DE69706566D1 - Verwendung von dem chelatbildner clioquinol zur herstellung eines arzneimittelszur behandlung von alzheimerschen krankheit - Google Patents
Verwendung von dem chelatbildner clioquinol zur herstellung eines arzneimittelszur behandlung von alzheimerschen krankheitInfo
- Publication number
- DE69706566D1 DE69706566D1 DE69706566T DE69706566T DE69706566D1 DE 69706566 D1 DE69706566 D1 DE 69706566D1 DE 69706566 T DE69706566 T DE 69706566T DE 69706566 T DE69706566 T DE 69706566T DE 69706566 D1 DE69706566 D1 DE 69706566D1
- Authority
- DE
- Germany
- Prior art keywords
- clioquinol
- imager
- chelate
- disease
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- QCDFBFJGMNKBDO-UHFFFAOYSA-N Clioquinol Chemical compound C1=CN=C2C(O)=C(I)C=C(Cl)C2=C1 QCDFBFJGMNKBDO-UHFFFAOYSA-N 0.000 title abstract 3
- 229960005228 clioquinol Drugs 0.000 title abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 239000013522 chelant Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 229930003779 Vitamin B12 Natural products 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000011715 vitamin B12 Substances 0.000 abstract 1
- 235000019163 vitamin B12 Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR96100286 | 1996-08-13 | ||
| PCT/IB1997/000983 WO1998006403A1 (en) | 1996-08-13 | 1997-08-08 | Use of the chelating agent clioquinol for the manufacture of a pharmaceutical composition for the treatment of alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69706566D1 true DE69706566D1 (de) | 2001-10-11 |
| DE69706566T2 DE69706566T2 (de) | 2002-07-11 |
Family
ID=10942479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69706566T Expired - Lifetime DE69706566T2 (de) | 1996-08-13 | 1997-08-08 | Verwendung von dem chelatbildner clioquinol zur herstellung eines arzneimittelszur behandlung von alzheimerschen krankheit |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6001852A (de) |
| EP (1) | EP0959888B1 (de) |
| JP (1) | JP2000516606A (de) |
| KR (1) | KR100489969B1 (de) |
| CN (1) | CN1114407C (de) |
| AT (1) | ATE205086T1 (de) |
| AU (1) | AU720643B2 (de) |
| BR (1) | BR9711194A (de) |
| CA (1) | CA2264097C (de) |
| CZ (2) | CZ295118B6 (de) |
| DE (1) | DE69706566T2 (de) |
| DK (1) | DK0959888T3 (de) |
| ES (1) | ES2162319T3 (de) |
| HK (1) | HK1022437A1 (de) |
| HU (1) | HUP9903906A3 (de) |
| IL (1) | IL128416A (de) |
| IS (1) | IS1907B (de) |
| NO (1) | NO316768B1 (de) |
| NZ (1) | NZ334124A (de) |
| PL (1) | PL188838B1 (de) |
| PT (1) | PT959888E (de) |
| RU (1) | RU2193406C2 (de) |
| SI (1) | SI0959888T1 (de) |
| SK (1) | SK283117B6 (de) |
| TR (1) | TR199900293T2 (de) |
| WO (1) | WO1998006403A1 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7045531B1 (en) | 1997-03-11 | 2006-05-16 | The General Hospital Corporation | Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator |
| CA2301706C (en) | 1997-08-21 | 2005-10-04 | P.N. Gerolymatos S.A. | Use of phanquinone for the treatment of alzheimer's disease |
| JP2001521002A (ja) * | 1997-10-24 | 2001-11-06 | コーネル リサーチ ファンデーション インク． | 脳の代謝機能不全のための栄養補充剤 |
| US5994323A (en) * | 1997-12-31 | 1999-11-30 | P.N. Gerolymatos S.A. | Pharmaceutical compositions comprising clioquinol in combination with vitamin B12 and therapeutic and prophylactic uses thereof |
| US20020025944A1 (en) * | 2000-04-28 | 2002-02-28 | Bush Ashley I. | Use of clioquinol for the therapy of Alzheimer's disease |
| US6638711B1 (en) | 1999-04-29 | 2003-10-28 | The General Hospital Corporation | Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation |
| US6323218B1 (en) * | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
| US20050112543A1 (en) * | 1998-03-11 | 2005-05-26 | The General Hospital Corporation | Method of screening for drugs useful in treating Alzheimer's disease |
| ATE285235T1 (de) | 1999-01-07 | 2005-01-15 | Gerolymatos P N Sa | Verwendung von phanquinon zur behandlung und vorbeugung von gedächtnisschwund |
| US6692234B2 (en) | 1999-03-22 | 2004-02-17 | Water Management Systems | Pump system with vacuum source |
| US20040054182A1 (en) * | 2000-02-09 | 2004-03-18 | Hideo Kato | 1h-imidazopyridine derivatives |
| FR2818551B1 (fr) * | 2000-12-22 | 2007-06-01 | Claude Marc Pierre Hannoun | Utilisation de chelateurs pour le traitement des maladies a prions |
| US6803379B2 (en) * | 2002-06-04 | 2004-10-12 | Jose A. Fernandez-Pol | Pharmacological agents and methods of treatment that inactivate pathogenic prokaryotic and eukaryotic cells and viruses by attacking highly conserved domains in structural metalloprotein and metalloenzyme targets |
| AU2002950217A0 (en) * | 2002-07-16 | 2002-09-12 | Prana Biotechnology Limited | 8- Hydroxy Quinoline Derivatives |
| KR101122782B1 (ko) | 2002-10-04 | 2012-04-12 | 프라나 바이오테크놀로지 리미티드 | 신경 활성 화합물 |
| US20080063599A1 (en) * | 2002-11-18 | 2008-03-13 | Jorge Setoain Quinquer | Compounds Which Can Be Used To Diagnose And Monitor Diseases Associated With The Formation Of Amyloid Protein Fibrils |
| CN1791408A (zh) * | 2003-04-03 | 2006-06-21 | 普拉纳生物技术有限公司 | 神经系统疾病的治疗 |
| WO2005049026A1 (en) * | 2003-11-19 | 2005-06-02 | Acrux Dds Pty Ltd | Method and composition for treatment or prophylaxis of amyloidosis disorders |
| US20060194723A1 (en) * | 2005-02-28 | 2006-08-31 | Rabinoff Michael D | Novel medication treatment and delivery strategies for Alzheimer's Disease, other disorders with memory impairment, and possible treatment strategies for memory improvement |
| US8865763B2 (en) | 2005-10-14 | 2014-10-21 | Alltech, Inc. | Methods and compositions for altering cell function |
| US8871715B2 (en) | 2005-10-14 | 2014-10-28 | Alltech, Inc. | Use of selenium compounds, especially selenium yeasts for altering cognitive function |
| TWI319708B (en) * | 2005-10-14 | 2010-01-21 | Methods and compositions for altering cell fuction | |
| RU2442793C2 (ru) * | 2005-11-30 | 2012-02-20 | Эбботт Лэборетриз | АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ |
| CA2683756A1 (en) | 2006-04-14 | 2007-10-25 | Prana Biotechnology Limited | Method of treatment of age-related macular degeneration(amd) |
| PT2468770T (pt) * | 2006-07-14 | 2018-03-09 | Genentech Inc | Anticorpo humanizado contra beta-amiloide |
| SG173385A1 (en) * | 2006-07-14 | 2011-08-29 | Ac Immune S A Ch | Humanized antibody against amyloid beta |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| RU2604181C2 (ru) | 2007-10-05 | 2016-12-10 | Дженентек, Инк. | Применение антитела против амилоида бета при глазных заболеваниях |
| ES2332687B1 (es) * | 2008-03-13 | 2011-01-10 | Proyecto De Biomedicina Cima, S.L. | Nuevos usos de 4pba y sus sales farmaceuticamente aceptables. |
| RU2607368C2 (ru) | 2010-07-30 | 2017-01-10 | Ац Иммуне С.А. | Безопасные и функциональные гуманизированные антитела |
| FR2966827B1 (fr) | 2010-10-27 | 2014-08-22 | Kimonella Ventures Ltd | Compose peptidique utile pour l'inhibition de la formation de plaques amyloides |
| EP2981525A4 (de) * | 2013-04-02 | 2016-12-21 | Annji Pharm Co Ltd | Multifunktionelle chinolinderivate als antineurodegenerative mittel |
| EP3135280B1 (de) | 2014-04-24 | 2023-09-20 | Omoidesouzou Co. Ltd. | Tranilast zur behandlung von kutaner amyloidose |
| KR20160057500A (ko) * | 2014-11-05 | 2016-05-24 | 아카데미아 시니카 | 클리오퀴놀을 포함하는 자폐증 스펙트럼 장애의 치료용 약학적 조성물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3174899A (en) * | 1960-12-30 | 1965-03-23 | Ciba Geigy Corp | Composition for the management of post antibiotic enteritis |
| US3178343A (en) * | 1962-11-27 | 1965-04-13 | Ciba Geigy Corp | Pharmaceutical compositions and method of using same |
| DE1617417A1 (de) * | 1966-12-08 | 1971-03-25 | Ciba Geigy | Pharmazeutisches Praeparat |
| DE3932338A1 (de) * | 1989-09-28 | 1991-04-11 | Nmi Naturwissenschaftl U Mediz | Verfahren zur praeventiven therapie von morbus alzheimer |
| GB9010039D0 (en) * | 1990-05-03 | 1990-06-27 | Reckitt & Colmann Prod Ltd | Medicament preparation |
| GB9108080D0 (en) * | 1991-04-15 | 1991-06-05 | Smithkline Beecham Plc | Pharmaceutical composition |
| US5206264A (en) * | 1991-11-04 | 1993-04-27 | Cypros Pharmaceutical Corporation | Use of disulfiram to prevent cardiovascular damage |
| CA2123211C (en) * | 1991-11-12 | 2008-09-16 | Colin L. Masters | A method for assaying and treating alzheimer's disease |
| US5607691A (en) * | 1992-06-12 | 1997-03-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
| AU1831195A (en) * | 1994-01-13 | 1995-08-01 | Research Foundation For Mental Hygiene, Inc. | Methods and compositions for treatment and diagnosis of alzheimer disease and other disorders |
| AU6580494A (en) * | 1994-05-11 | 1995-12-05 | P.N. Gerolymatos S.A. | Use of clioquinol for treating helicobacter, including (h. pylori), infections and related diseases |
| US5505958A (en) * | 1994-10-31 | 1996-04-09 | Algos Pharmaceutical Corporation | Transdermal drug delivery device and method for its manufacture |
-
1997
- 1997-08-08 PL PL97331822A patent/PL188838B1/pl not_active IP Right Cessation
- 1997-08-08 DE DE69706566T patent/DE69706566T2/de not_active Expired - Lifetime
- 1997-08-08 AU AU36324/97A patent/AU720643B2/en not_active Ceased
- 1997-08-08 CZ CZ2003491A patent/CZ295118B6/cs not_active IP Right Cessation
- 1997-08-08 KR KR10-1999-7001196A patent/KR100489969B1/ko not_active IP Right Cessation
- 1997-08-08 CN CN97197919A patent/CN1114407C/zh not_active Expired - Fee Related
- 1997-08-08 DK DK97932969T patent/DK0959888T3/da active
- 1997-08-08 SK SK179-99A patent/SK283117B6/sk not_active IP Right Cessation
- 1997-08-08 AT AT97932969T patent/ATE205086T1/de not_active IP Right Cessation
- 1997-08-08 JP JP10509541A patent/JP2000516606A/ja active Pending
- 1997-08-08 BR BR9711194-5A patent/BR9711194A/pt not_active Application Discontinuation
- 1997-08-08 CZ CZ1999484A patent/CZ292411B6/cs not_active IP Right Cessation
- 1997-08-08 WO PCT/IB1997/000983 patent/WO1998006403A1/en active IP Right Grant
- 1997-08-08 SI SI9730230T patent/SI0959888T1/xx unknown
- 1997-08-08 HU HU9903906A patent/HUP9903906A3/hu unknown
- 1997-08-08 EP EP97932969A patent/EP0959888B1/de not_active Expired - Lifetime
- 1997-08-08 NZ NZ334124A patent/NZ334124A/xx unknown
- 1997-08-08 TR TR1999/00293T patent/TR199900293T2/xx unknown
- 1997-08-08 ES ES97932969T patent/ES2162319T3/es not_active Expired - Lifetime
- 1997-08-08 CA CA002264097A patent/CA2264097C/en not_active Expired - Fee Related
- 1997-08-08 RU RU99105213/14A patent/RU2193406C2/ru not_active IP Right Cessation
- 1997-08-08 PT PT97932969T patent/PT959888E/pt unknown
- 1997-08-08 IL IL12841697A patent/IL128416A/en not_active IP Right Cessation
-
1998
- 1998-02-13 US US09/023,544 patent/US6001852A/en not_active Expired - Lifetime
-
1999
- 1999-02-09 NO NO19990595A patent/NO316768B1/no not_active Application Discontinuation
- 1999-02-10 IS IS4972A patent/IS1907B/is unknown
-
2000
- 2000-03-16 HK HK00101601A patent/HK1022437A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69706566D1 (de) | Verwendung von dem chelatbildner clioquinol zur herstellung eines arzneimittelszur behandlung von alzheimerschen krankheit | |
| DE69713620D1 (de) | Verwendung von arachidonsäure und/oder docohexaensäure zur herstellung eines arzneimittels zur behandlung von dyspraxia | |
| DE69424777T2 (de) | 3,4-diarylchromane zur behandlung von dermatitis | |
| ATE237610T1 (de) | Substituierte dimere carboxamid-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen | |
| ATE281162T1 (de) | Verwendung von gingko biloba extrakten zur herstellung eines arzneimittels zur behandlung der amyotrophen lateralsklerose | |
| GB9103764D0 (en) | Compositions | |
| HK1079688A1 (en) | Statin product for enhancing cognitive maintenance | |
| GEP20032914B (en) | Derivatives of 1,3,4-Oxadiazolone | |
| NO20000771D0 (no) | Anvendelse av fankinon for behandling av Alzheimers sykdom | |
| ATE548048T1 (de) | Oncomodulin zur behandlung von neurologishen erkrankungen | |
| DE69424415T2 (de) | Verwendung von efaroxan und dessen derivaten zur herstellung eines arzneimittels zur behandlung parkinsonscher krankheit | |
| ATE189385T1 (de) | Verwendung von benzonaphtalene-derivaten zur herstellung eines arzneimittels zur behandlung von krankheiten des nervensystems | |
| ATE186640T1 (de) | Verwendung von efaroxan und dessen derivaten zur herstellung eines arzneimittels zur behandlung neurogenerativer erkrankungen | |
| ATE201993T1 (de) | Verwendung von olanzapine zur herstellung eines arzneimittels zur behandlung der zerebralen fokalen ischämie | |
| MX9701528A (es) | Derivados de 1, 1, 2,- trifenilbut-1-eno para tratar la enfermedad de alzheimer. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |