SI1131039T1 - Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stress - Google Patents
Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stressInfo
- Publication number
- SI1131039T1 SI1131039T1 SI9930814T SI9930814T SI1131039T1 SI 1131039 T1 SI1131039 T1 SI 1131039T1 SI 9930814 T SI9930814 T SI 9930814T SI 9930814 T SI9930814 T SI 9930814T SI 1131039 T1 SI1131039 T1 SI 1131039T1
- Authority
- SI
- Slovenia
- Prior art keywords
- treating skin
- substance binding
- skin stress
- peripheral
- benzodiazepin receptor
- Prior art date
Links
- 230000002093 peripheral effect Effects 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title 1
- 102000004300 GABA-A Receptors Human genes 0.000 abstract 1
- 108090000839 GABA-A Receptors Proteins 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9814387A FR2785803B1 (fr) | 1998-11-17 | 1998-11-17 | Utilisation d'une substance se liant au recepteur peripherique des benzodiazepines dans le traitement des stress cutanes |
EP99972094A EP1131039B1 (fr) | 1998-11-17 | 1999-11-10 | Utilisation d'une substance se liant au recepteur peripherique des benzodiazepines dans le traitement des stress cutanes |
PCT/FR1999/002761 WO2000028947A2 (fr) | 1998-11-17 | 1999-11-10 | Utilisation d'une substance se liant au recepteur peripherique des benzodiazepines dans le traitement des stress cutanes |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1131039T1 true SI1131039T1 (en) | 2005-10-31 |
Family
ID=9532791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9930814T SI1131039T1 (en) | 1998-11-17 | 1999-11-10 | Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stress |
Country Status (18)
Country | Link |
---|---|
US (2) | US6767533B1 (xx) |
EP (1) | EP1131039B1 (xx) |
JP (1) | JP2002529486A (xx) |
KR (1) | KR20010089475A (xx) |
AT (1) | ATE298230T1 (xx) |
AU (1) | AU764786B2 (xx) |
CA (1) | CA2349919A1 (xx) |
CY (1) | CY1105144T1 (xx) |
DE (1) | DE69925928T2 (xx) |
DK (1) | DK1131039T3 (xx) |
ES (1) | ES2244246T3 (xx) |
FR (1) | FR2785803B1 (xx) |
HK (1) | HK1037966A1 (xx) |
HR (1) | HRP20010367A2 (xx) |
HU (1) | HUP0105058A2 (xx) |
PT (1) | PT1131039E (xx) |
SI (1) | SI1131039T1 (xx) |
WO (1) | WO2000028947A2 (xx) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1140106B1 (en) * | 1998-12-18 | 2005-08-03 | Scios Inc. | Treatment of diseases involving cyst formation |
US7572788B2 (en) * | 1999-04-30 | 2009-08-11 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
US20050113460A1 (en) * | 1999-04-30 | 2005-05-26 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
US20040176358A1 (en) * | 1999-04-30 | 2004-09-09 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
US20030119029A1 (en) * | 1999-04-30 | 2003-06-26 | Regents Of The University Of Michigan | Compositions and methods relating to novel benzodiazepine compounds and targets thereof |
DE60007960T2 (de) * | 1999-04-30 | 2004-10-21 | Univ Michigan Ann Arbor | Therapeutische Anwendungen von pro-apoptotischen Benzodiazepinen |
US20060025388A1 (en) * | 1999-04-30 | 2006-02-02 | Glick Gary D | Compositions and methods relating to novel compounds and targets thereof |
US7276348B2 (en) * | 1999-04-30 | 2007-10-02 | Regents Of The University Of Michigan | Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof |
DE10021468A1 (de) * | 2000-05-04 | 2001-11-08 | Basf Ag | Verwendung von PARP-Inhibitoren in kosmetischen Zubereitungen |
MXPA05002871A (es) | 2002-09-20 | 2005-10-05 | Arrow Therapeutics Ltd | Derivados de benzodiazaepina y composiciones farmaceuticas que los contienen. |
US20050272723A1 (en) * | 2004-04-27 | 2005-12-08 | The Regents Of The University Of Michigan | Methods and compositions for treating diseases and conditions associated with mitochondrial function |
US20060052369A1 (en) * | 2004-09-07 | 2006-03-09 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
FR2879450B1 (fr) * | 2004-12-20 | 2007-02-09 | Oreal | Antagonistes des recepteurs peripheriques des benzodiazepines pour le traitement des peaux seches |
FR2879451B1 (fr) * | 2004-12-20 | 2007-05-04 | Oreal | Utilisation de ligands du recepteur des benzodiazepines pour lutter contre les signes du vieillissement |
BRPI0517216A (pt) * | 2004-12-20 | 2008-09-30 | Oreal | uso cosmético de pelo menos um antagonista dos receptores periféricos das benzodizepinas e processo cosmético para combater as rugas ou as rìdulas |
WO2006067327A2 (fr) * | 2004-12-20 | 2006-06-29 | L'oreal | Antagonistes des recepteurs peripheriques des benzodiazepines pour le traitement des peaux seches |
JP2008528448A (ja) | 2005-01-03 | 2008-07-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 新規化合物に関連する組成物および方法、ならびにその標的 |
EP1893218A4 (en) * | 2005-06-01 | 2011-01-12 | Univ Michigan | NON-SOLVATED BENZODIAZEPINE PREPARATIONS AND METHODS |
EP1948191B1 (en) | 2005-11-01 | 2013-01-16 | The Regents of the University of Michigan | Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties |
KR20070058292A (ko) * | 2005-12-02 | 2007-06-08 | 엘지전자 주식회사 | 기록매체, 기록매체 기록재생 방법 및 장치와 기록매체클로징 방법 |
US7759338B2 (en) * | 2006-04-27 | 2010-07-20 | The Regents Of The University Of Michigan | Soluble 1,4 benzodiazepine compounds and stable salts thereof |
EP2037741B1 (en) | 2006-06-09 | 2013-11-27 | The Regents Of The University Of Michigan | Benzodiazepine derivatives for use in the treatment of immune, inflammatory and proliferative disorders |
EP2059813A2 (en) * | 2006-06-26 | 2009-05-20 | Technion Research & Development Foundation LTD. | Methods and kits for diagnosing cancer |
CA2680017C (en) | 2007-03-09 | 2013-11-12 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
BRPI0815782A2 (pt) * | 2007-08-31 | 2015-02-24 | Archimedes Dev Ltd | Composição para a dispensação intranasal de uma droga, uso de uma composição não aquosa, dispositivo para a dispensação nasal de drogas ou um cartucho de dose, usos de um veículo, não aquoso, e de uma droga de benzodiazepina e um veículo não aquoso |
CA2698248C (en) | 2007-09-14 | 2017-08-29 | The Regents Of The University Of Michigan | Phenyl acyl guanidine derivatives as f1f0-atpase inhibitors and the use thereof |
CA2703005A1 (en) | 2007-11-06 | 2009-05-14 | The Regents Of The University Of Michigan | Benzodiazepinone compounds useful in the treatment of skin conditions |
US8497307B2 (en) | 2008-09-11 | 2013-07-30 | The Regents Of The University Of Michigan | Aryl guanidine F1F0-ATPase inhibitors and related methods |
US8604023B2 (en) | 2009-04-17 | 2013-12-10 | The Regents Of The University Of Michigan | 1,4-benzodiazepinone compounds and their use in treating cancer |
US9075060B2 (en) | 2009-06-16 | 2015-07-07 | Technion Research & Development Foundation Limited | Methods for diagnosing oral or oral-pharyngeal cancer |
EP2470020A4 (en) | 2009-09-18 | 2013-03-13 | Univ Michigan | BENZODIAZEPINONE COMPOUNDS AND TREATMENT METHODS THEREWITH |
AU2010322287B2 (en) | 2009-11-17 | 2014-04-03 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
CA2780333C (en) | 2009-11-17 | 2016-05-24 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5279082A (en) * | 1975-12-25 | 1977-07-02 | Green Cross Corp:The | Preparation of anti-tumor compound |
JPS5473195A (en) * | 1977-11-22 | 1979-06-12 | Takeda Chem Ind Ltd | Preparation of tomaymycins |
JPS56121495A (en) * | 1980-02-29 | 1981-09-24 | Kyowa Hakko Kogyo Co Ltd | Preparation of benzodiazepine derivative |
IL101387A (en) * | 1992-03-26 | 1999-11-30 | Pharmos Ltd | Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets |
AU4673993A (en) * | 1992-07-28 | 1994-02-14 | Procter & Gamble Company, The | Pharmaceutical composition for topical use containing a crosslinked cationic polymer and an alkoxylated ether |
DE60007960T2 (de) * | 1999-04-30 | 2004-10-21 | Univ Michigan Ann Arbor | Therapeutische Anwendungen von pro-apoptotischen Benzodiazepinen |
-
1998
- 1998-11-17 FR FR9814387A patent/FR2785803B1/fr not_active Expired - Fee Related
-
1999
- 1999-11-10 ES ES99972094T patent/ES2244246T3/es not_active Expired - Lifetime
- 1999-11-10 EP EP99972094A patent/EP1131039B1/fr not_active Expired - Lifetime
- 1999-11-10 SI SI9930814T patent/SI1131039T1/xx unknown
- 1999-11-10 HU HU0105058A patent/HUP0105058A2/hu unknown
- 1999-11-10 KR KR1020017006238A patent/KR20010089475A/ko active IP Right Grant
- 1999-11-10 AT AT99972094T patent/ATE298230T1/de not_active IP Right Cessation
- 1999-11-10 DK DK99972094T patent/DK1131039T3/da active
- 1999-11-10 US US09/831,720 patent/US6767533B1/en not_active Expired - Fee Related
- 1999-11-10 CA CA002349919A patent/CA2349919A1/en not_active Abandoned
- 1999-11-10 WO PCT/FR1999/002761 patent/WO2000028947A2/fr not_active Application Discontinuation
- 1999-11-10 PT PT99972094T patent/PT1131039E/pt unknown
- 1999-11-10 AU AU11661/00A patent/AU764786B2/en not_active Ceased
- 1999-11-10 DE DE69925928T patent/DE69925928T2/de not_active Expired - Fee Related
- 1999-11-10 JP JP2000581995A patent/JP2002529486A/ja not_active Withdrawn
-
2001
- 2001-05-17 HR HR20010367A patent/HRP20010367A2/hr not_active Application Discontinuation
- 2001-12-11 HK HK01108691A patent/HK1037966A1/xx not_active IP Right Cessation
-
2004
- 2004-07-26 US US10/898,793 patent/US20050090489A1/en not_active Abandoned
-
2005
- 2005-09-21 CY CY20051101175T patent/CY1105144T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO2000028947A2 (fr) | 2000-05-25 |
US20050090489A1 (en) | 2005-04-28 |
EP1131039B1 (fr) | 2005-06-22 |
AU1166100A (en) | 2000-06-05 |
PT1131039E (pt) | 2005-11-30 |
EP1131039A2 (fr) | 2001-09-12 |
FR2785803A1 (fr) | 2000-05-19 |
ATE298230T1 (de) | 2005-07-15 |
HUP0105058A2 (hu) | 2002-05-29 |
JP2002529486A (ja) | 2002-09-10 |
HRP20010367A2 (en) | 2002-06-30 |
KR20010089475A (ko) | 2001-10-06 |
DE69925928T2 (de) | 2006-08-17 |
AU764786B2 (en) | 2003-08-28 |
CA2349919A1 (en) | 2000-05-25 |
DE69925928D1 (de) | 2005-07-28 |
DK1131039T3 (da) | 2005-10-17 |
FR2785803B1 (fr) | 2005-03-25 |
WO2000028947A3 (fr) | 2000-08-03 |
HK1037966A1 (en) | 2002-03-01 |
US6767533B1 (en) | 2004-07-27 |
ES2244246T3 (es) | 2005-12-01 |
CY1105144T1 (el) | 2010-03-03 |
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