SI1057826T1 - Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them - Google Patents

Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them

Info

Publication number
SI1057826T1
SI1057826T1 SI200030081T SI200030081T SI1057826T1 SI 1057826 T1 SI1057826 T1 SI 1057826T1 SI 200030081 T SI200030081 T SI 200030081T SI 200030081 T SI200030081 T SI 200030081T SI 1057826 T1 SI1057826 T1 SI 1057826T1
Authority
SI
Slovenia
Prior art keywords
nr1c
nr2r3
preparing
pharmaceutical compositions
compositions containing
Prior art date
Application number
SI200030081T
Other languages
English (en)
Slovenian (sl)
Inventor
Patrick Depreux
Said Yous
Gwenael Cheve
Gerald Guillaumet
Marie-Claude Viaud
Carlos Larraya
Caroline Bennejean
Philippe Delagrange
Pierre Regard
Carole Descamps-Francois
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of SI1057826T1 publication Critical patent/SI1057826T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
SI200030081T 1999-05-19 2000-05-22 Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them SI1057826T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9906331A FR2793793B1 (fr) 1999-05-19 1999-05-19 Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP00610050A EP1057826B1 (fr) 1999-05-19 2000-05-22 Dérivés carboxamides dimériques substitués, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
SI1057826T1 true SI1057826T1 (en) 2003-08-31

Family

ID=9545746

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030081T SI1057826T1 (en) 1999-05-19 2000-05-22 Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them

Country Status (21)

Country Link
US (1) US6310074B1 (xx)
EP (1) EP1057826B1 (xx)
JP (1) JP3688552B2 (xx)
KR (1) KR100472520B1 (xx)
CN (1) CN1128142C (xx)
AT (1) ATE237610T1 (xx)
AU (1) AU766322B2 (xx)
BR (1) BR0003313A (xx)
DE (1) DE60002126T2 (xx)
DK (1) DK1057826T3 (xx)
EA (1) EA003391B1 (xx)
ES (1) ES2197062T3 (xx)
FR (1) FR2793793B1 (xx)
HK (1) HK1030937A1 (xx)
HU (1) HUP0001961A3 (xx)
NO (1) NO20002548L (xx)
NZ (1) NZ504613A (xx)
PL (1) PL340165A1 (xx)
PT (1) PT1057826E (xx)
SI (1) SI1057826T1 (xx)
ZA (1) ZA200002490B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2291722T3 (es) * 2002-12-03 2008-03-01 Hoffmann La Roche Aminoalcoxiindoles como ligandos 5-ht6-receptores para el tratamiento de transtornos del snc.
JP5138938B2 (ja) 2003-12-19 2013-02-06 プレキシコン インコーポレーテッド Ｒｅｔ調節剤の開発のための化合物および方法
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
EP1885723A2 (en) * 2005-05-17 2008-02-13 Plexxikon, Inc. Pyrrolo[2,3-b]pyridine derivatives as protein kinase inhibitors
RS52010B (en) * 2005-06-22 2012-04-30 Plexxikon Inc. DERIVATI PIROLO [2, 3-B] PIRIDINA KAO INHIBITORI PROTEIN KINAZE
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
MX2009006688A (es) 2006-12-21 2009-06-30 Plexxikon Inc Compuestos y metodos para modulacion de cinasas, e indicaciones para ello.
CA2695004C (en) 2007-07-17 2016-01-19 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
PE20110208A1 (es) * 2008-07-30 2011-03-28 Ferrer Int Compuestos de 1,6-dihidro-2h-3-oxa-6-aza-as-indaceno
NZ594398A (en) 2009-04-03 2014-03-28 Plexxikon Inc Propane-1-sulfonic acid (3-[5-(4-chloro-phenyl)-1h-pyrrol [2, 3-b] pyridine-3-carbonyl]-2,4-difluoro-phenyl} -amide compositions and uses thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
US20110112127A1 (en) 2009-11-06 2011-05-12 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
ES2696023T3 (es) 2011-02-07 2019-01-11 Plexxikon Inc Compuestos y métodos para la modulación de quinasas e indicaciones para ello
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1639427A3 (ru) * 1987-07-03 1991-03-30 Глэксо Груп Лимитед (Фирма) Способ получени производных индола или их фармацевтически приемлемых солей
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ES2087463T3 (es) * 1991-11-18 1996-07-16 Lilly Industries Ltd Benzo(b)tiofen-2-carboxamidas para el tratamiento de trastornos del sistema nervioso central.
FR2689124A1 (fr) * 1992-03-27 1993-10-01 Adir Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2696453B1 (fr) * 1992-10-02 1994-12-23 Adir Nouveaux arylalkyl(thio)amides, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
CA2152160A1 (en) * 1992-12-21 1994-07-07 Tomoyuki Ikemoto N-substituted indole derivative
EP0767782B1 (en) * 1994-06-29 2001-10-31 Pfizer Inc. Aryl and heteroaryl alkoxynaphthalene derivatives
FR2731223A1 (fr) * 1995-03-02 1996-09-06 Pf Medicament Nouveaux derives bi-tryptaminiques, leur procede de preparation et leur utilisation a titre de medicaments

Also Published As

Publication number Publication date
EP1057826B1 (fr) 2003-04-16
FR2793793B1 (fr) 2004-02-27
KR20010029729A (ko) 2001-04-16
HU0001961D0 (en) 2000-07-28
EA200000431A3 (ru) 2001-02-26
ES2197062T3 (es) 2004-01-01
DE60002126T2 (de) 2004-03-18
NO20002548L (no) 2000-11-20
BR0003313A (pt) 2001-03-13
DE60002126D1 (de) 2003-05-22
FR2793793A1 (fr) 2000-11-24
PT1057826E (pt) 2003-08-29
CN1128142C (zh) 2003-11-19
AU3542000A (en) 2000-11-23
AU766322B2 (en) 2003-10-16
ZA200002490B (en) 2000-11-20
US6310074B1 (en) 2001-10-30
NO20002548D0 (no) 2000-05-18
EA200000431A2 (ru) 2000-12-25
EA003391B1 (ru) 2003-04-24
HUP0001961A2 (hu) 2001-08-28
HK1030937A1 (en) 2001-05-25
JP3688552B2 (ja) 2005-08-31
DK1057826T3 (da) 2003-07-21
JP2001011035A (ja) 2001-01-16
EP1057826A1 (fr) 2000-12-06
KR100472520B1 (ko) 2005-03-07
NZ504613A (en) 2001-06-29
HUP0001961A3 (en) 2002-10-28
ATE237610T1 (de) 2003-05-15
CN1277962A (zh) 2000-12-27
PL340165A1 (en) 2000-11-20

Similar Documents

Publication Publication Date Title
SI1057826T1 (en) Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them
ATE73657T1 (de) Verwendung von gamma-linolensaeure und verwandten verbindungen zur herstellung eubnes arzneimittels zur behandlung von endometriose.
IL127244A (en) Substituted amines, methods of their preparation and pharmaceutical compositions containing them
UA39158C2 (uk) Похідні n4-оксикарбоніл-5'-дезокси-5-фторцитидину та фармацевтичний препарат на їх основі
DE69706566D1 (de) Verwendung von dem chelatbildner clioquinol zur herstellung eines arzneimittelszur behandlung von alzheimerschen krankheit
DE3584281D1 (de) Tripeptidyl-argininaldehyde, verfahren zu ihrer herstellung und diese enthaltende arzneimittel sowie n-(monoalkyl)- und n,n-di-(alkyl)-xxx-l-prolin-dipeptide.
NZ284846A (en) 1-substituted-pyrazolo[3,4-b]pyridin-5-carboxylic acid derivatives, preparation, use, intermediates and pharmaceutical compositions thereof
UA32543C2 (uk) Арилацетаміди, що мають анальгетичну дію, спосіб їх одержання, фармацевтична композиція та спосіб її одержання
PL311122A1 (en) Water-solublederivatives of camptotectin, method of obtaining them and their application as anticarcinogenic agents
MY120683A (en) New phenylamidine derivatives, processes for their preparation and their use as pharmaceuticals.
GEP20032914B (en) Derivatives of 1,3,4-Oxadiazolone
HUT50844A (en) Process for producing new 2'-halogen methylidene, 2'-ethenylidene and 2'-ethinyladenosine derivatives and pharmaceutical compositions comprising same as active ingredient
BG101220A (en) N-substituted 3-azabicyclo (93.2.0) heptane derivatives,their preparation and use
MX9704034A (es) Derivados y composiciones de 1,1-dioxido de 2-arilcarboniloximetil-1,2,5-tiadiazolidin-3-ona substituido y metodo de uso.
BG104179A (en) Phanquinon administration for the treatment of the alzheimer's disease
NZ222045A (en) From diamides up to tetrapeptides for use as anticanvulsants
HUT46364A (en) Process for producing 1,12-dihydroxy-1,6,12,13-tetraaza-dicyclodocosane-2,5,13,16-tetron and pharmaceutical compositions comprising this compound as active ingredient
BG103196A (en) Crystalline pharmaceutical product
MY115795A (en) Substituted benzenesulfonylureas and -thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them
EP0369743A3 (en) Heterocyclic amides
EP0386920A3 (en) 2-hydroxy-3-thienyloxypropylamino derivatives
ZA944281B (en) Use of efaroxan and its derivatives for the preparation of a medicinal product intented for the treatment of parkinson's disease
NZ268476A (en) 14-substituted marcfortines, preparation and pharmaceutical compositions thereof
IL133222A0 (en) Pharmaceutical compositions containing cinchonine dichlorohydrate
HUT66350A (en) N-(2-hidroxi-3-aminopropoxy)-amids-imidates, process to prepare them and pharmaceutical compositions contg. said compounds