SI1940387T1 - Postopek za stereoselektivno pripravo (-) halofenata in njegovih intermediatov - Google Patents
Postopek za stereoselektivno pripravo (-) halofenata in njegovih intermediatovInfo
- Publication number
- SI1940387T1 SI1940387T1 SI200631502T SI200631502T SI1940387T1 SI 1940387 T1 SI1940387 T1 SI 1940387T1 SI 200631502 T SI200631502 T SI 200631502T SI 200631502 T SI200631502 T SI 200631502T SI 1940387 T1 SI1940387 T1 SI 1940387T1
- Authority
- SI
- Slovenia
- Prior art keywords
- halofenate
- intermediates
- stereoselective preparation
- stereoselective
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72030005P | 2005-09-23 | 2005-09-23 | |
| US11/525,200 US7714131B2 (en) | 2005-09-23 | 2006-09-20 | Process for the stereoselective preparation of (−)-halofenate and derivatives thereof |
| PCT/US2006/036928 WO2007038243A1 (en) | 2005-09-23 | 2006-09-21 | Process for the stereoselective preparation of (-)-halofenate and intermediates thereof |
| EP06815150A EP1940387B1 (en) | 2005-09-23 | 2006-09-21 | Process for the stereoselective preparation of (-)-halofenate and intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1940387T1 true SI1940387T1 (sl) | 2013-04-30 |
Family
ID=37894903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200631502T SI1940387T1 (sl) | 2005-09-23 | 2006-09-21 | Postopek za stereoselektivno pripravo (-) halofenata in njegovih intermediatov |
Country Status (18)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009121940A1 (en) * | 2008-04-03 | 2009-10-08 | Janssen Pharmaceutica Nv | Process for the preparation of (-)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester |
| JP5576791B2 (ja) * | 2008-06-03 | 2014-08-20 | 株式会社カネカ | 光学活性アミノ酸誘導体の製造方法 |
| US9023856B2 (en) | 2011-11-04 | 2015-05-05 | Cymabay Therapeutics, Inc. | Methods for treating hyperuricemia in patients with gout using halofenate or halogenic acid and a second urate-lowering agent |
| US9060987B2 (en) | 2011-11-04 | 2015-06-23 | Cymabay Therapeutics, Inc. | Methods for treating gout flares |
| WO2021236394A1 (en) | 2020-05-18 | 2021-11-25 | Cymabay Therapeutics, Inc. | Cb-0406 tromethamine salt |
| US20210355066A1 (en) | 2020-05-18 | 2021-11-18 | Cymabay Therapeutics, Inc. | CB-0406 choline salt |
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| US3444299A (en) | 1964-02-07 | 1969-05-13 | American Cyanamid Co | Methods for the control and prevention of helminths with phenylbenzothiazolium compounds |
| GB1097053A (en) | 1964-03-16 | 1967-12-29 | Dow Chemical Co | Substituted benzothiazolium compounds and complexes thereof for use in animal husbandry |
| US3378582A (en) | 1964-03-20 | 1968-04-16 | Merck & Co Inc | (alpha-phenoxy)-and (alpha-phenylthio)-omegaphenyl-alkanoic acids |
| US3517051A (en) | 1964-03-20 | 1970-06-23 | Merck & Co Inc | Phenoxy substituted phenylacetic acids |
| US3517050A (en) | 1966-10-03 | 1970-06-23 | Merck & Co Inc | Ester and amide derivative of (3-trifluoromethylphenoxy) (4 - halophenyl)acetic acid |
| NL6712585A (US07714131-20100511-C00042.png) | 1966-10-03 | 1968-04-04 | ||
| US3558778A (en) | 1966-10-27 | 1971-01-26 | Dow Chemical Co | Methods and compositions for use in animal husbandry |
| US3674836A (en) | 1968-05-21 | 1972-07-04 | Parke Davis & Co | 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof |
| BE754245A (fr) | 1969-08-01 | 1970-12-31 | Sumitomo Chemical Co | Derives d'acides phenoxy carboxyliques |
| DK133742B (da) | 1970-10-30 | 1976-07-12 | Merck & Co Inc | Fremgangsmåde til fremstilling af 2-acetamidoethyl-(3-trifluormethylphenoxy)-(4-chlorphenyl)-acetat. |
| US3953490A (en) | 1972-07-13 | 1976-04-27 | Merck & Co., Inc. | Preparation of (3-trifluoromethylphenoxy)(4-chlorophenyl)acetonitrile |
| US3860628A (en) | 1972-07-13 | 1975-01-14 | Merck & Co Inc | Cyanomethyl(3-trifluoromethylphenoxy)(4-chlorophenyl)acetate |
| US3923855A (en) | 1972-07-13 | 1975-12-02 | Merck & Co Inc | 2-sulfonyloxyethyl 3-trifluoromethylphenoxy-4{40 -chlorophenyl acetate |
| NL7309571A (US07714131-20100511-C00042.png) | 1972-07-28 | 1974-01-30 | ||
| US4110351A (en) | 1973-04-02 | 1978-08-29 | Richardson-Merrell Inc. | Hypolipidemic agents RO- or RS- substituted furoic acids, esters and salts |
| US3876791A (en) | 1973-11-30 | 1975-04-08 | Uniroyal Inc | Control of acarids using certain benzothiazoles or benzothiazolines |
| US4001268A (en) | 1974-08-07 | 1977-01-04 | The United States Of America As Represented By The Secretary Of The Air Force | Substituted phenyl-benzimidazo compounds |
| IL48707A0 (en) | 1974-12-30 | 1976-02-29 | Synthelabo | Novel phenylacetic acid derivatives,their preparation and pharmaceutical compositions containing them |
| JPS6039072B2 (ja) | 1976-07-28 | 1985-09-04 | 藤沢薬品工業株式会社 | Ｎ−置換フエニルアミノ脂肪酸誘導体 |
| JPS5371071A (en) | 1976-12-08 | 1978-06-24 | Teijin Ltd | Alpha-phenoxyacetic acid derivs. |
| US4250191A (en) | 1978-11-30 | 1981-02-10 | Edwards K David | Preventing renal failure |
| US4214095A (en) | 1979-01-25 | 1980-07-22 | Siegfried Aktiengesellschaft | Chlorobenzyl phenoxy alkoxylates |
| FR2455572B1 (fr) | 1979-05-04 | 1986-07-25 | Continental Pharma | Derives de phenylethylamine, leur preparation et utilisation dans le traitement des affections cardiovasculaires, et compositions les contenant |
| US4532135A (en) | 1981-02-09 | 1985-07-30 | Edwards K David G | Renoprotective treatments employing vasodilator compounds |
| US4508882A (en) | 1981-08-24 | 1985-04-02 | Asahi Glass Company Ltd. | Benzotriazole compound and homopolymer or copolymers thereof |
| EP0077938A3 (en) | 1981-10-23 | 1983-08-24 | Mitsubishi Kasei Corporation | N-(3-substituted aminophenyl) tetrahydrophthalimides and herbicidal composition |
| DE3236730A1 (de) | 1982-10-04 | 1984-04-05 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von benzoxazolyl- und benzthiazolyloxyphenoxypropionsaeurederivaten |
| US4528311A (en) | 1983-07-11 | 1985-07-09 | Iolab Corporation | Ultraviolet absorbing polymers comprising 2-hydroxy-5-acrylyloxyphenyl-2H-benzotriazoles |
| JPS60109578A (ja) | 1983-11-17 | 1985-06-15 | Mitsubishi Chem Ind Ltd | ３−（置換フエニル）−５−置換−１，３，４−オキサゾリン−２−オン類およびこれを有効成分とする除草剤 |
| DE3525284A1 (de) | 1985-07-16 | 1987-01-29 | Boehringer Mannheim Gmbh | Neue carbonsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung sowie arzneimittel, die diese verbindungen enthalten |
| US4714762A (en) | 1986-10-31 | 1987-12-22 | Warner-Lambert Company | Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof |
| US4786731A (en) | 1987-08-05 | 1988-11-22 | The Dow Chemical Company | Resolution of enantiomers of 2-(phenyl or phenoxy/propionic acids using optically active alkanolamines |
| JPH0670025B2 (ja) | 1987-08-07 | 1994-09-07 | 鐘紡株式会社 | ベンゾチアゾ−ル誘導体および該化合物を有効成分とする抗リウマチ剤 |
| GB8720365D0 (en) | 1987-08-28 | 1987-10-07 | Sandoz Ltd | Organic compounds |
| US4863802A (en) | 1987-12-31 | 1989-09-05 | General Electric Company | UV-stabilized coatings |
| JPH01305069A (ja) | 1988-05-31 | 1989-12-08 | Shionogi & Co Ltd | ベンゾトリアゾール誘導体およびそれを含有する発螢光試薬 |
| CA2034309C (en) | 1990-01-22 | 1997-04-01 | Takashi Iwaki | Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus |
| US5278314A (en) | 1991-02-12 | 1994-01-11 | Ciba-Geigy Corporation | 5-thio-substituted benzotriazole UV-absorbers |
| DE4111026A1 (de) | 1991-04-05 | 1992-10-08 | Boehringer Mannheim Gmbh | Optisch aktive carbonsaeuren sowie diese enthaltende arzneimittel |
| US5605930A (en) | 1991-10-21 | 1997-02-25 | The United States Of America As Represented By The Department Of Health And Human Services | Compositions and methods for treating and preventing pathologies including cancer |
| EP0559927B1 (en) | 1992-03-09 | 1997-03-05 | Hoechst Aktiengesellschaft | A simplified method for the production of vinyl glycine (2-aminobut-3-enioc acid) and a convenient resolution of a derivative |
| DE4303676A1 (de) | 1993-02-09 | 1994-08-11 | Bayer Ag | 1-Aryltriazolin(thi)one |
| US5874431A (en) | 1993-08-28 | 1999-02-23 | Cancer Research Campaign Technology Limited | Benzazole compounds |
| US5496826A (en) | 1994-09-02 | 1996-03-05 | Bristol-Myers Squibb Company | Pharmaceutical methods of using heterocyclic derivatives of N-phenylamides |
| US5455152A (en) | 1994-09-27 | 1995-10-03 | Eastman Kodak Company | Benzotriazole based UV absorbing monomers and photographic elements containing polymers formed from them |
| US5700819A (en) | 1994-11-29 | 1997-12-23 | Grelan Pharmaceutical Co., Ltd. | 2-substituted benzothiazole derivatives and prophylactic and therapeutic agents for the treatment of diabetic complications |
| PT748326E (pt) | 1994-12-28 | 2001-11-30 | Rhodia Chimie Sa | Difosfinas opticamente activas e processo para a sua preparacao por desdobramento da mistura racemica |
| GB9503946D0 (en) | 1995-02-28 | 1995-04-19 | Cancer Res Campaign Tech | Benzazole compounds |
| US5500332A (en) | 1995-04-26 | 1996-03-19 | Eastman Kodak Company | Benzotriazole based UV absorbers and photographic elements containing them |
| US5708186A (en) * | 1995-12-12 | 1998-01-13 | Merck & Co Inc | Stereoselective process |
| US6242464B1 (en) | 1996-01-22 | 2001-06-05 | Chiroscience Limited | Single isomer methylphenidate and resolution process |
| US5859051A (en) | 1996-02-02 | 1999-01-12 | Merck & Co., Inc. | Antidiabetic agents |
| US5766834A (en) | 1996-05-17 | 1998-06-16 | Eastman Kodak Company | Photographic element containing ultraviolet absorbing polymer |
| US5716987A (en) | 1996-06-21 | 1998-02-10 | Bristol-Myers Squibb Company | Prophylactic and therapeutic treatment of skin sensitization and irritation |
| JP2000516611A (ja) | 1996-08-14 | 2000-12-12 | ワーナー―ランバート・コンパニー | Ｍｃｐ―１アンタゴニストとしての２―フェニルベンズイミダゾール誘導体 |
| ID21543A (id) | 1996-11-22 | 1999-06-24 | Ciba Sc Holding Ag | Penggunaan turunan benzotriazol terpilih untuk melindungi kulit serta rambut manusia dan hewan dari efek-efek radiasi uv yang berbahaya |
| US5942532A (en) | 1997-09-05 | 1999-08-24 | Ortho Pharmaceutical Corporation | 2-substituted phenyl-benzimidazole antibacterial agents |
| ES2216322T3 (es) | 1997-11-07 | 2004-10-16 | Taiho Pharmaceutical Company, Limited | Derivados de bencimidazoles y sales de estos ultimos aceptables en el plano farmaceutico. |
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| US6013659A (en) | 1998-09-04 | 2000-01-11 | University Of Pittsburgh | Methods of reducing tumor colony number using novel benzothiazole compounds |
| DE19844876A1 (de) | 1998-09-30 | 2000-04-06 | Basf Ag | Verfahren zur Racematspaltung von Arylalkylcarbonsäureestern |
| IN189741B (US07714131-20100511-C00042.png) | 1998-11-09 | 2003-04-19 | Council Scient Ind Res | |
| CN1344256A (zh) | 1998-12-18 | 2002-04-10 | Axys药物公司 | (杂)芳基双环杂芳基衍生物,其制备方法和用作蛋白酶抑制剂的用途 |
| US7576131B2 (en) | 1999-06-04 | 2009-08-18 | Metabolex, Inc. | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia |
| US6262118B1 (en) | 1999-06-04 | 2001-07-17 | Metabolex, Inc. | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia |
| US6624194B1 (en) | 1999-06-04 | 2003-09-23 | Metabolex, Inc. | Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia |
| IL145071A0 (en) | 1999-12-27 | 2002-06-30 | Japan Tobacco Inc | Fused ring compounds and pharmaceutical compositions containing the same |
| WO2004078113A2 (en) | 2003-03-04 | 2004-09-16 | Pharmacia Corporation | Treatment and prevention of obesity with cox-2 inhibitors alone or in combination with weight-loss agents |
| RS20050937A (en) | 2003-06-20 | 2008-04-04 | Metabolex Inc., | Resolution of alpha- (phenoxy)phenylacetic acid derivatives |
| US7199259B2 (en) | 2003-06-20 | 2007-04-03 | Metabolex, Inc. | Resolution of α-(phenoxy)phenylacetic acid derivatives |
-
2006
- 2006-09-20 US US11/525,200 patent/US7714131B2/en not_active Expired - Fee Related
- 2006-09-21 EA EA200800884A patent/EA015673B1/ru not_active IP Right Cessation
- 2006-09-21 PL PL06815150T patent/PL1940387T3/pl unknown
- 2006-09-21 EP EP06815150A patent/EP1940387B1/en active Active
- 2006-09-21 WO PCT/US2006/036928 patent/WO2007038243A1/en active Application Filing
- 2006-09-21 PT PT68151505T patent/PT1940387E/pt unknown
- 2006-09-21 DK DK06815150.5T patent/DK1940387T3/da active
- 2006-09-21 BR BRPI0616188-0A patent/BRPI0616188A2/pt not_active IP Right Cessation
- 2006-09-21 AU AU2006294950A patent/AU2006294950A1/en not_active Abandoned
- 2006-09-21 SI SI200631502T patent/SI1940387T1/sl unknown
- 2006-09-21 RS RS20130001A patent/RS52608B/en unknown
- 2006-09-21 KR KR1020087009709A patent/KR101309605B1/ko not_active IP Right Cessation
- 2006-09-21 CA CA2623350A patent/CA2623350C/en not_active Expired - Fee Related
- 2006-09-21 ES ES06815150T patent/ES2394973T3/es active Active
- 2006-09-21 JP JP2008532404A patent/JP2009515817A/ja not_active Withdrawn
-
2008
- 2008-03-20 IL IL190325A patent/IL190325A/en not_active IP Right Cessation
- 2008-12-29 HK HK08114045.8A patent/HK1119953A1/xx not_active IP Right Cessation
-
2013
- 2013-01-02 HR HRP20130001TT patent/HRP20130001T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007038243A1 (en) | 2007-04-05 |
| DK1940387T3 (da) | 2013-01-02 |
| AU2006294950A1 (en) | 2007-04-05 |
| JP2009515817A (ja) | 2009-04-16 |
| EP1940387A1 (en) | 2008-07-09 |
| IL190325A (en) | 2013-04-30 |
| HK1119953A1 (en) | 2009-03-20 |
| US20070072858A1 (en) | 2007-03-29 |
| CA2623350C (en) | 2014-08-19 |
| EP1940387A4 (en) | 2010-11-03 |
| PL1940387T3 (pl) | 2013-02-28 |
| HRP20130001T1 (hr) | 2013-02-28 |
| EP1940387B1 (en) | 2012-11-28 |
| ES2394973T3 (es) | 2013-02-07 |
| BRPI0616188A2 (pt) | 2011-06-14 |
| US7714131B2 (en) | 2010-05-11 |
| KR101309605B1 (ko) | 2013-09-17 |
| PT1940387E (pt) | 2012-12-17 |
| RS52608B (en) | 2013-04-30 |
| EA015673B1 (ru) | 2011-10-31 |
| CA2623350A1 (en) | 2007-04-05 |
| KR20080050527A (ko) | 2008-06-05 |
| IL190325A0 (en) | 2009-09-22 |
| EA200800884A1 (ru) | 2008-12-30 |
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