SI21235A - Postopek laktonizacije za proizvodnjo simvastatina - Google Patents

Postopek laktonizacije za proizvodnjo simvastatina Download PDF

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Publication number
SI21235A
SI21235A SI200220005A SI200220005A SI21235A SI 21235 A SI21235 A SI 21235A SI 200220005 A SI200220005 A SI 200220005A SI 200220005 A SI200220005 A SI 200220005A SI 21235 A SI21235 A SI 21235A
Authority
SI
Slovenia
Prior art keywords
simvastatin
lactonization
reaction
product
minutes
Prior art date
Application number
SI200220005A
Other languages
English (en)
Slovenian (sl)
Inventor
Dandala Ramesh
Sebastian Sonny
Jagan Mohan Reddy Sanapureddy
Sivakumaran Meenakshisunderam
Original Assignee
Aurobindo Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurobindo Pharma Limited filed Critical Aurobindo Pharma Limited
Publication of SI21235A publication Critical patent/SI21235A/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI200220005A 2001-05-18 2002-05-16 Postopek laktonizacije za proizvodnjo simvastatina SI21235A (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN401CH2001 2001-05-18
PCT/IN2002/000122 WO2002094804A1 (en) 2001-05-18 2002-05-16 A process for lactonization to produce simvastatin

Publications (1)

Publication Number Publication Date
SI21235A true SI21235A (sl) 2003-12-31

Family

ID=11097002

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200220005A SI21235A (sl) 2001-05-18 2002-05-16 Postopek laktonizacije za proizvodnjo simvastatina

Country Status (6)

Country Link
EP (1) EP1294706A1 (ja)
JP (1) JP2004520445A (ja)
BG (1) BG107475A (ja)
SI (1) SI21235A (ja)
SK (1) SK702003A3 (ja)
WO (1) WO2002094804A1 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100423892B1 (ko) * 2001-12-03 2004-03-22 씨제이 주식회사 스타틴의 제조에 있어서 새로운 락톤화 방법
WO2005012279A1 (en) * 2003-08-04 2005-02-10 Biocon Limited Lactonization process
DE602004017784D1 (de) 2004-03-30 2008-12-24 Lupin Ltd Verbessertes verfahren zur herstellung von 4-hydroxypyran-2-onderivaten
ES2564250T3 (es) 2006-05-03 2016-03-21 Msn Laboratories Private Limited Nuevo proceso para estatinas y sus sales farmacéuticamente aceptables de las mismas
HUE028475T2 (en) 2006-10-09 2016-12-28 Msn Laboratories Private Ltd A novel process for the preparation of statins and their pharmaceutically acceptable salts
US8487105B2 (en) 2009-01-19 2013-07-16 Msn Laboratories Limited Process for preparing pitavastatin, intermediates and pharmaceuctically acceptable salts thereof
EP2526099B1 (en) 2010-01-18 2016-03-30 MSN Laboratories Limited Improved process for the preparation of amide intermediates and their use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
ZA9810764B (en) * 1998-04-22 1999-08-13 Ranbaxy Lab Ltd An improved process of lactonization in the preparation of statins.
US6380401B1 (en) * 1999-10-27 2002-04-30 Merck & Co., Inc. Lactonization process

Also Published As

Publication number Publication date
WO2002094804A1 (en) 2002-11-28
JP2004520445A (ja) 2004-07-08
BG107475A (bg) 2004-01-30
SK702003A3 (en) 2003-12-02
EP1294706A1 (en) 2003-03-26

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IF Valid on the event date
KO00 Lapse of patent

Effective date: 20060331