SI2244739T1 - Vodotopni polimeri, ki vsebujejo selen, in njihovi konjugati - Google Patents

Vodotopni polimeri, ki vsebujejo selen, in njihovi konjugati

Info

Publication number
SI2244739T1
SI2244739T1 SI200930390T SI200930390T SI2244739T1 SI 2244739 T1 SI2244739 T1 SI 2244739T1 SI 200930390 T SI200930390 T SI 200930390T SI 200930390 T SI200930390 T SI 200930390T SI 2244739 T1 SI2244739 T1 SI 2244739T1
Authority
SI
Slovenia
Prior art keywords
conjugates
selenium
containing water
soluble polymers
polymers
Prior art date
Application number
SI200930390T
Other languages
English (en)
Inventor
Menci Kunstelj
Viktor Menart
Gabriela Ambrozic
Porekar Vladka Gaberc
Original Assignee
Lek Pharmaceuticals D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals D.D. filed Critical Lek Pharmaceuticals D.D.
Publication of SI2244739T1 publication Critical patent/SI2244739T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C391/00—Compounds containing selenium

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200930390T 2008-02-27 2009-02-13 Vodotopni polimeri, ki vsebujejo selen, in njihovi konjugati SI2244739T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08003584A EP2095829A1 (en) 2008-02-27 2008-02-27 Selenium containing modifying agents and conjugates
EP09715402A EP2244739B1 (en) 2008-02-27 2009-02-13 Selenium-containing water-soluble polymers and their conjugates
PCT/EP2009/001039 WO2009106239A1 (en) 2008-02-27 2009-02-13 Selenium containing modifying agents and conjugates

Publications (1)

Publication Number Publication Date
SI2244739T1 true SI2244739T1 (sl) 2012-12-31

Family

ID=39545003

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200930390T SI2244739T1 (sl) 2008-02-27 2009-02-13 Vodotopni polimeri, ki vsebujejo selen, in njihovi konjugati

Country Status (9)

Country Link
US (1) US8389695B2 (sl)
EP (2) EP2095829A1 (sl)
JP (1) JP5349501B2 (sl)
CN (1) CN101965199B (sl)
AU (1) AU2009218835B2 (sl)
CA (1) CA2717276C (sl)
HK (1) HK1149498A1 (sl)
SI (1) SI2244739T1 (sl)
WO (1) WO2009106239A1 (sl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2314646A1 (en) * 2009-10-20 2011-04-27 ETH Zurich Diselenide-resins for oxidative protein folding
WO2014144878A2 (en) * 2013-03-15 2014-09-18 The Scripps Research Institute Novel thiol & amino modifying reagents for protein chemistry and methods of use thereof
US9670537B2 (en) 2014-06-06 2017-06-06 Titan Collaborative Kithe, Llc Borrelia Provocation Procedure kit
EP3040310B1 (en) * 2015-01-05 2017-03-01 Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs
JP6376979B2 (ja) * 2015-01-13 2018-08-22 行政院原子能委員會核能研究所 放射線感受性共重合体を構成成分とするナノキャリアの合成方法
CN113292050B (zh) * 2021-07-02 2023-08-29 安徽农业大学 纳米硒双球及其制备方法
CN114949242B (zh) * 2022-01-27 2023-09-22 暨南大学 含硒化合物在制备破骨细胞分化抑制剂中的应用
CN115677621A (zh) * 2022-10-24 2023-02-03 广州医科大学 苯并噻硒唑-1-酮化合物及其对映异构体的合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1055932A (en) 1975-10-22 1979-06-05 Hematech Inc. Blood substitute based on hemoglobin
DE2616086C2 (de) 1976-04-13 1986-04-03 Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg Substanz zur Verwendung in einem kolloidalen Blutvolumenersatzmittel aus Hydroxyethylstärke und Hämoglobin
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
IL77081A (en) 1984-12-04 1999-10-28 Genetics Inst AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin
US5104852A (en) * 1989-02-27 1992-04-14 The Ohio State University Method for the inhibition of the proliferation of cancer cells in a tumor sensitive to treatment with a selenodithiol by the injection into the tumor of a selenodithiol such as selenodiglutathione
CN1057534C (zh) 1993-08-17 2000-10-18 柯瑞英-艾格公司 促红细胞生成素类似物
US6043098A (en) * 1994-05-17 2000-03-28 Spallholz; Julian E. Method for the preparation of free radical pharmaceuticals, diagnostics and devices using selenium conjugates
CA2326618A1 (en) * 1998-04-15 1999-10-21 Baxter International Inc. Inhibition of xenoreactive antibodies
ES2367891T3 (es) * 2000-09-29 2011-11-10 Schering Corporation Interleucina-10 pegilada.
WO2004061094A1 (en) * 2002-12-30 2004-07-22 Gryphon Therapeutics, Inc. Water-soluble thioester and selenoester compounds and methods for making and using the same
ATE485331T1 (de) 2003-01-06 2010-11-15 Nektar Therapeutics Thiolselektive wasserlösliche polymerderivate
EP1586334A1 (en) 2004-04-15 2005-10-19 TRASTEC scpa G-CSF conjugates with peg
US20100016550A1 (en) * 2006-05-26 2010-01-21 Zheng Xin Dong Methods for Site-Specific Pegylation
BRPI0716680A2 (pt) 2006-11-02 2013-09-24 Daniel J Capon "composto, multÍmero, composiÇço, mÉtodo de afetar a atividade de um alvo, complexo, processo de produÇço do composto, mÉtodo de produÇço de um extensço de aminoÁcidos consecutivos, processo de produÇço de uma extensço de aminoacidos consecutivos , processo para a produÇço de um composto , mÉtodo de produÇço de uma proteina e polipeptÍdeo"

Also Published As

Publication number Publication date
US8389695B2 (en) 2013-03-05
WO2009106239A1 (en) 2009-09-03
JP2011523936A (ja) 2011-08-25
JP5349501B2 (ja) 2013-11-20
US20110092420A1 (en) 2011-04-21
EP2244739B1 (en) 2012-08-29
CN101965199A (zh) 2011-02-02
CN101965199B (zh) 2012-10-31
CA2717276A1 (en) 2009-09-03
EP2244739A1 (en) 2010-11-03
EP2095829A1 (en) 2009-09-02
HK1149498A1 (en) 2011-10-07
AU2009218835B2 (en) 2012-08-23
AU2009218835A1 (en) 2009-09-03
CA2717276C (en) 2013-05-21

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