JP2021521174A - 癌治療のためのエーテル型リン脂質類似体の分割投与 - Google Patents
癌治療のためのエーテル型リン脂質類似体の分割投与 Download PDFInfo
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Abstract
Description
この出願は、2018年4月10日に出願の米国仮特許出願第62/655,615号の優先権を主張し、その内容の全体が参照により本明細書に完全に組み込まれる。
本開示は、癌の治療のためにCLR1404を投与する投薬レジメンを提供する。本明細書に記載されるように、CLR1404の分割投与は、十分な耐性があり、CLR1404の同等量の単回投与よりも耐性が高い。第2世代のエーテル型リン脂質(「PLE」)類似体である放射性ヨウ素化されたCLR1404は、以下の構造
1.定義
2.本発明の化合物
3.本発明の組成物
4.分割投与
a.併用療法
b.癌
例示の目的で提示される以下の実施例を参照することで上述の内容の理解が深まるが、それら実施例は、本発明の範囲を限定することを意図するものではない。本発明は、以下の非限定的な実施例によって説明される複数の側面を有する。
実施例1
実施例3
a)有効量の131I標識18−(p−ヨードフェニル)オクタデシルホスホコリンまたはその塩を投与することを含み、前記131I標識18−(p−ヨードフェニル)オクタデシルホスホコリンまたはその塩は、分割用量として投与される、方法。
Claims (12)
- 対象の癌を治療する方法であって、
a)有効量の131I標識18−(p−ヨードフェニル)オクタデシルホスホコリンまたはその塩を投与することを含み、前記131I標識18−(p−ヨードフェニル)オクタデシルホスホコリンまたはその塩を分割用量として投与する、方法。 - 前記131I標識18−(p−ヨードフェニル)オクタデシルホスホコリンまたはその塩を、単回投薬サイクルに従って投与し、前記単回投薬サイクルは、1日目に単回用量を1回投与し4日目に単回用量を1回投与すること、1日目に単回用量を1回投与し5日目に単回用量を1回投与すること、1日目に単回用量を1回投与し6日目に単回用量を1回投与すること、1日目に単回用量を1回投与し7日目に単回用量を1回投与すること、1日目に単回用量を1回投与し8日目に単回用量を1回投与すること、1日目に単回用量を1回投与し9日目に単回用量を1回投与すること、1日目に単回用量を1回投与し10日目に単回用量を1回投与すること、1日目に単回用量を1回投与し11日目に単回用量を1回投与すること、1日目に単回用量を1回投与し12日目に単回用量を1回投与すること、および1日目に単回用量を1回投与し13日目に単回用量を1回投与することからなる群から選択される、請求項1に記載の方法。
- 前記単回投薬サイクルが、1日目に単回用量を1回投与し8日目(1日目から7日後)に単回用量を1回投与することである、請求項2に記載の方法。
- 前記対象がヒトである、請求項1に記載の方法。
- 前記131I標識18−(p−ヨードフェニル)オクタデシルホスホコリンまたはその塩が、対象の癌細胞に対して選択的である、請求項1に記載の方法。
- 前記131I標識18−(p−ヨードフェニル)オクタデシルホスホコリンまたはその塩を、1mCi〜100mCi/m2の用量範囲で投与する、請求項1に記載の方法。
- 前記用量が、対象の体重1kg当たり1mCi〜100mCiである、請求項1に記載の方法。
- 前記癌が、多発性骨髄腫、リンパ腫、神経芽細胞腫、肉腫、白血病、転移性腫瘍、肝臓がん、肺がん、脳腫瘍、膵臓がん、黒色腫、腺がん、DIPG、小児リンパ腫、または乳がんである、請求項1に記載の方法。
- 前記癌が分割用量放射に適している、請求項1に記載の方法。
- 前記方法が、化学療法、免疫療法、細胞療法、放射線増感療法、放射線防護療法、外部ビーム照射法、腫瘍切除術、切除療法、ならびに寒冷(低温)、熱(高温)、高周波、およびマイクロ波に基づく局所的な物理治療からなる群から選択される別の癌療法をさらに含む、請求項1に記載の方法。
- 前記131I標識18−(p−ヨードフェニル)オクタデシルホスホコリンまたはその塩を、1mCi〜100mCi/m2の用量範囲で、1日目に単回用量としてかつ8日目(1日目から7日後)に単回用量として投与する、請求項1に記載の方法。
- 前記用量が、対象の体重1kg当たり1mCi〜100mCiであり、そして1日目に単回用量としてかつ8日目(1日目から7日後)に単回用量として投与される、請求項7に記載の方法。
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JP2012530063A (ja) * | 2009-06-12 | 2012-11-29 | セレクター,インコーポレイティド | 癌の治療並びに癌幹細胞の造影および検出のためのエーテルおよびアルキルリン脂質化合物 |
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WO2019199998A1 (en) | 2019-10-17 |
MX2020010745A (es) | 2020-11-09 |
MA52250A (fr) | 2021-02-17 |
CA3096677A1 (en) | 2019-10-17 |
BR112020020758A2 (pt) | 2021-01-19 |
US20210106700A1 (en) | 2021-04-15 |
SG11202009550PA (en) | 2020-10-29 |
AU2019252254A1 (en) | 2020-10-15 |
IL277877A (en) | 2020-11-30 |
EA202092367A1 (ru) | 2021-01-12 |
EP3773754A1 (en) | 2021-02-17 |
KR20200143688A (ko) | 2020-12-24 |
CN112118871A (zh) | 2020-12-22 |
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