SI2723363T1 - Kombinacijska terapija za ishemijo - Google Patents

Kombinacijska terapija za ishemijo

Info

Publication number
SI2723363T1
SI2723363T1 SI201231412T SI201231412T SI2723363T1 SI 2723363 T1 SI2723363 T1 SI 2723363T1 SI 201231412 T SI201231412 T SI 201231412T SI 201231412 T SI201231412 T SI 201231412T SI 2723363 T1 SI2723363 T1 SI 2723363T1
Authority
SI
Slovenia
Prior art keywords
ischemia
combination therapy
therapy
combination
Prior art date
Application number
SI201231412T
Other languages
English (en)
Inventor
Michael Tymianski
Original Assignee
Nono Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nono Inc. filed Critical Nono Inc.
Publication of SI2723363T1 publication Critical patent/SI2723363T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1787—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Dermatology (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Nuclear Medicine (AREA)
SI201231412T 2011-06-24 2012-06-23 Kombinacijska terapija za ishemijo SI2723363T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161501117P 2011-06-24 2011-06-24
US201261617001P 2012-03-28 2012-03-28
PCT/IB2012/053178 WO2012176172A2 (en) 2011-06-24 2012-06-23 Combination therapy for ischemia
EP12802409.8A EP2723363B1 (en) 2011-06-24 2012-06-23 Combination therapy for ischemia

Publications (1)

Publication Number Publication Date
SI2723363T1 true SI2723363T1 (sl) 2018-12-31

Family

ID=47423033

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201231412T SI2723363T1 (sl) 2011-06-24 2012-06-23 Kombinacijska terapija za ishemijo

Country Status (18)

Country Link
US (3) US10064910B2 (sl)
EP (3) EP4052721A1 (sl)
JP (5) JP6401057B2 (sl)
KR (5) KR102425466B1 (sl)
CN (1) CN103648518B (sl)
AU (1) AU2012274910B2 (sl)
CA (1) CA2839630A1 (sl)
CY (1) CY1121379T1 (sl)
DK (2) DK2723363T3 (sl)
ES (2) ES2912042T3 (sl)
HR (2) HRP20220519T1 (sl)
HU (2) HUE040564T2 (sl)
LT (1) LT2723363T (sl)
PL (2) PL2723363T3 (sl)
PT (2) PT3427748T (sl)
RS (1) RS57798B1 (sl)
SI (1) SI2723363T1 (sl)
WO (1) WO2012176172A2 (sl)

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CN102458441A (zh) 2009-06-10 2012-05-16 诺诺公司 用于治疗神经疾病的模型系统和治疗方案
DK2723363T3 (en) 2011-06-24 2018-10-15 Nono Inc COMBINATION THERAPY AGAINST CREAM
US9241970B2 (en) 2011-12-13 2016-01-26 Nono Inc. Therapy for subarachnoid hemorrhage and ischemia
CZ2012476A3 (cs) * 2012-07-12 2014-01-22 Ústav organické chemie a biochemie Akademie věd ČR, v. v. i. Lipidované peptidy jako antiobezitika
US10220008B2 (en) 2013-08-14 2019-03-05 Stc.Unm Treatment and prevention of stroke and other neurological disorders
EP3074030A4 (en) * 2013-11-26 2017-08-16 Trustees of Dartmouth College Method for mitigating or alleviating synaptic and cognitive deficits
FR3021319B1 (fr) * 2014-05-22 2018-08-31 Sederma Peptides, compositions les comprenant et utilisations notamment cosmetiques
CZ309217B6 (cs) * 2014-05-27 2022-06-01 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Lipidované peptidy jako neuroprotektiva
AU2015265487B2 (en) * 2014-05-28 2020-08-13 Nono Inc. Chloride salt of TAT-NR2B9c
US9526768B2 (en) 2014-11-13 2016-12-27 Jennifer Mai Compositions for the treatment of cancer
CN104497106B (zh) * 2014-12-05 2017-05-10 华中科技大学 一种小分子多肽、其应用及产品
CN107312069B (zh) * 2016-04-27 2018-11-06 拜西欧斯（北京）生物技术有限公司 兴奋性神经毒性相关损伤的治疗肽
US11229675B2 (en) 2016-04-27 2022-01-25 Biocells (Beijing) Biotech Co., Ltd. Therapeutic peptides for excitatory neurotoxicity-related injuries
WO2017185250A1 (zh) * 2016-04-27 2017-11-02 拜西欧斯（北京）生物技术有限公司 兴奋性神经毒性相关损伤的治疗方法
CN107446016A (zh) * 2016-05-30 2017-12-08 上海交通大学 一种硬脂酸修饰的细胞穿膜肽及其制备与应用
CN106265594B (zh) * 2016-09-21 2019-07-26 南京医科大学 一种缺血性脑卒中靶向的红细胞膜仿生智能药物载体及其制备方法
CN106749559B (zh) * 2016-11-23 2020-09-04 郑州大学 一种基于细胞穿膜肽Tat(49-57)的抗菌肽及其合成方法
JP7109958B2 (ja) * 2017-04-04 2022-08-01 キヤノンメディカルシステムズ株式会社 磁気共鳴イメージングシステム、磁気共鳴イメージング装置、及び磁気共鳴イメージング方法
CN110799522B (zh) * 2017-07-05 2023-08-29 拜西欧斯（北京）生物技术有限公司 用于治疗、改善或预防脑出血的肽及其用途
BR112020000115A2 (pt) * 2017-07-05 2020-07-07 Biocells (Beijing) Biotech Co., Ltd. sais farmaceuticamente aceitáveis de polipeptídeos e uso dos mesmos
BR112020006321A2 (pt) 2017-09-30 2020-11-17 Biocells (Beijing) Biotech Co., Ltd. composição de peptídeos para tratamento de lesões relacionadas a neurotoxicidade excitatória
WO2019195741A1 (en) * 2018-04-06 2019-10-10 Northwestern University Bdnf mimetic peptide amphiphiles
JP7158904B2 (ja) * 2018-06-14 2022-10-24 社会福祉法人 恩賜財団済生会熊本病院 治療方針決定支援装置、治療方針決定支援装置の作動方法、および治療方針決定支援プログラム
JP2023514394A (ja) * 2020-02-19 2023-04-05 ノノ インコーポレイテッド プラスミンで切断可能なｐｓｄ－９５阻害剤及び再灌流を用いる脳卒中の併用療法
EP4106818A4 (en) * 2020-02-19 2024-03-20 Nono Inc INHIBITION OF REPERFUSION INJURY WITH A PSD-95 INHIBITOR
CN113735938A (zh) * 2021-07-30 2021-12-03 英纳氏(珠海)药业有限公司 一种神经保护多肽化合物及其应用
WO2023192848A1 (en) * 2022-03-28 2023-10-05 University Of Maryland, Baltimore Methods and compositions for the treatment of stroke
CN117422722B (zh) * 2023-12-19 2024-03-29 北京智源人工智能研究院 基于adc图像的肿瘤预后特征评估的方法和装置

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DK2723363T3 (en) 2011-06-24 2018-10-15 Nono Inc COMBINATION THERAPY AGAINST CREAM
US9241970B2 (en) 2011-12-13 2016-01-26 Nono Inc. Therapy for subarachnoid hemorrhage and ischemia
DK2800575T3 (da) 2011-12-13 2019-07-01 Nono Inc Behandling af subarachnoidalblødning og iskæmi

Also Published As

Publication number Publication date
EP2723363B1 (en) 2018-08-29
DK3427748T3 (da) 2022-04-19
HRP20181526T1 (hr) 2018-12-14
EP2723363A4 (en) 2014-12-10
KR102140169B1 (ko) 2020-07-31
CA2839630A1 (en) 2012-12-27
KR20190107195A (ko) 2019-09-18
WO2012176172A3 (en) 2013-03-28
AU2012274910A1 (en) 2014-01-16
JP2019038831A (ja) 2019-03-14
CY1121379T1 (el) 2020-05-29
AU2012274910B2 (en) 2017-05-11
HUE040564T2 (hu) 2019-03-28
HRP20220519T1 (hr) 2022-05-27
PT2723363T (pt) 2018-11-08
PL3427748T3 (pl) 2022-05-30
JP2017193535A (ja) 2017-10-26
PL2723363T3 (pl) 2018-12-31
US10064910B2 (en) 2018-09-04
DK2723363T3 (en) 2018-10-15
KR102425466B1 (ko) 2022-07-25
JP7085457B2 (ja) 2022-06-16
EP4052721A1 (en) 2022-09-07
JP2014520142A (ja) 2014-08-21
EP2723363A2 (en) 2014-04-30
CN103648518B (zh) 2016-11-16
US11878044B2 (en) 2024-01-23
JP2022188068A (ja) 2022-12-20
KR102296106B1 (ko) 2021-08-30
EP3427748A1 (en) 2019-01-16
JP7143374B2 (ja) 2022-09-28
ES2690994T3 (es) 2018-11-23
KR20200092437A (ko) 2020-08-03
LT2723363T (lt) 2018-10-25
US20190091283A1 (en) 2019-03-28
JP2020189859A (ja) 2020-11-26
KR102022116B1 (ko) 2019-09-18
EP3427748B1 (en) 2022-03-02
JP6401057B2 (ja) 2018-10-03
KR20140053971A (ko) 2014-05-08
HUE058238T2 (hu) 2022-07-28
US20210308209A1 (en) 2021-10-07
WO2012176172A2 (en) 2012-12-27
US10967041B2 (en) 2021-04-06
KR20220106862A (ko) 2022-07-29
CN103648518A (zh) 2014-03-19
US20140248257A1 (en) 2014-09-04
RS57798B1 (sr) 2018-12-31
KR20210109661A (ko) 2021-09-06
PT3427748T (pt) 2022-05-03
ES2912042T3 (es) 2022-05-24

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