SI2125821T1 - Postopek za pripravo sildenafila - Google Patents

Postopek za pripravo sildenafila

Info

Publication number
SI2125821T1
SI2125821T1 SI200730732T SI200730732T SI2125821T1 SI 2125821 T1 SI2125821 T1 SI 2125821T1 SI 200730732 T SI200730732 T SI 200730732T SI 200730732 T SI200730732 T SI 200730732T SI 2125821 T1 SI2125821 T1 SI 2125821T1
Authority
SI
Slovenia
Prior art keywords
compound
formula
iii
preparing
present
Prior art date
Application number
SI200730732T
Other languages
English (en)
Inventor
BOMBEK@Sergeja
STROPNIK@Tadej
Original Assignee
KRKA@tovarna@zdravil@d@d@@@Novo@mesto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KRKA@tovarna@zdravil@d@d@@@Novo@mesto filed Critical KRKA@tovarna@zdravil@d@d@@@Novo@mesto
Publication of SI2125821T1 publication Critical patent/SI2125821T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SI200730732T 2006-12-21 2007-12-21 Postopek za pripravo sildenafila SI2125821T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2006/003530 WO2008074194A1 (fr) 2006-12-21 2006-12-21 Procédé de préparation du sildénafil et de ses intermédiaires
PCT/EP2007/011355 WO2008074512A1 (en) 2006-12-21 2007-12-21 Process for the preparation of sildenafil
EP07857066A EP2125821B1 (en) 2006-12-21 2007-12-21 Process for the preparation of sildenafil

Publications (1)

Publication Number Publication Date
SI2125821T1 true SI2125821T1 (sl) 2011-11-30

Family

ID=39267890

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200730732T SI2125821T1 (sl) 2006-12-21 2007-12-21 Postopek za pripravo sildenafila

Country Status (12)

Country Link
US (1) US8071765B2 (sl)
EP (1) EP2125821B1 (sl)
CN (1) CN101563348B (sl)
AT (1) ATE516289T1 (sl)
EA (1) EA019160B1 (sl)
ES (1) ES2367976T3 (sl)
NO (1) NO20092573L (sl)
PL (1) PL2125821T3 (sl)
PT (1) PT2125821E (sl)
SI (1) SI2125821T1 (sl)
UA (1) UA99447C2 (sl)
WO (2) WO2008074194A1 (sl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101563348B (zh) * 2006-12-21 2011-08-24 上海特化医药科技有限公司 西地那非的制备方法及其中间体
AT512084A1 (de) 2011-10-20 2013-05-15 Univ Wien Tech Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren
CN102690273B (zh) * 2012-06-07 2014-11-05 杭州奥默医药技术有限公司 一种西地那非的制备方法
CN102993205B (zh) * 2012-12-27 2015-04-15 华润赛科药业有限责任公司 一种高收率制备高纯度西地那非游离碱的纯化方法
CN103755709B (zh) * 2014-01-15 2016-05-25 广东药学院 西地那非衍生物的微波辅助制备方法
CN105017255A (zh) * 2014-04-25 2015-11-04 浙江泰康药业集团有限公司 西地那非制备工艺
CN105085526B (zh) * 2014-05-15 2017-08-01 重庆圣华曦药业股份有限公司 一种改进的西地那非制备方法
CN104370915A (zh) * 2014-11-06 2015-02-25 成都医路康医学技术服务有限公司 枸橼酸西地那非的制备方法
CN107722018A (zh) * 2015-07-23 2018-02-23 青岛华之草医药科技有限公司 一种治疗男性勃起功能障碍的枸橼酸西地那非化合物
CN106117212B (zh) * 2016-06-25 2019-10-11 吉林医药学院 一种改进的西地那非合成工艺
WO2018069316A2 (en) 2016-10-10 2018-04-19 Transgene Sa Immunotherapeutic product and mdsc modulator combination therapy
CN108558890A (zh) * 2018-06-28 2018-09-21 重庆康刻尔制药有限公司 一种西地那非中间体合成方法
CN109970744A (zh) * 2019-04-10 2019-07-05 重庆康刻尔制药有限公司 一种枸橼酸西地那非中间体的合成方法
CN115872998B (zh) * 2021-08-03 2024-09-20 山东特珐曼药业有限公司 西地那非及其中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9311920D0 (en) 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) 1996-06-14 1996-08-14 Pfizer Ltd Novel process
CA2235642C (en) 1998-05-15 2007-11-13 Torcan Chemical Ltd. Processes for preparing sildenafil
CN1134419C (zh) 1999-07-27 2004-01-14 北京三雄高新技术开发有限责任公司 有用的昔多芬中间体及其制备
AU1888800A (en) 1999-09-13 2001-04-17 Cipla Limited A novel process for the synthesis of sildenafil citrate
GB0106661D0 (en) * 2001-03-16 2001-05-09 Pfizer Ltd Pharmaceutically active compounds
CN1208337C (zh) 2001-09-04 2005-06-29 广州白云山医药科技发展有限公司 喜勃酮的制备方法
CN1176081C (zh) 2002-04-29 2004-11-17 广州白云山医药科技发展有限公司 制备喜勃酮用的中间体及其制备方法
CN101563348B (zh) * 2006-12-21 2011-08-24 上海特化医药科技有限公司 西地那非的制备方法及其中间体

Also Published As

Publication number Publication date
EA019160B1 (ru) 2014-01-30
US8071765B2 (en) 2011-12-06
WO2008074512A1 (en) 2008-06-26
CN101563348B (zh) 2011-08-24
EA200900690A1 (ru) 2009-12-30
NO20092573L (no) 2009-09-18
ATE516289T1 (de) 2011-07-15
ES2367976T3 (es) 2011-11-11
WO2008074194A1 (fr) 2008-06-26
UA99447C2 (ru) 2012-08-27
PL2125821T3 (pl) 2011-12-30
PT2125821E (pt) 2011-07-27
EP2125821B1 (en) 2011-07-13
CN101563348A (zh) 2009-10-21
US20100048897A1 (en) 2010-02-25
EP2125821A1 (en) 2009-12-02

Similar Documents

Publication Publication Date Title
SI2125821T1 (sl) Postopek za pripravo sildenafila
TW200726754A (en) Chemical process
WO2009035130A3 (en) Process for producing 2,3,3,3-tetrafluoropropene
MX2009001816A (es) Procedimiento para la produccion de acido d,l-2-hidroxi-4-alquilti o butirico.
WO2007085895A3 (en) Fap inhibitors
MX2009007231A (es) Compuestos quimicos 637:piridopirimidindionas como inhibidores de la fosfodiesterasa 4.
SG158027A1 (en) Process for producing methionine
MY157406A (en) Process for the manufacture of acrolein and/or acrylic acid from glycerol
TW200738621A (en) Chemical process
DK2190426T3 (da) Griseofulvin-analoger til behandling af cancer ved hæmning af centrosomal clusterdannelse
TW200633977A (en) Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives
MX2010009950A (es) Metodo para purificar acido metacrilico.
MY157304A (en) Process for the preparation of a compound useful as an inhibator of tafia
WO2007029084A3 (en) A process for the preparation of carbapenem compounds
WO2007003200A3 (en) High yield synthesis methods for producing organic salts of strontium
WO2009029540A3 (en) Chemical production processes, systems, and catalyst compositions
CA2797442A1 (en) Process for the production of ferrous sulphate monohydrate
TW200633953A (en) Process for the production of anilines
TW200800942A (en) Chemical compounds
IL186979A0 (en) A process for the preparation of pyridine-methylsulfinyl compounds
WO2005016817A3 (en) Process for producing hydroxylamine
WO2007070238A3 (en) Processes for the preparation of modafinil and analogs thereof
CA2549947A1 (en) Process for producing ammonium polythiomolybdate
TW200722419A (en) Chemical compounds
EP1876264A4 (en) METHOD FOR PRODUCING A COMPOUND WITH A FLUOROSULFONYL GROUP BY A CLUTCH REACTION