SI2440253T1 - Alkil fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic - Google Patents

Alkil fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic

Info

Publication number
SI2440253T1
SI2440253T1 SI201032012T SI201032012T SI2440253T1 SI 2440253 T1 SI2440253 T1 SI 2440253T1 SI 201032012 T SI201032012 T SI 201032012T SI 201032012 T SI201032012 T SI 201032012T SI 2440253 T1 SI2440253 T1 SI 2440253T1
Authority
SI
Slovenia
Prior art keywords
imaging
detection
stem cells
cancer
phospholipid compounds
Prior art date
Application number
SI201032012T
Other languages
English (en)
Inventor
Jamey P. Weichert
Anatoly Pinchuk
Irawati Kandela
Marc Longino
William R. Clarke
Original Assignee
Cellectar, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellectar, Inc. filed Critical Cellectar, Inc.
Publication of SI2440253T1 publication Critical patent/SI2440253T1/sl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0408—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1021—Radioactive fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/02—Radiation therapy using microwaves

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI201032012T 2009-06-12 2010-06-11 Alkil fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic SI2440253T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18660009P 2009-06-12 2009-06-12
PCT/US2010/038294 WO2010144788A2 (en) 2009-06-12 2010-06-11 Ether and alkyl phospholipid compounds for treating cancer and imaging and detection of cancer stem cells
EP10786904.2A EP2440253B1 (en) 2009-06-12 2010-06-11 Alkyl phospholipid compounds for treating cancer and imaging and detection of cancer stem cells

Publications (1)

Publication Number Publication Date
SI2440253T1 true SI2440253T1 (sl) 2020-09-30

Family

ID=43306617

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201032012T SI2440253T1 (sl) 2009-06-12 2010-06-11 Alkil fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic
SI201032132T SI3708192T1 (sl) 2009-06-12 2010-06-11 Eter fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI201032132T SI3708192T1 (sl) 2009-06-12 2010-06-11 Eter fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic

Country Status (8)

Country Link
US (3) US20100316567A1 (sl)
EP (3) EP2440253B1 (sl)
JP (2) JP6092624B2 (sl)
DK (2) DK2440253T3 (sl)
ES (2) ES2799411T3 (sl)
RU (1) RU2012100765A (sl)
SI (2) SI2440253T1 (sl)
WO (1) WO2010144788A2 (sl)

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ES2440257T3 (es) 2004-03-02 2014-01-28 Cellectar, Inc. Análogo fosfolipídico para el diagnóstico in vivo de cánceres
US8540968B2 (en) 2004-03-02 2013-09-24 Cellectar, Inc. Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof
WO2010132428A1 (en) 2009-05-11 2010-11-18 Cellectar, Inc. Fluorescent phospholipid ether compounds, compositions, and methods of use
US8871181B2 (en) 2009-05-11 2014-10-28 Cellectar, Inc. Fluorescent phospholipid ether compounds, compositions, and methods of use
JP6092624B2 (ja) 2009-06-12 2017-03-08 セレクター，インコーポレイティド 癌の治療並びに癌幹細胞の造影および検出のためのエーテルおよびアルキルリン脂質化合物
US20110064660A1 (en) * 2009-09-11 2011-03-17 Pinchuk Anatoly Deuterated alkyl phospholipid compounds, compositions, and methods of use
RU2012114146A (ru) * 2009-09-11 2013-10-20 Селлектар, Инк. Нерадиоактивные фосфолипидные соединения, композиции и способы их применения
WO2016073737A1 (en) 2014-11-05 2016-05-12 The Regents Of The University Of California Methods of selecting and isolating cancer stem cells
CA2968145C (en) 2014-11-17 2023-06-27 Cellectar Biosciences, Inc. Phospholipid ether analogs as cancer-targeting drug vehicles
CN108430520B (zh) * 2015-11-06 2021-08-13 威斯康星校友研究基金会 长效钆基肿瘤靶向成像与治疗剂
JP2017135134A (ja) 2016-01-25 2017-08-03 パナソニックＩｐマネジメント株式会社 発光装置
US11147823B2 (en) * 2016-07-13 2021-10-19 Wisconsin Alumni Research Foundation Phospholipid ether analogs for imaging and targeted treatment of pediatric solid tumors
US11633506B2 (en) 2016-07-18 2023-04-25 Wisconsin Alumni Research Foundation Using targeted radiotherapy (TRT) to drive anti-tumor immune response to immunotherapies
AU2017300361A1 (en) * 2016-07-18 2019-02-07 Wisconsin Alumni Research Foundation Radiohalogenated agents for In Situ Immune Modulated Cancer Vaccination
KR102332958B1 (ko) * 2016-07-25 2021-11-29 위스콘신 얼럼나이 리서어치 화운데이션 암 영상화 및 치료를 위한 방사성 인지질 금속 킬레이트
CN109789207B (zh) * 2016-07-25 2022-11-18 威斯康星校友研究基金会 用于原位免疫调节的癌症疫苗接种的靶向放射治疗螯合物
KR20200088374A (ko) * 2017-11-10 2020-07-22 위스콘신 얼럼나이 리서어치 화운데이션 면역요법에 대한 항-종양 면역 반응을 유도하기 위해 표적화된 방사선요법(trt)을 이용하는 방법
JP2021521174A (ja) * 2018-04-10 2021-08-26 セレクター・バイオサイエンシズ・インコーポレイテッド 癌治療のためのエーテル型リン脂質類似体の分割投与
JP2022551495A (ja) * 2019-10-10 2022-12-09 セレクター・バイオサイエンシズ・インコーポレイテッド リン脂質－フラバグリン抱合体及び標的化されたがん治療のためのリン脂質－フラバグリン抱合体の使用方法
IL291980A (en) * 2019-10-10 2022-06-01 Cellectar Biosciences Inc Fractionated Dose of a Phospholipid Ether Analogue for Cancer Treatment

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Also Published As

Publication number Publication date
US20130343991A1 (en) 2013-12-26
RU2012100765A (ru) 2013-07-20
WO2010144788A3 (en) 2014-03-20
EP2440253B1 (en) 2020-05-13
EP2440253A2 (en) 2012-04-18
SI3708192T1 (sl) 2023-12-29
EP4248999A3 (en) 2023-11-15
US9339564B2 (en) 2016-05-17
EP2440253A4 (en) 2016-01-13
US10004818B2 (en) 2018-06-26
DK3708192T3 (da) 2023-11-06
US20100316567A1 (en) 2010-12-16
US20160228588A1 (en) 2016-08-11
JP6092624B2 (ja) 2017-03-08
EP3708192B1 (en) 2023-08-02
JP2016011303A (ja) 2016-01-21
DK2440253T3 (da) 2020-07-20
WO2010144788A2 (en) 2010-12-16
EP4248999A2 (en) 2023-09-27
ES2799411T3 (es) 2020-12-17
ES2959862T3 (es) 2024-02-28
EP3708192A1 (en) 2020-09-16
JP2012530063A (ja) 2012-11-29

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