SI1140933T1 - Process for preparing n6-substituted deaza-adenosine derivatives - Google Patents

Process for preparing n6-substituted deaza-adenosine derivatives

Info

Publication number
SI1140933T1
SI1140933T1 SI9930688T SI9930688T SI1140933T1 SI 1140933 T1 SI1140933 T1 SI 1140933T1 SI 9930688 T SI9930688 T SI 9930688T SI 9930688 T SI9930688 T SI 9930688T SI 1140933 T1 SI1140933 T1 SI 1140933T1
Authority
SI
Slovenia
Prior art keywords
preparing
adenosine derivatives
substituted
deaza
substituted deaza
Prior art date
Application number
SI9930688T
Other languages
English (en)
Slovenian (sl)
Inventor
Adam W. Sledeski
Luc Grondard
Matthew R. Powers
Tory H. Powner
Michael K. O'brien
Ching T. Tsuei
Patrick Leon
Gregory G. Kubiak
Laurence Pailleres-Hubert
Benoit Viguier
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of SI1140933T1 publication Critical patent/SI1140933T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI9930688T 1998-12-31 1999-12-15 Process for preparing n6-substituted deaza-adenosine derivatives SI1140933T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11448698P 1998-12-31 1998-12-31
US11602899P 1999-01-15 1999-01-15
PCT/US1999/029841 WO2000040584A2 (en) 1998-12-31 1999-12-15 Process for preparing n6-substituted deaza-adenosine derivatives
EP99966299A EP1140933B1 (en) 1998-12-31 1999-12-15 Process for preparing n6-substituted deaza-adenosine derivatives

Publications (1)

Publication Number Publication Date
SI1140933T1 true SI1140933T1 (en) 2005-02-28

Family

ID=26812247

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9930688T SI1140933T1 (en) 1998-12-31 1999-12-15 Process for preparing n6-substituted deaza-adenosine derivatives

Country Status (16)

Country Link
US (1) US6429315B1 (xx)
EP (1) EP1140933B1 (xx)
JP (1) JP2002534430A (xx)
KR (1) KR20010089751A (xx)
CN (1) CN1383427A (xx)
AT (1) ATE275565T1 (xx)
AU (1) AU2187100A (xx)
BR (1) BR9917000A (xx)
CA (1) CA2358962A1 (xx)
DE (1) DE69920045T2 (xx)
DK (1) DK1140933T3 (xx)
ES (1) ES2228163T3 (xx)
HK (1) HK1040239A1 (xx)
PT (1) PT1140933E (xx)
SI (1) SI1140933T1 (xx)
WO (1) WO2000040584A2 (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002534430A (ja) 1998-12-31 2002-10-15 アベンティス・ファーマスーティカルズ・プロダクツ・インコーポレイテツド Ｎ６−置換デアザアデノシン誘導体類の製造法
GT200500281A (es) * 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0607944D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607948D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607953D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607950D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
ATE549337T1 (de) 2006-04-21 2012-03-15 Novartis Ag Purinderivate zur verwendung als adenosin-a2a- rezeptoragonisten
EP1889846A1 (en) 2006-07-13 2008-02-20 Novartis AG Purine derivatives as A2a agonists
EP1903044A1 (en) * 2006-09-14 2008-03-26 Novartis AG Adenosine Derivatives as A2A Receptor Agonists
CA2669108A1 (en) * 2006-11-10 2008-05-15 Novartis Ag Cyclopentene diol monoacetate derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5561134A (en) 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
US5652366A (en) 1990-09-25 1997-07-29 Rhone-Poulenc Rorer Pharmaceuticals Inc. DI (1R)-(-)camphosulfonic acid) salt, preparation thereof and use thereof
AU654507B2 (en) 1990-09-25 1994-11-10 Rhone-Poulenc Rorer International (Holdings) Inc. Compounds having antihypertensive and anti-ischemic properties
US5545769A (en) 1994-09-29 1996-08-13 E. I. Du Pont De Nemours And Company Process for the manufacture of selected halogenated hydrocarbons containing fluorine and hydrogen and compositions provided therein
US5684159A (en) 1995-05-30 1997-11-04 Rhone-Poulenc Rorer S.A. L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
FR2734822B1 (fr) 1995-05-30 1997-07-04 Rhone Poulenc Rorer Sa Nouveaux derives du 2-azabicyclo(2.2.1)heptane, leur preparation et leur application
CZ203998A3 (cs) 1996-01-02 1999-11-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Způsob přípravy 2,4-dihydroxypyridinu a 2,4-dihydroxy-3-nitropyridinu
UA51716C2 (uk) * 1996-07-08 2002-12-16 Авентіс Фармасьютікалз Продактс Інк. Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування
AU732332B2 (en) 1996-09-12 2001-04-12 Aventis Pharmaceuticals Inc. Stereospecific preparation of chiral 1-aryl- and 1-heteroaryl-2-substituted ethyl-2-amines
ATE301120T1 (de) 1996-12-11 2005-08-15 Aventis Pharma Inc Herstellung von (1s-(1a,2b,3b,4(s*)))-4-(7-((1-(3-chlor-2-thien l)methyl)propyl)amino)-3h-imidazo(4,5-b)pyridin 3-yl)-n-ethyl-2,3- dihydroxycyclopentancarboxamid
JP2002534430A (ja) 1998-12-31 2002-10-15 アベンティス・ファーマスーティカルズ・プロダクツ・インコーポレイテツド Ｎ６−置換デアザアデノシン誘導体類の製造法

Also Published As

Publication number Publication date
DE69920045D1 (de) 2004-10-14
WO2000040584A3 (en) 2000-11-02
WO2000040584A2 (en) 2000-07-13
JP2002534430A (ja) 2002-10-15
DK1140933T3 (da) 2004-12-20
HK1040239A1 (en) 2002-05-31
US6429315B1 (en) 2002-08-06
KR20010089751A (ko) 2001-10-08
ATE275565T1 (de) 2004-09-15
EP1140933A2 (en) 2001-10-10
PT1140933E (pt) 2004-12-31
AU2187100A (en) 2000-07-24
EP1140933B1 (en) 2004-09-08
CA2358962A1 (en) 2000-07-13
ES2228163T3 (es) 2005-04-01
DE69920045T2 (de) 2005-09-29
BR9917000A (pt) 2001-12-11
CN1383427A (zh) 2002-12-04

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