SI21234A - Postopek laktonizacije za proizvodnjo izredno čistega simvastatina - Google Patents

Postopek laktonizacije za proizvodnjo izredno čistega simvastatina Download PDF

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Publication number
SI21234A
SI21234A SI200220004A SI200220004A SI21234A SI 21234 A SI21234 A SI 21234A SI 200220004 A SI200220004 A SI 200220004A SI 200220004 A SI200220004 A SI 200220004A SI 21234 A SI21234 A SI 21234A
Authority
SI
Slovenia
Prior art keywords
formula
lactonization
simvastatin
water
reaction mixture
Prior art date
Application number
SI200220004A
Other languages
English (en)
Slovenian (sl)
Inventor
Dandala Ramesh
Sebastian Sonny
Subramanyam Dandala
Sunderam Sivakumaran Meenakshi
Original Assignee
Aurobindo Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurobindo Pharma Limited filed Critical Aurobindo Pharma Limited
Publication of SI21234A publication Critical patent/SI21234A/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI200220004A 2001-05-18 2002-05-16 Postopek laktonizacije za proizvodnjo izredno čistega simvastatina SI21234A (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN402CH2001 2001-05-18
PCT/IN2002/000121 WO2002094803A1 (en) 2001-05-18 2002-05-16 A process for lactonization to produce highly pure simvastatin

Publications (1)

Publication Number Publication Date
SI21234A true SI21234A (sl) 2003-12-31

Family

ID=29765110

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200220004A SI21234A (sl) 2001-05-18 2002-05-16 Postopek laktonizacije za proizvodnjo izredno čistega simvastatina

Country Status (7)

Country Link
US (1) US6825362B2 (cg-RX-API-DMAC7.html)
EP (1) EP1387835A1 (cg-RX-API-DMAC7.html)
JP (1) JP2004520444A (cg-RX-API-DMAC7.html)
BG (1) BG107477A (cg-RX-API-DMAC7.html)
SI (1) SI21234A (cg-RX-API-DMAC7.html)
SK (1) SK692003A3 (cg-RX-API-DMAC7.html)
WO (1) WO2002094803A1 (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1732912B1 (en) 2004-03-30 2008-11-12 Lupin Ltd. An improved method for manufacture of 4-hydroxy pyran-2-one derivatives
WO2006059346A2 (en) * 2004-12-01 2006-06-08 Morepen Laboratories Limited An improved process for lactonization to produce highly pure statins
PL2018153T3 (pl) * 2006-04-26 2012-09-28 Rosemont Pharmaceuticals Ltd Ciekłe kompozycje doustne
EP2288378A4 (en) * 2008-04-16 2011-12-14 Univ Utah Res Found PHARMACOLOGICAL TARGETING OF VEGETABLE ILLNESS
CN112759570B (zh) * 2021-02-08 2023-04-14 龙曦宁（上海）医药科技有限公司 一种合成辛伐他汀杂质d的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN186879B (cg-RX-API-DMAC7.html) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
IN186880B (cg-RX-API-DMAC7.html) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
US6380401B1 (en) * 1999-10-27 2002-04-30 Merck & Co., Inc. Lactonization process
US6573385B1 (en) * 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
KR100407758B1 (ko) * 2001-08-27 2003-12-01 씨제이 주식회사 스타틴의 제조에 있어서 락톤화 방법

Also Published As

Publication number Publication date
US6825362B2 (en) 2004-11-30
BG107477A (bg) 2004-01-30
SK692003A3 (en) 2003-12-02
WO2002094803A1 (en) 2002-11-28
US20040077884A1 (en) 2004-04-22
JP2004520444A (ja) 2004-07-08
EP1387835A1 (en) 2004-02-11

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Legal Events

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IF Valid on the event date
KO00 Lapse of patent

Effective date: 20070130