NO20092573L - Fremgangsmate for fremstilling av sildenafil - Google Patents

Fremgangsmate for fremstilling av sildenafil

Info

Publication number
NO20092573L
NO20092573L NO20092573A NO20092573A NO20092573L NO 20092573 L NO20092573 L NO 20092573L NO 20092573 A NO20092573 A NO 20092573A NO 20092573 A NO20092573 A NO 20092573A NO 20092573 L NO20092573 L NO 20092573L
Authority
NO
Norway
Prior art keywords
compound
formula
iii
preparing
present
Prior art date
Application number
NO20092573A
Other languages
English (en)
Inventor
Tadej Stropnik
Guanghui Tian
Yi Zhu
Zheng Liu
Zhen Wang
Jingsham Shen
Sergeja Bombek
Original Assignee
Krka Tovarna Zdravil Dd Novo Mesto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka Tovarna Zdravil Dd Novo Mesto filed Critical Krka Tovarna Zdravil Dd Novo Mesto
Publication of NO20092573L publication Critical patent/NO20092573L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Det beskrives en fremgangsmåte for fremstilling av forbindelsen med formel (I): som omfatter konvertering av en forbindelse valgt fra gruppen bestående av forbindelser med formlene (II), (III) og(IV): der X er halogen, i ett eller flere trinn, for å gi forbindelsen med formel (I). Det beskrives videre en fremgangsmåte for fremstilling av et farmasøytisk preparat omfattende forbindelsen med formel (I) eller et farmasøytisk akseptabelt salt eller solvat derav. Videre beskrives det mellomprodukter som er egnet for bruk i ovenfor angitte fremgangsmåter, og videre beskrives fremgangsmåter for disses fremstilling.
NO20092573A 2006-12-21 2009-07-07 Fremgangsmate for fremstilling av sildenafil NO20092573L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2006/003530 WO2008074194A1 (fr) 2006-12-21 2006-12-21 Procédé de préparation du sildénafil et de ses intermédiaires
PCT/EP2007/011355 WO2008074512A1 (en) 2006-12-21 2007-12-21 Process for the preparation of sildenafil

Publications (1)

Publication Number Publication Date
NO20092573L true NO20092573L (no) 2009-09-18

Family

ID=39267890

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092573A NO20092573L (no) 2006-12-21 2009-07-07 Fremgangsmate for fremstilling av sildenafil

Country Status (12)

Country Link
US (1) US8071765B2 (no)
EP (1) EP2125821B1 (no)
CN (1) CN101563348B (no)
AT (1) ATE516289T1 (no)
EA (1) EA019160B1 (no)
ES (1) ES2367976T3 (no)
NO (1) NO20092573L (no)
PL (1) PL2125821T3 (no)
PT (1) PT2125821E (no)
SI (1) SI2125821T1 (no)
UA (1) UA99447C2 (no)
WO (2) WO2008074194A1 (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101563348B (zh) * 2006-12-21 2011-08-24 上海特化医药科技有限公司 西地那非的制备方法及其中间体
AT512084A1 (de) 2011-10-20 2013-05-15 Univ Wien Tech Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren
CN102690273B (zh) * 2012-06-07 2014-11-05 杭州奥默医药技术有限公司 一种西地那非的制备方法
CN102993205B (zh) * 2012-12-27 2015-04-15 华润赛科药业有限责任公司 一种高收率制备高纯度西地那非游离碱的纯化方法
CN103755709B (zh) * 2014-01-15 2016-05-25 广东药学院 西地那非衍生物的微波辅助制备方法
CN105017255A (zh) * 2014-04-25 2015-11-04 浙江泰康药业集团有限公司 西地那非制备工艺
CN105085526B (zh) * 2014-05-15 2017-08-01 重庆圣华曦药业股份有限公司 一种改进的西地那非制备方法
CN104370915A (zh) * 2014-11-06 2015-02-25 成都医路康医学技术服务有限公司 枸橼酸西地那非的制备方法
CN107722018A (zh) * 2015-07-23 2018-02-23 青岛华之草医药科技有限公司 一种治疗男性勃起功能障碍的枸橼酸西地那非化合物
CN106117212B (zh) * 2016-06-25 2019-10-11 吉林医药学院 一种改进的西地那非合成工艺
WO2018069316A2 (en) 2016-10-10 2018-04-19 Transgene Sa Immunotherapeutic product and mdsc modulator combination therapy
CN108558890A (zh) * 2018-06-28 2018-09-21 重庆康刻尔制药有限公司 一种西地那非中间体合成方法
CN109970744A (zh) * 2019-04-10 2019-07-05 重庆康刻尔制药有限公司 一种枸橼酸西地那非中间体的合成方法
CN115872998B (zh) * 2021-08-03 2024-09-20 山东特珐曼药业有限公司 西地那非及其中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9311920D0 (en) 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) 1996-06-14 1996-08-14 Pfizer Ltd Novel process
CA2235642C (en) 1998-05-15 2007-11-13 Torcan Chemical Ltd. Processes for preparing sildenafil
CN1134419C (zh) 1999-07-27 2004-01-14 北京三雄高新技术开发有限责任公司 有用的昔多芬中间体及其制备
AU1888800A (en) 1999-09-13 2001-04-17 Cipla Limited A novel process for the synthesis of sildenafil citrate
GB0106661D0 (en) * 2001-03-16 2001-05-09 Pfizer Ltd Pharmaceutically active compounds
CN1208337C (zh) 2001-09-04 2005-06-29 广州白云山医药科技发展有限公司 喜勃酮的制备方法
CN1176081C (zh) 2002-04-29 2004-11-17 广州白云山医药科技发展有限公司 制备喜勃酮用的中间体及其制备方法
CN101563348B (zh) * 2006-12-21 2011-08-24 上海特化医药科技有限公司 西地那非的制备方法及其中间体

Also Published As

Publication number Publication date
SI2125821T1 (sl) 2011-11-30
EA019160B1 (ru) 2014-01-30
US8071765B2 (en) 2011-12-06
WO2008074512A1 (en) 2008-06-26
CN101563348B (zh) 2011-08-24
EA200900690A1 (ru) 2009-12-30
ATE516289T1 (de) 2011-07-15
ES2367976T3 (es) 2011-11-11
WO2008074194A1 (fr) 2008-06-26
UA99447C2 (ru) 2012-08-27
PL2125821T3 (pl) 2011-12-30
PT2125821E (pt) 2011-07-27
EP2125821B1 (en) 2011-07-13
CN101563348A (zh) 2009-10-21
US20100048897A1 (en) 2010-02-25
EP2125821A1 (en) 2009-12-02

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