SI0922048T1 - PROCESS FOR THE PREPARATION OF N- (1-n-BUTYL-4-PIPERIDINYL)METHYL) -3,4-DIHYDRO -2H-(1,3) OXAZINO(3,2-a) INDOLE-10-CARBOXAMIDE AND SALTS AND INTERMEDIATES IN THE PROCESS - Google Patents

PROCESS FOR THE PREPARATION OF N- (1-n-BUTYL-4-PIPERIDINYL)METHYL) -3,4-DIHYDRO -2H-(1,3) OXAZINO(3,2-a) INDOLE-10-CARBOXAMIDE AND SALTS AND INTERMEDIATES IN THE PROCESS

Info

Publication number
SI0922048T1
SI0922048T1 SI9730095T SI9730095T SI0922048T1 SI 0922048 T1 SI0922048 T1 SI 0922048T1 SI 9730095 T SI9730095 T SI 9730095T SI 9730095 T SI9730095 T SI 9730095T SI 0922048 T1 SI0922048 T1 SI 0922048T1
Authority
SI
Slovenia
Prior art keywords
oxazino
carboxamide
piperidinyl
indole
dihydro
Prior art date
Application number
SI9730095T
Other languages
English (en)
Inventor
Michael Fedouloff
Gillian Elizabeth Smith
David William Guest
John Bryce Strachan
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9617188.9A external-priority patent/GB9617188D0/en
Priority claimed from GBGB9618968.3A external-priority patent/GB9618968D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of SI0922048T1 publication Critical patent/SI0922048T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
SI9730095T 1996-08-16 1997-08-11 PROCESS FOR THE PREPARATION OF N- (1-n-BUTYL-4-PIPERIDINYL)METHYL) -3,4-DIHYDRO -2H-(1,3) OXAZINO(3,2-a) INDOLE-10-CARBOXAMIDE AND SALTS AND INTERMEDIATES IN THE PROCESS SI0922048T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9617188.9A GB9617188D0 (en) 1996-08-16 1996-08-16 Pharmaceuticals
GBGB9618968.3A GB9618968D0 (en) 1996-09-11 1996-09-11 Pharmaceuticals
PCT/EP1997/004413 WO1998007728A1 (en) 1996-08-16 1997-08-11 PROCESS FOR THE PREPARATION OF N-[(1-nBUTYL-4-PIPERIDYL)METHYL] -3,4-DIHYDRO -2H-[1,3] OXAZINO[3,2-a] INDOLE-10-CARBOXAMIDE AND SALTS AND INTERMEDIATES IN THE PROCESS
EP97940076A EP0922048B1 (en) 1996-08-16 1997-08-11 PROCESS FOR THE PREPARATION OF N- (1-n-BUTYL-4-PIPERIDINYL)METHYL] -3,4-DIHYDRO -2H-[1,3] OXAZINO[3,2-a] INDOLE-10-CARBOXAMIDE AND SALTS AND INTERMEDIATES IN THE PROCESS

Publications (1)

Publication Number Publication Date
SI0922048T1 true SI0922048T1 (en) 2001-02-28

Family

ID=26309880

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9730095T SI0922048T1 (en) 1996-08-16 1997-08-11 PROCESS FOR THE PREPARATION OF N- (1-n-BUTYL-4-PIPERIDINYL)METHYL) -3,4-DIHYDRO -2H-(1,3) OXAZINO(3,2-a) INDOLE-10-CARBOXAMIDE AND SALTS AND INTERMEDIATES IN THE PROCESS

Country Status (24)

Country Link
EP (1) EP0922048B1 (cs)
JP (1) JP3911297B2 (cs)
KR (1) KR100494278B1 (cs)
CN (1) CN1104435C (cs)
AR (1) AR008297A1 (cs)
AT (1) ATE197588T1 (cs)
AU (1) AU717177B2 (cs)
BR (1) BR9711189A (cs)
CA (1) CA2263480C (cs)
CZ (1) CZ290517B6 (cs)
DE (1) DE69703554T2 (cs)
DK (1) DK0922048T3 (cs)
ES (1) ES2151743T3 (cs)
GR (1) GR3034895T3 (cs)
IL (1) IL128499A (cs)
NO (1) NO311574B1 (cs)
NZ (1) NZ334064A (cs)
PL (1) PL185815B1 (cs)
PT (1) PT922048E (cs)
SA (1) SA97180430B1 (cs)
SI (1) SI0922048T1 (cs)
TR (1) TR199900321T2 (cs)
TW (1) TW427990B (cs)
WO (1) WO1998007728A1 (cs)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9815481D0 (en) * 1998-07-16 1998-09-16 Smithkline Beecham Plc Pharmaceuticals
US20020091271A1 (en) 1998-07-16 2002-07-11 Smithkline Beecham Plc Process for the preparation of an indole derivative
GB9815483D0 (en) * 1998-07-16 1998-09-16 Smithkline Beecham Plc Pharmaceuticals
US6277456B1 (en) * 1999-09-24 2001-08-21 Brady Worldwide, Inc. Labeling media and method of making
PL365048A1 (en) * 2000-08-07 2004-12-27 Laboratoire Glaxosmithkline S.A.S. Use of 5ht4 receptor antagonists in the manufacture of a medicament for the prophylaxis or treatment of atrial fibrillation
AU782863C (en) * 2000-08-07 2006-08-31 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU782870C (en) * 2000-08-07 2007-03-15 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
DE60306120T2 (de) * 2002-02-14 2006-11-09 Glaxo Group Ltd., Greenford Pharmazeutische formulierung, die n-((1-n-butyl-4-piperidinyl)menthyl)-3,4-dihydro-2h-(1,3)oxazino(3,2-a)indol-10-carboxamid oder ein entsprechendes salz hiervon enthält, sowie deren herstellungsprozess, welcher trockengranulierung beinhaltet
GB0211230D0 (en) 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
ITMI20030287A1 (it) 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20030972A1 (it) 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU671102B2 (en) * 1992-03-12 1996-08-15 Smithkline Beecham Plc Condensed indole derivatives as 5HT4-receptor antagonists

Also Published As

Publication number Publication date
NO311574B1 (no) 2001-12-10
CA2263480A1 (en) 1998-02-26
JP2000516240A (ja) 2000-12-05
EP0922048B1 (en) 2000-11-15
CZ51699A3 (cs) 1999-07-14
KR20000068174A (ko) 2000-11-25
AR008297A1 (es) 1999-12-29
PT922048E (pt) 2001-03-30
KR100494278B1 (ko) 2005-06-13
DE69703554D1 (de) 2000-12-21
CN1233250A (zh) 1999-10-27
TR199900321T2 (xx) 1999-04-21
TW427990B (en) 2001-04-01
ATE197588T1 (de) 2000-12-15
PL185815B1 (pl) 2003-08-29
NO990697L (no) 1999-02-15
ES2151743T3 (es) 2001-01-01
CA2263480C (en) 2007-03-06
HK1020731A1 (en) 2000-06-09
PL331647A1 (en) 1999-08-02
CZ290517B6 (cs) 2002-08-14
DK0922048T3 (da) 2001-01-08
NZ334064A (en) 2000-08-25
WO1998007728A1 (en) 1998-02-26
IL128499A0 (en) 2000-01-31
EP0922048A1 (en) 1999-06-16
AU717177B2 (en) 2000-03-16
GR3034895T3 (en) 2001-02-28
DE69703554T2 (de) 2001-07-05
IL128499A (en) 2002-11-10
SA97180430B1 (ar) 2006-10-29
JP3911297B2 (ja) 2007-05-09
NO990697D0 (no) 1999-02-15
AU4204897A (en) 1998-03-06
CN1104435C (zh) 2003-04-02
BR9711189A (pt) 1999-08-17

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