SI2908873T1 - TRANSDERMAL SYSTEM FOR DELIVERY - Google Patents
TRANSDERMAL SYSTEM FOR DELIVERY Download PDFInfo
- Publication number
- SI2908873T1 SI2908873T1 SI201430560T SI201430560T SI2908873T1 SI 2908873 T1 SI2908873 T1 SI 2908873T1 SI 201430560 T SI201430560 T SI 201430560T SI 201430560 T SI201430560 T SI 201430560T SI 2908873 T1 SI2908873 T1 SI 2908873T1
- Authority
- SI
- Slovenia
- Prior art keywords
- nitrite
- hydrogel
- layer
- active agent
- polymer
- Prior art date
Links
- 230000037317 transdermal delivery Effects 0.000 title claims 2
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims abstract 8
- 239000000017 hydrogel Substances 0.000 claims abstract 7
- -1 hydrogen ions Chemical class 0.000 claims abstract 7
- 239000013543 active substance Substances 0.000 claims abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 3
- 239000001257 hydrogen Substances 0.000 claims abstract 3
- 239000003814 drug Substances 0.000 claims abstract 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 2
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 229960004194 lidocaine Drugs 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical group [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims 2
- 229960002372 tetracaine Drugs 0.000 claims 2
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims 2
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- 230000003444 anaesthetic effect Effects 0.000 claims 1
- 229960005274 benzocaine Drugs 0.000 claims 1
- 229960003150 bupivacaine Drugs 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920003174 cellulose-based polymer Polymers 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 229960003920 cocaine Drugs 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000003589 local anesthetic agent Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- HLNRBHDRGMNBEG-UHFFFAOYSA-N nitrous acid Chemical compound ON=O.ON=O HLNRBHDRGMNBEG-UHFFFAOYSA-N 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229960001549 ropivacaine Drugs 0.000 claims 1
- 235000010288 sodium nitrite Nutrition 0.000 claims 1
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 1
- 229940100640 transdermal system Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/009—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/114—Nitric oxide, i.e. NO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201309092A GB201309092D0 (en) | 2013-05-20 | 2013-05-20 | Transdermal delivery system |
| PCT/GB2014/051544 WO2014188175A1 (en) | 2013-05-20 | 2014-05-20 | Transdermal delivery system |
| EP14727614.1A EP2908873B1 (en) | 2013-05-20 | 2014-05-20 | Transdermal delivery system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2908873T1 true SI2908873T1 (en) | 2018-04-30 |
Family
ID=48747065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201430560T SI2908873T1 (en) | 2013-05-20 | 2014-05-20 | TRANSDERMAL SYSTEM FOR DELIVERY |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10010648B2 (enExample) |
| EP (1) | EP2908873B1 (enExample) |
| JP (1) | JP6446035B2 (enExample) |
| CN (1) | CN105431175B (enExample) |
| AU (1) | AU2014270116B2 (enExample) |
| DK (1) | DK2908873T3 (enExample) |
| ES (1) | ES2658037T3 (enExample) |
| GB (1) | GB201309092D0 (enExample) |
| HR (1) | HRP20180079T1 (enExample) |
| HU (1) | HUE035847T2 (enExample) |
| LT (1) | LT2908873T (enExample) |
| NO (1) | NO2908873T3 (enExample) |
| PL (1) | PL2908873T3 (enExample) |
| PT (1) | PT2908873T (enExample) |
| RS (1) | RS56833B1 (enExample) |
| SI (1) | SI2908873T1 (enExample) |
| SM (1) | SMT201800030T1 (enExample) |
| WO (1) | WO2014188175A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201420761D0 (en) | 2014-11-21 | 2015-01-07 | Edixomed Ltd And First Water Ltd | Dressing system |
| GB201520990D0 (en) | 2015-11-27 | 2016-01-13 | Edixomed Ltd | Dressing system |
| TWI605843B (zh) * | 2016-12-21 | 2017-11-21 | 嘉藥學校財團法人嘉南藥理大學 | 氣相經皮吸收系統 |
| WO2019166572A1 (en) | 2018-02-28 | 2019-09-06 | Pharming Intellectual Property B.V. | Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor |
| US12220493B2 (en) | 2018-07-16 | 2025-02-11 | Systagenix Wound Management, Limited | Nitric oxide producing collagen/ORC dressing |
| EP3908241A4 (en) * | 2019-01-11 | 2022-12-07 | Noxsano Inc. | COMPOSITION FOR GENERATION OF ELECTROCHEMICAL GASOTRANSMITTER AND BIMETALLIC CELLS FOR GENERATION OF GASOTRANSMITTER |
| EP3980032A1 (en) * | 2019-06-04 | 2022-04-13 | Thirty Respiratory Limited | Methods and compositions for generating nitric oxide and uses thereof to deliver nitric oxide via the respiratory tract |
| GB2599576B (en) | 2019-06-04 | 2023-09-13 | Thirty Holdings Ltd | Methods and compositions for generating nitric oxide and uses thereof |
| CA3172240A1 (en) * | 2020-04-02 | 2021-10-07 | Maria ASPIOTI | Wound dressing |
| GB202004868D0 (en) * | 2020-04-02 | 2020-05-20 | Smith & Nephew | Wound care compositions and methods of preparation thereof |
| GB2610721B (en) | 2020-04-23 | 2024-07-31 | Thirty Respiratory Ltd | Compositions for treating and combatting tuberculosis |
| EP4138795A1 (en) | 2020-04-23 | 2023-03-01 | Thirty Respiratory Limited | Nitric oxide or nitric oxide releasing compositions for use in treating sars-cov and sars-cov-2 |
| CN113101053A (zh) * | 2021-03-30 | 2021-07-13 | 上海健康医学院 | 一种可释放一氧化氮的创伤敷料 |
| US12514756B1 (en) | 2024-10-08 | 2026-01-06 | Covidien Lp | Dermal patch and systems, kits, and methods associated therewith |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA837139B (en) | 1982-10-26 | 1984-05-30 | Kennecott Corp | Two high hot rolling mill process and narrow strip product |
| EP0139127A1 (en) | 1983-08-22 | 1985-05-02 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Transdermal drug delivery device and its preparation |
| EP1100556B1 (en) | 1998-07-31 | 2003-11-12 | First Water Limited | Bioadhesive compositions and biomedical electrodes containing them |
| GB9905425D0 (en) | 1999-03-09 | 1999-05-05 | Queen Mary & Westfield College | Pharmaceutical composition |
| GB0021317D0 (en) | 2000-08-30 | 2000-10-18 | Queen Mary & Westfield College | Transdermal pharmaceutical delivery composition |
| CA2323382C (en) | 2000-10-17 | 2004-04-13 | Pharma Mag Inc. | Wound dressing |
| GB0715556D0 (en) | 2007-08-09 | 2007-09-19 | Insense Ltd | Improvements relating to skin dressings |
| GB0715554D0 (en) | 2007-08-09 | 2007-09-19 | Insense Ltd | Improvements relating to skin dressings |
| US20100055161A1 (en) | 2008-08-27 | 2010-03-04 | Dong June Ahn | Hydrogel face mask for delivering skin care agents |
| CA2777066C (en) | 2009-10-14 | 2020-02-18 | TheraVasc, LLC | Pharmaceutical formulations of nitrite and uses thereof |
| ES2675879T3 (es) | 2009-12-22 | 2018-07-13 | Rigshospitalet, Copenhagen University Hospital | Productos para el cuidado de heridas |
| GB201309091D0 (en) * | 2013-05-20 | 2013-07-03 | Edixomed Ltd | Dressing system |
-
2013
- 2013-05-20 GB GB201309092A patent/GB201309092D0/en not_active Ceased
-
2014
- 2014-05-20 EP EP14727614.1A patent/EP2908873B1/en active Active
- 2014-05-20 SI SI201430560T patent/SI2908873T1/en unknown
- 2014-05-20 HR HRP20180079TT patent/HRP20180079T1/hr unknown
- 2014-05-20 US US14/892,218 patent/US10010648B2/en active Active
- 2014-05-20 SM SM20180030T patent/SMT201800030T1/it unknown
- 2014-05-20 CN CN201480029019.7A patent/CN105431175B/zh active Active
- 2014-05-20 PL PL14727614T patent/PL2908873T3/pl unknown
- 2014-05-20 PT PT147276141T patent/PT2908873T/pt unknown
- 2014-05-20 AU AU2014270116A patent/AU2014270116B2/en active Active
- 2014-05-20 NO NO14727614A patent/NO2908873T3/no unknown
- 2014-05-20 HU HUE14727614A patent/HUE035847T2/en unknown
- 2014-05-20 ES ES14727614.1T patent/ES2658037T3/es active Active
- 2014-05-20 JP JP2016514478A patent/JP6446035B2/ja active Active
- 2014-05-20 WO PCT/GB2014/051544 patent/WO2014188175A1/en not_active Ceased
- 2014-05-20 DK DK14727614.1T patent/DK2908873T3/en active
- 2014-05-20 LT LTEP14727614.1T patent/LT2908873T/lt unknown
- 2014-05-20 RS RS20180044A patent/RS56833B1/sr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN105431175B (zh) | 2018-12-28 |
| JP6446035B2 (ja) | 2018-12-26 |
| GB201309092D0 (en) | 2013-07-03 |
| EP2908873A1 (en) | 2015-08-26 |
| RS56833B1 (sr) | 2018-04-30 |
| LT2908873T (lt) | 2018-02-12 |
| SMT201800030T1 (it) | 2018-03-08 |
| NO2908873T3 (enExample) | 2018-03-17 |
| AU2014270116A1 (en) | 2015-12-10 |
| JP2016518458A (ja) | 2016-06-23 |
| AU2014270116B2 (en) | 2017-12-21 |
| PT2908873T (pt) | 2018-01-23 |
| WO2014188175A1 (en) | 2014-11-27 |
| ES2658037T3 (es) | 2018-03-08 |
| HUE035847T2 (en) | 2018-05-28 |
| US20160089473A1 (en) | 2016-03-31 |
| EP2908873B1 (en) | 2017-10-18 |
| CN105431175A (zh) | 2016-03-23 |
| DK2908873T3 (en) | 2018-01-22 |
| US10010648B2 (en) | 2018-07-03 |
| HRP20180079T1 (hr) | 2018-04-06 |
| PL2908873T3 (pl) | 2018-06-29 |
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