2018-11-27
RS58700B1 (sr) 2019-06-28
SMT201900136T1 (it) 2019-05-10
JP2018150302A (ja) 2018-09-27
US9096594B2 (en) 2015-08-04
US20150313890A1 (en) 2015-11-05
US20220160702A1 (en) 2022-05-26
US20140107141A1 (en) 2014-04-17
US11052080B2 (en) 2021-07-06
PT2909204T (pt) 2019-03-21
US12419885B2 (en) 2025-09-23
DK2909204T3 (en) 2019-04-01
CA2887701C (en) 2020-12-15
JP6606691B2 (ja) 2019-11-20
HRP20190406T1 (hr) 2019-05-31
US20200061050A9 (en) 2020-02-27
EP2909204A1 (en) 2015-08-26
EP2909204B1 (en) 2018-12-05
US20190175584A1 (en) 2019-06-13
HUE043853T2 (hu) 2019-09-30
JP6321662B2 (ja) 2018-05-09
ES2719776T3 (es) 2019-07-16
CA2887701A1 (en) 2014-04-17

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