SI1441770T1 - Vaginalna formulacija lidokaina za zdravljenje uterine disritmije - Google Patents

Vaginalna formulacija lidokaina za zdravljenje uterine disritmije

Info

Publication number
SI1441770T1
SI1441770T1 SI200230452T SI200230452T SI1441770T1 SI 1441770 T1 SI1441770 T1 SI 1441770T1 SI 200230452 T SI200230452 T SI 200230452T SI 200230452 T SI200230452 T SI 200230452T SI 1441770 T1 SI1441770 T1 SI 1441770T1
Authority
SI
Slovenia
Prior art keywords
dysrhythmias
lidocaine
uterine
treatment
vaginal formulation
Prior art date
Application number
SI200230452T
Other languages
English (en)
Slovenian (sl)
Inventor
Howard L Levine
William J Bologna
Ziegler Dominique De
Original Assignee
Columbia Lab Bermuda Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia Lab Bermuda Ltd filed Critical Columbia Lab Bermuda Ltd
Publication of SI1441770T1 publication Critical patent/SI1441770T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SI200230452T 2001-10-29 2002-10-28 Vaginalna formulacija lidokaina za zdravljenje uterine disritmije SI1441770T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33068401P 2001-10-29 2001-10-29
US10/278,912 US20030114394A1 (en) 2001-10-29 2002-10-24 Vaginally administered anti-dysrhythmic agents for treating pelvic pain
EP02785326A EP1441770B1 (en) 2001-10-29 2002-10-28 Vaginal formulation of lidocaine for treating uterine dysrhythmia
PCT/EP2002/012042 WO2003037381A1 (en) 2001-10-29 2002-10-28 Vaginally administerd anti-dysrhythmic agents for treating pelvic pain and infertility

Publications (1)

Publication Number Publication Date
SI1441770T1 true SI1441770T1 (sl) 2007-02-28

Family

ID=26959337

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200230452T SI1441770T1 (sl) 2001-10-29 2002-10-28 Vaginalna formulacija lidokaina za zdravljenje uterine disritmije
SI200230886T SI1764111T1 (sl) 2001-10-29 2002-10-28 AntidisritmiŽŤna sredstva za vaginalno dajanje za zdravljenje materniŽŤne disritmije

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200230886T SI1764111T1 (sl) 2001-10-29 2002-10-28 AntidisritmiŽŤna sredstva za vaginalno dajanje za zdravljenje materniŽŤne disritmije

Country Status (33)

Country Link
US (1) US20030114394A1 (enExample)
EP (2) EP1441770B1 (enExample)
JP (2) JP2005511564A (enExample)
KR (2) KR20050040820A (enExample)
CN (1) CN100404072C (enExample)
AR (1) AR037048A1 (enExample)
AT (2) ATE346614T1 (enExample)
AU (1) AU2002350644B2 (enExample)
BR (1) BR0213585A (enExample)
CA (1) CA2465132C (enExample)
CY (2) CY1106000T1 (enExample)
DE (2) DE60234725D1 (enExample)
DK (2) DK1441770T3 (enExample)
ES (2) ES2336238T3 (enExample)
GE (1) GEP20094614B (enExample)
HR (1) HRP20040479B1 (enExample)
HU (1) HUP0402389A3 (enExample)
IL (3) IL161513A0 (enExample)
MA (1) MA26230A1 (enExample)
ME (1) ME00255B (enExample)
MX (1) MXPA04003976A (enExample)
MY (2) MY149482A (enExample)
NO (1) NO333544B1 (enExample)
NZ (1) NZ532295A (enExample)
PE (1) PE20030692A1 (enExample)
PL (2) PL369790A1 (enExample)
PT (2) PT1764111E (enExample)
RS (1) RS51414B (enExample)
RU (2) RU2345758C2 (enExample)
SI (2) SI1441770T1 (enExample)
UA (1) UA90077C2 (enExample)
WO (1) WO2003037381A1 (enExample)
ZA (1) ZA200402944B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7341737B2 (en) * 1997-06-11 2008-03-11 Kimberly-Clark Worldwide, Inc. Medicated tampon
US7344732B2 (en) * 2002-01-10 2008-03-18 Kimberly-Clark Worldwide, Inc. Medicated tampon
CH697081A5 (de) * 2002-01-22 2008-04-30 Andreas F Dr Schaub Zusammensetzung für die Unterstützung der Geburt eines menschlichen Föten.
US20050244402A1 (en) * 2004-04-30 2005-11-03 Villanueva Julie M Absorption of pain-causing agents
DE102004054552A1 (de) * 2004-11-11 2006-05-18 Hcb Happy Child Birth Holding Ag Neue Zusammensetzung zur Erleichterung der Humangeburt
US7527614B2 (en) 2005-03-25 2009-05-05 Kimberly-Clark Worldwide, Inc. Protective tube for a medicated tampon
US7993667B2 (en) 2005-03-25 2011-08-09 Kimberly-Clark Worldwide, Inc. Methods of manufacturing a medicated tampon assembly
US7919453B2 (en) 2005-03-25 2011-04-05 Kimberly-Clark Worldwide, Inc. Dosage cap assembly for an applicator
US7744556B2 (en) 2005-03-25 2010-06-29 Kimberly-Clark Worldwide, Inc. Delivery tube assembly for an applicator
US7708726B2 (en) 2005-04-28 2010-05-04 Kimberly-Clark Worldwide, Inc. Dosage form cap for an applicator
US20070253994A1 (en) * 2006-04-28 2007-11-01 Medtronic, Inc. Intraspinal Drug Delivery Methods and Devices To Alleviate Chronic Pelvic Pain
US20080108824A1 (en) * 2006-09-28 2008-05-08 Med Institute, Inc Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices
WO2008039995A2 (en) * 2006-09-28 2008-04-03 Vance Products Incorporated, D/Ba Cook Urological Incorporated Medical device including a bioactive in a non-ionic and an ionic form and methods of preparation thereof
US20080081829A1 (en) * 2006-09-28 2008-04-03 Med Institute, Inc Medical Device Including an Anesthetic and Method of Preparation Thereof
ES2696999T3 (es) * 2007-06-26 2019-01-21 Allergan Pharmaceuticals Int Ltd Dispositivos de administración intravaginal de medicamentos para la administración de macromoléculas y medicamentos solubles en agua
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US8475823B2 (en) * 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
MX2010011880A (es) * 2008-04-29 2011-05-25 Pharnext Nuevos enfoques terapeuticos para tratar la enfermedad del alzheimer y trastornos relacionados mediante una modulacion de la respuesta de estres celular.
BRPI0803568B8 (pt) * 2008-08-14 2021-05-25 Biolab San Us Farm Ltda composição mucoaderente
RU2538674C2 (ru) * 2012-09-10 2015-01-10 Открытое акционерное общество "Всероссийский научный центр по безопасности биологически активных веществ" (ОАО "ВНЦ БАВ") Фармацевтическая композиция, обладающая пролонгированной противоаритмической активностью
WO2015051336A1 (en) 2013-10-03 2015-04-09 David Wise Compositions and methods for treating pelvic pain and other conditions
JP6654057B2 (ja) * 2016-02-10 2020-02-26 国立大学法人 筑波大学 局所麻酔薬を含有するポリイオンコンプレックスを有効成分とする局所疼痛制御用組成物
WO2017165707A1 (en) * 2016-03-24 2017-09-28 Juniper Pharmaceuticals, Inc. Vaginal administration of agents for treating and preventing pain associated with gynecological medical procedures
BR102018008324A2 (pt) * 2018-04-25 2019-11-05 Laboratórios Ferring Ltda. composição farmacêutica de uso tópico e processo de fabricação de composição farmacêutica de uso tópico

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3387419A (en) * 1965-10-22 1968-06-11 Kamberg Henry Decking with trim strip
JPH0830004B2 (ja) * 1983-11-14 1996-03-27 コロンビア ラボラトリーズ インコーポレイテッド 生物接着性組成物およびそれにより治療する方法
US5234957A (en) * 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5387419A (en) * 1988-03-31 1995-02-07 The University Of Michigan System for controlled release of antiarrhythmic agents
CA2072623C (en) * 1989-11-03 2001-03-27 Matthew T. Scholz Bioadhesive composition and patch
US5332576A (en) * 1991-02-27 1994-07-26 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
IT1250421B (it) * 1991-05-30 1995-04-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
US5700485A (en) * 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5508045A (en) * 1992-10-09 1996-04-16 The Regents Of The University Of California Method and agents for control and management of labor during pregnancy
US5543150A (en) * 1993-09-15 1996-08-06 Columbia Laboratories, Inc. Method of progesterone delivery and affect thereof
US5667492A (en) * 1994-10-07 1997-09-16 Columbia Laboratories, Inc. Use and composition of an anti-sexually transmitted diseases formulation
GB9610359D0 (en) * 1996-05-17 1996-07-24 Edko Trading Representation Pharmaceutical compositions
US5663492A (en) * 1996-06-05 1997-09-02 Alapati; Rama Rao System for continuous analysis and modification of characteristics of a liquid hydrocarbon stream
US5985861A (en) * 1996-11-04 1999-11-16 Columbia Laboratories, Inc. Progesterone for treating or reducing ischemia
US5993856A (en) * 1997-01-24 1999-11-30 Femmepharma Pharmaceutical preparations and methods for their administration
US5977143A (en) * 1997-02-15 1999-11-02 Edelstam; Greta Medicament against infertility which reduces phagocytosis of spermatozoa in women
US6210710B1 (en) * 1997-04-28 2001-04-03 Hercules Incorporated Sustained release polymer blend for pharmaceutical applications
CA2207227A1 (en) * 1997-06-09 1998-12-09 Johnson & Johnson Inc. Plant seed germination mat
US6197327B1 (en) * 1997-06-11 2001-03-06 Umd, Inc. Device and method for treatment of dysmenorrhea
US5989535A (en) * 1997-08-15 1999-11-23 Soma Technologies Polymeric bioadhesive emulsions and suspensions and methods of treatment
US6248358B1 (en) * 1998-08-25 2001-06-19 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets and methods of making and using the same
DE69819748T2 (de) * 1997-09-12 2004-09-30 Columbia Laboratories (Bermuda) Ltd. Arzneimittel zur behandlung von dysmenorrhöe und verfrühten wehen
DE69833000T2 (de) * 1997-09-26 2006-09-07 Noven Pharmaceuticals, Inc., Miami Bio-klebemittelzusammensetzungen
US6135153A (en) * 1998-01-02 2000-10-24 Cleland, Sr. John Anesthesia delivery systems and methods
US6180355B1 (en) * 1998-05-07 2001-01-30 University Of Maryland, Baltimore Method for diagnosing and treating chronic pelvic pain syndrome
US6207696B1 (en) * 1998-09-15 2001-03-27 Cytos Pharamaceuticals, Llc Compositions and methods for the prophylaxis and treatment of dysmenorrhea, endometriosis, and pre-term labor, using histidine
US6486207B2 (en) * 1998-12-10 2002-11-26 Nexmed (Holdings), Inc. Compositions and methods for amelioration of human female sexual dysfunction
US6264973B1 (en) * 1999-08-26 2001-07-24 Fei Enterprises, Ltd. Apparatus and method for anesthetizing the cervical region of a female
AU7331300A (en) * 1999-08-27 2001-03-26 Merck & Co., Inc. Method for treating or preventing chronic prostatitis or chronic pelvic pain syndrome
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane

Also Published As

Publication number Publication date
UA90077C2 (uk) 2010-04-12
DE60216495T2 (de) 2007-07-26
ZA200402944B (en) 2005-03-30
HUP0402389A3 (en) 2012-09-28
SI1764111T1 (sl) 2010-04-30
RU2004116346A (ru) 2005-03-10
HRP20040479B1 (hr) 2009-02-28
MXPA04003976A (es) 2004-07-08
EP1764111B1 (en) 2009-12-09
MA26230A1 (fr) 2004-07-01
CY1106000T1 (el) 2011-04-06
HK1102221A1 (en) 2007-11-09
EP1764111A1 (en) 2007-03-21
DE60216495D1 (de) 2007-01-11
BR0213585A (pt) 2004-08-24
PT1764111E (pt) 2010-01-29
RS36704A (sr) 2006-10-27
CN100404072C (zh) 2008-07-23
AU2002350644B2 (en) 2008-05-08
HRP20040479A2 (en) 2004-10-31
HUP0402389A2 (hu) 2005-03-29
NO333544B1 (no) 2013-07-08
US20030114394A1 (en) 2003-06-19
GEP20094614B (en) 2009-02-25
MEP34908A (bs) 2011-02-10
EP1441770B1 (en) 2006-11-29
NZ532295A (en) 2006-12-22
PE20030692A1 (es) 2003-08-28
IL211288A (en) 2014-02-27
CA2465132A1 (en) 2003-05-08
EP1441770A1 (en) 2004-08-04
IL161513A0 (en) 2004-09-27
ES2275928T3 (es) 2007-06-16
ATE346614T1 (de) 2006-12-15
AR037048A1 (es) 2004-10-20
RS51414B (sr) 2011-02-28
HK1063293A1 (en) 2004-12-24
CN1578675A (zh) 2005-02-09
RU2008133235A (ru) 2010-02-20
KR20100088718A (ko) 2010-08-10
NO20042208L (no) 2004-07-29
RU2476212C2 (ru) 2013-02-27
JP2005511564A (ja) 2005-04-28
JP2011201909A (ja) 2011-10-13
PL369790A1 (en) 2005-05-02
IL211288A0 (en) 2011-04-28
MY145215A (en) 2012-01-13
DK1764111T3 (da) 2010-04-06
CA2465132C (en) 2012-04-24
DK1441770T3 (da) 2007-03-19
PT1441770E (pt) 2007-01-31
PL402549A1 (pl) 2013-08-05
WO2003037381A1 (en) 2003-05-08
ATE451123T1 (de) 2009-12-15
ME00255B (me) 2011-05-10
RU2345758C2 (ru) 2009-02-10
KR20050040820A (ko) 2005-05-03
IL161513A (en) 2011-12-29
DE60234725D1 (de) 2010-01-21
CY1110288T1 (el) 2015-01-14
ES2336238T3 (es) 2010-04-09
MY149482A (en) 2013-08-30

Similar Documents

Publication Publication Date Title
SI1764111T1 (sl) AntidisritmiŽŤna sredstva za vaginalno dajanje za zdravljenje materniŽŤne disritmije
HUS1500048I1 (hu) Ivermectin helyi kiszerelése dermatológiai állapotok kezelésére
PL1608407T3 (pl) Dyspergowana kompozycja środka przeciw-zapalnego
DK1250138T3 (da) Fulvestrantformulering
NO20014379L (no) Anvendelse av Xenon for behandling av Neurointoksikasjoner
ATE491436T1 (de) Zusammensetzungen gegen infektionen zur behandlung erkrankten gewebes wie z.b. fieberbläschen
IL172735A0 (en) Dispersible formulation of an anti-inflammatory agent
PT1506781E (pt) Composicao para tratamento vaginal
AU2002339157A1 (en) Inhibitors of the notch signalling pathway for use in the treatment of cancer
NO20031442D0 (no) Morfolin-acetamidderivater for behandling av inflammatoriske sykdommer
EP1438062A4 (en) METHOD AND COMPOSITIONS FOR TREATING SKIN Lions
PT1392292E (pt) Piranoindazoles e sua utilizacao para o tratamento de glaucoma
BR0105828B1 (pt) dispositivo para locomoÇço de deficientes fÍsicos.
IS6918A (is) Meðferð erfiðra æxla með notkun epóþílon afleiða
PT1413305E (pt) Derivados aril (ou heteroaril) azolilcabrinol para o tratamento de incontinencia urinaria
NO20041968L (no) Anvendelse av cystationin
SI1475379T1 (sl) Uporaba derivatov skopinskega estra za pripravo zdravil
IS2490B (is) Bensóþíasól- og bensoxasól-4,7-díonafleiður og notkun þeirra sem cdc25 fosfatasatálma
DE50207870D1 (de) Abschlussbandage
PT1268482E (pt) Piranoindois para o tratamento de glaucoma
AR028398A1 (es) Ciclipostinas, procedimiento para su preparacion, y utilizacion de las mismas
PT1385512E (pt) Utilizacao de derivados de piridoindolona para preparacao de medicamentos anticancerigenos
ES1049954Y (es) Zocalo para alojamiento de hembrillas y microreles.
IL146655A0 (en) The use of leptin in fertility
PT1363614E (pt) Utilizacao de 2-amino-1-(4-hidroxi-3-metanossulfonamidofenil) etanol para o tratamento de incontinencia urinaria